KEGG   PATHWAY: bstr00260
Entry
bstr00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Bacillus stercoris
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
bstr00260  Glycine, serine and threonine metabolism
bstr00260

Module
bstr_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:bstr00260]
bstr_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:bstr00260]
bstr_M00555  Betaine biosynthesis, choline => betaine [PATH:bstr00260]
bstr_M00621  Glycine cleavage system [PATH:bstr00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Bacillus stercoris [GN:bstr]
Gene
QI003_02155  thrD; aspartate kinase [KO:K00928] [EC:2.7.2.4]
QI003_08985  dapG; aspartate kinase [KO:K00928] [EC:2.7.2.4]
QI003_12410  dapG; aspartate kinase [KO:K00928] [EC:2.7.2.4]
QI003_17415  lysCA; aspartate kinase [KO:K00928] [EC:2.7.2.4]
QI003_08980  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
QI003_12405  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
QI003_19495  hom; homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
QI003_19485  thrB; homoserine kinase [KO:K00872] [EC:2.7.1.39]
QI003_19490  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
QI003_21945  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
QI003_20800  yvcT; D-glycerate dehydrogenase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
QI003_23615  glxK; glycerate kinase [KO:K00865] [EC:2.7.1.165]
QI003_20425  gpmI; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
QI003_10055  2-hydroxyacid dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
QI003_11460  serA; phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
QI003_13485  2-hydroxyacid dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
QI003_14890  serA; phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
QI003_05465  serC; 3-phosphoserine/phosphohydroxythreonine transaminase [KO:K00831] [EC:2.6.1.52]
QI003_17660  ysaA; HAD family hydrolase [KO:K25528] [EC:3.1.3.3]
QI003_09095  glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]
QI003_12520  glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]
QI003_09090  tdh; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
QI003_12515  tdh; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
QI003_10200  flavin monoamine oxidase family protein [KO:K00274] [EC:1.4.3.4]
QI003_13630  flavin monoamine oxidase family protein [KO:K00274] [EC:1.4.3.4]
QI003_15665  gcvPA; aminomethyl-transferring glycine dehydrogenase subunit GcvPA [KO:K00282] [EC:1.4.4.2]
QI003_15660  gcvPB; aminomethyl-transferring glycine dehydrogenase subunit GcvPB [KO:K00283] [EC:1.4.4.2]
QI003_15670  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
QI003_04405  acoL; acetoin dehydrogenase complex dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
QI003_07895  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
QI003_15405  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
QI003_19865  gcvH; glycine cleavage system protein GcvH [KO:K02437]
QI003_01355  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
QI003_18855  gbsB; choline dehydrogenase [KO:K11440] [EC:1.1.1.1]
QI003_18860  betB; betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
QI003_16790  mccB; bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase [KO:K17217] [EC:4.4.1.1 4.4.1.2]
QI003_08525  sdaAB; L-serine ammonia-lyase, iron-sulfur-dependent subunit beta [KO:K01752] [EC:4.3.1.17]
QI003_08530  sdaAA; L-serine ammonia-lyase, iron-sulfur-dependent, subunit alpha [KO:K01752] [EC:4.3.1.17]
QI003_11950  sdaAB; L-serine ammonia-lyase, iron-sulfur-dependent subunit beta [KO:K01752] [EC:4.3.1.17]
QI003_11955  sdaAA; L-serine ammonia-lyase, iron-sulfur-dependent, subunit alpha [KO:K01752] [EC:4.3.1.17]
QI003_10780  ilvA; threonine ammonia-lyase IlvA [KO:K01754] [EC:4.3.1.19]
QI003_14210  ilvA; threonine ammonia-lyase IlvA [KO:K01754] [EC:4.3.1.19]
QI003_15250  dsdA; D-serine ammonia-lyase [KO:K01753] [EC:4.3.1.18]
QI003_20680  racX; broad specificity amino-acid racemase RacX [KO:K25316] [EC:5.1.1.10]
QI003_11235  trpA; tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
QI003_14665  trpA; tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
QI003_11240  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
QI003_14670  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
bstr00010  Glycolysis / Gluconeogenesis
bstr00020  Citrate cycle (TCA cycle)
bstr00230  Purine metabolism
bstr00250  Alanine, aspartate and glutamate metabolism
bstr00270  Cysteine and methionine metabolism
bstr00290  Valine, leucine and isoleucine biosynthesis
bstr00300  Lysine biosynthesis
bstr00330  Arginine and proline metabolism
bstr00460  Cyanoamino acid metabolism
bstr00470  D-Amino acid metabolism
bstr00564  Glycerophospholipid metabolism
bstr00600  Sphingolipid metabolism
bstr00620  Pyruvate metabolism
bstr00630  Glyoxylate and dicarboxylate metabolism
bstr00640  Propanoate metabolism
bstr00680  Methane metabolism
bstr00860  Porphyrin metabolism
bstr00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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