KEGG   PATHWAY: aalt03040
Entry
aalt03040                   Pathway                                
Name
Spliceosome - Alternaria alternata
Description
After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified.
Class
Genetic Information Processing; Transcription
Pathway map
aalt03040  Spliceosome
aalt03040

Other DBs
GO: 0005681
Organism
Alternaria alternata [GN:aalt]
Gene
CC77DRAFT_1059872  P-loop containing nucleoside triphosphate hydrolase protein [KO:K12811] [EC:5.6.2.7]
CC77DRAFT_980139  ATP-dependent RNA helicase-like protein sub2 [KO:K12812] [EC:5.6.2.7]
CC77DRAFT_947309  P-loop containing nucleoside triphosphate hydrolase protein [KO:K12813] [EC:5.6.2.6]
CC77DRAFT_923999  transcriptional repressor rco-1 [KO:K12816]
CC77DRAFT_1020618  P-loop containing nucleoside triphosphate hydrolase protein [KO:K12818] [EC:5.6.2.6]
CC77DRAFT_1015153  pre-mRNA-splicing factor SLU7 [KO:K12819]
CC77DRAFT_960229  pre-mRNA splicing factor ATP-dependent RNA helicase PRP16 [KO:K12820] [EC:5.6.2.6]
CC77DRAFT_1019772  Sm-like ribonucleo protein [KO:K11086]
CC77DRAFT_1091459  Sm-like ribonucleo protein [KO:K11087]
CC77DRAFT_1063912  small nuclear ribonucleo protein Sm D2 [KO:K11096]
CC77DRAFT_929981  Sm-like ribonucleo protein [KO:K11088]
CC77DRAFT_1017695  small nuclear ribonucleo protein E [KO:K11097]
CC77DRAFT_1067601  small nuclear ribonucleo protein F [KO:K11098]
CC77DRAFT_1060355  small nuclear ribonucleo protein-like protein G [KO:K11099]
CC77DRAFT_949804  RNA-binding domain-containing protein [KO:K11093]
CC77DRAFT_1061163  zf-U1-domain-containing protein [KO:K11095]
CC77DRAFT_1019183  U1 snRNP-associated protein Usp104 [KO:K12821]
CC77DRAFT_1058419  hypothetical protein [KO:K12822]
CC77DRAFT_1028648  hypothetical protein [KO:K12823] [EC:5.6.2.7]
CC77DRAFT_941030  U2 small nuclear ribonucleo protein A [KO:K11092]
CC77DRAFT_1094996  hypothetical protein [KO:K11094]
CC77DRAFT_1030833  RNA-binding domain-containing protein [KO:K11094]
CC77DRAFT_978094  hypothetical protein [KO:K12825]
CC77DRAFT_959797  hypothetical protein [KO:K12826]
CC77DRAFT_1018630  hypothetical protein [KO:K12827]
CC77DRAFT_1012758  splicing factor 3B subunit 1 [KO:K12828]
CC77DRAFT_941890  DUF382-domain-containing protein [KO:K12829]
CC77DRAFT_939848  hypothetical protein [KO:K12830]
CC77DRAFT_130164  RNA-binding domain-containing protein [KO:K12831]
CC77DRAFT_1017859  splicing factor 3B subunit 5/RDS3 complex subunit 10 [KO:K12832]
CC77DRAFT_495001  RNA-binding domain-containing protein [KO:K12833]
CC77DRAFT_1056638  PHF5-like protein [KO:K12834]
CC77DRAFT_1022713  RNA-binding domain-containing protein [KO:K12836]
CC77DRAFT_1024295  hypothetical protein [KO:K12837]
CC77DRAFT_935779  hypothetical protein [KO:K12839]
CC77DRAFT_231563  hypothetical protein [KO:K12840]
CC77DRAFT_1017173  hypothetical protein [KO:K12842]
CC77DRAFT_1066477  U6 snRNA-associated Sm-like protein LSm2 [KO:K12621]
CC77DRAFT_968469  Sm-like ribonucleo protein [KO:K12622]
CC77DRAFT_1021501  Sm-like ribonucleo protein [KO:K12623]
CC77DRAFT_1060931  LSM-domain-containing protein [KO:K12624]
CC77DRAFT_961712  Sm-like ribonucleo protein [KO:K12625]
CC77DRAFT_940038  U6 snRNA-associated Sm-like protein LSm7 [KO:K12626]
CC77DRAFT_935887  Sm-like ribonucleo protein [KO:K12627]
CC77DRAFT_943563  PRP3-domain-containing protein [KO:K12843]
CC77DRAFT_1024438  U4/U6 small nuclear ribonucleo protein Prp4 [KO:K12662]
CC77DRAFT_991339  hypothetical protein [KO:K09567] [EC:5.2.1.8]
CC77DRAFT_1019554  peptidyl-prolyl cis-trans isomerase H [KO:K09567] [EC:5.2.1.8]
