KEGG   PATHWAY: bry00260
Entry
bry00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Bacillus rugosus
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
bry00260  Glycine, serine and threonine metabolism
bry00260

Module
bry_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:bry00260]
bry_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:bry00260]
bry_M00555  Betaine biosynthesis, choline => betaine [PATH:bry00260]
bry_M00621  Glycine cleavage system [PATH:bry00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Bacillus rugosus [GN:bry]
Gene
M0696_09065  dapG; aspartate kinase [KO:K00928] [EC:2.7.2.4]
M0696_02195  aspartate kinase [KO:K00928] [EC:2.7.2.4]
M0696_14260  aspartate kinase [KO:K00928] [EC:2.7.2.4]
M0696_09060  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
M0696_16230  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
M0696_16220  thrB; homoserine kinase [KO:K00872] [EC:2.7.1.39]
M0696_16225  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
M0696_18760  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
M0696_17555  D-glycerate dehydrogenase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
M0696_20385  glycerate kinase [KO:K00865] [EC:2.7.1.165]
M0696_17080  gpmI; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
M0696_10040  2-hydroxyacid dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
M0696_11400  serA; phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
M0696_05640  serC; 3-phosphoserine/phosphohydroxythreonine transaminase [KO:K00831] [EC:2.6.1.52]
M0696_14495  HAD family hydrolase [KO:K25528] [EC:3.1.3.3]
M0696_09175  glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]
M0696_09170  tdh; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
M0696_10250  flavin monoamine oxidase family protein [KO:K00274] [EC:1.4.3.4]
M0696_12180  gcvPA; aminomethyl-transferring glycine dehydrogenase subunit GcvPA [KO:K00282] [EC:1.4.4.2]
M0696_12175  gcvPB; aminomethyl-transferring glycine dehydrogenase subunit GcvPB [KO:K00283] [EC:1.4.4.2]
M0696_12185  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
M0696_04570  acoL; acetoin dehydrogenase complex dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
M0696_07975  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
M0696_11930  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
M0696_16520  gcvH; glycine cleavage system protein GcvH [KO:K02437]
M0696_01360  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
M0696_15610  gbsB; choline dehydrogenase [KO:K11440] [EC:1.1.1.1]
M0696_15615  betB; betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
M0696_13610  bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase [KO:K17217] [EC:4.4.1.1 4.4.1.2]
M0696_08605  sdaAB; L-serine ammonia-lyase, iron-sulfur-dependent subunit beta [KO:K01752] [EC:4.3.1.17]
M0696_08610  sdaAA; L-serine ammonia-lyase, iron-sulfur-dependent, subunit alpha [KO:K01752] [EC:4.3.1.17]
M0696_10715  ilvA; threonine ammonia-lyase IlvA [KO:K01754] [EC:4.3.1.19]
M0696_11775  dsdA; D-serine ammonia-lyase [KO:K01753] [EC:4.3.1.18]
M0696_17345  amino acid racemase [KO:K25316] [EC:5.1.1.10]
M0696_11175  trpA; tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
M0696_11180  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
bry00010  Glycolysis / Gluconeogenesis
bry00020  Citrate cycle (TCA cycle)
bry00230  Purine metabolism
bry00250  Alanine, aspartate and glutamate metabolism
bry00270  Cysteine and methionine metabolism
bry00290  Valine, leucine and isoleucine biosynthesis
bry00300  Lysine biosynthesis
bry00330  Arginine and proline metabolism
bry00460  Cyanoamino acid metabolism
bry00470  D-Amino acid metabolism
bry00564  Glycerophospholipid metabolism
bry00600  Sphingolipid metabolism
bry00620  Pyruvate metabolism
bry00630  Glyoxylate and dicarboxylate metabolism
bry00640  Propanoate metabolism
bry00680  Methane metabolism
bry00860  Porphyrin metabolism
bry00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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