Entry Name Endocytosis - Auxenochlorella protothecoides
Description Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
Class Cellular Processes; Transport and catabolismBRITE hierarchy
Pathway map Ortholog table Other DBs Organism Auxenochlorella protothecoides [GN:
apro ]
Gene F751_3047 Stromal 70 kDa heat shock-related protein, chloroplastic [KO:K03283 ]
F751_2915 Vacuolar protein sorting-associated protein 28-like protein 2 [KO:K12184 ]
F751_1197 Vacuolar protein sorting-associated protein 22-like protein 1 [KO:K12188 ]
F751_4581 Vacuolar protein sorting-associated protein 20-like protein 1 [KO:K12195 ]
F751_4434 Vacuolar protein sorting-associated protein 32-like protein 1 [KO:K12194 ]
F751_1350 Vacuolar protein sorting-associated protein 24-like protein 1 [KO:K12193 ]
F751_4703 Vacuolar protein sorting-associated protein 2-like protein 1 [KO:K12191 ]
F751_2224 Vacuolar protein sorting-associated protein 2-like protein 3 [KO:K12192 ]
F751_5551 Vacuolar protein sorting-associated protein VTA1-like protein [KO:K12199 ]
F751_3184 Vacuolar protein sorting-associated protein 45-like protein [KO:K12479 ]
F751_6650 putative ADP-ribosylation factor GTPase-activating protein AGD5 [KO:K12486 ]
F751_4695 putative ADP-ribosylation factor GTPase-activating protein AGD5 [KO:K12486 ]
F751_3805 ADP-ribosylation factor GTPase-activating protein AGD7 [KO:K12492 ]
F751_3291 putative ADP-ribosylation factor GTPase-activating protein AGD9 [KO:K12493 ]
F751_2921 Brefeldin A-inhibited guanine nucleotide-exchange protein 2 [KO:K18442 ]
Compound C04549 1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
C11556 1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
Reference Authors Acconcia F, Sigismund S, Polo S
Title Ubiquitin in trafficking: the network at work.
Journal Reference Authors Donaldson JG, Porat-Shliom N, Cohen LA
Title Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling.
Journal Reference Authors Sorkin A
Title Cargo recognition during clathrin-mediated endocytosis: a team effort.
Journal Reference Authors Raiborg C, Stenmark H
Title The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins.
Journal Reference Authors Scita G, Di Fiore PP
Title The endocytic matrix.
Journal Reference Authors Le Roy C, Wrana JL
Title Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling.
Journal Reference Authors Jovic M, Sharma M, Rahajeng J, Caplan S
Title The early endosome: a busy sorting station for proteins at the crossroads.
Journal Reference Authors Pietiainen VM, Marjomaki V, Heino J, Hyypia T
Title Viral entry, lipid rafts and caveosomes.
Journal Reference Authors Grant BD, Donaldson JG
Title Pathways and mechanisms of endocytic recycling.
Journal Reference Authors Cullen PJ, Korswagen HC
Title Sorting nexins provide diversity for retromer-dependent trafficking events.
Journal Related apro04070 Phosphatidylinositol signaling system
apro04130 SNARE interactions in vesicular transport
KO pathway LinkDB All DBs
