KEGG   PATHWAY: bhm02010
Entry
bhm02010                    Pathway                                
Name
ABC transporters - Bordetella holmesii 44057
Description
The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
Class
Environmental Information Processing; Membrane transport
Pathway map
bhm02010  ABC transporters
bhm02010

Other DBs
GO: 0043190 0043191 0043192
TC: 3.A.1
Organism
Bordetella holmesii 44057 [GN:bhm]
Gene
D558_2483  sulfate ABC transporter, sulfate-binding family protein [KO:K23163]
D558_2484  cysT; sulfate ABC transporter, permease protein CysT [KO:K02046]
D558_2485  cysW; sulfate ABC transporter, permease protein CysW [KO:K02047]
D558_2486  cysA; sulfate ABC transporter, ATP-binding family protein [KO:K02045] [EC:7.3.2.3]
D558_3302  NMT1-like family protein [KO:K15551]
D558_3300  binding--dependent transport system inner membrane component family protein [KO:K15552]
D558_0928  NMT1-like family protein [KO:K15553]
D558_1331  NMT1-like family protein [KO:K15553]
D558_3085  NMT1-like family protein [KO:K15553]
D558_0913  NMT1-like family protein [KO:K15553]
D558_0929  binding--dependent transport system inner membrane component family protein [KO:K15554]
D558_0930  binding--dependent transport system inner membrane component family protein [KO:K15554]
D558_0914  binding--dependent transport system inner membrane component family protein [KO:K15554]
D558_3087  binding--dependent transport system inner membrane component family protein [KO:K15554]
D558_0931  ABC transporter family protein [KO:K15555] [EC:7.6.2.14]
D558_0915  ABC transporter family protein [KO:K15555] [EC:7.6.2.14]
D558_1332  ABC transporter family protein [KO:K15555] [EC:7.6.2.14]
D558_3086  ABC transporter family protein [KO:K15555] [EC:7.6.2.14]
D558_2931  modA; molybdate ABC transporter, periplasmic molybdate-binding protein [KO:K02020]
D558_2932  modB; molybdate ABC transporter, permease protein [KO:K02018]
D558_2933  ABC transporter family protein [KO:K02017] [EC:7.3.2.5]
D558_3616  putative iron binding protein [KO:K02012]
D558_0603  bacterial extracellular solute-binding family protein [KO:K02012]
D558_1314  bacterial extracellular solute-binding family protein [KO:K02012]
D558_2385  putative 2-aminoethylphosphonate ABC transporter, periplasmic 2-aminoethylphosphonate-binding protein [KO:K02012]
D558_0534  bacterial extracellular solute-binding family protein [KO:K02012]
D558_3100  bacterial extracellular solute-binding family protein [KO:K02012]
D558_3617  binding--dependent transport system inner membrane component family protein [KO:K02011]
D558_0602  binding--dependent transport system inner membrane component family protein [KO:K02011]
D558_1312  binding--dependent transport system inner membrane component family protein [KO:K02011]
D558_2382  putative 2-aminoethylphosphonate ABC transporter, permease protein [KO:K02011]
D558_3099  binding--dependent transport system inner membrane component family protein [KO:K02011]
D558_0532  binding--dependent transport system inner membrane component family protein [KO:K02011]
D558_3618  ABC transporter family protein [KO:K02010] [EC:7.2.2.7]
D558_0600  ABC transporter family protein [KO:K02010] [EC:7.2.2.7]
D558_1311  ABC transporter family protein [KO:K02010] [EC:7.2.2.7]
D558_2381  putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein [KO:K02010] [EC:7.2.2.7]
D558_0535  ABC transporter family protein [KO:K02010] [EC:7.2.2.7]
D558_2531  bacterial extracellular solute-binding family protein [KO:K11073]
D558_2534  binding--dependent transport system inner membrane component family protein [KO:K11074]
D558_2533  binding--dependent transport system inner membrane component family protein [KO:K11075]
D558_2532  polyamine ABC transporter, ATP-binding family protein [KO:K11076] [EC:7.6.2.16]
D558_0751  substrate binding domain of ABC-type glycine betaine transport system family protein [KO:K02002]
