Orcinus orca (killer whale): 101271664
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Entry
101271664 CDS
T05247
Symbol
PDHA1
Name
(RefSeq) pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial isoform X1
KO
K00161
pyruvate dehydrogenase E1 component subunit alpha [EC:
1.2.4.1
]
Organism
oor
Orcinus orca (killer whale)
Pathway
oor00010
Glycolysis / Gluconeogenesis
oor00020
Citrate cycle (TCA cycle)
oor00620
Pyruvate metabolism
oor00785
Lipoic acid metabolism
oor01100
Metabolic pathways
oor01200
Carbon metabolism
oor01210
2-Oxocarboxylic acid metabolism
oor04066
HIF-1 signaling pathway
oor04922
Glucagon signaling pathway
oor05230
Central carbon metabolism in cancer
oor05415
Diabetic cardiomyopathy
Module
oor_M00307
Pyruvate oxidation, pyruvate => acetyl-CoA
Brite
KEGG Orthology (KO) [BR:
oor00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00010 Glycolysis / Gluconeogenesis
101271664 (PDHA1)
00020 Citrate cycle (TCA cycle)
101271664 (PDHA1)
00620 Pyruvate metabolism
101271664 (PDHA1)
09108 Metabolism of cofactors and vitamins
00785 Lipoic acid metabolism
101271664 (PDHA1)
09130 Environmental Information Processing
09132 Signal transduction
04066 HIF-1 signaling pathway
101271664 (PDHA1)
09150 Organismal Systems
09152 Endocrine system
04922 Glucagon signaling pathway
101271664 (PDHA1)
09160 Human Diseases
09161 Cancer: overview
05230 Central carbon metabolism in cancer
101271664 (PDHA1)
09166 Cardiovascular disease
05415 Diabetic cardiomyopathy
101271664 (PDHA1)
Enzymes [BR:
oor01000
]
1. Oxidoreductases
1.2 Acting on the aldehyde or oxo group of donors
1.2.4 With a disulfide as acceptor
1.2.4.1 pyruvate dehydrogenase (acetyl-transferring)
101271664 (PDHA1)
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Motif
Pfam:
E1_dh
DXP_synthase_N
TPP_enzyme_C
Motif
Other DBs
NCBI-GeneID:
101271664
NCBI-ProteinID:
XP_033273273
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All DBs
Position
X:16575299..16648828
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AA seq
390 aa
AA seq
DB search
MRKMLAAVSRVLLGVAQKPASRVLVASRNFANDATFEIKKCDLHRLEEGPPVTTVLTRED
GLKYYRMMQTVRRMELKADQLYKQKIIRGFCHLCDGQEACCVGLEAGINPTDHLITAYRA
HGFTFTRGLSVRAILAELTGRRGGCAKGKGGSMHMYAKNFYGGNGIVGAQVPLGAGIALA
CKYNGKDEICLTLYGDGAANQGQIFEAYNMAALWKLPCIFICENNRYGMGTSVERAAAST
DYYKRGDFIPGLRVDGMDILCVREATRFAAAYCRAGKGPILMELQTYRYHGHSMSDPGVS
YRTREEIQEVRSKSDPIMLLKDRMVNSNLASVEELKEIDVDVRKEIEDAAQFATADPEPP
LEELGYHIYCSDLPFEVRGANQWIKFKSIS
NT seq
1173 nt
NT seq
+upstream
nt +downstream
nt
atgaggaagatgctcgccgccgtctcccgcgtgttgttgggcgtcgcccagaagccggca
agcagagtgctggtggcatcccgtaattttgcaaatgatgctacatttgaaattaagaaa
tgtgatcttcaccggctggaagagggccctcctgtcactacggtgctcaccagggaggat
gggctcaaatactacaggatgatgcagactgttcgtcgaatggagttaaaagcagatcag
ctatataaacagaaaattattcgtggtttctgtcacttgtgtgatggtcaggaagcttgt
tgtgtgggcctggaggccggcataaaccccacagaccatctgatcacagcatatcgggct
cacggctttacgtttactcgtgggctttctgtccgagcaattctcgcagagcttacagga
cgaagaggaggttgtgctaaaggaaaaggaggatcgatgcatatgtacgccaagaacttc
tacgggggcaatggcatcgtgggagctcaggtgcccctgggagctgggattgctctggcc
tgtaagtataacggaaaagatgaaatctgtttgactttgtatggtgatggcgctgctaat
cagggtcagatattcgaagcttacaatatggcggctttgtggaaattgccttgtattttc
atctgtgagaataaccgctatgggatgggaacatctgtggagagagcagcagccagcact
gattactacaagagaggcgacttcattcctgggctgagggtagatggaatggatatcctg
tgtgtccgggaggccacaaggtttgcagctgcctattgtagagctggaaaggggcccata
ctgatggagctgcagacttaccgttaccatgggcacagcatgagtgatcctggagtcagt
taccgtacacgagaagaaattcaggaagttagaagtaagagcgaccctatcatgcttctc
aaggataggatggtgaacagcaatctggccagtgttgaagaactaaaggaaattgatgtt
gacgtgagaaaagaaattgaggatgctgcccagtttgctacagctgaccctgaaccacct
ttggaagaactcggctatcacatctactgcagcgatctgccttttgaagtccggggtgca
aaccagtggatcaagtttaagtccatcagttaa
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