KEGG   PATHWAY: bur00480
Entry
bur00480                    Pathway                                
Name
Glutathione metabolism - Burkholderia lata
Class
Metabolism; Metabolism of other amino acids
Pathway map
bur00480  Glutathione metabolism
bur00480

Module
bur_M00118  Glutathione biosynthesis, glutamate => glutathione [PATH:bur00480]
Other DBs
GO: 0006749
Organism
Burkholderia lata [GN:bur]
Gene
Bcep18194_B0996  gamma-glutamyltransferase 1, Threonine peptidase, MEROPS family T03 [KO:K00681] [EC:2.3.2.2 3.4.19.13]
Bcep18194_B1850  gamma-glutamyltransferase 1, Threonine peptidase, MEROPS family T03 [KO:K00681] [EC:2.3.2.2 3.4.19.13]
Bcep18194_A6223  gamma-glutamyltransferase 1, Threonine peptidase, MEROPS family T03 [KO:K00681] [EC:2.3.2.2 3.4.19.13]
Bcep18194_A6001  gamma-glutamyltransferase 2, Threonine peptidase, MEROPS family T03 [KO:K00681] [EC:2.3.2.2 3.4.19.13]
Bcep18194_C6623  gamma-glutamyltransferase 1, Threonine peptidase, MEROPS family T03 [KO:K00681] [EC:2.3.2.2 3.4.19.13]
Bcep18194_A6024  ChaC-like protein [KO:K07232] [EC:4.3.2.7]
Bcep18194_A4923  ChaC-like protein [KO:K07232] [EC:4.3.2.7]
Bcep18194_B2574  5-oxoprolinase (ATP-hydrolyzing) [KO:K01469] [EC:3.5.2.9]
Bcep18194_A6280  LamB/YcsF family protein [KO:K07160] [EC:3.5.2.9]
Bcep18194_A6386  LamB/YcsF family protein [KO:K07160] [EC:3.5.2.9]
Bcep18194_A6384  conserved hypothetical protein [KO:K23123] [EC:3.5.2.9]
Bcep18194_A6385  Allophanate hydrolase subunit 2 [KO:K23124] [EC:3.5.2.9]
Bcep18194_A3250  Enzymatic protein of unknown function [KO:K06048] [EC:6.3.2.2 6.3.-.-]
Bcep18194_A6193  Glutamate--cysteine ligase GshA [KO:K01919] [EC:6.3.2.2]
Bcep18194_A6505  glutamate-cysteine ligase [KO:K01919] [EC:6.3.2.2]
Bcep18194_A6192  glutathione synthase [KO:K01920] [EC:6.3.2.3]
Bcep18194_A5797  aminopeptidase A, Metallo peptidase, MEROPS family M17 [KO:K01255] [EC:3.4.11.1]
Bcep18194_A3582  Peptidase M1, membrane alanine aminopeptidase [KO:K01256] [EC:3.4.11.2]
Bcep18194_A4126  alanyl aminopeptidase, Metallo peptidase, MEROPS family M01 [KO:K01256] [EC:3.4.11.2]
Bcep18194_B2249  Glutathione S-transferase-like protein [KO:K00799] [EC:2.5.1.18]
Bcep18194_B2348  Glutathione S-transferase-like protein [KO:K00799] [EC:2.5.1.18]
Bcep18194_B2439  Glutathione S-transferase-like protein [KO:K00799] [EC:2.5.1.18]
Bcep18194_C7686  Glutathione S-transferase-like protein [KO:K00799] [EC:2.5.1.18]
Bcep18194_C7338  Glutathione S-transferase-like protein [KO:K00799] [EC:2.5.1.18]
Bcep18194_C7480  Glutathione S-transferase-like protein [KO:K00799] [EC:2.5.1.18]
Bcep18194_B2137  Glutathione S-transferase-like protein [KO:K00799] [EC:2.5.1.18]
Bcep18194_B2557  Glutathione S-transferase-like protein [KO:K00799] [EC:2.5.1.18]
