KEGG   PATHWAY: asla02010
Entry
asla02010                   Pathway                                
Name
ABC transporters - Actinomyces slackii
Description
The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
Class
Environmental Information Processing; Membrane transport
Pathway map
asla02010  ABC transporters
asla02010

Other DBs
GO: 0043190 0043191 0043192
TC: 3.A.1
Organism
Actinomyces slackii [GN:asla]
Gene
NCTC11923_02487  modA; Molybdate-binding periplasmic protein precursor [KO:K02020]
NCTC11923_02488  cysA; Sulfate/thiosulfate import ATP-binding protein CysA [KO:K02017 K02018] [EC:7.3.2.5]
NCTC11923_00797  thiB; Thiamine-binding periplasmic protein precursor [KO:K02064]
NCTC11923_00798  modB; Molybdenum transport system permease protein modB [KO:K02063]
NCTC11923_00799  fbpC; Fe(3+) ions import ATP-binding protein FbpC [KO:K02062] [EC:7.6.2.15]
NCTC11923_00106  opuAC; Glycine betaine-binding protein precursor [KO:K02002]
NCTC11923_00105  proW; Glycine betaine/L-proline transport system permease protein proW [KO:K02001]
NCTC11923_00104  proV_1; Glycine betaine/L-proline transport ATP-binding protein ProV [KO:K02000] [EC:7.6.2.9]
NCTC11923_01280  Substrate binding domain of ABC-type glycine betaine transport system [KO:K05845]
NCTC11923_01278  yehY_1; Putative osmoprotectant uptake system permease protein yehY [KO:K05846]
NCTC11923_01279  yehY_2; Putative osmoprotectant uptake system permease protein yehY [KO:K05846]
NCTC11923_01277  proV_2; Glycine betaine/L-proline transport ATP-binding protein ProV [KO:K05847] [EC:7.6.2.9]
NCTC11923_00191  ugpC; sn-glycerol-3-phosphate import ATP-binding protein UgpC [KO:K10112] [EC:7.5.2.-]
NCTC11923_01177  Maltose-binding periplasmic proteins/domains [KO:K10117]
NCTC11923_01314  P39 [KO:K10117]
NCTC11923_02107  Maltose-binding periplasmic proteins/domains [KO:K10117]
NCTC11923_01178  ycjO_4; Inner membrane ABC transporter permease protein ycjO [KO:K10118]
NCTC11923_01315  ugpA_2; sn-glycerol-3-phosphate transport system permease protein ugpA [KO:K10118]
NCTC11923_02106  ycjO_7; Inner membrane ABC transporter permease protein ycjO [KO:K10118]
NCTC11923_01179  ycjP_4; Inner membrane ABC transporter permease protein ycjP [KO:K10119]
NCTC11923_01316  ycjP_6; Inner membrane ABC transporter permease protein ycjP [KO:K10119]
NCTC11923_02105  ycjP_11; Inner membrane ABC transporter permease protein ycjP [KO:K10119]
NCTC11923_00387  carbohydrate ABC transporter, N-acetylglucosamine/diacetylchitobiose-binding protein [KO:K10232]
NCTC11923_02344  Probable ABC transporter-binding protein DR_1438 precursor [KO:K10236]
NCTC11923_02343  ycjO_9; Inner membrane ABC transporter permease protein ycjO [KO:K10237]
NCTC11923_02342  ycjP_13; Inner membrane ABC transporter permease protein ycjP [KO:K10238]
NCTC11923_00061  sbpA; Multiple sugar-binding periplasmic protein sbpA precursor [KO:K10546]
NCTC11923_00059  xylH; Xylose transport system permease protein xylH [KO:K10547]
NCTC11923_00060  xylG; Xylose import ATP-binding protein XylG [KO:K10548] [EC:7.5.2.-]
NCTC11923_01227  tmpC; Purine nucleoside receptor A [KO:K07335]
NCTC11923_01229  ABC-type uncharacterized transport system, permease component [KO:K23535]
NCTC11923_01230  ABC-type uncharacterized transport system, permease component [KO:K23536]
NCTC11923_01228  araG; Arabinose import ATP-binding protein AraG [KO:K23537]
