KEGG   PATHWAY: acoo04142
Entry
acoo04142                   Pathway                                
Name
Lysosome - Adelges cooleyi (spruce gall adelgid)
Description
Lysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than 40 hydrolases in an acidic environment (pH of about 5). After synthesis in the ER, lysosomal enzymes are decorated with mannose-6-phosphate residues, which are recognized by mannose-6-phosphate receptors in the trans-Golgi network. They are packaged into clathrin-coated vesicles and are transported to late endosomes. Substances for digestion are acquired by the lysosomes via a series of processes including endocytosis, phagocytosis, and autophagy.
Class
Cellular Processes; Transport and catabolism
Pathway map
acoo04142  Lysosome
acoo04142

Other DBs
GO: 0005764
Organism
Adelges cooleyi (spruce gall adelgid) [GN:acoo]
Gene
126832898  V-type proton ATPase 116 kDa subunit a 1-like isoform X1 [KO:K02154]
126834001  V-type proton ATPase 116 kDa subunit a 1 isoform X1 [KO:K02154]
126837875  V-type proton ATPase 116 kDa subunit a 1-like [KO:K02154]
126846452  V-type proton ATPase subunit d [KO:K02146]
126841560  V-type proton ATPase subunit H-like isoform X1 [KO:K02144]
126842259  V-type proton ATPase subunit H-like [KO:K02144]
126835082  V-type proton ATPase subunit H-like [KO:K02144]
126835369  V-type proton ATPase subunit H-like isoform X1 [KO:K02144]
126837446  V-type proton ATPase subunit H-like [KO:K02144]
126842804  V-type proton ATPase subunit S1 [KO:K03662]
126838123  V-type proton ATPase 16 kDa proteolipid subunit c [KO:K02155]
126839031  V-type proton ATPase 21 kDa proteolipid subunit c'' [KO:K03661]
126839236  dmX-like protein 1 isoform X1 [KO:K24155]
126844776  WD repeat-containing protein 7 isoform X1 [KO:K24738]
126841027  nuclear receptor coactivator 7 isoform X1 [KO:K25442]
126841889  cathepsin B-like isoform X1 [KO:K01363] [EC:3.4.22.1]
126833763  cathepsin B-like cysteine proteinase 3 [KO:K01363] [EC:3.4.22.1]
126842805  cathepsin B-like cysteine proteinase 4 [KO:K01363] [EC:3.4.22.1]
126835430  cathepsin B-like cysteine proteinase 4 [KO:K01363] [EC:3.4.22.1]
126844065  cathepsin B-like cysteine proteinase 3 [KO:K01363] [EC:3.4.22.1]
126844144  cathepsin B-like isoform X1 [KO:K01363] [EC:3.4.22.1]
126844146  cathepsin B-like [KO:K01363] [EC:3.4.22.1]
126844147  cathepsin B-like [KO:K01363] [EC:3.4.22.1]
126844148  cathepsin B-like [KO:K01363] [EC:3.4.22.1]
126844149  cathepsin B-like isoform X1 [KO:K01363] [EC:3.4.22.1]
126844150  cathepsin B-like [KO:K01363] [EC:3.4.22.1]
126844151  cathepsin B-like [KO:K01363] [EC:3.4.22.1]
126844160  cathepsin B-like [KO:K01363] [EC:3.4.22.1]
126835565  cathepsin B-like cysteine proteinase 3 [KO:K01363] [EC:3.4.22.1]
126835570  cathepsin B-like cysteine proteinase 4 [KO:K01363] [EC:3.4.22.1]
126835572  cathepsin B-like [KO:K01363] [EC:3.4.22.1]
126836109  cathepsin B-like [KO:K01363] [EC:3.4.22.1]
126844492  cathepsin B-like cysteine proteinase 3 [KO:K01363] [EC:3.4.22.1]
126844816  cathepsin B-like [KO:K01363] [EC:3.4.22.1]
126836181  cathepsin B-like isoform X1 [KO:K01363] [EC:3.4.22.1]
126836182  cathepsin B-like [KO:K01363] [EC:3.4.22.1]
126844965  cathepsin B-like [KO:K01363] [EC:3.4.22.1]
126844966  cathepsin B-like cysteine proteinase 4 [KO:K01363] [EC:3.4.22.1]
126845377  cathepsin B-like [KO:K01363] [EC:3.4.22.1]
126836954  uncharacterized protein LOC126836954 [KO:K01363] [EC:3.4.22.1]
126837016  cathepsin B-like [KO:K01363] [EC:3.4.22.1]
126837070  cathepsin B-like [KO:K01363] [EC:3.4.22.1]
126837071  cathepsin B-like isoform X1 [KO:K01363] [EC:3.4.22.1]
126837073  cathepsin B-like [KO:K01363] [EC:3.4.22.1]
126837074  cathepsin B-like [KO:K01363] [EC:3.4.22.1]
126837075  cathepsin B-like [KO:K01363] [EC:3.4.22.1]