D558_0750  binding--dependent transport system inner membrane component family protein [KO:K02001]
D558_0749  proV; glycine betaine/L-proline transport ATP binding subunit [KO:K02000] [EC:7.6.2.9]
D558_1572  putative signal peptide protein [KO:K07323]
D558_1279  mce related family protein [KO:K02067]
D558_1574  mce related family protein [KO:K02067]
D558_1281  hypothetical protein [KO:K02066]
D558_1575  hypothetical protein [KO:K02066]
D558_1280  ABC transporter family protein [KO:K02065]
D558_1576  ABC transporter family protein [KO:K02065]
D558_0460  basic membrane family protein [KO:K07335]
D558_3591  bacterial extracellular solute-binding family protein [KO:K05813]
D558_3592  binding--dependent transport system inner membrane component family protein [KO:K05814]
D558_3593  binding--dependent transport system inner membrane component family protein [KO:K05815]
D558_3594  ABC transporter family protein [KO:K05816] [EC:7.6.2.10]
D558_3115  pstS; phosphate ABC transporter, phosphate-binding protein PstS [KO:K02040]
D558_3116  pstA; phosphate ABC transporter, permease protein PstA [KO:K02038]
D558_3117  pstB; phosphate ABC transporter, ATP-binding protein [KO:K02036] [EC:7.3.2.1]
D558_0388  phnD; phosphate/phosphite/phosphonate ABC transporter, periplasmic binding protein [KO:K02044]
D558_0390  phosphonate ABC transporter, permease protein PhnE [KO:K02042]
D558_0391  phosphonate ABC transporter, permease protein PhnE [KO:K02042]
D558_0389  phnC; phosphonate ABC transporter, ATP-binding protein [KO:K02041] [EC:7.3.2.2]
D558_3648  bacterial extracellular solute-binding s, 3 family protein [KO:K10036]
D558_3647  amino ABC transporter, permease , 3-TM region, His/Glu/Gln/Arg/opine family domain protein [KO:K10037]
D558_3646  ABC transporter family protein [KO:K10038] [EC:7.4.2.1]
D558_1890  bacterial extracellular solute-binding s, 3 family protein [KO:K09969]
D558_1184  bacterial extracellular solute-binding s, 3 family protein [KO:K09969]
D558_1891  amino ABC transporter, permease , 3-TM region, His/Glu/Gln/Arg/opine family domain protein [KO:K09970]
D558_1892  amino ABC transporter, permease , 3-TM region, His/Glu/Gln/Arg/opine family domain protein [KO:K09971]
D558_1893  hypothetical protein [KO:K09972] [EC:7.4.2.1]
D558_2234  bacterial extracellular solute-binding s, 3 family protein [KO:K02424]
D558_2233  amino ABC transporter, permease , 3-TM region, His/Glu/Gln/Arg/opine family domain protein [KO:K10009]
D558_2232  ABC transporter family protein [KO:K10010] [EC:7.4.2.1]
D558_1924  periplasmic binding domain protein [KO:K01999]
D558_3596  leucine-, isoleucine-, valine-, threonine-, and alanine-binding protein [KO:K01999]
D558_1207  periplasmic binding family protein [KO:K01999]
D558_1196  receptor ligand binding region family protein [KO:K01999]
D558_3795  receptor ligand binding region family protein [KO:K01999]
D558_0942  periplasmic binding domain protein [KO:K01999]
D558_0961  receptor ligand binding region family protein [KO:K01999]
D558_2242  receptor ligand binding region family protein [KO:K01999]
D558_2252  branched-chain amino acid ABC transporter, periplasmic branched-chain amino acid-binding protein [KO:K01999]
D558_2716  receptor ligand binding region family protein [KO:K01999]
D558_0614  receptor ligand binding region family protein [KO:K01999]
D558_1998  receptor ligand binding region family protein [KO:K01999]
D558_1424  putative substrate binding protein of ABC transporter system [KO:K01999]
D558_2316  periplasmic binding domain protein [KO:K01999]
D558_3329  receptor ligand binding region family protein [KO:K01999]
D558_3541  periplasmic binding domain protein [KO:K01999]
D558_3587  leucine-, isoleucine-, valine-, threonine-, and alanine-binding protein [KO:K01999]
D558_3223  receptor ligand binding region family protein [KO:K01999]
D558_0885  periplasmic binding domain protein [KO:K01999]