NCTC11923_01342  P39 [KO:K17315]
NCTC11923_01343  ycjO_5; Inner membrane ABC transporter permease protein ycjO [KO:K17316]
NCTC11923_01344  ycjP_7; Inner membrane ABC transporter permease protein ycjP [KO:K17317]
NCTC11923_01134  rbsB; D-ribose-binding periplasmic protein precursor [KO:K10439]
NCTC11923_01133  rbsC; Ribose transport system permease protein rbsC [KO:K10440]
NCTC11923_01132  rbsA; Ribose import ATP-binding protein RbsA [KO:K10441] [EC:7.5.2.7]
NCTC11923_00933  pstS2; Phosphate-binding protein pstS 2 precursor [KO:K02040]
NCTC11923_00934  pstC; Phosphate transport system permease protein pstC [KO:K02037]
NCTC11923_00935  pstA; Phosphate transport system permease protein pstA [KO:K02038]
NCTC11923_00936  pstB3; Phosphate import ATP-binding protein PstB 3 [KO:K02036] [EC:7.3.2.1]
NCTC11923_02152  peb1A; PEB1 [KO:K10005]
NCTC11923_02151  artQ; Arginine transport system permease protein ArtQ [KO:K10006]
NCTC11923_02150  tcyL; L-cystine transport system permease protein tcyL [KO:K10007]
NCTC11923_02153  artM; Arginine transport ATP-binding protein ArtM [KO:K10008] [EC:7.4.2.1]
NCTC11923_00619  metQ; Methionine-binding lipoprotein metQ precursor [KO:K02073]
NCTC11923_00618  metP; Methionine import system permease protein MetP [KO:K02072]
NCTC11923_00617  metN; Methionine import ATP-binding protein MetN [KO:K02071]
NCTC11923_00021  oppA; Periplasmic oligopeptide-binding protein precursor [KO:K15580]
NCTC11923_00020  dppB; Dipeptide transport system permease protein dppB [KO:K15581]
NCTC11923_00019  gsiD; Glutathione transport system permease protein gsiD [KO:K15582]
NCTC11923_00018  gsiA_1; Glutathione import ATP-binding protein GsiA [KO:K10823 K15583]
NCTC11923_00597  yhfQ; Putative ABC transporter substrate-binding lipoprotein yhfQ precursor [KO:K25286]
NCTC11923_00596  fepD; Ferric enterobactin transport system permease protein fepD [KO:K23186]
NCTC11923_00595  yfhA; Probable siderophore transport system permease protein yfhA [KO:K23187]
NCTC11923_00594  yusV_1; Probable siderophore transport system ATP-binding protein YusV [KO:K23188] [EC:7.2.2.17 7.2.2.-]
NCTC11923_01235  Uncharacterized periplasmic iron-binding protein HI_0362 precursor [KO:K11601]
NCTC11923_01237  mntB_1; Manganese transport system membrane protein mntB [KO:K11602]
NCTC11923_01236  lptB_2; Lipopolysaccharide export system ATP-binding protein LptB [KO:K11603] [EC:7.2.2.5]
NCTC11923_01672  adcA; Probable zinc transport system zinc-binding lipoprotein AdcA precursor [KO:K09815]
NCTC11923_01670  mntB_2; Manganese transport system membrane protein mntB [KO:K09816]
NCTC11923_01671  glnQ; Glutamine transport ATP-binding protein GlnQ [KO:K09817] [EC:7.2.2.20]
NCTC11923_00023  bioY2; Biotin ECF transporter S component BioY2 [KO:K03523]
NCTC11923_02338  cobalt transport protein CbiQ [KO:K16785]
NCTC11923_02549  ABC-2 type transporter [KO:K09690]
NCTC11923_00415  Uncharacterized protein conserved in bacteria [KO:K20460]
NCTC11923_00414  Uncharacterized protein conserved in bacteria [KO:K20461]
NCTC11923_00416  drrA_2; Daunorubicin/doxorubicin resistance ATP-binding protein DrrA [KO:K20459]
NCTC11923_01923  lantibiotic protection ABC transporter permease subunit, MutE/EpiE family [KO:K20491]
NCTC11923_01922  Fluoroquinolones export ATP-binding protein Rv2688c/MT2762 [KO:K20490]
