Orcinus orca (killer whale): 101283355 Help Entry 101283355         CDS       T05247                                  Symbol INSR Name (RefSeq) insulin receptor isoform X1   KO K04527   insulin receptor [EC:2.7.10.1] Organism oor  Orcinus orca (killer whale) Pathway oor04010   MAPK signaling pathway oor04014   Ras signaling pathway oor04015   Rap1 signaling pathway oor04022   cGMP-PKG signaling pathway oor04066   HIF-1 signaling pathway oor04068   FoxO signaling pathway oor04072   Phospholipase D signaling pathway oor04150   mTOR signaling pathway oor04151   PI3K-Akt signaling pathway oor04152   AMPK signaling pathway oor04211   Longevity regulating pathway oor04213   Longevity regulating pathway - multiple species oor04520   Adherens junction oor04910   Insulin signaling pathway oor04913   Ovarian steroidogenesis oor04923   Regulation of lipolysis in adipocytes oor04930   Type II diabetes mellitus oor04931   Insulin resistance oor04932   Non-alcoholic fatty liver disease oor04960   Aldosterone-regulated sodium reabsorption oor05010   Alzheimer disease oor05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:oor00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     101283355 (INSR)    04014 Ras signaling pathway     101283355 (INSR)    04015 Rap1 signaling pathway     101283355 (INSR)    04066 HIF-1 signaling pathway     101283355 (INSR)    04068 FoxO signaling pathway     101283355 (INSR)    04072 Phospholipase D signaling pathway     101283355 (INSR)    04022 cGMP-PKG signaling pathway     101283355 (INSR)    04151 PI3K-Akt signaling pathway     101283355 (INSR)    04152 AMPK signaling pathway     101283355 (INSR)    04150 mTOR signaling pathway     101283355 (INSR)  09140 Cellular Processes   09144 Cellular community - eukaryotes    04520 Adherens junction     101283355 (INSR)  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     101283355 (INSR)    04923 Regulation of lipolysis in adipocytes     101283355 (INSR)    04913 Ovarian steroidogenesis     101283355 (INSR)   09155 Excretory system    04960 Aldosterone-regulated sodium reabsorption     101283355 (INSR)   09149 Aging    04211 Longevity regulating pathway     101283355 (INSR)    04213 Longevity regulating pathway - multiple species     101283355 (INSR)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     101283355 (INSR)   09166 Cardiovascular disease    05415 Diabetic cardiomyopathy     101283355 (INSR)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     101283355 (INSR)    04932 Non-alcoholic fatty liver disease     101283355 (INSR)    04931 Insulin resistance     101283355 (INSR)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:oor01001]     101283355 (INSR)   09183 Protein families: signaling and cellular processes    04090 CD molecules [BR:oor04090]     101283355 (INSR) Enzymes [BR:oor01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.1  receptor protein-tyrosine kinase      101283355 (INSR) Protein kinases [BR:oor01001]  Receptor tyrosine kinases (RTK)   INSR family [OT]    101283355 (INSR) CD molecules [BR:oor04090]  