D558_1925  branched-chain amino acid transport system / permease component family protein [KO:K01997]
D558_1204  branched-chain amino acid transport system / permease component family protein [KO:K01997]
D558_1197  branched-chain amino acid transport system / permease component family protein [KO:K01997]
D558_0963  branched-chain amino acid transport system / permease component family protein [KO:K01997]
D558_2243  branched-chain amino acid transport system / permease component family protein [KO:K01997]
D558_2250  branched-chain amino acid transport system / permease component family protein [KO:K01997]
D558_2718  branched-chain amino acid transport system / permease component family protein [KO:K01997]
D558_0613  branched-chain amino acid transport system / permease component family protein [KO:K01997]
D558_1997  branched-chain amino acid transport system / permease component family protein [KO:K01997]
D558_1421  branched-chain amino acid transport system / permease component family protein [KO:K01997]
D558_3336  branched-chain amino acid transport system / permease component family protein [KO:K01997]
D558_3540  branched-chain amino acid transport system / permease component family protein [KO:K01997 K01998]
D558_3586  branched-chain amino acid transport system / permease component family protein [KO:K01997]
D558_1198  branched-chain amino acid transport system / permease component family protein [KO:K01995 K01998]
D558_3791  branched-chain amino acid transport system / permease component family protein [KO:K01995 K01998]
D558_2244  branched-chain amino acid transport system / permease component family protein [KO:K01995 K01998]
D558_1205  branched-chain amino acid transport system / permease component family protein [KO:K01998]
D558_1926  branched-chain amino acid transport system / permease component family protein [KO:K01998]
D558_0940  branched-chain amino acid transport system / permease component family protein [KO:K01998]
D558_0964  branched-chain amino acid transport system / permease component family protein [KO:K01998]
D558_2248  branched-chain amino acid transport system / permease component family protein [KO:K01998]
D558_2719  branched-chain amino acid transport system / permease component family protein [KO:K01998]
D558_1995  branched-chain amino acid transport system / permease component family protein [KO:K01998]
D558_1420  branched-chain amino acid transport system / permease component family protein [KO:K01998]
D558_3335  branched-chain amino acid transport system / permease component family protein [KO:K01998]
D558_3585  branched-chain amino acid transport system / permease component family protein [KO:K01998]
D558_1928  ABC transporter family protein [KO:K01995]
D558_1203  ABC transporter family protein [KO:K01995]
D558_0610  ABC transporter family protein [KO:K01995]
D558_0965  ABC transporter family protein [KO:K01995]
D558_2720  ABC transporter family protein [KO:K01995]
D558_1994  ABC transporter family protein [KO:K01995]
D558_1423  ABC transporter family protein [KO:K01995]
D558_3332  ABC transporter family protein [KO:K01995]
D558_3539  ABC transporter family protein [KO:K01995]
D558_3584  ABC transporter family protein [KO:K01995]
D558_3790  ABC transporter family protein [KO:K01996]
D558_1199  ABC transporter family protein [KO:K01996]
D558_1208  ABC transporter family protein [KO:K01996]
D558_1929  ABC transporter family protein [KO:K01996]
D558_0609  ABC transporter family protein [KO:K01996]
D558_0937  ABC transporter family protein [KO:K01996]
D558_0966  ABC transporter family protein [KO:K01996]
D558_2245  ABC transporter family protein [KO:K01996]
D558_2721  ABC transporter family protein [KO:K01996]
D558_1993  ABC transporter family protein [KO:K01996]
D558_3330  ABC transporter family protein [KO:K01996]
D558_3583  ABC transporter family protein [KO:K01996]
D558_3538  ABC transporter family protein [KO:K01996]
D558_0648  lipo, YaeC family protein [KO:K02073]
