KEGG   PATHWAY: bgm00260
Entry
bgm00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Bordetella genomosp. 13
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
bgm00260  Glycine, serine and threonine metabolism
bgm00260

Module
bgm_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:bgm00260]
bgm_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:bgm00260]
bgm_M00033  Ectoine biosynthesis, aspartate => ectoine [PATH:bgm00260]
bgm_M00621  Glycine cleavage system [PATH:bgm00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Bordetella genomosp. 13 [GN:bgm]
Gene
CAL15_11765  aspartate kinase [KO:K00928] [EC:2.7.2.4]
CAL15_09745  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
CAL15_15125  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
CAL15_09805  homoserine kinase [KO:K02204] [EC:2.7.1.39]
CAL15_15120  threonine synthase [KO:K01733] [EC:4.2.3.1]
CAL15_17145  threonine synthase [KO:K01733] [EC:4.2.3.1]
CAL15_09220  threonine aldolase [KO:K01620] [EC:4.1.2.48]
CAL15_16560  low-specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
CAL15_20760  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
CAL15_16580  serine--glyoxylate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
CAL15_09130  glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
CAL15_01310  glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
CAL15_15380  glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
CAL15_19530  glycerate kinase [KO:K00865] [EC:2.7.1.165]
CAL15_22350  gpmA; phosphoglyceromutase [KO:K01834] [EC:5.4.2.11]
CAL15_13405  histidine phosphatase family protein [KO:K15634] [EC:5.4.2.11]
CAL15_21850  3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
CAL15_24150  3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
CAL15_21550  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
CAL15_15975  phosphoserine transaminase [KO:K00831] [EC:2.6.1.52]
CAL15_17135  phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
CAL15_04150  glycine dehydrogenase (aminomethyl-transferring) [KO:K00281] [EC:1.4.4.2]
CAL15_04140  glycine cleavage system protein T [KO:K00605] [EC:2.1.2.10]
CAL15_16250  dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
CAL15_08095  dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
CAL15_13980  dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
CAL15_04145  glycine cleavage system protein H [KO:K02437]
CAL15_17530  CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
CAL15_19730  aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
CAL15_10405  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
CAL15_17505  threonine ammonia-lyase [KO:K01754] [EC:4.3.1.19]
CAL15_02560  threonine ammonia-lyase, biosynthetic [KO:K01754] [EC:4.3.1.19]
CAL15_23170  serine/threonine dehydratase [KO:K01754] [EC:4.3.1.19]
CAL15_17710  amino acid deaminase [KO:K01753] [EC:4.3.1.18]
CAL15_16870  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
CAL15_16875  tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
CAL15_10355  diaminobutyrate--2-oxoglutarate transaminase [KO:K00836] [EC:2.6.1.76]
CAL15_10360  diaminobutyrate acetyltransferase [KO:K06718] [EC:2.3.1.178]
CAL15_10350  ectC; L-ectoine synthase [KO:K06720] [EC:4.2.1.108]
CAL15_10345  ectoine hydroxylase [KO:K10674] [EC:1.14.11.55]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
bgm00010  Glycolysis / Gluconeogenesis
bgm00020  Citrate cycle (TCA cycle)
bgm00230  Purine metabolism
bgm00250  Alanine, aspartate and glutamate metabolism
bgm00270  Cysteine and methionine metabolism
bgm00290  Valine, leucine and isoleucine biosynthesis
bgm00300  Lysine biosynthesis
bgm00330  Arginine and proline metabolism
bgm00460  Cyanoamino acid metabolism
bgm00470  D-Amino acid metabolism
bgm00564  Glycerophospholipid metabolism
bgm00620  Pyruvate metabolism
bgm00630  Glyoxylate and dicarboxylate metabolism
bgm00640  Propanoate metabolism
bgm00680  Methane metabolism
bgm00860  Porphyrin metabolism
bgm00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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