KEGG   PATHWAY: bst02010
Entry
bst02010                    Pathway                                
Name
ABC transporters - Bacillus subtilis subsp. spizizenii TU-B-10
Description
The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
Class
Environmental Information Processing; Membrane transport
Pathway map
bst02010  ABC transporters
bst02010

Other DBs
GO: 0043190 0043191 0043192
TC: 3.A.1
Organism
Bacillus subtilis subsp. spizizenii TU-B-10 [GN:bst]
Gene
GYO_1170  SsuA [KO:K15553]
GYO_1171  putative aliphatic sulfonates transport permease protein SsuC [KO:K15554]
GYO_1169  SsuB [KO:K15555] [EC:7.6.2.14]
GYO_3649  modA; molybdate ABC transporter, periplasmic molybdate-binding protein [KO:K02020]
GYO_3650  modB; molybdate ABC transporter, permease protein [KO:K02018]
GYO_0504  glycine betaine-binding protein [KO:K02002]
GYO_0503  glycine betaine transport system permease protein opuAB [KO:K02001]
GYO_0502  glycine betaine transport ATP-binding protein opuAA [KO:K02000] [EC:7.6.2.9]
GYO_3698  choline-binding protein [KO:K05845]
GYO_3704  glycine betaine/carnitine/choline-binding protein [KO:K05845]
GYO_3697  choline transport system permease protein opuBD [KO:K05846]
GYO_3699  choline transport system permease protein opuBB [KO:K05846]
GYO_3703  glycine betaine/carnitine/choline transport system permease proteinopuCD [KO:K05846]
GYO_3705  glycine betaine/carnitine/choline transport system permease proteinopuCB [KO:K05846]
GYO_3700  choline transport ATP-binding protein opuBA [KO:K05847] [EC:7.6.2.9]
GYO_3706  glycine betaine/carnitine/choline transport ATP-binding protein opuCA [KO:K05847] [EC:7.6.2.9]
GYO_3555  putative ABC transporter ATP-binding protein YcjV [KO:K10112] [EC:7.5.2.-]
GYO_4285  multiple sugar-binding transport ATP-binding protein MsmK [KO:K10112] [EC:7.5.2.-]
GYO_3748  YvfK [KO:K15770]
GYO_3795  YvdG [KO:K15770]
GYO_3747  YvfL [KO:K15771]
GYO_3794  YvdH [KO:K15771]
GYO_3746  YvfM [KO:K15772]
GYO_3793  YvdI [KO:K15772]
GYO_3276  multiple sugar-binding protein [KO:K10117]
GYO_3560  putative ABC transporter extracellular-binding protein yurOprecursor [KO:K10117]
GYO_3559  ABC sugar transporter, inner membrane subunit [KO:K10118]
GYO_3277  sugar transport protein [KO:K10118]
GYO_3558  ABC sugar transporter, inner membrane subunit [KO:K10119]
GYO_3278  maltose transport protein [KO:K10119]
GYO_0970  lipoprotein LplA [KO:K17318]
GYO_0971  protein LplB [KO:K17319]
GYO_0972  protein LplC [KO:K17320]
GYO_3125  putative arabinose-binding protein [KO:K17234]
GYO_3124  L-arabinose transport system permease protein AraP [KO:K17235]
GYO_3123  L-arabinose transport system permease protein AraQ [KO:K17236]
GYO_3443  YufN [KO:K07335]
GYO_3445  sugar ABC transporter [KO:K23535]
GYO_3446  sugar ABC transporter [KO:K23536]
GYO_3444  ABC transporter [KO:K23537]
GYO_3955  D-ribose-binding protein [KO:K10439]
GYO_3954  ribose transport system permease protein RbsC [KO:K10440]
GYO_3953  ribose transport ATP-binding protein RbsA [KO:K10441] [EC:7.5.2.7]
GYO_3952  high affinity ribose transport protein RbsD [KO:K06726] [EC:5.4.99.62]
GYO_2764  pstS; PstS [KO:K02040]
GYO_2763  pstC; phosphate ABC transporter, permease protein PstC [KO:K02037]
GYO_2762  pstA; phosphate ABC transporter, permease protein PstA [KO:K02038]
GYO_2760  phosphate ABC transporter, ATP-binding protein [KO:K02036] [EC:7.3.2.1]