D558_3574  NLPA lipofamily protein [KO:K02073]
D558_1804  lipo, YaeC family protein [KO:K02073]
D558_0649  binding--dependent transport system inner membrane component family protein [KO:K02072]
D558_0650  ABC transporter family protein [KO:K02071]
D558_2342  bacterial extracellular solute-binding s, 5 Middle family protein [KO:K13889]
D558_2343  glutathione transport system permease protein gsiC [KO:K13890]
D558_2344  gsiD; glutathione transport system permease protein gsiD [KO:K13891]
D558_2341  nickel import ATP-binding protein NikE [KO:K13892]
D558_0049  periplasmic solute binding family protein [KO:K11604]
D558_0051  fecCD transport family protein [KO:K11605]
D558_0052  ABC 3 transport family protein [KO:K11606]
D558_0050  ABC transporter family protein [KO:K11607]
D558_2240  bioY family protein [KO:K03523]
D558_2239  cobalt transport family protein [KO:K16783]
D558_2238  ABC transporter family protein [KO:K16784] [EC:7.6.2.-]
D558_3603  putative capsule polysaccharide export inner-membrane protein [KO:K10107]
D558_3605  ABC-2 type transporter family protein [KO:K09688]
D558_3604  putative capsule polysaccharide exporter, ATP-binding protein [KO:K09689] [EC:7.6.2.12]
D558_1857  ABC-2 type transporter family protein [KO:K09690]
D558_1858  ABC transporter family protein [KO:K09691] [EC:7.5.2.14]
D558_3889  lolD; lipo-releasing system ATP-binding protein LolD [KO:K09810] [EC:7.6.2.-]
D558_2313  putative permease YjgP/YjgQ family protein [KO:K07091]
D558_1956  putative permease YjgP/YjgQ family protein [KO:K11720]
D558_1822  ABC transporter family protein [KO:K06861] [EC:7.5.2.5]
D558_1888  ftsX-like permease family protein [KO:K09811]
D558_1889  ftsE; cell division ATP-binding protein FtsE [KO:K09812]
D558_2557  msbA; lipid A export permease/ATP-binding protein MsbA [KO:K11085] [EC:7.5.2.6]
D558_0774  ABC transporter family protein [KO:K12541]
D558_1834  cydC; thiol reductant ABC exporter, CydC subunit [KO:K16012]
D558_1833  cydD; thiol reductant ABC exporter, CydD subunit [KO:K16013]
D558_0976  ABC transporter family protein [KO:K05685] [EC:7.6.2.-]
Compound
C00009  Orthophosphate
C00025  L-Glutamate
C00031  D-Glucose
C00032  Heme
C00034  Manganese
C00037  Glycine
C00038  Zinc cation
C00041  L-Alanine
C00047  L-Lysine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00062  L-Arginine
C00064  L-Glutamine
C00065  L-Serine
C00070  Copper
C00077  L-Ornithine
C00079  L-Phenylalanine
C00086  Urea
C00088  Nitrite
C00089  Sucrose
C00093  sn-Glycerol 3-phosphate
C00095  D-Fructose
C00098  Oligopeptide
C00107  Dipeptide
C00114  Choline
C00116  Glycerol
C00120  Biotin
C00121  D-Ribose
C00123  L-Leucine
C00134  Putrescine
C00135  L-Histidine
C00137  myo-Inositol
C00140  N-Acetyl-D-glucosamine
C00148  L-Proline
C00151  L-Amino acid
C00159  D-Mannose
C00175  Cobalt ion
C00181  D-Xylose
C00183  L-Valine
C00185  Cellobiose
C00188  L-Threonine
C00208  Maltose
C00212  Adenosine
C00243  Lactose
C00244  Nitrate
C00245  Taurine
C00255  Riboflavin
C00259  L-Arabinose
C00288  HCO3-
C00291  Nickel
C00294  Inosine
C00299  Uridine
C00315  Spermidine
C00320  Thiosulfate
C00330  Deoxyguanosine
C00333  D-Galacturonate
C00338  Lipopolysaccharide
C00378  Thiamine
C00379  Xylitol
C00387  Guanosine
C00392  Mannitol
C00407  L-Isoleucine
C00430  5-Aminolevulinate
C00470  Pectate
C00475  Cytidine
C00487  Carnitine
C00491  L-Cystine
C00492  Raffinose
C00503  Erythritol
C00526  Deoxyuridine
C00559  Deoxyadenosine
C00719  Betaine
C00794  D-Sorbitol
C00855  D-Methionine
C00865  Phospholipid
C00881  Deoxycytidine
C00919  Choline sulfate
C00973  Cyclomaltodextrin
C01083  alpha,alpha-Trehalose
C01153  Orthophosphoric monoester
C01157  Hydroxyproline
C01177  Inositol 1-phosphate
C01181  4-Trimethylammoniobutanoate
C01279  4-Amino-5-hydroxymethyl-2-methylpyrimidine
C01330  Sodium cation
C01417  Cyanate
C01487  D-Allose
C01606  Phthalate
C01630  Xylobiose
C01667  Bacitracin
