KEGG   PATHWAY: apuu00260
Entry
apuu00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Aspergillus puulaauensis
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
apuu00260  Glycine, serine and threonine metabolism
apuu00260

Module
apuu_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:apuu00260]
apuu_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:apuu00260]
apuu_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:apuu00260]
apuu_M00621  Glycine cleavage system [PATH:apuu00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Aspergillus puulaauensis [GN:apuu]
Gene
APUU_70440A  HOM3; aspartokinase [KO:K00928] [EC:2.7.2.4]
APUU_31099A  uncharacterized protein [KO:K00133] [EC:1.2.1.11]
APUU_60860A  uncharacterized protein [KO:K00003] [EC:1.1.1.3]
APUU_30679S  uncharacterized protein [KO:K00003] [EC:1.1.1.3]
APUU_70421S  THR1; trihydroxynaphthalene reductase [KO:K00872] [EC:2.7.1.39]
APUU_30496A  THR4; threonine synthase [KO:K01733] [EC:4.2.3.1]
APUU_71188S  uncharacterized protein [KO:K01620] [EC:4.1.2.48]
APUU_41638S  GLY1; threonine aldolase [KO:K01620] [EC:4.1.2.48]
APUU_60150S  uncharacterized protein [KO:K01620] [EC:4.1.2.48]
APUU_80389S  uncharacterized protein [KO:K01620] [EC:4.1.2.48]
APUU_10843S  SHM1; glycine hydroxymethyltransferase shm1 [KO:K00600] [EC:2.1.2.1]
APUU_30471S  SHM2; serine hydroxymethyltransferase, cytosolic [KO:K00600] [EC:2.1.2.1]
APUU_50367A  uncharacterized protein [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
APUU_21610A  uncharacterized protein [KO:K00865] [EC:2.7.1.165]
APUU_30469A  uncharacterized protein [KO:K15633] [EC:5.4.2.12]
APUU_80728S  uncharacterized protein [KO:K15918] [EC:2.7.1.31]
APUU_70448A  SER3; phosphoglycerate dehydrogenase Ser3 [KO:K00058] [EC:1.1.1.95 1.1.1.399]
APUU_20803S  SER1; putative secondary metabolism biosynthetic enzyme [KO:K00831] [EC:2.6.1.52]
APUU_31125A  uncharacterized protein [KO:K01079] [EC:3.1.3.3]
APUU_41449A  uncharacterized protein [KO:K16066] [EC:1.1.1.381 1.1.1.-]
APUU_11411A  putative secondary metabolism biosynthetic enzyme [KO:K16066] [EC:1.1.1.381 1.1.1.-]
APUU_11964A  uncharacterized protein [KO:K16066] [EC:1.1.1.381 1.1.1.-]
APUU_30779S  uncharacterized protein [KO:K16066] [EC:1.1.1.381 1.1.1.-]
APUU_20614A  HEM1; mitochondrial 5-aminolevulinate synthase [KO:K00643] [EC:2.3.1.37]
APUU_10378S  uncharacterized protein [KO:K00274] [EC:1.4.3.4]
APUU_20277S  uncharacterized protein [KO:K00274] [EC:1.4.3.4]
APUU_30082A  uncharacterized protein [KO:K00274] [EC:1.4.3.4]
APUU_30100A  uncharacterized protein [KO:K00274] [EC:1.4.3.4]
APUU_31346A  uncharacterized protein [KO:K00274] [EC:1.4.3.4]
APUU_41067A  uncharacterized protein [KO:K00276] [EC:1.4.3.21]
APUU_60666S  uncharacterized protein [KO:K00276] [EC:1.4.3.21]
APUU_60808A  uncharacterized protein [KO:K00276] [EC:1.4.3.21]
APUU_61070S  uncharacterized protein [KO:K00276] [EC:1.4.3.21]
APUU_61292A  uncharacterized protein [KO:K00276] [EC:1.4.3.21]
APUU_80268A  CAO1; copper amine oxidase [KO:K00276] [EC:1.4.3.21]
APUU_30202A  uncharacterized protein [KO:K00276] [EC:1.4.3.21]
APUU_80745A  GCV2; glycine decarboxylase subunit P [KO:K00281] [EC:1.4.4.2]
APUU_50542S  GCV1; aminomethyltransferase, mitochondrial [KO:K00605] [EC:2.1.2.10]
APUU_70794S  LPD1; dihydrolipoamide dehydrogenase precursor [KO:K00382] [EC:1.8.1.4]
APUU_50697A  GCV3; glycine cleavage system H-protein subunit [KO:K02437]
APUU_50261A  uncharacterized protein [KO:K00273] [EC:1.4.3.3]
APUU_11970A  uncharacterized protein [KO:K00273] [EC:1.4.3.3]
APUU_12300A  uncharacterized protein [KO:K00273] [EC:1.4.3.3]
APUU_20065S  uncharacterized protein [KO:K00273] [EC:1.4.3.3]
APUU_20154A  uncharacterized protein [KO:K00273] [EC:1.4.3.3]
APUU_40254A  uncharacterized protein [KO:K00273] [EC:1.4.3.3]
APUU_41037A  CHO1; CDP-diacylglycerol-serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
APUU_21808S  uncharacterized protein [KO:K00130] [EC:1.2.1.8]
APUU_10234S  uncharacterized protein [KO:K00309] [EC:1.5.3.10]
APUU_60910A  uncharacterized protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
APUU_11102A  uncharacterized protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
APUU_70303A  uncharacterized protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
APUU_70330S  uncharacterized protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
APUU_21565S  uncharacterized protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
APUU_21940A  uncharacterized protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
APUU_30880A  uncharacterized protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
APUU_31212S  uncharacterized protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
APUU_40164S  uncharacterized protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
APUU_10826A  CYS4; cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
APUU_10376S  CYS3_1; cystathionine gamma-lyase cys3 [KO:K01758] [EC:4.4.1.1]
APUU_21781S  CYS3_2; cystathionine gamma-lyase cys3 [KO:K01758] [EC:4.4.1.1]
APUU_40561S  uncharacterized protein [KO:K01754] [EC:4.3.1.19]
APUU_60164S  uncharacterized protein [KO:K01754] [EC:4.3.1.19]
APUU_30210S  uncharacterized protein [KO:K01754] [EC:4.3.1.19]
APUU_40525S  uncharacterized protein [KO:K17989] [EC:4.3.1.17 4.3.1.19]
APUU_60427A  uncharacterized protein [KO:K17989] [EC:4.3.1.17 4.3.1.19]
APUU_40792A  uncharacterized protein [KO:K01694] [EC:4.2.1.20]
APUU_51259A  TRP5; tryptophan synthetase [KO:K01694] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
apuu00010  Glycolysis / Gluconeogenesis
apuu00020  Citrate cycle (TCA cycle)
apuu00230  Purine metabolism
apuu00250  Alanine, aspartate and glutamate metabolism
apuu00270  Cysteine and methionine metabolism
apuu00290  Valine, leucine and isoleucine biosynthesis
apuu00300  Lysine biosynthesis
apuu00330  Arginine and proline metabolism
apuu00460  Cyanoamino acid metabolism
apuu00470  D-Amino acid metabolism
apuu00564  Glycerophospholipid metabolism
apuu00600  Sphingolipid metabolism
apuu00620  Pyruvate metabolism
apuu00630  Glyoxylate and dicarboxylate metabolism
apuu00640  Propanoate metabolism
apuu00680  Methane metabolism
apuu00860  Porphyrin metabolism
apuu00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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