KEGG   PATHWAY: bpc02010
Entry
bpc02010                    Pathway                                
Name
ABC transporters - Bordetella pertussis CS
Description
The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
Class
Environmental Information Processing; Membrane transport
Pathway map
bpc02010  ABC transporters
bpc02010

Other DBs
GO: 0043190 0043191 0043192
TC: 3.A.1
Organism
Bordetella pertussis CS [GN:bpc]
Gene
BPTD_0961  sbp; sulfate-binding protein precursor [KO:K23163]
BPTD_0964  cysA; sulfate transport ATP-binding protein [KO:K02045] [EC:7.3.2.3]
BPTD_1463  hypothetical protein [KO:K05772]
BPTD_1462  ABC transporter ATP-binding protein [KO:K06857] [EC:7.3.2.6]
BPTD_3619  periplasmic solute-binding protein [KO:K15551]
BPTD_3620  ABC transport system permease protein [KO:K15552]
BPTD_0472  hypothetical protein [KO:K15553]
BPTD_3798  putative periplasmic protein [KO:K15553]
BPTD_3796  ABC transporter permease protein [KO:K15554]
BPTD_0470  ABC transporter, permease component [KO:K15554]
BPTD_3797  ABC transporter ATP-binding protein [KO:K15555] [EC:7.6.2.14]
BPTD_0471  ABC-transporter, ATP-binding component [KO:K15555] [EC:7.6.2.14]
BPTD_3068  putative molybdate-binding periplasmic protein [KO:K02020]
BPTD_3058  modB; molybdate-binding periplasmic protein precursor [KO:K02020]
BPTD_3057  modC; molybdenum transport system permease protein [KO:K02018]
BPTD_3056  modD; molybdenum transport ATP-binding protein [KO:K02017] [EC:7.3.2.5]
BPTD_1587  putative iron binding protein [KO:K02012]
BPTD_2234  putative periplasmic protein [KO:K02012]
BPTD_2513  hypothetical protein [KO:K02012]
BPTD_2231  putative regulatory lipoprotein [KO:K02012]
BPTD_1442  ABC transporter permease [KO:K02011]
BPTD_1586  putative inner membrane component of binding-protein-dependent transport system [KO:K02011]
BPTD_2236  putative ABC transport permease [KO:K02011]
BPTD_2512  ABC transport protein, solute-binding protein [KO:K02011]
BPTD_2237  putative ABC transport ATP-binding subunit [KO:K02010] [EC:7.2.2.7]
BPTD_2511  ABC transport protein, ATP-binding component [KO:K02010] [EC:7.2.2.7]
BPTD_1441  ABC transporter ATP-binding protein [KO:K02010] [EC:7.2.2.7]
BPTD_2307  putative polyamine transport protein [KO:K11073]
BPTD_2304  putative inner membrane permease polyamine transport protein [KO:K11074]
BPTD_2305  putative inner membrane permease polyamine transport protein [KO:K11075]
BPTD_2306  putative polyamine transport ATP-binding protein [KO:K11076] [EC:7.6.2.16]
BPTD_3519  putative solute-binding periplasmic protein [KO:K02002]
BPTD_2023  putative periplasmic substrate-binding protein [KO:K02002]
BPTD_2024  putative binding-protein-dependent transport protein [KO:K02001]
BPTD_2025  putative ABC-transporter ATP-binding protein [KO:K02000] [EC:7.6.2.9]
BPTD_2784  ABC transport protein, ATP-binding component [KO:K10112] [EC:7.5.2.-]
BPTD_3706  hypothetical protein [KO:K07323]
BPTD_3704  hypothetical protein [KO:K02067]
BPTD_3703  hypothetical protein [KO:K02066]
BPTD_0095  putative integral membrane protein [KO:K02066]
BPTD_3702  putative ABC transporter, ATP-binding protein [KO:K02065]
BPTD_0096  ABC transporter ATP-binding protein [KO:K02065]
BPTD_2595  hypothetical protein [KO:K17321]
BPTD_2597  putative ABC transport protein, inner membrane component [KO:K17323]
BPTD_2599  ABC transporter ATP-binding protein [KO:K17325]
BPTD_0119  extracellular solute-binding protein [KO:K05813]
BPTD_1271  ugpB; glycerol-3-phosphate-binding periplasmic protein precursor [KO:K05813]
BPTD_0118  inner membrane component of binding-protein-dependent transport system [KO:K05814]
BPTD_1272  ugpA; sn-glycerol-3-phosphate transport system, permease protein [KO:K05814]