Proteins   101283355 (INSR) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  PK_Tyr_Ser-Thr Recep_L_domain Pkinase Furin-like Insulin_TMD fn3 Kinase-like DUF4476 B2 Motif Other DBs NCBI-GeneID:  101283355 NCBI-ProteinID:  XP_004277332 LinkDB All DBs Position 3:complement(5299282..5428749) Genome browser AA seq 1382 aa AA seqDB search MGAGGGRGAAAVPLLVAVAALLVGAAGHLYPGEVCPGMDIRNNLTRLHELANCSVIEGHL QILLMFKTRPEDFRDLSFPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYAL VIFEMVHLKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKDDNE ECGDICPGAAKGKTNCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTAEGLCCHSECL GNCSEPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFCQDLHNKCKNSRRQG CHQYVIHNNKCIPECPSGYTMNSSNLMCTPCLGPCPKVCHLLEGEKTIDSVTSAQELRGC TIINGSLIINIRGGNNLAAELEANLGLIEEISGYLKIRRSYALVSLSFFRKLRLIRGETL EIGNYSFYALDNQNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQE RNDIALKTNGDQASCENELLKFSYIRTSYDKILLKWEPYWPPDFRDLLGFMLFYKEAPYQ NVTEFDGQDACGSNSWTVVDIDPPMRSNDPKSQNHPGWLMRGLKPWTQYAIFVKTLVTFS DERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVFWE RQEEDGELYELDYCLKGLKLPSRTWSPPFESEGSQKHNQSEYEESAGECCSCPKTDSQIL KELEESSFRKTFEDYLHNVVFIPRKSSSGPVAEDTRPSRKRRALGDVGNMTAAVPTIPGF PNTSSTSAPTSSEEHRPFEKVVNKESLVISGLRHFTGYRIELQACNQDSPEERCSVAAYV SARTMPEAKADDIVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGEEELHLCV SRRHFALERGCRLRGLPPGNYSVRVRATSLAGNGSWTEATYFYVTDYLDMPSNIAKIIIG PLIFVFLFSVVIGSIYLFLRKRQPDGPLGPLYASSNPEYLSASDVFPCSVYVPDEWEVPR EKITLLRELGQGSFGMVYEGNARDIVKGEAETRVAVKTVNESASLRERIEFLNEASVMKG FTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMA AEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPV RWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGFLDQPDN CPERVTDLMRMCWQFNPKMRPTFLEIVDLLKDELHPSFPEVSFFHSEENKVPESEELEME FEDMESVPLDRSSHVQREEAGGRDGGSALGLKRNYQEHIPYTHMNGGKKNGRILTLPRSN PS NT seq 4149 nt NT seq  +upstreamnt  +downstreamnt atgggcgccgggggcgggcggggggcggcggccgtgccactgctggtggccgttgccgcg ctgctggtgggcgccgcgggccacctgtaccctggagaggtgtgccccggcatggatatc cggaataacctcacccggctgcacgagctggccaactgctcggtcatcgaaggacatttg cagatcctattgatgttcaaaacgagacctgaggacttccgagacctcagtttccccaag ctcatcatgatcactgattacttgctgctcttccgggtctatgggctggagagcctgaag gacctgttccccaacctcacggtcatccggggctcccgcctcttctttaactacgcgctg gtcatcttcgagatggttcacctgaaggagcttggcctctacaacttgatgaacattacc cggggctccgttcgcatcgagaagaacaatgaactctgctacctggccactatcgactgg tctcgcatcctggattccgtggaggataattacatcgtgctgaacaaagacgacaatgag gagtgtggggacatttgtccaggcgctgcgaagggcaagaccaactgccctgccaccgtc atcaacgggcaatttgtggagcggtgttggacgcacagccactgccagaaagtgtgtccg accatctgtaagtctcacggctgcaccgctgagggtctctgttgccacagtgagtgcttg ggcaactgctctgagcctgacgaccccaccaagtgtgtggcctgtcgcaacttctacctg gatggcaggtgcgtggagacctgcccgcccccctactaccacttccaagactggcgctgt gtgaacttcagcttctgccaggacctgcacaacaaatgcaagaactctcggaggcagggc tgccaccagtatgtcattcacaataacaagtgcatccctgagtgcccctccgggtacacg atgaattccagcaacttgatgtgtactccatgcctgggcccctgtcccaaggtgtgccac ctcctggaaggcgagaagaccattgactcagtgacatctgcccaggagctccgaggctgc accatcatcaacggaagcttaatcatcaacattcgagggggcaacaacctggcagctgag ctagaggccaaccttggactcattgaagaaatttcagggtatctgaaaatccgccgatca