KEGG   PATHWAY: apln00260
Entry
apln00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Agrilus planipennis (emerald ash borer)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
apln00260  Glycine, serine and threonine metabolism
apln00260

Module
apln_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:apln00260]
apln_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:apln00260]
apln_M00621  Glycine cleavage system [PATH:apln00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Agrilus planipennis (emerald ash borer) [GN:apln]
Gene
108732622  probable low-specificity L-threonine aldolase 2 [KO:K01620] [EC:4.1.2.48]
108735925  serine hydroxymethyltransferase, cytosolic isoform X1 [KO:K00600] [EC:2.1.2.1]
108738087  serine--pyruvate aminotransferase, mitochondrial-like [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
108738088  serine--pyruvate aminotransferase-like [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
108738078  serine--pyruvate aminotransferase-like [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
108736029  glyoxylate reductase/hydroxypyruvate reductase [KO:K00049] [EC:1.1.1.79 1.1.1.81]
108736693  glycerate kinase [KO:K11529] [EC:2.7.1.165]
108737580  phosphoglycerate mutase 2 [KO:K01834] [EC:5.4.2.11]
108732942  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
108735718  probable phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
108743058  phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
108741261  5-aminolevulinate synthase, erythroid-specific, mitochondrial [KO:K00643] [EC:2.3.1.37]
112906798  glycine dehydrogenase (decarboxylating), mitochondrial-like [KO:K00281] [EC:1.4.4.2]
108744977  glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]
108735872  aminomethyltransferase, mitochondrial [KO:K00605] [EC:2.1.2.10]
108734247  dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]
108732442  uncharacterized protein LOC108732442 [KO:K02437]
108734659  uncharacterized protein LOC108734659 [KO:K02437]
108742477  LOW QUALITY PROTEIN: D-aspartate oxidase [KO:K00273] [EC:1.4.3.3]
108744729  alanine--glyoxylate aminotransferase 2, mitochondrial-like [KO:K00827] [EC:2.6.1.44 2.6.1.40]
108744670  alanine--glyoxylate aminotransferase 2, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]
108734302  putative aldehyde dehydrogenase family 7 member A1 homolog [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
108738448  sarcosine dehydrogenase, mitochondrial [KO:K00314] [EC:1.5.8.3]
108742572  cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
108738603  cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
112906288  cystathionine gamma-lyase-like [KO:K01758] [EC:4.4.1.1]
108741735  putative cystathionine gamma-lyase 2 [KO:K01758] [EC:4.4.1.1]
108742392  putative cystathionine gamma-lyase 2 isoform X1 [KO:K01758] [EC:4.4.1.1]
108734932  cystathionine gamma-lyase-like [KO:K01758] [EC:4.4.1.1]
108734934  cystathionine gamma-lyase-like [KO:K01758] [EC:4.4.1.1]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
apln00010  Glycolysis / Gluconeogenesis
apln00020  Citrate cycle (TCA cycle)
apln00230  Purine metabolism
apln00250  Alanine, aspartate and glutamate metabolism
apln00270  Cysteine and methionine metabolism
apln00290  Valine, leucine and isoleucine biosynthesis
apln00330  Arginine and proline metabolism
apln00470  D-Amino acid metabolism
apln00564  Glycerophospholipid metabolism
apln00600  Sphingolipid metabolism
apln00620  Pyruvate metabolism
apln00630  Glyoxylate and dicarboxylate metabolism
apln00640  Propanoate metabolism
apln00860  Porphyrin metabolism
apln00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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