C01674  Chitobiose
C01682  Nopaline
C01684  D-Rhamnose
C01762  Xanthosine
C01834  Lipoprotein
C01835  Maltotriose
C01935  Maltodextrin
C01946  Oleandomycin
C02160  Isomaltotriose
C02273  Digalacturonate
C03557  2-Aminoethylphosphonate
C03611  Galactose oligosaccharide
C03619  Methyl beta-D-galactoside
C04114  (E)-4-(Trimethylammonio)but-2-enoate
C04137  Octopine
C05349  Ciprofloxacin
C05402  Melibiose
C05512  Deoxyinosine
C05776  Vitamin B12
C06227  Fe(III)hydroxamate
C06229  Fe(III)dicitrate
C06230  Fe-enterobactin
C06232  Molybdate
C06687  Norfloxacin
C06705  Capsular polysaccharide
C06706  Lipo-oligosaccharide
C06707  Teichoic acid
C06767  Hemine
C07662  Sparfloxacin
C07663  Moxifloxacin
C11612  Polymyxin B
C13768  Colistin sulfate
C14818  Fe2+
C14819  Fe3+
C15521  Alkanesulfonate
C15719  Coelichelin
C16421  AI-2
C16692  Mannopine
C19609  Nickel(2+)
C19872  N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20570  alpha-1,5-L-Arabinobiose
C20571  alpha-1,5-L-Arabinotriose
C20572  alpha-1,5-L-Arabinotetraose
C20573  Aldotetraouronic acid
C20679  Tungstate
C21066  D-Galactofuranose
C22040  S-Methyl-L-cysteine
G00457  Maltotetraose
Reference
PMID:9799792
  Authors
Tomii K, Kanehisa M.
  Title
A comparative analysis of ABC transporters in complete microbial genomes.
  Journal
Genome Res 8:1048-59 (1998)
DOI:10.1101/gr.8.10.1048
Reference
PMID:18424520
  Authors
Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A
  Title
Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
J Bacteriol 190:4460-9 (2008)
DOI:10.1128/JB.00270-08
Reference
PMID:18375759
  Authors
Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ
  Title
Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
Proc Natl Acad Sci U S A 105:5537-42 (2008)
DOI:10.1073/pnas.0801196105
Reference
PMID:10557362
  Authors
Omata T, Price GD, Badger MR, Okamura M, Gohta S, Ogawa T
  Title
Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942.
  Journal
Proc Natl Acad Sci U S A 96:13571-6 (1999)
DOI:10.1073/pnas.96.23.13571
Reference
PMID:11731493
  Authors
Quintero MJ, Montesinos ML, Herrero A, Flores E
  Title
Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence.
  Journal
Genome Res 11:2034-40 (2001)
DOI:10.1101/gr.196301
Reference
PMID:16135226
  Authors
Picossi S, Montesinos ML, Pernil R, Lichtle C, Herrero A, Flores E
  Title
ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.
  Journal
Mol Microbiol 57:1582-92 (2005)
DOI:10.1111/j.1365-2958.2005.04791.x
Reference
PMID:11929526
  Authors
Valladares A, Montesinos ML, Herrero A, Flores E.
  Title
An ABC-type, high-affinity urea permease identified in cyanobacteria.
  Journal
Mol Microbiol 43:703-15 (2002)
DOI:10.1046/j.1365-2958.2002.02778.x
Reference
PMID:18326572
  Authors
Richard-Fogal CL, Frawley ER, Kranz RG
  Title
Topology and function of CcmD in cytochrome c maturation.
  Journal
J Bacteriol 190:3489-93 (2008)
DOI:10.1128/JB.00146-08
Reference
PMID:16109926
  Authors
Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H
  Title
The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
  Journal
J Bacteriol 187:5861-7 (2005)
DOI:10.1128/JB.187.17.5861-5867.2005
Reference
PMID:17873039
  Authors
Novikova M, Metlitskaya A, Datsenko K, Kazakov T, Kazakov A, Wanner B, Severinov K
  Title
The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C.
  Journal
J Bacteriol 189:8361-5 (2007)
DOI:10.1128/JB.01028-07
Reference
PMID:17214741
  Authors
Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI
  Title
Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.
  Journal
Mol Microbiol 63:895-910 (2007)
DOI:10.1111/j.1365-2958.2006.05549.x
Reference
PMID:18805970
  Authors
Yamanaka H, Kobayashi H, Takahashi E, Okamoto K
  Title
MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II.
  Journal
J Bacteriol 190:7693-8 (2008)
DOI:10.1128/JB.00853-08
KO pathway
ko02010   
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