KEGG   PATHWAY: ago03008
Entry
ago03008                    Pathway                                
Name
Ribosome biogenesis in eukaryotes - Eremothecium gossypii
Description
Ribosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It requires hundreds of factors not present in the mature particle. In the absence of these proteins, ribosome biogenesis is stalled and cell growth is terminated even under optimal growth conditions. The primary pre-rRNA transcript is assembled into the 90S pre-ribosome, which contains both 40S and 60S assembly factors. Within this complex, the pre-rRNA is cleaved. pre-60S ribosomes are subjected to several sequential processing steps in the nucleoplasm involving numerous assembly intermediates before it is exported to the cytoplasm and matured into the 60S ribosomal subunit. The pre-40S ribosome is matured to the small ribosomal subunit in the cytoplasm by cleavage.
Class
Genetic Information Processing; Translation
Pathway map
ago03008  Ribosome biogenesis in eukaryotes
ago03008

Organism
Eremothecium gossypii [GN:ago]
Gene
AGOS_ACR087C  ACR087Cp [KO:K03115]
AGOS_AGR163W  AGR163Wp [KO:K03115]
AGOS_ADL102C  ADL102Cp [KO:K03097] [EC:2.7.11.1]
AGOS_ADR204W  ADR204Wp [KO:K03097] [EC:2.7.11.1]
AGOS_ADR029W  ADR029Wp [KO:K14544]
AGOS_AFR705W  AFR705Wp [KO:K14545]
AGOS_AFR398W  AFR398Wp [KO:K14546]
AGOS_AFR307C  AFR307Cp [KO:K14547]
AGOS_AGR367C  AGR367Cp [KO:K14548]
AGOS_ABL044C  ABL044Cp [KO:K14549]
AGOS_AFR074C  AFR074Cp [KO:K14550]
AGOS_ABL069C  ABL069Cp [KO:K14551]
AGOS_ACR162C  ACR162Cp [KO:K14552]
AGOS_AEL153W  AEL153Wp [KO:K14553]
AGOS_AER081C  AER081Cp [KO:K14554]
AGOS_AGR180W  AGR180Wp [KO:K14555]
AGOS_AGL196C  AGL196Cp [KO:K14556]
AGOS_AER317W  AER317Wp [KO:K14557]
AGOS_AAR057W  AAR057Wp [KO:K14558]
AGOS_ACR031W  ACR031Wp [KO:K14559]
AGOS_ADL131C  ADL131Cp [KO:K14560]
AGOS_AER430W  AER430Wp [KO:K14561]
AGOS_AER214C  rRNA methyltransferase NOP1 [KO:K14563] [EC:2.1.1.-]
AGOS_ACL144C  ACL144Cp [KO:K14564]
AGOS_AFR328C  AFR328Cp [KO:K14565]
AGOS_AEL070W  small nucleolar ribonucleoprotein SNU13 [KO:K12845]
AGOS_AAL007C  AAL007Cp [KO:K11131] [EC:5.4.99.-]
AGOS_ABL115W  ABL115Wp [KO:K11129]
AGOS_AEL096W  AEL096Wp [KO:K11128]
AGOS_AGR354W  AGR354Wp [KO:K11130]
AGOS_AEL102W  AEL102Wp [KO:K14566]
AGOS_ADL353C  ADL353Cp [KO:K14567]
AGOS_AFR538C  AFR538Cp [KO:K03685] [EC:3.1.26.3]
AGOS_AFR686C  AFR686Cp [KO:K14568] [EC:2.1.1.260]
AGOS_AFL113C  AFL113Cp [KO:K14569]
AGOS_AGR346C  AGR346Cp [KO:K14521] [EC:2.3.1.-]
AGOS_ACL015W  ACL015Wp [KO:K11108]
AGOS_ABL187C  ABL187Cp [KO:K01164] [EC:3.1.26.5]
AGOS_AFR348C  AFR348Cp [KO:K14522] [EC:3.1.26.5]
AGOS_AFR610W  AFR610Wp [KO:K03538] [EC:3.1.26.5]
AGOS_ADR362C  ADR362Cp [KO:K03537] [EC:3.1.26.5]
