KEGG PATHWAY: bfn00260

PATHWAY: bfn00260

Entry

bfn00260                    Pathway

Name

Glycine, serine and threonine metabolism - Paraburkholderia fungorum

Description

Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].

Class

Metabolism; Amino acid metabolism

Pathway map

bfn00260

Glycine, serine and threonine metabolism

Module

bfn_M00018

Threonine biosynthesis, aspartate => homoserine => threonine [PATH:bfn00260]

bfn_M00020

Serine biosynthesis, glycerate-3P => serine [PATH:bfn00260]

bfn_M00555

Betaine biosynthesis, choline => betaine [PATH:bfn00260]

bfn_M00621

Glycine cleavage system [PATH:bfn00260]

bfn_M00919

Ectoine degradation, ectoine => aspartate [PATH:bfn00260]

bfn_M00975

Betaine degradation, bacteria, betaine => pyruvate [PATH:bfn00260]

Other DBs

GO:	0006544 0006563 0070178 0006566

Organism

Paraburkholderia fungorum [GN:bfn]

Gene

OI25_2977

aspartate kinase, monofunctional class [KO:K00928] [EC:2.7.2.4]

OI25_5302

asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]

OI25_3354

ACT domain protein [KO:K00003] [EC:1.1.1.3]

OI25_5252

thrB; homoserine kinase [KO:K02204] [EC:2.7.1.39]

OI25_3355

thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]

OI25_2602

beta-eliminating lyase family protein [KO:K01620] [EC:4.1.2.48]

OI25_6497

beta-eliminating lyase family protein [KO:K01620] [EC:4.1.2.48]

OI25_934

beta-eliminating lyase family protein [KO:K00600] [EC:2.1.2.1]

OI25_4016

glyA2; serine hydroxymethyltransferase 2 [KO:K00600] [EC:2.1.2.1]

OI25_5414

aminotransferase class-V family protein [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]

OI25_909

beta-eliminating lyase family protein [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]

OI25_5838

D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain protein [KO:K00018] [EC:1.1.1.29]

OI25_7295

hprA; glycerate dehydrogenase [KO:K00018] [EC:1.1.1.29]

OI25_6270

putative 2-hydroxyacid dehydrogenase [KO:K00018] [EC:1.1.1.29]

OI25_7351

D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain protein [KO:K00018] [EC:1.1.1.29]

OI25_7363

D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain protein [KO:K00018] [EC:1.1.1.29]

OI25_4798

D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain protein [KO:K12972] [EC:1.1.1.79 1.1.1.81]

OI25_1249

D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain protein [KO:K12972] [EC:1.1.1.79 1.1.1.81]

OI25_4760

D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain protein [KO:K12972] [EC:1.1.1.79 1.1.1.81]

OI25_3280

D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain protein [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]

OI25_5022

D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain protein [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]

OI25_2492

D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain protein [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]

OI25_3458

glycerate kinase family protein [KO:K00865] [EC:2.7.1.165]

OI25_1168

gpmA; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]

OI25_2066

histidine phosphatase super family protein [KO:K15634] [EC:5.4.2.11]

OI25_7345

D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]

OI25_6062

D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]

OI25_1394

D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]

OI25_2412

serC; phosphoserine transaminase [KO:K00831] [EC:2.6.1.52]

OI25_3426

serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]

OI25_935

short chain dehydrogenase family protein [KO:K16066] [EC:1.1.1.381 1.1.1.-]

OI25_5448

kbl; glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]

OI25_5447

tdh; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]

OI25_3600

copper amine oxidase, enzyme domain protein [KO:K00276] [EC:1.4.3.21]

OI25_1563

gcvP; glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]

OI25_1565

gcvT; glycine cleavage system T protein [KO:K00605] [EC:2.1.2.10]

OI25_6

lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]

OI25_2839

lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]

OI25_1564

gcvH; glycine cleavage system H protein [KO:K02437]

OI25_445

pssA; CDP-diacylglycerol-serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]

OI25_4021

betA; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]

OI25_4020

betB; betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]

OI25_3027

aldehyde dehydrogenase family protein [KO:K00130] [EC:1.2.1.8]

OI25_4009

ring hydroxylating alpha subunit family protein [KO:K00479] [EC:1.14.13.251]

OI25_4008

2Fe-2S iron-sulfur cluster binding domain protein [KO:K21832] [EC:1.14.13.251]

OI25_4013

flavin oxidoreductase / NADH oxidase family protein [KO:K21833] [EC:1.5.7.3]

OI25_4012

4Fe-4S dicluster domain protein [KO:K21834]