126837076  cathepsin B-like cysteine proteinase 3 [KO:K01363] [EC:3.4.22.1]
126837867  cathepsin B-like cysteine proteinase 4 [KO:K01363] [EC:3.4.22.1]
126847533  cathepsin B-like cysteine proteinase 5 isoform X1 [KO:K01363] [EC:3.4.22.1]
126842177  lysosomal aspartic protease-like [KO:K01379] [EC:3.4.23.5]
126834694  uncharacterized protein LOC126834694 [KO:K01379] [EC:3.4.23.5]
126833688  cathepsin L isoform X1 [KO:K01373] [EC:3.4.22.41]
126839337  procathepsin L [KO:K01365] [EC:3.4.22.15]
126844741  hemoglobinase-like [KO:K01369] [EC:3.4.22.34]
126836607  legumain-like [KO:K01369] [EC:3.4.22.34]
126837014  uncharacterized protein LOC126837014 [KO:K01369] [EC:3.4.22.34]
126837130  legumain-like isoform X1 [KO:K01369] [EC:3.4.22.34]
126837131  legumain-like [KO:K01369] [EC:3.4.22.34]
126837132  legumain-like [KO:K01369] [EC:3.4.22.34]
126837136  legumain-like isoform X1 [KO:K01369] [EC:3.4.22.34]
126837137  legumain-like [KO:K01369] [EC:3.4.22.34]
126837138  legumain-like [KO:K01369] [EC:3.4.22.34]
126837139  legumain-like [KO:K01369] [EC:3.4.22.34]
126838881  beta-galactosidase-like [KO:K12309] [EC:3.2.1.23]
126840784  beta-galactosidase-like [KO:K12309] [EC:3.2.1.23]
126837188  beta-galactosidase-like [KO:K12309] [EC:3.2.1.23]
126838772  beta-galactosidase-like [KO:K12309] [EC:3.2.1.23]
126842750  lysosomal alpha-glucosidase-like [KO:K12316] [EC:3.2.1.20]
126834629  lysosomal acid glucosylceramidase [KO:K01201] [EC:3.2.1.45]
126841779  alpha-N-acetylgalactosaminidase [KO:K01204] [EC:3.2.1.49]
126846159  alpha-N-acetylgalactosaminidase-like [KO:K01204] [EC:3.2.1.49]
126838058  alpha-N-acetylgalactosaminidase-like [KO:K01204] [EC:3.2.1.49]
126843560  beta-glucuronidase isoform X1 [KO:K01195] [EC:3.2.1.31]
126847140  beta-glucuronidase-like [KO:K01195] [EC:3.2.1.31]
126833270  alpha-L-fucosidase [KO:K01206] [EC:3.2.1.51]
126833874  chitooligosaccharidolytic beta-N-acetylglucosaminidase-like isoform X1 [KO:K12373] [EC:3.2.1.52]
126833875  chitooligosaccharidolytic beta-N-acetylglucosaminidase-like [KO:K12373] [EC:3.2.1.52]
126834872  beta-hexosaminidase subunit beta-like [KO:K12373] [EC:3.2.1.52]
126839081  beta-mannosidase isoform X1 [KO:K01192] [EC:3.2.1.25]
126846238  lysosomal alpha-mannosidase-like [KO:K12311] [EC:3.2.1.24]
126838035  lysosomal alpha-mannosidase-like [KO:K12311] [EC:3.2.1.24]
126838037  lysosomal alpha-mannosidase-like [KO:K12311] [EC:3.2.1.24]
126838626  lysosomal alpha-mannosidase-like isoform X1 [KO:K12311] [EC:3.2.1.24]
126835208  hyaluronidase-like [KO:K01197] [EC:3.2.1.35]
126839335  arylsulfatase B-like isoform X1 [KO:K01135] [EC:3.1.6.12]
126839494  arylsulfatase B-like [KO:K01135] [EC:3.1.6.12]
126836234  arylsulfatase B-like isoform X1 [KO:K01135] [EC:3.1.6.12]
126839911  lipase 3-like [KO:K01052] [EC:3.1.1.13]
126835643  gastric triacylglycerol lipase-like [KO:K01052] [EC:3.1.1.13]
126836353  phospholipase A2 group XV-like [KO:K06129] [EC:3.1.1.5]
126838128  cell-death-related nuclease 7 [KO:K01158] [EC:3.1.22.1]
126840830  prostatic acid phosphatase-like isoform X1 [KO:K14410] [EC:3.1.3.2]
126844308  prostatic acid phosphatase-like isoform X1 [KO:K14410] [EC:3.1.3.2]
126838179  prostatic acid phosphatase-like [KO:K14410] [EC:3.1.3.2]
126846686  lysosomal acid phosphatase-like [KO:K14410] [EC:3.1.3.2]
126846795  lysosomal acid phosphatase-like [KO:K14410] [EC:3.1.3.2]
126846797  lysosomal acid phosphatase-like [KO:K14410] [EC:3.1.3.2]
126833197  sphingomyelin phosphodiesterase isoform X1 [KO:K12350] [EC:3.1.4.12]
126833228  sphingomyelin phosphodiesterase-like [KO:K12350] [EC:3.1.4.12]
126847445  N(4)-(Beta-N-acetylglucosaminyl)-L-asparaginase- like [KO:K01444] [EC:3.5.1.26]
126839417  uncharacterized protein LOC126839417 isoform X1 [KO:K12382]
126836810  lysosomal thioesterase PPT2 homolog [KO:K01074] [EC:3.1.2.22]