AGOS_ACL177W  ACL177Wp [KO:K14524] [EC:3.1.26.5]
AGOS_AGR216W  AGR216Wp [KO:K14526] [EC:3.1.26.5]
AGOS_AFR017C  AFR017Cp [KO:K14528] [EC:3.1.26.5]
AGOS_AAL046C  AAL046Cp [KO:K03539] [EC:3.1.26.5]
AGOS_AEL228W  AEL228Wp [KO:K14531]
AGOS_AGL160W  AGL160Wp [KO:K14532]
AGOS_AGL332W  AGL332Wp [KO:K14570] [EC:3.1.-.-]
AGOS_AGR052C  AGR052Cp [KO:K14570] [EC:3.1.-.-]
AGOS_ACR217C  ACR217Cp [KO:K13288] [EC:3.1.-.-]
AGOS_ADL046C  ADL046Cp [KO:K12618] [EC:3.1.13.-]
AGOS_AGR303W  AGR303Wp [KO:K12619] [EC:3.1.13.-]
AGOS_AGR194W  AGR194Wp [KO:K06943]
AGOS_ABR120C  ABR120Cp [KO:K14537]
AGOS_ADR008W  ADR008Wp [KO:K14538]
AGOS_AFR188W  AFR188Wp [KO:K14571]
AGOS_AGR074C  AGR074Cp [KO:K14572]
AGOS_AGL250W  AGL250Wp [KO:K14573]
AGOS_AAR139W  AAR139Wp [KO:K11883]
AGOS_AFL091W  AFL091Wp [KO:K14758] [EC:2.7.11.1]
AGOS_AGR294C  AGR294Cp [KO:K07936]
AGOS_ADL128C  ADL128Cp [KO:K14290]
AGOS_AER299C  60S ribosomal export protein NMD3 [KO:K07562]
AGOS_AAL104C  AAL104Cp [KO:K14284]
AGOS_AER089W  AER089Wp [KO:K14543]
AGOS_ADL030C  ADL030Cp [KO:K03264]
AGOS_AAL154C  AAL154Cp [KO:K14574]
AGOS_AFR031C  AFR031Cp [KO:K14536] [EC:3.6.5.-]
AGOS_AFL042C  AFL042Cp [KO:K14539] [EC:3.6.1.-]
AGOS_AER065C  AER065Cp [KO:K14575]
AGOS_ACL150W  ACL150Wp [KO:K18532] [EC:2.7.4.3]
AGOS_AER257W  AER257Wp [KO:K07178] [EC:2.7.11.1]
AGOS_ABL166W  ABL166Wp [KO:K07179] [EC:2.7.11.1]
AGOS_RDN18_1  18S ribosomal RNA copy 1 [KO:K01979]
AGOS_RDN18_20  18S ribosomal RNA copy 20 [KO:K01979]
AGOS_RDN18_35  18S ribosomal RNA copy 35 [KO:K01979]
AGOS_RDN18_28  18S ribosomal RNA copy 28 [KO:K01979]
AGOS_RDN18_16  18S ribosomal RNA copy 16 [KO:K01979]
AGOS_RDN18_9  18S ribosomal RNA copy 9 [KO:K01979]
AGOS_RDN18_36  18S ribosomal RNA copy 36 [KO:K01979]
AGOS_RDN18_25  18S ribosomal RNA copy 25 [KO:K01979]
AGOS_RDN18_23  18S ribosomal RNA copy 23 [KO:K01979]
AGOS_RDN18_10  18S ribosomal RNA copy 10 [KO:K01979]
AGOS_RDN18_18  18S ribosomal RNA copy 18 [KO:K01979]
AGOS_RDN18_24  18S ribosomal RNA copy 24 [KO:K01979]
AGOS_RDN18_19  18S ribosomal RNA copy 19 [KO:K01979]
AGOS_RDN18_30  18S ribosomal RNA copy 30 [KO:K01979]
AGOS_RDN18_26  18S ribosomal RNA copy 26 [KO:K01979]
AGOS_RDN18_8  18S ribosomal RNA copy 8 [KO:K01979]
AGOS_RDN18_15  18S ribosomal RNA copy 15 [KO:K01979]
AGOS_RDN18_31  18S ribosomal RNA copy 31 [KO:K01979]
AGOS_RDN18_7  18S ribosomal RNA copy 7 [KO:K01979]
AGOS_RDN18_29  18S ribosomal RNA copy 29 [KO:K01979]
AGOS_RDN18_21  18S ribosomal RNA copy 21 [KO:K01979]
AGOS_RDN18_39  18S ribosomal RNA copy 39 [KO:K01979]
AGOS_RDN18_6  18S ribosomal RNA copy 6 [KO:K01979]
AGOS_RDN18_5  18S ribosomal RNA copy 5 [KO:K01979]
AGOS_RDN18_38  18S ribosomal RNA copy 38 [KO:K01979]
