KEGG   PATHWAY: ach00260
Entry
ach00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Pseudarthrobacter chlorophenolicus
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
ach00260  Glycine, serine and threonine metabolism
ach00260

Module
ach_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:ach00260]
ach_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:ach00260]
ach_M00555  Betaine biosynthesis, choline => betaine [PATH:ach00260]
ach_M00621  Glycine cleavage system [PATH:ach00260]
ach_M00975  Betaine degradation, bacteria, betaine => pyruvate [PATH:ach00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Pseudarthrobacter chlorophenolicus [GN:ach]
Gene
Achl_0689  aspartate kinase [KO:K00928] [EC:2.7.2.4]
Achl_2733  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
Achl_2356  Homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
Achl_2354  homoserine kinase [KO:K00872] [EC:2.7.1.39]
Achl_2355  threonine synthase [KO:K01733] [EC:4.2.3.1]
Achl_1651  Threonine aldolase [KO:K01620] [EC:4.1.2.48]
Achl_3596  Glycine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
Achl_0535  Glycine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
Achl_1189  Glycine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
Achl_3439  Glycerate kinase [KO:K00865] [EC:2.7.1.165]
Achl_0440  Glycerate kinase [KO:K00865] [EC:2.7.1.165]
Achl_0194  Glycerate kinase [KO:K00865] [EC:2.7.1.165]
Achl_0239  Glycerate kinase [KO:K00865] [EC:2.7.1.165]
Achl_0847  phosphoglycerate mutase 1 family [KO:K01834] [EC:5.4.2.11]
Achl_2276  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
Achl_0132  D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding [KO:K00058] [EC:1.1.1.95 1.1.1.399]
Achl_0910  phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
Achl_1874  phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
Achl_1354  2-amino-3-ketobutyrate coenzyme A ligase [KO:K00639] [EC:2.3.1.29]
Achl_1353  Alcohol dehydrogenase GroES domain protein [KO:K00060] [EC:1.1.1.103]
Achl_1737  Alcohol dehydrogenase GroES domain protein [KO:K00060] [EC:1.1.1.103]
Achl_3572  Amine oxidase (copper-containing) [KO:K00276] [EC:1.4.3.21]
Achl_0881  glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
Achl_0538  glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
Achl_0882  glycine cleavage system T protein [KO:K00605] [EC:2.1.2.10]
Achl_0537  glycine cleavage system T protein [KO:K00605] [EC:2.1.2.10]
Achl_1606  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
Achl_0536  glycine cleavage system H protein [KO:K02437]
Achl_1541  glycine cleavage system H protein [KO:K02437]
Achl_3303  peptidase M24 [KO:K08688] [EC:3.5.3.3]
Achl_3687  glucose-methanol-choline oxidoreductase [KO:K17755] [EC:1.1.3.17]
Achl_3494  glucose-methanol-choline oxidoreductase [KO:K17755] [EC:1.1.3.17]
Achl_3686  Aldehyde Dehydrogenase [KO:K00130] [EC:1.2.1.8]
Achl_3495  Aldehyde Dehydrogenase [KO:K00130] [EC:1.2.1.8]
Achl_2799  Aldehyde Dehydrogenase [KO:K00130] [EC:1.2.1.8]
Achl_0573  Aldehyde Dehydrogenase [KO:K00130] [EC:1.2.1.8]
Achl_3689  Rieske (2Fe-2S) domain protein [KO:K00479] [EC:1.14.13.251]
Achl_3690  Oxidoreductase FAD-binding domain protein [KO:K21832] [EC:1.14.13.251]
Achl_3463  glycine cleavage T protein (aminomethyl transferase) [KO:K00309] [EC:1.5.3.10]
Achl_3469  FAD dependent oxidoreductase [KO:K00309] [EC:1.5.3.10]
Achl_3678  Sarcosine oxidase [KO:K00301] [EC:1.5.3.1]
Achl_3521  Sarcosine oxidase [KO:K00301] [EC:1.5.3.1]
Achl_3593  sarcosine oxidase, alpha subunit family [KO:K00302] [EC:1.5.3.24 1.5.3.1]
Achl_3595  sarcosine oxidase, beta subunit family [KO:K00303] [EC:1.5.3.24 1.5.3.1]
Achl_3592  Sarcosine oxidase [KO:K00305] [EC:1.5.3.24 1.5.3.1]
Achl_3594  sarcosine oxidase, delta subunit family [KO:K00304] [EC:1.5.3.24 1.5.3.1]
Achl_0289  Pyridoxal-5'-phosphate-dependent protein beta subunit [KO:K01697] [EC:4.2.1.22]
Achl_2762  cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
Achl_3591  L-serine dehydratase 1 [KO:K01752] [EC:4.3.1.17]
Achl_0883  L-serine dehydratase 1 [KO:K01752] [EC:4.3.1.17]
Achl_0534  L-serine dehydratase 1 [KO:K01752] [EC:4.3.1.17]
Achl_3420  Pyridoxal-5'-phosphate-dependent protein beta subunit [KO:K01754] [EC:4.3.1.19]
Achl_1237  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
Achl_1684  tryptophan synthase, alpha subunit [KO:K01695] [EC:4.2.1.20]
Achl_0140  tryptophan synthase, beta subunit [KO:K01696] [EC:4.2.1.20]
Achl_1683  tryptophan synthase, beta subunit [KO:K01696] [EC:4.2.1.20]
Achl_0512  Pyridoxal-dependent decarboxylase [KO:K13745] [EC:4.1.1.86]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
ach00010  Glycolysis / Gluconeogenesis
ach00020  Citrate cycle (TCA cycle)
ach00230  Purine metabolism
ach00250  Alanine, aspartate and glutamate metabolism
ach00270  Cysteine and methionine metabolism
ach00290  Valine, leucine and isoleucine biosynthesis
ach00300  Lysine biosynthesis
ach00330  Arginine and proline metabolism
ach00460  Cyanoamino acid metabolism
ach00470  D-Amino acid metabolism
ach00564  Glycerophospholipid metabolism
ach00600  Sphingolipid metabolism
ach00620  Pyruvate metabolism
ach00630  Glyoxylate and dicarboxylate metabolism
ach00640  Propanoate metabolism
ach00680  Methane metabolism
ach00860  Porphyrin metabolism
ach00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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