126838389  palmitoyl-protein thioesterase 1 [KO:K01074] [EC:3.1.2.22]
126832989  tetraspanin-9-like [KO:K06497]
126842899  CD63 antigen-like [KO:K06497]
126843162  CD63 antigen [KO:K06497]
126835373  tetraspanin-9-like [KO:K06497]
126843267  NPC intracellular cholesterol transporter 1-like [KO:K12385]
126834971  MD-2-related lipid-recognition protein-like [KO:K13443]
126834972  MD-2-related lipid-recognition protein-like [KO:K13443]
126834973  MD-2-related lipid-recognition protein-like isoform X1 [KO:K13443]
126845738  NPC intracellular cholesterol transporter 2 homolog a-like [KO:K13443]
126841908  cystinosin homolog isoform X1 [KO:K12386]
126833130  putative inorganic phosphate cotransporter [KO:K12301]
126833194  putative inorganic phosphate cotransporter isoform X1 [KO:K12301]
126847687  sialin-like [KO:K12301]
126843764  protein Malvolio [KO:K21398]
126841949  lysosomal-associated transmembrane protein 4B [KO:K12387]
126838765  integumentary mucin C.1-like [KO:K06546]
126844659  battenin [KO:K12389]
126838113  heparan-alpha-glucosaminide N-acetyltransferase isoform X1 [KO:K10532] [EC:2.3.1.78]
126843459  formylglycine-generating enzyme [KO:K13444] [EC:1.8.3.7]
126847416  clathrin heavy chain [KO:K04646]
126837631  AP-1 complex subunit gamma-1 [KO:K12391]
126834176  AP-1 complex subunit beta-1 [KO:K12392]
126846464  AP-1 complex subunit mu-1 [KO:K12393]
126838295  AP-1 complex subunit sigma-2 isoform X1 [KO:K12394]
126846556  AP-3 complex subunit delta-1 [KO:K12396]
126839425  AP-3 complex subunit beta-2 isoform X1 [KO:K12397]
126835655  AP-3 complex subunit mu-2 [KO:K12398]
126839427  AP-3 complex subunit sigma-1 [KO:K12399]
126843356  ADP-ribosylation factor-binding protein GGA1 isoform X1 [KO:K12404]
126835404  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog [KO:K19363]
126835530  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog [KO:K19363]
Compound
C00002  ATP
C00008  ADP
C00159  D-Mannose
C00275  D-Mannose 6-phosphate
Reference
PMID:12628346
  Authors
Eskelinen EL, Tanaka Y, Saftig P
  Title
At the acidic edge: emerging functions for lysosomal membrane proteins.
  Journal
Trends Cell Biol 13:137-45 (2003)
DOI:10.1016/S0962-8924(03)00005-9
Reference
PMID:1883197
  Authors
Neufeld EF
  Title
Lysosomal storage diseases.
  Journal
Annu Rev Biochem 60:257-80 (1991)
DOI:10.1146/annurev.bi.60.070191.001353
Reference
PMID:2943218
  Authors
von Figura K, Hasilik A
  Title
Lysosomal enzymes and their receptors.
  Journal
Annu Rev Biochem 55:167-93 (1986)
DOI:10.1146/annurev.bi.55.070186.001123
Reference
PMID:15987739
  Authors
Janvier K, Bonifacino JS
  Title
Role of the endocytic machinery in the sorting of lysosome-associated membrane proteins.
  Journal
Mol Biol Cell 16:4231-42 (2005)
DOI:10.1091/mbc.E05-03-0213
Reference
PMID:18635948
  Authors
Vergarajauregui S, Puertollano R
  Title
Mucolipidosis type IV: the importance of functional lysosomes for efficient autophagy.
  Journal
Autophagy 4:832-4 (2008)
DOI:10.4161/auto.6567
Reference
PMID:34249946
  Authors
Jaskolka MC, Winkley SR, Kane PM
  Title
RAVE and Rabconnectin-3 Complexes as Signal Dependent Regulators of Organelle Acidification.
  Journal
Front Cell Dev Biol 9:698190 (2021)
DOI:10.3389/fcell.2021.698190
Reference
PMID:34646033
  Authors
Majdoul S, Compton AA
  Title
Lessons in self-defence: inhibition of virus entry by intrinsic immunity.
  Journal
Nat Rev Immunol 10.1038/s41577-021-00626-8 (2021)
DOI:10.1038/s41577-021-00626-8
Related
pathway
acoo00511  Other glycan degradation
acoo00531  Glycosaminoglycan degradation
acoo04130  SNARE interactions in vesicular transport
acoo04140  Autophagy - animal
acoo04144  Endocytosis
KO pathway
ko04142   
LinkDB

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