CC77DRAFT_1026106  U4/U6 small nuclear ribonucleo protein Prp31 [KO:K12844]
CC77DRAFT_941527  L30e-like protein [KO:K12845]
CC77DRAFT_1026272  cysteine proteinase [KO:K12847]
CC77DRAFT_307704  hypothetical protein [KO:K11984]
CC77DRAFT_77949  hypothetical protein [KO:K12848]
CC77DRAFT_1015294  PRP38-domain-containing protein [KO:K12849]
CC77DRAFT_1019475  P-loop containing nucleoside triphosphate hydrolase protein [KO:K12852]
CC77DRAFT_1049339  pre-mRNA splicing factor [KO:K12854] [EC:5.6.2.6]
CC77DRAFT_1067982  hypothetical protein [KO:K12855]
CC77DRAFT_990270  PROCN-domain-containing protein [KO:K12856]
CC77DRAFT_946800  cell cycle control protein-like protein cwf17 [KO:K12857]
CC77DRAFT_849452  pre-mRNA-splicing ATP-dependent RNA helicase PRP28 [KO:K12858] [EC:5.6.2.7]
CC77DRAFT_297844  4A/4B type thioredoxin-like protein [KO:K12859]
CC77DRAFT_92840  thioredoxin-like protein-like protein 4A [KO:K12859]
CC77DRAFT_671236  Prp19-domain-containing protein [KO:K10599] [EC:2.3.2.27]
CC77DRAFT_959943  hypothetical protein [KO:K12860]
CC77DRAFT_1037637  hypothetical protein [KO:K12861]
CC77DRAFT_793877  pre-mRNA-splicing factor prp46 [KO:K12862]
CC77DRAFT_1004498  Cwf15/Cwc15 cell cycle control protein [KO:K12863]
CC77DRAFT_1025075  DUF1716-domain-containing protein [KO:K12864]
CC77DRAFT_1019642  heat shock protein-like protein [KO:K03283]
CC77DRAFT_74722  heat shock protein 70 [KO:K03283]
CC77DRAFT_1038844  hypothetical protein [KO:K06063]
CC77DRAFT_1061573  pre-mRNA-splicing factor syf1 [KO:K12867]
CC77DRAFT_768790  pre-mRNA-splicing factor syf2 [KO:K12868]
CC77DRAFT_1100242  pre-mRNA-splicing factor clf1 [KO:K12869]
CC77DRAFT_1015454  Isy1-like splicing factor [KO:K12870]
CC77DRAFT_1034842  peptidyl-prolyl cis-trans isomerase [KO:K12733] [EC:5.2.1.8]
CC77DRAFT_1022511  hypothetical protein [KO:K12871]
CC77DRAFT_1024281  hypothetical protein [KO:K12872]
CC77DRAFT_934884  cell cycle control protein cwf14 [KO:K12873]
CC77DRAFT_997461  hypothetical protein [KO:K12874]
CC77DRAFT_1018631  ATP-dependent RNA helicase fal1 [KO:K13025] [EC:5.6.2.7]
CC77DRAFT_935936  RNA-binding domain-containing protein [KO:K12876]
CC77DRAFT_1067556  Mago nashi protein [KO:K12877]
CC77DRAFT_1034272  nuclear matrix protein [KO:K12878]
CC77DRAFT_990433  hypothetical protein [KO:K12879]
CC77DRAFT_976496  WD40 repeat-like protein [KO:K12880]
CC77DRAFT_1093697  hypothetical protein [KO:K12881]
CC77DRAFT_1021299  cap binding protein [KO:K12882]
CC77DRAFT_733946  nuclear cap-binding protein subunit 2 [KO:K12883]
CC77DRAFT_1004289  RNA-binding domain-containing protein [KO:K12897]
Reference
PMID:19239890
  Authors
Wahl MC, Will CL, Luhrmann R
  Title
The spliceosome: design principles of a dynamic RNP machine.
  Journal
Cell 136:701-18 (2009)
DOI:10.1016/j.cell.2009.02.009
Reference
PMID:10978320
  Authors
Morris DP, Greenleaf AL
  Title
The splicing factor, Prp40, binds the phosphorylated carboxyl-terminal domain of RNA polymerase II.
  Journal
J Biol Chem 275:39935-43 (2000)
DOI:10.1074/jbc.M004118200
Reference
PMID:17537823
  Authors
Chen YI, Moore RE, Ge HY, Young MK, Lee TD, Stevens SW
  Title
Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.
  Journal
Nucleic Acids Res 35:3928-44 (2007)
DOI:10.1093/nar/gkm347
Reference
PMID:19733268
  Authors
Ritchie DB, Schellenberg MJ, MacMillan AM
  Title
Spliceosome structure: piece by piece.
  Journal
Biochim Biophys Acta 1789:624-33 (2009)
DOI:10.1016/j.bbagrm.2009.08.010
KO pathway
ko03040   
LinkDB

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