AGOS_RDN18_17  18S ribosomal RNA copy 17 [KO:K01979]
AGOS_RDN18_33  18S ribosomal RNA copy 33 [KO:K01979]
AGOS_RDN18_4  18S ribosomal RNA copy 4 [KO:K01979]
AGOS_RDN18_13  18S ribosomal RNA copy 13 [KO:K01979]
AGOS_RDN18_22  18S ribosomal RNA copy 22 [KO:K01979]
AGOS_RDN18_11  18S ribosomal RNA copy 11 [KO:K01979]
AGOS_RDN18_37  18S ribosomal RNA copy 37 [KO:K01979]
AGOS_RDN18_32  18S ribosomal RNA copy 32 [KO:K01979]
AGOS_RDN18_3  18S ribosomal RNA copy 3 [KO:K01979]
AGOS_RDN18_34  18S ribosomal RNA copy 34 [KO:K01979]
AGOS_RDN18_27  18S ribosomal RNA copy 27 [KO:K01979]
AGOS_RDN18_14  18S ribosomal RNA copy 14 [KO:K01979]
AGOS_RDN18_12  18S ribosomal RNA copy 12 [KO:K01979]
AGOS_RDN18_2  18S ribosomal RNA copy 2 [KO:K01979]
AGOS_RDN58_1  5.8S ribosomal RNA copy 1 [KO:K01986]
AGOS_RDN58_35  5.8S ribosomal RNA copy 35 [KO:K01986]
AGOS_RDN58_18  5.8S ribosomal RNA copy 18 [KO:K01986]
AGOS_RDN58_21  5.8S ribosomal RNA copy 21 [KO:K01986]
AGOS_RDN58_36  5.8S ribosomal RNA copy 36 [KO:K01986]
AGOS_RDN58_15  5.8S ribosomal RNA copy 15 [KO:K01986]
AGOS_RDN58_9  5.8S ribosomal RNA copy 9 [KO:K01986]
AGOS_RDN58_17  5.8S ribosomal RNA copy 17 [KO:K01986]
AGOS_RDN58_27  5.8S ribosomal RNA copy 27 [KO:K01986]
AGOS_RDN58_3  5.8S ribosomal RNA copy 3 [KO:K01986]
AGOS_RDN58_8  5.8S ribosomal RNA copy 8 [KO:K01986]
AGOS_RDN58_31  5.8S ribosomal RNA copy 31 [KO:K01986]
AGOS_RDN58_22  5.8S ribosomal RNA copy 22 [KO:K01986]
AGOS_RDN58_24  5.8S ribosomal RNA copy 24 [KO:K01986]
AGOS_RDN58_12  5.8S ribosomal RNA copy 12 [KO:K01986]
AGOS_RDN58_28  5.8S ribosomal RNA copy 28 [KO:K01986]
AGOS_RDN58_16  5.8S ribosomal RNA copy 16 [KO:K01986]
AGOS_RDN58_4  5.8S ribosomal RNA copy 4 [KO:K01986]
AGOS_RDN58_39  5.8S ribosomal RNA copy 39 [KO:K01986]
AGOS_RDN58_5  5.8S ribosomal RNA copy 5 [KO:K01986]
AGOS_RDN58_10  5.8S ribosomal RNA copy 10 [KO:K01986]
AGOS_RDN58_13  5.8S ribosomal RNA copy 13 [KO:K01986]
AGOS_RDN58_30  5.8S ribosomal RNA copy 30 [KO:K01986]
AGOS_RDN58_25  5.8S ribosomal RNA copy 25 [KO:K01986]
AGOS_RDN58_38  5.8S ribosomal RNA copy 38 [KO:K01986]
AGOS_RDN58_34  5.8S ribosomal RNA copy 34 [KO:K01986]
AGOS_RDN58_11  5.8S ribosomal RNA copy 11 [KO:K01986]
AGOS_RDN58_29  5.8S ribosomal RNA copy 29 [KO:K01986]
AGOS_RDN58_2  5.8S ribosomal RNA copy 2 [KO:K01986]
AGOS_RDN58_14  5.8S ribosomal RNA copy 14 [KO:K01986]
AGOS_RDN58_37  5.8S ribosomal RNA copy 37 [KO:K01986]
AGOS_RDN58_32  5.8S ribosomal RNA copy 32 [KO:K01986]
AGOS_RDN58_20  5.8S ribosomal RNA copy 20 [KO:K01986]
AGOS_RDN58_33  5.8S ribosomal RNA copy 33 [KO:K01986]
AGOS_RDN58_26  5.8S ribosomal RNA copy 26 [KO:K01986]
AGOS_RDN58_19  5.8S ribosomal RNA copy 19 [KO:K01986]
AGOS_RDN58_6  5.8S ribosomal RNA copy 6 [KO:K01986]