GYO_2761  phosphate ABC transporter, ATP-binding protein [KO:K02036] [EC:7.3.2.1]
GYO_0576  putative amino-acid ABC transporter extracellular-binding protein yckKprecursor [KO:K02424]
GYO_0546  YckB [KO:K02424]
GYO_0575  putative amino-acid ABC transporter permease protein YckJ [KO:K10009]
GYO_0545  YckA [KO:K10009]
GYO_0574  YckI [KO:K10010] [EC:7.4.2.1]
GYO_4358  amino acid ABC transporter, periplasmic amino acid-binding portion [KO:K16961]
GYO_4357  amino acid ABC transporter, permease protein [KO:K16962]
GYO_4356  putative amino-acid ABC transporter ATP-binding protein YtmN [KO:K16963]
GYO_2643  amino acid abc transporter, amino acid-binding protein [KO:K23059]
GYO_2642  YqiY [KO:K17077]
GYO_2641  YqiZ [KO:K23060] [EC:7.4.2.1]
GYO_1199  YhcJ [KO:K02073]
GYO_3574  YusA [KO:K02073]
GYO_3575  YusB [KO:K02072]
GYO_3576  YusC [KO:K02071]
GYO_4036  putative periplasmic binding protein [KO:K11959]
GYO_4035  urtB; ABC transporter [KO:K11960]
GYO_4034  urtC; putative membrane protein [KO:K11961]
GYO_4033  urtD; ABC transporter [KO:K11962]
GYO_4032  urtE; ABC transporter [KO:K11963]
GYO_1447  oppA; oligopeptide-binding protein OppA [KO:K15580]
GYO_1448  oppB; oligopeptide transport system permease protein OppB [KO:K15581]
GYO_1449  oppC; oligopeptide transport system permease protein OppC [KO:K15582]
GYO_1450  oppD; oligopeptide transport ATP-binding protein OppD [KO:K15583]
GYO_1451  oppF; oligopeptide transport ATP-binding protein OppF [KO:K10823]
GYO_1615  dipeptide-binding protein DppE [KO:K16199]
GYO_1612  dipeptide transport system permease protein DppB [KO:K16200]
GYO_1613  dipeptide transport system permease protein DppC [KO:K16201]
GYO_1614  dipeptide transport ATP-binding protein DppD [KO:K16202]
GYO_1017  iron(III) dicitrate-binding periplasmic protein [KO:K23181]
GYO_1015  iron(III) dicitrate transport system permease protein FecD [KO:K23182]
GYO_1016  ferrichrome transport system permease protein FhuB [KO:K23183]
GYO_1014  ferrichrome transport ATP-binding protein FhuC [KO:K23184] [EC:7.2.2.18]
GYO_0488  zinc-binding lipoprotein adcA [KO:K09815]
GYO_2918  zinc-binding lipoprotein AdcA [KO:K09815]
GYO_0489  zinc uptake system ATP-binding protein zurA [KO:K09817] [EC:7.2.2.20]
GYO_3331  manganese-binding lipoprotein MntA [KO:K11707]
GYO_3329  mntC; manganese transport system membrane protein MntC [KO:K11708]
GYO_3328  manganese transport system membrane protein MntD [KO:K11709]
GYO_3330  manganese transport system ATP-binding protein MntB [KO:K11710] [EC:7.2.2.5]
GYO_1339  conserved hypothetical protein [KO:K03523]
GYO_3495  transmembranal protein BioY [KO:K03523]
GYO_0173  cobalt transport family protein [KO:K16785]
GYO_1644  cobalt transport protein [KO:K16785]
GYO_0170  yveK; cobalt import ATP-binding protein CbiO 1 [KO:K16786] [EC:7.-.-.-]
GYO_3925  tagG; teichoic acid translocation permease protein TagG [KO:K09692]
GYO_3924  tagH; teichoic acids export ATP-binding protein TagH [KO:K09693] [EC:7.5.2.4]
GYO_0477  protein NatB [KO:K09696]
GYO_0476  ATP-binding transport protein NatA [KO:K09697] [EC:7.2.2.4]
GYO_3288  bacitracin export permease protein BceB [KO:K11632]
GYO_3289  bacitracin export ATP-binding protein BceA [KO:K11631]
GYO_3690  SpaE [KO:K20491]
GYO_3689  SpaG [KO:K20492]
GYO_3691  bacitracin transport ATP-binding protein BcrA [KO:K20490]