BPTD_0117  inner membrane component of binding-protein-dependent transport system [KO:K05815]
BPTD_1273  ugpE; sn-glycerol-3-phosphate transport system permease protein [KO:K05815]
BPTD_0120  sugar ABC transporter, ATP-binding protein [KO:K05816] [EC:7.6.2.10]
BPTD_1274  ugpC; glycerol-3-phosphate transporter ATP-binding subunit [KO:K05816] [EC:7.6.2.10]
BPTD_1064  pstS; phosphate-binding periplasmic protein precursor [KO:K02040]
BPTD_1063  pstC; phosphate transport system permease protein [KO:K02037]
BPTD_1062  pstA; phosphate transport system permease protein [KO:K02038]
BPTD_1061  pstB; phosphate transport ATP-binding protein [KO:K02036] [EC:7.3.2.1]
BPTD_3431  hypothetical protein [KO:K02044]
BPTD_3427  binding-protein-dependent transport system permease protein [KO:K02042]
BPTD_3428  binding-protein-dependent transport systems inner membrane component [KO:K02042]
BPTD_1555  glnH; glutamine ABC transporter periplasmic protein [KO:K10036]
BPTD_1556  glnP; glutamine ABC transporter permease protein [KO:K10037]
BPTD_1557  glnQ; glutamine ABC transporter ATP-binding protein [KO:K10038] [EC:7.4.2.1]
BPTD_0055  amino-acid ABC transporter binding protein precursor [KO:K10001]
BPTD_0766  extracellular solute-binding protein [KO:K10001]
BPTD_0053  gltK; glutamate/aspartate transport system permease protein [KO:K10002]
BPTD_0768  gltK; glutamate/aspartate transport system permease protein [KO:K10002]
BPTD_0054  gltJ; glutamate/aspartate transport system permease protein [KO:K10003]
BPTD_0769  gltL; glutamate/aspartate transport ATP-binding protein [KO:K10004] [EC:7.4.2.1]
BPTD_0567  amino acid-binding periplasmic protein [KO:K09969]
BPTD_3774  putative ABC transporter periplasmic amino acid-binding protein [KO:K09969]
BPTD_1511  putative extracellular solute-binding protein [KO:K09969]
BPTD_3773  putative amino acid ABC transporter permease protein [KO:K09970]
BPTD_3772  putative amino acid ABC transporter permease protein [KO:K09971]
BPTD_3771  putative amino acid ABC transporter ATP-binding protein [KO:K09972] [EC:7.4.2.1]
BPTD_1350  putative amino-acid ABC transporter, periplasmic amino acid-binding protein [KO:K02424]
BPTD_1349  putative amino-acid ABC transporter, permease protein [KO:K10009]
BPTD_1348  putative amino-acid ABC transporter, ATP-binding protein [KO:K10010] [EC:7.4.2.1]
BPTD_2842  putative branched-chain amino acid-binding protein [KO:K01999]
BPTD_3279  putative binding-protein-dependent transport protein [KO:K01999]
BPTD_3515  hypothetical protein [KO:K01999]
BPTD_3522  hypothetical protein [KO:K01999]
BPTD_3661  hypothetical protein [KO:K01999]
BPTD_3157  putative amino acid binding precursor protein [KO:K01999]
BPTD_0629  putative leu/Ile/val-binding protein precursor [KO:K01999]
BPTD_1089  livK; putative amino acids binding protein [KO:K01999]
BPTD_1920  branched-chain amino acid-binding protein [KO:K01999]
BPTD_2375  putative ABC transport protein, substrate-binding component [KO:K01999]
BPTD_1488  hypothetical protein [KO:K01999]
BPTD_0232  putative ABC transporter substrate binding protein [KO:K01999]
BPTD_1267  livJ; leu/Ile/val-binding protein precursor [KO:K01999]
BPTD_1275  livJ; leu/Ile/val-binding protein precursor [KO:K01999]
BPTD_2057  putative ABC-transporter substrate-binding protein [KO:K01999]
BPTD_2703  putative ABC transport solute-binding protein [KO:K01999]
BPTD_3379  putative branched-chain amino acid binding protein [KO:K01999]
BPTD_3516  branched-chain amino acid transport system permease protein [KO:K01997]
BPTD_3521  putative branched-chain amino acid transport permease [KO:K01997]
BPTD_3665  branched-chain amino acid transport system permease [KO:K01997]
BPTD_3154  putative ABC transpoter permease protein [KO:K01997]