AGOS_RDN58_7  5.8S ribosomal RNA copy 7 [KO:K01986]
AGOS_RDN58_23  5.8S ribosomal RNA copy 23 [KO:K01986]
AGOS_RDNA25_1  25S ribosomal RNA copy 1 [KO:K01982]
AGOS_RDNA25_33  25S ribosomal RNA copy 33 [KO:K01982]
AGOS_RDNA25_18  25S ribosomal RNA copy 18 [KO:K01982]
AGOS_RDNA25_27  25S ribosomal RNA copy 27 [KO:K01982]
AGOS_RDNA25_32  25S ribosomal RNA copy 32 [KO:K01982]
AGOS_RDNA25_10  25S ribosomal RNA copy 10 [KO:K01982]
AGOS_RDNA25_26  25S ribosomal RNA copy 26 [KO:K01982]
AGOS_RDNA25_6  25S ribosomal RNA copy 6 [KO:K01982]
AGOS_RDNA25_31  25S ribosomal RNA copy 31 [KO:K01982]
AGOS_RDNA25_7  25S ribosomal RNA copy 7 [KO:K01982]
AGOS_RDNA25_39  25S ribosomal RNA copy 39 [KO:K01982]
AGOS_RDNA25_30  25S ribosomal RNA copy 30 [KO:K01982]
AGOS_RDNA25_9  25S ribosomal RNA copy 9 [KO:K01982]
AGOS_RDNA25_22  25S ribosomal RNA copy 22 [KO:K01982]
AGOS_RDNA25_20  25S ribosomal RNA copy 20 [KO:K01982]
AGOS_RDNA25_12  25S ribosomal RNA copy 12 [KO:K01982]
AGOS_RDNA25_28  25S ribosomal RNA copy 28 [KO:K01982]
AGOS_RDNA25_17  25S ribosomal RNA copy 17 [KO:K01982]
AGOS_RDNA25_8  25S ribosomal RNA copy 8 [KO:K01982]
AGOS_RDNA25_5  25S ribosomal RNA copy 5 [KO:K01982]
AGOS_RDNA25_21  25S ribosomal RNA copy 21 [KO:K01982]
AGOS_RDNA25_29  25S ribosomal RNA copy 29 [KO:K01982]
AGOS_RDNA25_13  25S ribosomal RNA copy 13 [KO:K01982]
AGOS_RDNA25_11  25S ribosomal RNA copy 11 [KO:K01982]
AGOS_RDNA25_36  25S ribosomal RNA copy 36 [KO:K01982]
AGOS_RDNA25_38  25S ribosomal RNA copy 38 [KO:K01982]
AGOS_RDNA25_14  25S ribosomal RNA copy 14 [KO:K01982]
AGOS_RDNA25_19  25S ribosomal RNA copy 19 [KO:K01982]
AGOS_RDNA25_37  25S ribosomal RNA copy 37 [KO:K01982]
AGOS_RDNA25_4  25S ribosomal RNA copy 4 [KO:K01982]
AGOS_RDNA25_16  25S ribosomal RNA copy 16 [KO:K01982]
AGOS_RDNA25_25  25S ribosomal RNA copy 25 [KO:K01982]
AGOS_RDNA25_2  25S ribosomal RNA copy 2 [KO:K01982]
AGOS_RDNA25_23  25S ribosomal RNA copy 23 [KO:K01982]
AGOS_RDNA25_3  25S ribosomal RNA copy 3 [KO:K01982]
AGOS_RDNA25_34  25S ribosomal RNA copy 34 [KO:K01982]
AGOS_RDNA25_15  25S ribosomal RNA copy 15 [KO:K01982]
AGOS_RDNA25_24  25S ribosomal RNA copy 24 [KO:K01982]
AGOS_RDNA25_35  25S ribosomal RNA copy 35 [KO:K01982]
AGOS_RDN5_16  5S ribosomal RNA copy 16 [KO:K01981]
AGOS_RDN5_17  5S ribosomal RNA copy 17 [KO:K01981]
AGOS_RDN5_18  5S ribosomal RNA copy 18 [KO:K01981]
AGOS_RDN5_19  5S ribosomal RNA copy 19 [KO:K01981]
AGOS_RDN5_2  5S ribosomal RNA copy 2 [KO:K01981]
AGOS_RDN5_1  5S ribosomal RNA copy 1 [KO:K01981]
AGOS_RDN5_10  5S ribosomal RNA copy 10 [KO:K01981]
AGOS_RDN5_11  5S ribosomal RNA copy 11 [KO:K01981]
AGOS_RDN5_12  5S ribosomal RNA copy 12 [KO:K01981]
