KEGG   PATHWAY: apre01230
Entry
apre01230                   Pathway                                
Name
Biosynthesis of amino acids - Actinosynnema pretiosum
Description
This map presents a modular architecture of the biosynthesis pathways of twenty amino acids, which may be viewed as consisting of the core part and its extensions. The core part is the KEGG module for conversion of three-carbon compounds from glyceraldehyde-3P to pyruvate [MD:M00002], together with the pathways around serine and glycine. This KEGG module is the most conserved one in the KEGG MODULE database and is found in almost all the completely sequenced genomes. The extensions are the pathways containing the reaction modules RM001, RM033, RM032, and RM002 for biosynthesis of branched-chain amino acids (left) and basic amino acids (bottom), and the pathways for biosynthesis of histidine and aromatic amino acids (top right). It is interesting to note that the so-called essential amino acids that cannot be synthesized in human and other organisms generally appear in these extensions. Furthermore, the bottom extension of basic amino acids appears to be most divergent containing multiple pathways for lysine biosynthesis and multiple gene sets for arginine biosynthesis.
Class
Pathway map
apre01230  Biosynthesis of amino acids
apre01230

Module
apre_M00002  Glycolysis, core module involving three-carbon compounds [PATH:apre01230]
apre_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:apre01230]
apre_M00007  Pentose phosphate pathway, non-oxidative phase, fructose 6P => ribose 5P [PATH:apre01230]
apre_M00010  Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate [PATH:apre01230]
apre_M00015  Proline biosynthesis, glutamate => proline [PATH:apre01230]
apre_M00016  Lysine biosynthesis, succinyl-DAP pathway, aspartate => lysine [PATH:apre01230]
apre_M00017  Methionine biosynthesis, aspartate => homoserine => methionine [PATH:apre01230]
apre_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:apre01230]
apre_M00019  Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine [PATH:apre01230]
apre_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:apre01230]
apre_M00026  Histidine biosynthesis, PRPP => histidine [PATH:apre01230]
apre_M00028  Ornithine biosynthesis, glutamate => ornithine [PATH:apre01230]
apre_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:apre01230]
apre_M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate [PATH:apre01230]
apre_M00570  Isoleucine biosynthesis, threonine => 2-oxobutanoate => isoleucine [PATH:apre01230]
apre_M00844  Arginine biosynthesis, ornithine => arginine [PATH:apre01230]
Organism
Actinosynnema pretiosum [GN:apre]
KO pathway
ko01230   
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