Cutibacterium acnes KPA171202: PPA0323
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Entry
PPA0323 CDS
T00188
Name
(GenBank) uroporphyrinogen-III synthase, HemD
KO
K13542
uroporphyrinogen III methyltransferase / synthase [EC:
2.1.1.107
4.2.1.75
]
Organism
pac
Cutibacterium acnes KPA171202
Pathway
pac00860
Porphyrin metabolism
pac01100
Metabolic pathways
pac01110
Biosynthesis of secondary metabolites
pac01120
Microbial metabolism in diverse environments
pac01240
Biosynthesis of cofactors
Brite
KEGG Orthology (KO) [BR:
pac00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00860 Porphyrin metabolism
PPA0323
Enzymes [BR:
pac01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.107 uroporphyrinogen-III C-methyltransferase
PPA0323
4. Lyases
4.2 Carbon-oxygen lyases
4.2.1 Hydro-lyases
4.2.1.75 uroporphyrinogen-III synthase
PPA0323
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Gene cluster
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Motif
Pfam:
HEM4
TP_methylase
B12-binding
Motif
Other DBs
NCBI-ProteinID:
AAT82078
UniProt:
Q6AAY8
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Position
372405..374120
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AA seq
571 aa
AA seq
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MTDEAHQPTPQPAGDLGTASSQARVQFVGTGPGDPNLLTLGAVDAINRAQVIVISCAEHR
MLLGSDFLGLRPDVRIVLAGGVDEEAAVLPSQPGTGAPTPVDVDEHCADVTATVIDAASQ
GLEVVRLVSGDPFLDGDIGAEAAAVARADYDVDVVPGVTGMTAVPEYAGLTLHGHDVQLI
GDAACQRDIAGHGSNWSDQGLVVVNTEAGKLKEVVKHAIESGRGEDEPAALICHGATTQQ
TTHTVTLGELPQTAKTARLGDAEPVHVAIGKVVEAPEREQLDWYESKPLFGWNILIPRTR
DHSATLPSRLQSYGAHSLDVPTISMEPPRTPQQMDKAIRGLVEGRYEWVVFTSANAVRAV
SEKLEQIGLDARAYSGLRIAAIFDSTINALAEWGVRPDFVPSGEQSTRALAAVFPAFDEA
LDPINRVFVPRADIATESLSADLSELGWEVEDVVGYRTVRAAPPPAETREAIKTGKFDAV
VFTSSTTVRNLVGIAGKPHKHTVVAAVGMRTAETCREHGLTVDVIAPEPTALSLADALAD
FAAKRRDDMVAKGLPVVRPSQRKRRGRHPSR
NT seq
1716 nt
NT seq
+upstream
nt +downstream
nt
atgactgacgaggctcaccagccgacgccgcagccggccggtgatctgggcactgcgtcg
tctcaggccagggtgcagtttgtgggtaccggtccaggagatccgaatctgttgaccctt
ggagctgttgacgccatcaatcgcgctcaggtcatcgtcatttcgtgcgctgagcaccgc
atgctgctgggcagtgattttcttggacttcgccccgacgtcagaatcgtgttggcgggt
ggtgttgatgaagaagccgccgtcctacccagtcagccagggactggcgctccgactccc
gtcgacgtggacgaacactgcgctgacgttactgccaccgttattgatgccgcctcccaa
ggccttgaagtcgttcgtctcgtttctggggatcctttccttgatggcgatattggcgcg
gaggctgccgctgtggctcgcgctgattatgacgtcgacgttgttcccggtgtcactggc
atgaccgctgtcccggagtacgccggactgaccttgcatggccatgacgtccagctcatc
ggggacgctgcatgtcagcgcgatattgctggacatggttcgaactggtcagatcagggg
cttgtcgtcgtcaataccgaggcaggcaagcttaaagaagtcgtcaaacacgcgattgaa
tctggacgcggtgaggatgagcccgcggcccttatctgccatggcgcgacgacccagcag
accactcataccgtcaccctcggtgagttaccacagaccgctaagacagcgcgcctgggt
gacgctgagccggttcacgtcgccatcggcaaagttgtcgaagcccccgaacgtgagcag
ctcgattggtacgagtccaagccgttatttggctggaacattctcatcccgcgcacccgt
gaccactccgcgaccctgccctcgcgactacagagttacggtgctcattcccttgatgtt
cccacgatttcgatggagcctccgcgtactcctcagcagatggataaagctattcgcggt
cttgttgagggacgttacgagtgggtcgtctttacttctgccaacgcggtacgtgccgtt
tcggagaagctagagcagatcggtctggacgctcgcgcgtactcaggcttgcggattgcc
gcgatcttcgactcgactatcaacgctttggctgaatggggtgttcgacccgatttcgtg
ccatcgggcgagcagtccacccgagctctggccgcggtattcccggcctttgacgaggcc
ctcgaccccattaaccgcgttttcgtgccgcgtgccgacatcgccactgagtccctgtcg
gccgacctatctgaactgggatgggaggtcgaagacgtcgtcgggtatcgcaccgtgcga
gctgccccgccgccagctgagacccgtgaagccattaagaccggcaaattcgacgccgtc
gtgtttacctcctcgacgactgtgcgcaacctcgtcggtattgccggaaaaccacataag
cacaccgtggtcgccgccgttggtatgcgcaccgctgaaacctgccgtgagcacggcctg
accgtcgatgtcatagcccccgagccgactgcgttgagcttggctgacgccttggcggat
ttcgctgcgaagcgccgtgacgacatggttgccaagggcctgccggtagttcggccctcc
cagcgcaagcgtcgtggccgtcatccgtcacgctga
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