Papio anubis (olive baboon): 101008394
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Entry
101008394 CDS
T07474
Symbol
MAP2K1
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 1 isoform X1
KO
K04368
mitogen-activated protein kinase kinase 1 [EC:
2.7.12.2
]
Organism
panu
Papio anubis (olive baboon)
Pathway
panu01521
EGFR tyrosine kinase inhibitor resistance
panu01522
Endocrine resistance
panu04010
MAPK signaling pathway
panu04012
ErbB signaling pathway
panu04014
Ras signaling pathway
panu04015
Rap1 signaling pathway
panu04022
cGMP-PKG signaling pathway
panu04024
cAMP signaling pathway
panu04062
Chemokine signaling pathway
panu04066
HIF-1 signaling pathway
panu04068
FoxO signaling pathway
panu04071
Sphingolipid signaling pathway
panu04072
Phospholipase D signaling pathway
panu04114
Oocyte meiosis
panu04140
Autophagy - animal
panu04148
Efferocytosis
panu04150
mTOR signaling pathway
panu04151
PI3K-Akt signaling pathway
panu04210
Apoptosis
panu04218
Cellular senescence
panu04270
Vascular smooth muscle contraction
panu04370
VEGF signaling pathway
panu04371
Apelin signaling pathway
panu04380
Osteoclast differentiation
panu04510
Focal adhesion
panu04540
Gap junction
panu04550
Signaling pathways regulating pluripotency of stem cells
panu04613
Neutrophil extracellular trap formation
panu04620
Toll-like receptor signaling pathway
panu04650
Natural killer cell mediated cytotoxicity
panu04660
T cell receptor signaling pathway
panu04662
B cell receptor signaling pathway
panu04664
Fc epsilon RI signaling pathway
panu04666
Fc gamma R-mediated phagocytosis
panu04668
TNF signaling pathway
panu04720
Long-term potentiation
panu04722
Neurotrophin signaling pathway
panu04725
Cholinergic synapse
panu04726
Serotonergic synapse
panu04730
Long-term depression
panu04810
Regulation of actin cytoskeleton
panu04910
Insulin signaling pathway
panu04912
GnRH signaling pathway
panu04914
Progesterone-mediated oocyte maturation
panu04915
Estrogen signaling pathway
panu04916
Melanogenesis
panu04917
Prolactin signaling pathway
panu04919
Thyroid hormone signaling pathway
panu04921
Oxytocin signaling pathway
panu04926
Relaxin signaling pathway
panu04928
Parathyroid hormone synthesis, secretion and action
panu04929
GnRH secretion
panu04934
Cushing syndrome
panu04935
Growth hormone synthesis, secretion and action
panu05010
Alzheimer disease
panu05022
Pathways of neurodegeneration - multiple diseases
panu05034
Alcoholism
panu05132
Salmonella infection
panu05135
Yersinia infection
panu05160
Hepatitis C
panu05161
Hepatitis B
panu05163
Human cytomegalovirus infection
panu05164
Influenza A
panu05165
Human papillomavirus infection
panu05166
Human T-cell leukemia virus 1 infection
panu05167
Kaposi sarcoma-associated herpesvirus infection
panu05170
Human immunodeficiency virus 1 infection
panu05200
Pathways in cancer
panu05205
Proteoglycans in cancer
panu05206
MicroRNAs in cancer
panu05207
Chemical carcinogenesis - receptor activation
panu05208
Chemical carcinogenesis - reactive oxygen species
panu05210
Colorectal cancer
panu05211
Renal cell carcinoma
panu05212
Pancreatic cancer
panu05213
Endometrial cancer
panu05214
Glioma
panu05215
Prostate cancer
panu05216
Thyroid cancer
panu05218
Melanoma
panu05219
Bladder cancer
panu05220
Chronic myeloid leukemia
panu05221
Acute myeloid leukemia
panu05223
Non-small cell lung cancer
panu05224
Breast cancer
panu05225
Hepatocellular carcinoma
panu05226
Gastric cancer
panu05230
Central carbon metabolism in cancer
panu05231
Choline metabolism in cancer
panu05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:
panu00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
101008394 (MAP2K1)