GYO_4422  membrane protein, putative [KO:K16916]
GYO_4423  ABC transporter, ATP-binding protein [KO:K16917]
GYO_3865  conserved hypothetical protein [KO:K09811]
GYO_3866  ftsE; cell division ATP-binding protein FtsE [KO:K09812]
GYO_3292  YtrF [KO:K16918]
GYO_3295  YtrC [KO:K16919]
GYO_3294  YtrC [KO:K16919]
GYO_3296  YtrB [KO:K16921]
GYO_3293  YtrE [KO:K16920]
GYO_1262  YheI [KO:K18889]
GYO_1768  ABC transporter, ATP-binding protein [KO:K18889]
GYO_1769  ABC transporter, ATP-binding protein [KO:K18890]
GYO_1263  ABC transporter, ATP-binding protein [KO:K18890]
GYO_3818  multidrug resistance ABC transporter ATP-binding and permease protein [KO:K18104] [EC:7.6.2.2]
GYO_1089  multidrug ABC transporter ATP-binding protein [KO:K18887]
GYO_1090  ABC transporter [KO:K18888]
GYO_4274  ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease/ATP-binding protein CydC [KO:K16012]
GYO_4275  cydD; ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease/ATP-binding protein CydD [KO:K16013]
GYO_0813  nucleotide binding protein ExpZ [KO:K18231]
Compound
C00009  Orthophosphate
C00025  L-Glutamate
C00031  D-Glucose
C00032  Heme
C00034  Manganese
C00037  Glycine
C00038  Zinc cation
C00041  L-Alanine
C00047  L-Lysine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00062  L-Arginine
C00064  L-Glutamine
C00065  L-Serine
C00070  Copper
C00077  L-Ornithine
C00079  L-Phenylalanine
C00086  Urea
C00088  Nitrite
C00089  Sucrose
C00093  sn-Glycerol 3-phosphate
C00095  D-Fructose
C00098  Oligopeptide
C00107  Dipeptide
C00114  Choline
C00116  Glycerol
C00120  Biotin
C00121  D-Ribose
C00123  L-Leucine
C00134  Putrescine
C00135  L-Histidine
C00137  myo-Inositol
C00140  N-Acetyl-D-glucosamine
C00148  L-Proline
C00151  L-Amino acid
C00159  D-Mannose
C00175  Cobalt ion
C00181  D-Xylose
C00183  L-Valine
C00185  Cellobiose
C00188  L-Threonine
C00208  Maltose
C00212  Adenosine
C00243  Lactose
C00244  Nitrate
C00245  Taurine
C00255  Riboflavin
C00259  L-Arabinose
C00288  HCO3-
C00291  Nickel
C00294  Inosine
C00299  Uridine
C00315  Spermidine
C00320  Thiosulfate
C00330  Deoxyguanosine
C00333  D-Galacturonate
C00338  Lipopolysaccharide
C00378  Thiamine
C00379  Xylitol
C00387  Guanosine
C00392  Mannitol
C00407  L-Isoleucine
C00430  5-Aminolevulinate
C00470  Pectate
C00475  Cytidine
C00487  Carnitine
C00491  L-Cystine
C00492  Raffinose
C00503  Erythritol
C00526  Deoxyuridine
C00559  Deoxyadenosine
C00719  Betaine
C00794  D-Sorbitol
C00855  D-Methionine
C00865  Phospholipid
C00881  Deoxycytidine
C00919  Choline sulfate
C00973  Cyclomaltodextrin
C01083  alpha,alpha-Trehalose
C01153  Orthophosphoric monoester
C01157  Hydroxyproline
C01177  Inositol 1-phosphate
C01181  4-Trimethylammoniobutanoate
C01279  4-Amino-5-hydroxymethyl-2-methylpyrimidine
C01330  Sodium cation
C01417  Cyanate
C01487  D-Allose
C01606  Phthalate
C01630  Xylobiose
C01667  Bacitracin
C01674  Chitobiose
C01682  Nopaline
C01684  D-Rhamnose
C01762  Xanthosine
C01834  Lipoprotein
C01835  Maltotriose
C01935  Maltodextrin
C01946  Oleandomycin
C02160  Isomaltotriose
C02273  Digalacturonate
C03557  2-Aminoethylphosphonate
C03611  Galactose oligosaccharide
C03619  Methyl beta-D-galactoside
C04114  (E)-4-(Trimethylammonio)but-2-enoate
C04137  Octopine
C05349  Ciprofloxacin
C05402  Melibiose
C05512  Deoxyinosine