OI25_4011

electron transfer flavoFAD-binding domain protein [KO:K25960]

OI25_4010

electron transfer flavodomain protein [KO:K25961]

OI25_4025

sarcosine oxidase, alpha subunit [KO:K00302] [EC:1.5.3.24 1.5.3.1]

OI25_4027

sarcosine oxidase, beta subunit [KO:K00303] [EC:1.5.3.24 1.5.3.1]

OI25_4024

sarcosine oxidase, gamma subunit [KO:K00305] [EC:1.5.3.24 1.5.3.1]

OI25_4026

sarcosine oxidase, delta subunit [KO:K00304] [EC:1.5.3.24 1.5.3.1]

OI25_1561

L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]

OI25_4028

L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]

OI25_3933

eutB; ectoine utilization protein EutB [KO:K01754] [EC:4.3.1.19]

OI25_3442

psdht; phenylserine dehydratase [KO:K01754] [EC:4.3.1.19]

OI25_3751

ilvA; threonine ammonia-lyase, biosynthetic [KO:K01754] [EC:4.3.1.19]

OI25_1066

ilvA; threonine ammonia-lyase, biosynthetic [KO:K01754] [EC:4.3.1.19]

OI25_1072

putative D-serine deaminase (D-serine dehydratase) protein [KO:K01753] [EC:4.3.1.18]

OI25_2829

aspartate racemase family protein [KO:K25316] [EC:5.1.1.10]

OI25_5296

trpA; tryptophan synthase, alpha subunit [KO:K01695] [EC:4.2.1.20]

OI25_5298

trpB; tryptophan synthase, beta subunit [KO:K01696] [EC:4.2.1.20]

OI25_3926

eutD; ectoine utilization protein EutD [KO:K15783] [EC:3.5.4.44]

OI25_3931

eutE; ectoine utilization protein EutE [KO:K15784] [EC:3.5.1.125]

OI25_3928

aminotransferase class-III family protein [KO:K15785] [EC:2.6.1.76]

OI25_3929

aldehyde dehydrogenase family protein [KO:K15786] [EC:1.2.1.-]

Compound

C00011

CO2

C00014

Ammonia

C00022

Pyruvate

C00037

Glycine

C00048

Glyoxylate

C00049

L-Aspartate

C00065

L-Serine

C00078

L-Tryptophan

C00097

L-Cysteine

C00101

Tetrahydrofolate

C00109

2-Oxobutanoate

C00114

Choline

C00143

5,10-Methylenetetrahydrofolate

C00168

Hydroxypyruvate

C00188

L-Threonine

C00197

3-Phospho-D-glycerate

C00213

Sarcosine

C00258

D-Glycerate

C00263

L-Homoserine

C00300

Creatine

C00430

5-Aminolevulinate

C00441

L-Aspartate 4-semialdehyde

C00546

Methylglyoxal

C00576

Betaine aldehyde

C00581

Guanidinoacetate

C00631

2-Phospho-D-glycerate

C00719

Betaine

C00740

D-Serine

C00986

1,3-Diaminopropane

C01005

O-Phospho-L-serine

C01026

N,N-Dimethylglycine

C01102

O-Phospho-L-homoserine

C01242

[Protein]-S8-aminomethyldihydrolipoyllysine

C01888

Aminoacetone

C02051

Lipoylprotein

C02291

L-Cystathionine

C02737

Phosphatidylserine

C02972

Dihydrolipoylprotein

C03082

4-Phospho-L-aspartate

C03194

(R)-1-Aminopropan-2-ol

C03232

3-Phosphonooxypyruvate

C03283

L-2,4-Diaminobutanoate

C03508

L-2-Amino-3-oxobutanoic acid

C05519

L-Allothreonine

C06231

Ectoine

C06442

N(gamma)-Acetyldiaminobutyrate

C16432

5-Hydroxyectoine

C19929

N(alpha)-Acetyl-L-2,4-diaminobutyrate

Reference

Authors

Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).

Title

[Cellular Functions and Metabolic Maps] (In Japanese)

Journal

Tokyo Kagaku Dojin (1997)

Reference

PMID:11823218

Authors

Kuhlmann AU, Bremer E.

Title

Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.

Journal

Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002

Reference

PMID:10473374

Authors

Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.

Title

Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.

Journal

Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999

Reference

PMID:17636255

Authors

Bursy J, Pierik AJ, Pica N, Bremer E.

Title

Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.

Journal

J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200

Reference

PMID:16707670

Authors

Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.

Title

The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.

Journal

J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06

Reference

PMID:15470257

Authors

Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J

Title

FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.

Journal

Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004

Reference

PMID:7639721