NCTC11923_01443  Fluoroquinolones export permease protein Rv2686c/MT2760 [KO:K16905]
NCTC11923_01442  Uncharacterised protein [KO:K16906]
NCTC11923_01441  Fluoroquinolones export ATP-binding protein Rv2688c/MT2762 [KO:K16907] [EC:7.6.2.-]
NCTC11923_02360  ftsX; Cell division protein FtsX [KO:K09811]
NCTC11923_02361  ftsE_1; Cell division ATP-binding protein FtsE [KO:K09812]
NCTC11923_02336  irtA_2; Iron import ATP-binding/permease protein IrtA [KO:K14698] [EC:7.-.-.-]
NCTC11923_02335  irtB; Iron import ATP-binding/permease protein IrtB [KO:K14699] [EC:7.-.-.-]
NCTC11923_00338  Putative multidrug export ATP-binding/permease protein SAV1866 [KO:K18887]
NCTC11923_00339  yheH; Probable multidrug resistance ABC transporter ATP-binding/permease protein YheH [KO:K18888]
NCTC11923_01574  Probable ABC transporter ATP-binding protein HI_0664 [KO:K16012]
NCTC11923_01809  Probable ABC transporter ATP-binding protein HI_0664 [KO:K16012]
NCTC11923_01575  cydD; ATP-binding/permease protein CydD [KO:K16013]
NCTC11923_01808  apxIB; RTX-I toxin determinant B [KO:K16013]
Compound
C00009  Orthophosphate
C00025  L-Glutamate
C00031  D-Glucose
C00032  Heme
C00034  Manganese
C00037  Glycine
C00038  Zinc cation
C00041  L-Alanine
C00047  L-Lysine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00062  L-Arginine
C00064  L-Glutamine
C00065  L-Serine
C00070  Copper
C00077  L-Ornithine
C00079  L-Phenylalanine
C00086  Urea
C00088  Nitrite
C00089  Sucrose
C00093  sn-Glycerol 3-phosphate
C00095  D-Fructose
C00098  Oligopeptide
C00107  Dipeptide
C00114  Choline
C00116  Glycerol
C00120  Biotin
C00121  D-Ribose
C00123  L-Leucine
C00134  Putrescine
C00135  L-Histidine
C00137  myo-Inositol
C00140  N-Acetyl-D-glucosamine
C00148  L-Proline
C00151  L-Amino acid
C00159  D-Mannose
C00175  Cobalt ion
C00181  D-Xylose
C00183  L-Valine
C00185  Cellobiose
C00188  L-Threonine
C00208  Maltose
C00212  Adenosine
C00243  Lactose
C00244  Nitrate
C00245  Taurine
C00255  Riboflavin
C00259  L-Arabinose
C00288  HCO3-
C00291  Nickel
C00294  Inosine
C00299  Uridine
C00315  Spermidine
C00320  Thiosulfate
C00330  Deoxyguanosine
C00333  D-Galacturonate
C00338  Lipopolysaccharide
C00378  Thiamine
C00379  Xylitol
C00387  Guanosine
C00392  Mannitol
C00407  L-Isoleucine
C00430  5-Aminolevulinate
C00470  Pectate
C00475  Cytidine
C00487  Carnitine
C00491  L-Cystine
C00492  Raffinose
C00503  Erythritol
C00526  Deoxyuridine
C00559  Deoxyadenosine
C00719  Betaine
C00794  D-Sorbitol
C00855  D-Methionine
C00865  Phospholipid
C00881  Deoxycytidine
C00919  Choline sulfate
C00973  Cyclomaltodextrin
C01083  alpha,alpha-Trehalose
C01153  Orthophosphoric monoester
C01157  Hydroxyproline
C01177  Inositol 1-phosphate
C01181  4-Trimethylammoniobutanoate
C01279  4-Amino-5-hydroxymethyl-2-methylpyrimidine
C01330  Sodium cation
C01417  Cyanate
C01487  D-Allose
C01606  Phthalate
C01630  Xylobiose
C01667  Bacitracin
C01674  Chitobiose
C01682  Nopaline
C01684  D-Rhamnose
C01762  Xanthosine
C01834  Lipoprotein
C01835  Maltotriose
C01935  Maltodextrin
C01946  Oleandomycin
C02160  Isomaltotriose
C02273  Digalacturonate
C03557  2-Aminoethylphosphonate
C03611  Galactose oligosaccharide
C03619  Methyl beta-D-galactoside
C04114  (E)-4-(Trimethylammonio)but-2-enoate
C04137  Octopine
C05349  Ciprofloxacin
C05402  Melibiose
C05512  Deoxyinosine