BPTD_0628  branched-chain amino acid ABC transporter, permease protein [KO:K01997]
BPTD_1087  livH; high-affinity branched-chain amino acid transport system permease protein [KO:K01997]
BPTD_1921  putative permease component of branched-chain amino acid transport system [KO:K01997 K01998]
BPTD_0231  branched chain amino acid ABC transporter permease [KO:K01997]
BPTD_1266  livH; high-affinity branched-chain amino acid transport system, permease protein [KO:K01997]
BPTD_2056  putative ABC-transporter permease component [KO:K01997]
BPTD_2702  putative ABC transport protein, inner membrane component [KO:K01997]
BPTD_2839  branched chain amino acid ABC transporter permease [KO:K01997]
BPTD_3381  putative branched-chain amino acid transport permease [KO:K01997]
BPTD_3517  putative branched-chain amino acid transport system protein [KO:K01995 K01998]
BPTD_0627  branched-chain amino acid ABC transporter, permease protein [KO:K01995 K01998]
BPTD_0230  branched chain amino acid ABC transporter permease [KO:K01998]
BPTD_1265  livM; leucine/isoleucine/valine transporter permease subunit [KO:K01998]
BPTD_2701  putative ABC transport protein, ATP-binding component [KO:K01998]
BPTD_2838  branched chain amino acid ABC transporter permease [KO:K01998]
BPTD_3380  putative branched-chain amino acid transport permease [KO:K01998]
BPTD_3520  putative branched-chain amino acid transport permease [KO:K01998]
BPTD_3664  branched-chain amino acid transport system permease [KO:K01998]
BPTD_3153  putative ABC transporter permease protein [KO:K01998]
BPTD_3524  ABC transporter ATP-binding protein [KO:K01995]
BPTD_3156  putative ABC transporter ATP-binding protein [KO:K01995]
BPTD_1086  livG; high-affinity branched-chain amino acid transport ATP-binding protein [KO:K01995]
BPTD_1922  putative ATP-binding component of branched-chain amino acid ABC transporter [KO:K01995]
BPTD_1630  livG; high-affinity branched-chain amino acid transport, ATP-binding protein [KO:K01995]
BPTD_0229  putative branched-chain amino acid transporter, ATP-binding protein [KO:K01995]
BPTD_1264  livG; leucine/isoleucine/valine transporter ATP-binding subunit [KO:K01995]
BPTD_2700  putative ABC transport protein, ATP-binding component [KO:K01995]
BPTD_2837  livG; high-affinity branched-chain amino acid transport ATP-binding protein [KO:K01995]
BPTD_3382  putative branched-chain amino acid transport ATP-binding ABC transporter [KO:K01995]
BPTD_3663  branched-chain amino acid transport ATP-binding protein [KO:K01995 K01996]
BPTD_0228  high-affinity branched-chain amino acid transporter, ATP-binding protein [KO:K01996]
BPTD_1090  livF; high-affinity branched-chain amino acid transport ATP-binding protein [KO:K01996]
BPTD_1631  livF; high-affinity branched-chain amino acid transport, ATP-binding protein [KO:K01996]
BPTD_1923  putative ATP-binding component of ABC transporter [KO:K01996]
BPTD_1263  livF; high-affinity branched-chain amino acid transport, ATP-binding protein [KO:K01996]
BPTD_2699  putative ABC transport protein, ATP-binding component [KO:K01996]
BPTD_2836  livF; high-affinity branched-chain amino acid transport ATP-binding protein [KO:K01996]
BPTD_3383  putative branched-chain amino acid transport ATP-binding ABC transporter [KO:K01996]
BPTD_3523  ABC transporter ATP-binding protein [KO:K01996]
BPTD_3155  putative ABC transporter ATP-binding protein [KO:K01996]
BPTD_0626  branched-chain amino acid ABC transporter, ATP-binding protein [KO:K01996]
BPTD_2771  hypothetical protein [KO:K02073]
BPTD_0379  hypothetical protein [KO:K02073]
BPTD_1282  hypothetical protein [KO:K02073]
BPTD_3386  hypothetical protein [KO:K02073]
BPTD_2770  ABC transport protein, inner membrane component [KO:K02072]