AGOS_RDN5_13  5S ribosomal RNA copy 13 [KO:K01981]
AGOS_RDN5_14  5S ribosomal RNA copy 14 [KO:K01981]
AGOS_RDN5_15  5S ribosomal RNA copy 15 [KO:K01981]
AGOS_RDN5_20  5S ribosomal RNA copy 20 [KO:K01981]
AGOS_RDN5_9  5S ribosomal RNA copy 9 [KO:K01981]
AGOS_RDN5_21  5S ribosomal RNA copy 21 [KO:K01981]
AGOS_RDN5_22  5S ribosomal RNA copy 22 [KO:K01981]
AGOS_RDN5_23  5S ribosomal RNA copy 23 [KO:K01981]
AGOS_RDN5_24  5S ribosomal RNA copy 24 [KO:K01981]
AGOS_RDN5_25  5S ribosomal RNA copy 25 [KO:K01981]
AGOS_RDN5_26  5S ribosomal RNA copy 26 [KO:K01981]
AGOS_RDN5_27  5S ribosomal RNA copy 27 [KO:K01981]
AGOS_RDN5_28  5S ribosomal RNA copy 28 [KO:K01981]
AGOS_RDN5_29  5S ribosomal RNA copy 29 [KO:K01981]
AGOS_RDN5_3  5S ribosomal RNA copy 3 [KO:K01981]
AGOS_RDN5_30  5S ribosomal RNA copy 30 [KO:K01981]
AGOS_RDN5_31  5S ribosomal RNA copy 31 [KO:K01981]
AGOS_RDN5_32  5S ribosomal RNA copy 32 [KO:K01981]
AGOS_RDN5_33  5S ribosomal RNA copy 33 [KO:K01981]
AGOS_RDN5_34  5S ribosomal RNA copy 34 [KO:K01981]
AGOS_RDN5_35  5S ribosomal RNA copy 35 [KO:K01981]
AGOS_RDN5_36  5S ribosomal RNA copy 36 [KO:K01981]
AGOS_RDN5_37  5S ribosomal RNA copy 37 [KO:K01981]
AGOS_RDN5_38  5S ribosomal RNA copy 38 [KO:K01981]
AGOS_RDN5_39  5S ribosomal RNA copy 39 [KO:K01981]
AGOS_RDN5_4  5S ribosomal RNA copy 4 [KO:K01981]
AGOS_RDN5_5  5S ribosomal RNA copy 5 [KO:K01981]
AGOS_RDN5_6  5S ribosomal RNA copy 6 [KO:K01981]
AGOS_RDN5_7  5S ribosomal RNA copy 7 [KO:K01981]
AGOS_RDN5_8  5S ribosomal RNA copy 8 [KO:K01981]
AGOS_AgSNR17  AgSNR17 [KO:K14483]
AGOS_AgSNRNME1  AgSNRNME1 [KO:K26477]
Reference
PMID:20174677
  Authors
Freed EF, Bleichert F, Dutca LM, Baserga SJ
  Title
When ribosomes go bad: diseases of ribosome biogenesis.
  Journal
Mol Biosyst 6:481-93 (2010)
DOI:10.1039/b919670f
Reference
PMID:17515605
  Authors
Perez-Fernandez J, Roman A, De Las Rivas J, Bustelo XR, Dosil M
  Title
The 90S preribosome is a multimodular structure that is assembled through a hierarchical mechanism.
  Journal
Mol Cell Biol 27:5414-29 (2007)
DOI:10.1128/MCB.00380-07
Reference
PMID:19850913
  Authors
Strunk BS, Karbstein K
  Title
Powering through ribosome assembly.
  Journal
RNA 15:2083-104 (2009)
DOI:10.1261/rna.1792109
Reference
PMID:15120992
  Authors
Granneman S, Baserga SJ
  Title
Ribosome biogenesis: of knobs and RNA processing.
  Journal
Exp Cell Res 296:43-50 (2004)
DOI:10.1016/j.yexcr.2004.03.016
Reference
PMID:19879902
  Authors
Kressler D, Hurt E, Bassler J
  Title
Driving ribosome assembly.
  Journal
Biochim Biophys Acta 1803:673-83 (2010)
DOI:10.1016/j.bbamcr.2009.10.009
Related
pathway
ago03010  Ribosome
KO pathway
ko03008   
LinkDB

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