C05776  Vitamin B12
C06227  Fe(III)hydroxamate
C06229  Fe(III)dicitrate
C06230  Fe-enterobactin
C06232  Molybdate
C06687  Norfloxacin
C06705  Capsular polysaccharide
C06706  Lipo-oligosaccharide
C06707  Teichoic acid
C06767  Hemine
C07662  Sparfloxacin
C07663  Moxifloxacin
C11612  Polymyxin B
C13768  Colistin sulfate
C14818  Fe2+
C14819  Fe3+
C15521  Alkanesulfonate
C15719  Coelichelin
C16421  AI-2
C16692  Mannopine
C19609  Nickel(2+)
C19872  N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20570  alpha-1,5-L-Arabinobiose
C20571  alpha-1,5-L-Arabinotriose
C20572  alpha-1,5-L-Arabinotetraose
C20573  Aldotetraouronic acid
C20679  Tungstate
C21066  D-Galactofuranose
C22040  S-Methyl-L-cysteine
G00457  Maltotetraose
Reference
PMID:9799792
  Authors
Tomii K, Kanehisa M.
  Title
A comparative analysis of ABC transporters in complete microbial genomes.
  Journal
Genome Res 8:1048-59 (1998)
DOI:10.1101/gr.8.10.1048
Reference
  Authors
Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A
  Title
Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
J Bacteriol 190:4460-9 (2008)
DOI:10.1128/JB.00270-08
Reference
  Authors
Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ
  Title
Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
Proc Natl Acad Sci U S A 105:5537-42 (2008)
DOI:10.1073/pnas.0801196105
Reference
  Authors
Omata T, Price GD, Badger MR, Okamura M, Gohta S, Ogawa T
  Title
Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942.
  Journal
Proc Natl Acad Sci U S A 96:13571-6 (1999)
DOI:10.1073/pnas.96.23.13571
Reference
  Authors
Quintero MJ, Montesinos ML, Herrero A, Flores E
  Title
Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence.
  Journal
Genome Res 11:2034-40 (2001)
DOI:10.1101/gr.196301
Reference
  Authors
Picossi S, Montesinos ML, Pernil R, Lichtle C, Herrero A, Flores E
  Title
ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.
  Journal
Mol Microbiol 57:1582-92 (2005)
DOI:10.1111/j.1365-2958.2005.04791.x
Reference
  Authors
Valladares A, Montesinos ML, Herrero A, Flores E.
  Title
An ABC-type, high-affinity urea permease identified in cyanobacteria.
  Journal
Mol Microbiol 43:703-15 (2002)
DOI:10.1046/j.1365-2958.2002.02778.x
Reference
  Authors
Richard-Fogal CL, Frawley ER, Kranz RG
  Title
Topology and function of CcmD in cytochrome c maturation.
  Journal
J Bacteriol 190:3489-93 (2008)
DOI:10.1128/JB.00146-08
Reference
  Authors
Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H
  Title
The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
  Journal
J Bacteriol 187:5861-7 (2005)
DOI:10.1128/JB.187.17.5861-5867.2005
Reference
  Authors
Novikova M, Metlitskaya A, Datsenko K, Kazakov T, Kazakov A, Wanner B, Severinov K
  Title
The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C.
  Journal
J Bacteriol 189:8361-5 (2007)
DOI:10.1128/JB.01028-07
Reference
  Authors
Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI
  Title
Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.
  Journal
Mol Microbiol 63:895-910 (2007)
DOI:10.1111/j.1365-2958.2006.05549.x
Reference
  Authors
Yamanaka H, Kobayashi H, Takahashi E, Okamoto K
  Title
MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II.
  Journal
J Bacteriol 190:7693-8 (2008)
DOI:10.1128/JB.00853-08
KO pathway
ko02010   
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