tatgccctcgtgtcactttccttcttccggaagttacgtctgattcgaggggagaccttg gaaatcgggaactactctttctatgccttggacaaccagaacctaaggcagctgtgggac tggagcaaacacaacctcaccatcactcaggggaaactcttcttccactataatcccaaa ctctgcttgtcagaaattcacaagatggaggaagtttcaggaaccaaggggcgccaggag agaaacgacattgccctgaagaccaatggggaccaggcgtcctgtgaaaatgaattactt aaattttcttacattcggacatcttatgacaagatcttgctgaaatgggagccgtattgg ccccccgacttccgagacctcctgggattcatgctcttctacaaagaggccccttatcag aacgtgacggagtttgatgggcaggatgcatgtggctccaacagctggaccgtggtagat attgacccgcctatgaggtccaacgaccccaagtcacagaaccaccccgggtggctaatg cgtggtctcaagccctggacccagtacgccatctttgtcaagaccttggtcactttctct gatgaacgccgcacatacggggccaagagcgacatcatctatgtccagacagatgccact aatccttctgtccccctggatcccatctcggtgtctaattcttcgtctcagattattctg aagtggaagcctccctctgaccccaatggcaacatcacacactacttggtattctgggag agacaggaggaagacggtgaactgtatgaattagattattgcctcaaagggttgaagctg ccctcccggacctggtctccaccgttcgagtctgaggggtcccagaagcacaatcagagt gagtacgaagagtctgccggtgaatgctgttcctgcccgaagaccgactctcagatcctc aaggagttggaggagtcctcattcaggaaaacattcgaagattacctgcacaatgtcgtt ttcatccccagaaaatcctcttcaggccctgttgccgaggacactaggccgtcgaggaaa cgcagggccctcggtgatgtggggaatatgacagcggccgtgcccaccattccaggattc cccaatacgtcctcaaccagcgcacctacgagctcagaggagcacagaccattcgagaaa gtggtgaacaaggagtctctggtcatctctggcctgcgtcactttactggctatcgcatt gagctgcaggcttgcaaccaggattcccccgaggagaggtgcagcgtggctgcatacgtc agtgccaggaccatgcccgaagccaaggcagatgatattgttggccccgtgacccacgaa atcttcgagaacaacgtcgttcacttgatgtggcaggagcccaaggaacccaacggtctg atcgtgctgtacgaagtgagttatcgacgatacggcgaagaggagctgcacctctgcgtc tcccgcaggcattttgctctggagcggggctgcaggctgcgtggtctgccacccgggaat tacagtgtgcgagttcgggccacctccctggcgggcaatggctcttggacggaagccacc tatttctacgtcacagactatttagacatgccatcaaatattgcaaaaattatcatcggg cccctcatctttgtctttctcttcagtgtcgtgatcgggagtatttatctattcctgaga aagaggcagccggatgggccactgggaccactgtatgcttcttcaaaccccgagtacctc agtgccagcgatgtgtttccctgctctgtgtacgtgccggatgagtgggaggtgcctcga gagaagatcacgctcctgcgagaactggggcagggctccttcggcatggtgtacgagggc aacgccagggacattgtcaagggtgaggcggagacccgagtggcggtgaagacggtgaac gagtctgccagcctgcgagagcggatcgaatttctcaacgaggcctcagtcatgaagggc ttcacctgccaccacgtggtccgcctcctgggggtggtatccaaaggccagccgacgctc gtggtgatggagctgatggctcatggggacttgaagagctacctccgttccctgcggcct gaggccgagaataaccccggccgccctccccctaccctgcaagagatgattcagatggct gcggagatcgccgacgggatggcgtacctgaacgccaagaagtttgtacaccgggacctc gcagctcgaaactgcatggttgcccacgattttaccgtcaaaattggagactttggaatg accagagacatctacgaaacggattactaccggaaagggggaaagggtctgctccccgtg cggtggatggcacctgaatcgctgaaggacggggtctttaccacttcttcggacatgtgg tcctttggcgtggtcctttgggaaattaccagcttggcggaacagccttaccaaggccta tcaaacgagcaggtgttaaaatttgtcatggatggagggtttctggatcaacccgacaac tgtcctgagagagtcaccgacctgatgcgcatgtgttggcagttcaaccccaagatgcgg ccgaccttcctggaaattgtcgacctgctcaaggacgagctgcaccccagttttcccgaa gtttccttcttccacagcgaggagaacaaggtgcccgagagcgaggagctggagatggaa tttgaggacatggagagtgtccccctggaccggtcctcacatgtgcagagggaggaggcc gggggccgggatggagggtccgcactggggctaaagagaaactatcaggaacacatcccc tacacccacatgaacgggggcaagaaaaacggacgcattctgactctgccccggtctaat ccttcctaa

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