Entry
Name
ABC transporters - Actinokineospora sp. UTMC 2448
Description
The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
Class
Environmental Information Processing; Membrane transport
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Actinokineospora sp. UTMC 2448 [GN:
actu ]
Gene
Actkin_01425 ssuC_2; Putative aliphatic sulfonates transport permease protein SsuC [KO:K15554 ]
Actkin_00767 phnV; Putative 2-aminoethylphosphonate transport system permease protein PhnV [KO:K02063 ]
Actkin_05454 opuCB_1; Glycine betaine/carnitine/choline transport system permease protein OpuCB [KO:K05846 ]
Actkin_05455 opuCB_2; Glycine betaine/carnitine/choline transport system permease protein OpuCB [KO:K05846 ]
Actkin_02648 mlaE_1; putative phospholipid ABC transporter permease protein MlaE [KO:K02066 ]
Actkin_02649 mlaE_2; putative phospholipid ABC transporter permease protein MlaE [KO:K02066 ]
Actkin_05961 mlaE_3; putative phospholipid ABC transporter permease protein MlaE [KO:K02066 ]
Actkin_05962 mlaE_4; putative phospholipid ABC transporter permease protein MlaE [KO:K02066 ]
Actkin_05716 mglA_2; Galactose/methyl galactoside import ATP-binding protein MglA [KO:K23537 ]
Actkin_05737 ytfQ_2; ABC transporter periplasmic-binding protein YtfQ precursor [KO:K10439 ]
Actkin_02867 ytfQ_1; ABC transporter periplasmic-binding protein YtfQ precursor [KO:K23508 ]
Actkin_02915 braC_1; Leucine-, isoleucine-, valine-, threonine-, and alanine-binding protein precursor [KO:K01999 ]
Actkin_03629 braC_2; Leucine-, isoleucine-, valine-, threonine-, and alanine-binding protein precursor [KO:K01999 ]
Actkin_04084 braC_3; Leucine-, isoleucine-, valine-, threonine-, and alanine-binding protein precursor [KO:K01999 ]
Actkin_02911 lptB_1; Lipopolysaccharide export system ATP-binding protein LptB [KO:K01995 ]
Actkin_03625 lptB_2; Lipopolysaccharide export system ATP-binding protein LptB [KO:K01995 ]
Actkin_04081 lptB_4; Lipopolysaccharide export system ATP-binding protein LptB [KO:K01995 ]
Actkin_00782 putative monoacyl phosphatidylinositol tetramannoside-binding protein LpqW precursor [KO:K13889 ]
Actkin_00990 putative monoacyl phosphatidylinositol tetramannoside-binding protein LpqW precursor [KO:K13889 ]
Actkin_01952 yfiZ; putative siderophore transport system permease protein YfiZ precursor [KO:K23186 ]
Actkin_01951 yfhA; putative siderophore transport system permease protein YfhA [KO:K23187 ]
Actkin_03065 fepG_1; Ferric enterobactin transport system permease protein FepG [KO:K23187 ]
Actkin_04522 ecfT; Energy-coupling factor transporter transmembrane protein EcfT [KO:K02008 ]
Actkin_01373 drrA_6; Daunorubicin/doxorubicin resistance ATP-binding protein DrrA [KO:K09695 ]
Actkin_00355 drrB_2; Daunorubicin/doxorubicin resistance ABC transporter permease protein DrrB [KO:K18233 ]
Actkin_00354 drrA_3; Daunorubicin/doxorubicin resistance ATP-binding protein DrrA [KO:K18232 ]
Actkin_04380 drrA_13; Daunorubicin/doxorubicin resistance ATP-binding protein DrrA [KO:K18232 ]
Actkin_02860 irtA_1; Iron import ATP-binding/permease protein IrtA [KO:K14698 ] [EC:7.-.-.-]
Actkin_03292 irtA_2; Iron import ATP-binding/permease protein IrtA [KO:K14698 ] [EC:7.-.-.-]
Actkin_02861 irtB_1; Iron import ATP-binding/permease protein IrtB [KO:K14699 ] [EC:7.-.-.-]
Actkin_03293 irtB_2; Iron import ATP-binding/permease protein IrtB [KO:K14699 ] [EC:7.-.-.-]
Compound
C00093 sn-Glycerol 3-phosphate
C01153 Orthophosphoric monoester
C01181 4-Trimethylammoniobutanoate
C01279 4-Amino-5-hydroxymethyl-2-methylpyrimidine
C03557 2-Aminoethylphosphonate
C03611 Galactose oligosaccharide
C03619 Methyl beta-D-galactoside
C04114 (E)-4-(Trimethylammonio)but-2-enoate
C06705 Capsular polysaccharide
C19872 N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20570 alpha-1,5-L-Arabinobiose
C20571 alpha-1,5-L-Arabinotriose
C20572 alpha-1,5-L-Arabinotetraose
Reference
Authors
Tomii K, Kanehisa M.
Title
A comparative analysis of ABC transporters in complete microbial genomes.
Journal
Reference
Authors
Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A
Title
Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.
Journal
Reference
Authors
Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ
Title
Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
Journal
Reference
Authors
Omata T, Price GD, Badger MR, Okamura M, Gohta S, Ogawa T
Title
Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942.
Journal
Reference
Authors
Quintero MJ, Montesinos ML, Herrero A, Flores E
Title
Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence.
Journal
Reference
Authors
Picossi S, Montesinos ML, Pernil R, Lichtle C, Herrero A, Flores E
Title
ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.
Journal
Reference
Authors
Valladares A, Montesinos ML, Herrero A, Flores E.
Title
An ABC-type, high-affinity urea permease identified in cyanobacteria.
Journal
Reference
Authors
Richard-Fogal CL, Frawley ER, Kranz RG
Title
Topology and function of CcmD in cytochrome c maturation.
Journal
Reference
Authors
Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H
Title
The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
Journal
Reference
Authors
Novikova M, Metlitskaya A, Datsenko K, Kazakov T, Kazakov A, Wanner B, Severinov K
Title
The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C.
Journal
Reference
Authors
Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI
Title
Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.
Journal
Reference
Authors
Yamanaka H, Kobayashi H, Takahashi E, Okamoto K
Title
MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II.
Journal
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