BPTD_2769  ABC transport protein, ATP-binding component [KO:K02071]
BPTD_2353  putative binding-protein-dependent transport periplasmic protein [KO:K13889]
BPTD_2352  putative binding-protein-dependent transport permease [KO:K13890]
BPTD_2351  putative binding-protein-dependent transport permease [KO:K13891]
BPTD_2354  putative ABC transporter ATP-binding subunit [KO:K13892]
BPTD_3514  BioY family protein [KO:K03523]
BPTD_3513  putative cobalt transport protein [KO:K16783]
BPTD_3512  ABC transporter ATP-binding protein [KO:K16784] [EC:7.6.2.-]
BPTD_1605  kpsE; capsule polysaccharide export inner-membrane protein [KO:K10107]
BPTD_1603  kpsM; putative polysialic acid transport protein [KO:K09688]
BPTD_1604  kpsT; polysialic acid transport ATP-binding protein [KO:K09689] [EC:7.6.2.12]
BPTD_1206  nodJ; ABC transporter, permease protein [KO:K09694]
BPTD_1205  nodI; ABC, transporter, ATP-binding protein [KO:K09695]
BPTD_1099  lolC; lipoprotein releasing system transmembrane protein [KO:K09808]
BPTD_1100  lolD; lipoprotein releasing system ATP-binding protein [KO:K09810] [EC:7.6.2.-]
BPTD_2377  putative integral membrane protein [KO:K07091]
BPTD_0320  hypothetical protein [KO:K11720]
BPTD_0703  ABC transporter [KO:K06861] [EC:7.5.2.5]
BPTD_3776  putative permease protein [KO:K09811]
BPTD_3775  ftsE; cell division ATP-binding protein [KO:K09812]
BPTD_2280  putative ABC transporter [KO:K11085] [EC:7.5.2.6]
BPTD_0762  cyaB; cyclolysin secretion ATP-binding protein [KO:K11004]
BPTD_0895  ABC transporter, ATP-binding protein [KO:K24821]
BPTD_0267  ABC transporter ATP-binding protein [KO:K16012]
BPTD_0268  ABC transporter ATP-binding protein [KO:K16013]
Compound
C00009  Orthophosphate
C00025  L-Glutamate
C00031  D-Glucose
C00032  Heme
C00034  Manganese
C00037  Glycine
C00038  Zinc cation
C00041  L-Alanine
C00047  L-Lysine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00062  L-Arginine
C00064  L-Glutamine
C00065  L-Serine
C00070  Copper
C00077  L-Ornithine
C00079  L-Phenylalanine
C00086  Urea
C00088  Nitrite
C00089  Sucrose
C00093  sn-Glycerol 3-phosphate
C00095  D-Fructose
C00098  Oligopeptide
C00107  Dipeptide
C00114  Choline
C00116  Glycerol
C00120  Biotin
C00121  D-Ribose
C00123  L-Leucine
C00134  Putrescine
C00135  L-Histidine
C00137  myo-Inositol
C00140  N-Acetyl-D-glucosamine
C00148  L-Proline
C00151  L-Amino acid
C00159  D-Mannose
C00175  Cobalt ion
C00181  D-Xylose
C00183  L-Valine
C00185  Cellobiose
C00188  L-Threonine
C00208  Maltose
C00212  Adenosine
C00243  Lactose
C00244  Nitrate
C00245  Taurine
C00255  Riboflavin
C00259  L-Arabinose
C00288  HCO3-
C00291  Nickel
C00294  Inosine
C00299  Uridine
C00315  Spermidine
C00320  Thiosulfate
C00330  Deoxyguanosine
C00333  D-Galacturonate
C00338  Lipopolysaccharide
C00378  Thiamine
C00379  Xylitol
C00387  Guanosine
C00392  Mannitol
C00407  L-Isoleucine
C00430  5-Aminolevulinate
C00470  Pectate
C00475  Cytidine
C00487  Carnitine
C00491  L-Cystine
C00492  Raffinose
C00503  Erythritol
C00526  Deoxyuridine
C00559  Deoxyadenosine
C00719  Betaine
C00794  D-Sorbitol
C00855  D-Methionine
C00865  Phospholipid
C00881  Deoxycytidine
C00919  Choline sulfate
C00973  Cyclomaltodextrin
C01083  alpha,alpha-Trehalose
C01153  Orthophosphoric monoester
C01157  Hydroxyproline
C01177  Inositol 1-phosphate
C01181  4-Trimethylammoniobutanoate
C01279  4-Amino-5-hydroxymethyl-2-methylpyrimidine
C01330  Sodium cation
C01417  Cyanate
C01487  D-Allose
C01606  Phthalate
C01630  Xylobiose
C01667  Bacitracin
C01674  Chitobiose
C01682  Nopaline
C01684  D-Rhamnose
C01762  Xanthosine
C01834  Lipoprotein
C01835  Maltotriose
C01935  Maltodextrin
C01946  Oleandomycin
C02160  Isomaltotriose
C02273  Digalacturonate
