KEGG   PATHWAY: bgy00260
Entry
bgy00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Bacillus glycinifermentans
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
bgy00260  Glycine, serine and threonine metabolism
bgy00260

Module
bgy_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:bgy00260]
bgy_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:bgy00260]
bgy_M00555  Betaine biosynthesis, choline => betaine [PATH:bgy00260]
bgy_M00621  Glycine cleavage system [PATH:bgy00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Bacillus glycinifermentans [GN:bgy]
Gene
BGLY_0477  yclM; aspartate kinase [KO:K00928] [EC:2.7.2.4]
BGLY_3382  lysC; Aspartokinase 2 [KO:K00928] [EC:2.7.2.4]
BGLY_2095  dapG; Aspartokinase 1 [KO:K00928] [EC:2.7.2.4]
BGLY_2094  asd; Aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
BGLY_3795  hom; Homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
BGLY_3793  thrB; Homoserine kinase [KO:K00872] [EC:2.7.1.39]
BGLY_3794  thrC; Threonine synthase [KO:K01733] [EC:4.2.3.1]
BGLY_4340  glyA; Serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
BGLY_4112  yvcT; 2-ketogluconate reductase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
BGLY_0013  glycerate kinase [KO:K00865] [EC:2.7.1.165]
BGLY_4047  gpmI; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
BGLY_2717  serA; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
BGLY_1116  serC; Phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
BGLY_3429  ysaA; putative uncharacterized hydrolase YsaA [KO:K25528] [EC:3.1.3.3]
BGLY_2118  kbl; 2-amino-3-ketobutyrate CoA ligase [KO:K00639] [EC:2.3.1.29]
BGLY_2117  tdh; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
BGLY_2226  yobN; putative L-amino-acid oxidase YobN [KO:K00274] [EC:1.4.3.4]
BGLY_2908  gcvPA; putative glycine dehydrogenase (decarboxylating) subunit 1 [KO:K00282] [EC:1.4.4.2]
BGLY_2907  gcvPB; putative glycine dehydrogenase (decarboxylating) subunit 2 [KO:K00283] [EC:1.4.4.2]
BGLY_2909  gcvT; Aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
BGLY_1671  pdhD; Dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
BGLY_2861  bfmBC; Dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
BGLY_0871  dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
BGLY_3855  gcvH; Glycine cleavage system H protein [KO:K02437]
BGLY_3727  pssA; phosphatidylserine synthase [KO:K17103] [EC:2.7.8.8]
BGLY_3656  gbsB; Alcohol dehydrogenase [KO:K11440] [EC:1.1.1.1]
BGLY_3657  gbsA; Betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
BGLY_3172  mccB; Cystathionine gamma-lyase [KO:K17217] [EC:4.4.1.1 4.4.1.2]
BGLY_1801  sdaAB; putative L-serine dehydratase, beta chain [KO:K01752] [EC:4.3.1.17]
BGLY_1802  sdaAA; putative L-serine dehydratase, alpha chain [KO:K01752] [EC:4.3.1.17]
BGLY_2567  ilvA; L-threonine dehydratase biosynthetic IlvA [KO:K01754] [EC:4.3.1.19]
BGLY_0227  aspartate racemase [KO:K25316] [EC:5.1.1.10]
BGLY_2673  trpA; Tryptophan synthase alpha chain [KO:K01695] [EC:4.2.1.20]
BGLY_2674  trpB; Tryptophan synthase beta chain [KO:K01696] [EC:4.2.1.20]
BGLY_1214  diaminobutyrate-2-oxoglutarate aminotransferase [KO:K00836] [EC:2.6.1.76]
BGLY_1215  diaminobutyrate decarboxylase [KO:K13745] [EC:4.1.1.86]
BGLY_0426  L-2,4-diaminobutyrate decarboxylase [KO:K13745] [EC:4.1.1.86]
BGLY_1045  pyridoxal-dependent decarboxylase [KO:K13745] [EC:4.1.1.86]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
bgy00010  Glycolysis / Gluconeogenesis
bgy00020  Citrate cycle (TCA cycle)
bgy00230  Purine metabolism
bgy00250  Alanine, aspartate and glutamate metabolism
bgy00270  Cysteine and methionine metabolism
bgy00290  Valine, leucine and isoleucine biosynthesis
bgy00300  Lysine biosynthesis
bgy00330  Arginine and proline metabolism
bgy00460  Cyanoamino acid metabolism
bgy00470  D-Amino acid metabolism
bgy00564  Glycerophospholipid metabolism
bgy00600  Sphingolipid metabolism
bgy00620  Pyruvate metabolism
bgy00630  Glyoxylate and dicarboxylate metabolism
bgy00640  Propanoate metabolism
bgy00680  Methane metabolism
bgy00860  Porphyrin metabolism
bgy00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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