04012 ErbB signaling pathway
101008394 (MAP2K1)
04014 Ras signaling pathway
101008394 (MAP2K1)
04015 Rap1 signaling pathway
101008394 (MAP2K1)
04370 VEGF signaling pathway
101008394 (MAP2K1)
04371 Apelin signaling pathway
101008394 (MAP2K1)
04668 TNF signaling pathway
101008394 (MAP2K1)
04066 HIF-1 signaling pathway
101008394 (MAP2K1)
04068 FoxO signaling pathway
101008394 (MAP2K1)
04072 Phospholipase D signaling pathway
101008394 (MAP2K1)
04071 Sphingolipid signaling pathway
101008394 (MAP2K1)
04024 cAMP signaling pathway
101008394 (MAP2K1)
04022 cGMP-PKG signaling pathway
101008394 (MAP2K1)
04151 PI3K-Akt signaling pathway
101008394 (MAP2K1)
04150 mTOR signaling pathway
101008394 (MAP2K1)
09140 Cellular Processes
09141 Transport and catabolism
04140 Autophagy - animal
101008394 (MAP2K1)
04148 Efferocytosis
101008394 (MAP2K1)
09143 Cell growth and death
04114 Oocyte meiosis
101008394 (MAP2K1)
04210 Apoptosis
101008394 (MAP2K1)
04218 Cellular senescence
101008394 (MAP2K1)
09144 Cellular community - eukaryotes
04510 Focal adhesion
101008394 (MAP2K1)
04540 Gap junction
101008394 (MAP2K1)
04550 Signaling pathways regulating pluripotency of stem cells
101008394 (MAP2K1)
09142 Cell motility
04810 Regulation of actin cytoskeleton
101008394 (MAP2K1)
09150 Organismal Systems
09151 Immune system
04613 Neutrophil extracellular trap formation
101008394 (MAP2K1)
04620 Toll-like receptor signaling pathway
101008394 (MAP2K1)
04650 Natural killer cell mediated cytotoxicity
101008394 (MAP2K1)
04660 T cell receptor signaling pathway
101008394 (MAP2K1)
04662 B cell receptor signaling pathway
101008394 (MAP2K1)
04664 Fc epsilon RI signaling pathway
101008394 (MAP2K1)
04666 Fc gamma R-mediated phagocytosis
101008394 (MAP2K1)
04062 Chemokine signaling pathway
101008394 (MAP2K1)
09152 Endocrine system
04910 Insulin signaling pathway
101008394 (MAP2K1)
04929 GnRH secretion
101008394 (MAP2K1)
04912 GnRH signaling pathway
101008394 (MAP2K1)
04915 Estrogen signaling pathway
101008394 (MAP2K1)
04914 Progesterone-mediated oocyte maturation
101008394 (MAP2K1)
04917 Prolactin signaling pathway
101008394 (MAP2K1)
04921 Oxytocin signaling pathway
101008394 (MAP2K1)
04926 Relaxin signaling pathway
101008394 (MAP2K1)
04935 Growth hormone synthesis, secretion and action
101008394 (MAP2K1)
04919 Thyroid hormone signaling pathway
101008394 (MAP2K1)
04928 Parathyroid hormone synthesis, secretion and action
101008394 (MAP2K1)
04916 Melanogenesis
101008394 (MAP2K1)
09153 Circulatory system
04270 Vascular smooth muscle contraction
101008394 (MAP2K1)
09156 Nervous system
04725 Cholinergic synapse
101008394 (MAP2K1)
04726 Serotonergic synapse
101008394 (MAP2K1)
04720 Long-term potentiation
101008394 (MAP2K1)
04730 Long-term depression
101008394 (MAP2K1)
04722 Neurotrophin signaling pathway
101008394 (MAP2K1)
09158 Development and regeneration
04380 Osteoclast differentiation
101008394 (MAP2K1)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
101008394 (MAP2K1)
05206 MicroRNAs in cancer
101008394 (MAP2K1)
05205 Proteoglycans in cancer
101008394 (MAP2K1)
05207 Chemical carcinogenesis - receptor activation
101008394 (MAP2K1)
05208 Chemical carcinogenesis - reactive oxygen species
101008394 (MAP2K1)
05230 Central carbon metabolism in cancer
101008394 (MAP2K1)
05231 Choline metabolism in cancer
101008394 (MAP2K1)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
101008394 (MAP2K1)
09162 Cancer: specific types
05210 Colorectal cancer
101008394 (MAP2K1)
05212 Pancreatic cancer
101008394 (MAP2K1)
05225 Hepatocellular carcinoma
101008394 (MAP2K1)
05226 Gastric cancer
101008394 (MAP2K1)
05214 Glioma
101008394 (MAP2K1)