C05776  Vitamin B12
C06227  Fe(III)hydroxamate
C06229  Fe(III)dicitrate
C06230  Fe-enterobactin
C06232  Molybdate
C06687  Norfloxacin
C06705  Capsular polysaccharide
C06706  Lipo-oligosaccharide
C06707  Teichoic acid
C06767  Hemine
C07662  Sparfloxacin
C07663  Moxifloxacin
C11612  Polymyxin B
C13768  Colistin sulfate
C14818  Fe2+
C14819  Fe3+
C15521  Alkanesulfonate
C15719  Coelichelin
C16421  AI-2
C16692  Mannopine
C19609  Nickel(2+)
C19872  N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20570  alpha-1,5-L-Arabinobiose
C20571  alpha-1,5-L-Arabinotriose
C20572  alpha-1,5-L-Arabinotetraose
C20573  Aldotetraouronic acid
C20679  Tungstate
C21066  D-Galactofuranose
C22040  S-Methyl-L-cysteine
G00457  Maltotetraose
Reference
PMID:9799792
  Authors
Tomii K, Kanehisa M.
  Title
A comparative analysis of ABC transporters in complete microbial genomes.
  Journal
Genome Res 8:1048-59 (1998)
DOI:10.1101/gr.8.10.1048
Reference
  Authors
Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A
  Title
Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
J Bacteriol 190:4460-9 (2008)
DOI:10.1128/JB.00270-08
Reference
  Authors
Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ
  Title
Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
Proc Natl Acad Sci U S A 105:5537-42 (2008)
DOI:10.1073/pnas.0801196105
Reference
  Authors
Omata T, Price GD, Badger MR, Okamura M, Gohta S, Ogawa T
  Title
Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942.
  Journal
Proc Natl Acad Sci U S A 96:13571-6 (1999)
DOI:10.1073/pnas.96.23.13571
Reference
  Authors
Quintero MJ, Montesinos ML, Herrero A, Flores E
  Title
Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence.
  Journal
Genome Res 11:2034-40 (2001)
DOI:10.1101/gr.196301
Reference
  Authors
Picossi S, Montesinos ML, Pernil R, Lichtle C, Herrero A, Flores E
  Title
ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.
  Journal
Mol Microbiol 57:1582-92 (2005)
DOI:10.1111/j.1365-2958.2005.04791.x
Reference
  Authors
Valladares A, Montesinos ML, Herrero A, Flores E.
  Title
An ABC-type, high-affinity urea permease identified in cyanobacteria.
  Journal
Mol Microbiol 43:703-15 (2002)
DOI:10.1046/j.1365-2958.2002.02778.x
Reference
  Authors
Richard-Fogal CL, Frawley ER, Kranz RG
  Title
Topology and function of CcmD in cytochrome c maturation.
  Journal
J Bacteriol 190:3489-93 (2008)
DOI:10.1128/JB.00146-08
Reference
  Authors
Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H
  Title
The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
  Journal
J Bacteriol 187:5861-7 (2005)
DOI:10.1128/JB.187.17.5861-5867.2005
Reference
  Authors
Novikova M, Metlitskaya A, Datsenko K, Kazakov T, Kazakov A, Wanner B, Severinov K
  Title
The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C.
  Journal
J Bacteriol 189:8361-5 (2007)
DOI:10.1128/JB.01028-07
Reference
  Authors
Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI
  Title
Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.
  Journal
Mol Microbiol 63:895-910 (2007)
DOI:10.1111/j.1365-2958.2006.05549.x
Reference
  Authors
Yamanaka H, Kobayashi H, Takahashi E, Okamoto K
  Title
MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II.
  Journal
J Bacteriol 190:7693-8 (2008)
DOI:10.1128/JB.00853-08
KO pathway
ko02010   
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