C03557  2-Aminoethylphosphonate
C03611  Galactose oligosaccharide
C03619  Methyl beta-D-galactoside
C04114  (E)-4-(Trimethylammonio)but-2-enoate
C04137  Octopine
C05349  Ciprofloxacin
C05402  Melibiose
C05512  Deoxyinosine
C05776  Vitamin B12
C06227  Fe(III)hydroxamate
C06229  Fe(III)dicitrate
C06230  Fe-enterobactin
C06232  Molybdate
C06687  Norfloxacin
C06705  Capsular polysaccharide
C06706  Lipo-oligosaccharide
C06707  Teichoic acid
C06767  Hemine
C07662  Sparfloxacin
C07663  Moxifloxacin
C11612  Polymyxin B
C13768  Colistin sulfate
C14818  Fe2+
C14819  Fe3+
C15521  Alkanesulfonate
C15719  Coelichelin
C16421  AI-2
C16692  Mannopine
C19609  Nickel(2+)
C19872  N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20570  alpha-1,5-L-Arabinobiose
C20571  alpha-1,5-L-Arabinotriose
C20572  alpha-1,5-L-Arabinotetraose
C20573  Aldotetraouronic acid
C20679  Tungstate
C21066  D-Galactofuranose
C22040  S-Methyl-L-cysteine
G00457  Maltotetraose
Reference
PMID:9799792
  Authors
Tomii K, Kanehisa M.
  Title
A comparative analysis of ABC transporters in complete microbial genomes.
  Journal
Genome Res 8:1048-59 (1998)
DOI:10.1101/gr.8.10.1048
Reference
PMID:18424520
  Authors
Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A
  Title
Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
J Bacteriol 190:4460-9 (2008)
DOI:10.1128/JB.00270-08
Reference
PMID:18375759
  Authors
Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ
  Title
Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
Proc Natl Acad Sci U S A 105:5537-42 (2008)
DOI:10.1073/pnas.0801196105
Reference
PMID:10557362
  Authors
Omata T, Price GD, Badger MR, Okamura M, Gohta S, Ogawa T
  Title
Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942.
  Journal
Proc Natl Acad Sci U S A 96:13571-6 (1999)
DOI:10.1073/pnas.96.23.13571
Reference
PMID:11731493
  Authors
Quintero MJ, Montesinos ML, Herrero A, Flores E
  Title
Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence.
  Journal
Genome Res 11:2034-40 (2001)
DOI:10.1101/gr.196301
Reference
PMID:16135226
  Authors
Picossi S, Montesinos ML, Pernil R, Lichtle C, Herrero A, Flores E
  Title
ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.
  Journal
Mol Microbiol 57:1582-92 (2005)
DOI:10.1111/j.1365-2958.2005.04791.x
Reference
PMID:11929526
  Authors
Valladares A, Montesinos ML, Herrero A, Flores E.
  Title
An ABC-type, high-affinity urea permease identified in cyanobacteria.
  Journal
Mol Microbiol 43:703-15 (2002)
DOI:10.1046/j.1365-2958.2002.02778.x
Reference
PMID:18326572
  Authors
Richard-Fogal CL, Frawley ER, Kranz RG
  Title
Topology and function of CcmD in cytochrome c maturation.
  Journal
J Bacteriol 190:3489-93 (2008)
DOI:10.1128/JB.00146-08
Reference
PMID:16109926
  Authors
Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H
  Title
The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
  Journal
J Bacteriol 187:5861-7 (2005)
DOI:10.1128/JB.187.17.5861-5867.2005
Reference
PMID:17873039
  Authors
Novikova M, Metlitskaya A, Datsenko K, Kazakov T, Kazakov A, Wanner B, Severinov K
  Title
The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C.
  Journal
J Bacteriol 189:8361-5 (2007)
DOI:10.1128/JB.01028-07
Reference
PMID:17214741
  Authors
Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI
  Title
Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.
  Journal
Mol Microbiol 63:895-910 (2007)
DOI:10.1111/j.1365-2958.2006.05549.x
Reference
PMID:18805970
  Authors
Yamanaka H, Kobayashi H, Takahashi E, Okamoto K
  Title
MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II.
  Journal
J Bacteriol 190:7693-8 (2008)
DOI:10.1128/JB.00853-08
KO pathway
ko02010   
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