05216 Thyroid cancer
101008394 (MAP2K1)
05221 Acute myeloid leukemia
101008394 (MAP2K1)
05220 Chronic myeloid leukemia
101008394 (MAP2K1)
05218 Melanoma
101008394 (MAP2K1)
05211 Renal cell carcinoma
101008394 (MAP2K1)
05219 Bladder cancer
101008394 (MAP2K1)
05215 Prostate cancer
101008394 (MAP2K1)
05213 Endometrial cancer
101008394 (MAP2K1)
05224 Breast cancer
101008394 (MAP2K1)
05223 Non-small cell lung cancer
101008394 (MAP2K1)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
101008394 (MAP2K1)
05170 Human immunodeficiency virus 1 infection
101008394 (MAP2K1)
05161 Hepatitis B
101008394 (MAP2K1)
05160 Hepatitis C
101008394 (MAP2K1)
05164 Influenza A
101008394 (MAP2K1)
05163 Human cytomegalovirus infection
101008394 (MAP2K1)
05167 Kaposi sarcoma-associated herpesvirus infection
101008394 (MAP2K1)
05165 Human papillomavirus infection
101008394 (MAP2K1)
09171 Infectious disease: bacterial
05132 Salmonella infection
101008394 (MAP2K1)
05135 Yersinia infection
101008394 (MAP2K1)
09164 Neurodegenerative disease
05010 Alzheimer disease
101008394 (MAP2K1)
05022 Pathways of neurodegeneration - multiple diseases
101008394 (MAP2K1)
09165 Substance dependence
05034 Alcoholism
101008394 (MAP2K1)
09167 Endocrine and metabolic disease
04934 Cushing syndrome
101008394 (MAP2K1)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
101008394 (MAP2K1)
01522 Endocrine resistance
101008394 (MAP2K1)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
panu01001
]
101008394 (MAP2K1)
Enzymes [BR:
panu01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.12 Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
2.7.12.2 mitogen-activated protein kinase kinase
101008394 (MAP2K1)
Protein kinases [BR:
panu01001
]
Serine/threonine kinases: STE group
STE7 family
101008394 (MAP2K1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Pkinase
PK_Tyr_Ser-Thr
ABC1
Pkinase_fungal
Kinase-like
Seadorna_VP7
Haspin_kinase
Motif
Other DBs
NCBI-GeneID:
101008394
NCBI-ProteinID:
XP_003901137
Ensembl:
ENSPANG00000016664
UniProt:
A0A2I3LF26
LinkDB
All DBs
Position
7:complement(122753820..122863781)
Genome browser
AA seq
393 aa
AA seq
DB search
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY
SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY
GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF
IKRSDAEEVDFAGWLCSTIGLHQPSTPTHAAGV
NT seq
1182 nt
NT seq
+upstream
nt +downstream
nt
atgcccaagaagaagccgacgcccatccagctgaacccggcccccgacggctccgcggtt
aacgggaccagctctgcggagaccaacttggaggccttgcagaagaagctggaggagcta
gagcttgatgagcagcagcgaaagcgccttgaggcctttctcacccagaagcagaaggtg
ggagaattgaaggatgacgactttgagaagatcagtgagctgggggccggcaatggtggt
gtggtgttcaaggtctcccacaagccttctggcctggtcatggccagaaagctaattcat
ctggagatcaaacccgcaatccggaaccagatcataagggaactgcaggttctgcatgag
tgcaactctccatacatcgtgggcttctatggtgcattctacagtgatggcgagatcagt
atctgcatggagcacatggatggaggttctctggatcaagtcctgaagaaagctggaaga
attcctgaacaaattttaggaaaagttagcattgctgtaataaaaggcctgacatatctg
agggagaagcacaagatcatgcacagagatgtcaagccctccaacatcctagtcaactcc
cgtggggagatcaagctctgtgactttggggtcagcgggcagctcatcgactccatggcc
aactccttcgtgggcacaaggtcctacatgtcgccagaaagactccaggggactcattac
tctgtgcagtcagacatctggagcatgggactgtctctggtagagatggcggttgggagg
tatcccatccctcctccagatgccaaggagctggaactgatgtttgggtgccaggtggag
ggagatgcggctgagaccccacctaggccaaggacccccgggaggccccttagctcatat
ggaatggacagccgacctcccatggcaatttttgagttgttggattacatagtcaacgag
cctcctccaaaattgcccagtggagttttcagtctggaatttcaagattttgtgaataaa
tgcttaataaaaaaccccgcagagagagcagatttgaagcaactcatggttcatgctttt
atcaagagatctgatgctgaggaagtggattttgcaggttggctctgctccactatcggc
cttcaccagcccagcacaccaacccatgctgctggcgtctaa
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