Bcep18194_B2771  Glutathione S-transferase-like protein [KO:K00799] [EC:2.5.1.18]
Bcep18194_A6295  Glutathione S-transferase-like protein [KO:K00799] [EC:2.5.1.18]
Bcep18194_A6303  Glutathione S-transferase-like protein [KO:K00799] [EC:2.5.1.18]
Bcep18194_B0039  Glutathione S-transferase-like protein [KO:K00799] [EC:2.5.1.18]
Bcep18194_B0183  Glutathione S-transferase-like protein [KO:K00799] [EC:2.5.1.18]
Bcep18194_B0203  Glutathione S-transferase-like protein [KO:K00799] [EC:2.5.1.18]
Bcep18194_A4988  Glutathione S-transferase-like protein [KO:K00799] [EC:2.5.1.18]
Bcep18194_A3782  Glutathione S-transferase-like protein [KO:K00799] [EC:2.5.1.18]
Bcep18194_A5554  Glutathione S-transferase-like protein [KO:K00799] [EC:2.5.1.18]
Bcep18194_A6379  Glutathione S-transferase-like protein [KO:K00799] [EC:2.5.1.18]
Bcep18194_B2364  Glutathione S-transferase-like protein [KO:K00799] [EC:2.5.1.18]
Bcep18194_A6352  NADPH-glutathione reductase [KO:K00383] [EC:1.8.1.7]
Bcep18194_A5855  Isocitrate dehydrogenase (NADP+) [KO:K00031] [EC:1.1.1.42]
Bcep18194_A5856  isocitrate dehydrogenase (NADP) [KO:K00031] [EC:1.1.1.42]
Bcep18194_B2181  6-phosphogluconate dehydrogenase (decarboxylating) [KO:K00033] [EC:1.1.1.44 1.1.1.343]
Bcep18194_B0242  glucose-6-phosphate 1-dehydrogenase [KO:K00036] [EC:1.1.1.49 1.1.1.363]
Bcep18194_A4070  glucose-6-phosphate 1-dehydrogenase [KO:K00036] [EC:1.1.1.49 1.1.1.363]
Bcep18194_C7246  Glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
Bcep18194_A5344  Glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
Bcep18194_A3651  Alkyl hydroperoxide reductase/Thiol specific antioxidant/Mal allergen [KO:K24138] [EC:1.11.1.25 1.11.1.27]
Bcep18194_B2075  ornithine decarboxylase [KO:K01581] [EC:4.1.1.17]
Bcep18194_C7063  Spermidine synthase-like protein [KO:K00797] [EC:2.5.1.16]
Bcep18194_B0816  Spermine synthase [KO:K00797] [EC:2.5.1.16]
Bcep18194_A3721  spermidine synthase [KO:K00797] [EC:2.5.1.16]
Compound
C00005  NADPH
C00006  NADP+
C00024  Acetyl-CoA
C00025  L-Glutamate
C00037  Glycine
C00051  Glutathione
C00072  Ascorbate
C00077  L-Ornithine
C00097  L-Cysteine
C00127  Glutathione disulfide
C00134  Putrescine
C00151  L-Amino acid
C00315  Spermidine
C00669  gamma-L-Glutamyl-L-cysteine
C00750  Spermine
C01322  RX
C01419  Cys-Gly
C01672  Cadaverine
C01879  5-Oxoproline
C02090  Trypanothione
C02320  R-S-Glutathione
C03170  Trypanothione disulfide
C03646  Bis-gamma-glutamylcystine
C03740  (5-L-Glutamyl)-L-amino acid
C05422  Dehydroascorbate
C05726  S-Substituted L-cysteine
C05727  S-Substituted N-acetyl-L-cysteine
C05729  R-S-Cysteinylglycine
C05730  Glutathionylspermidine
C16562  Glutathionylspermine
C16563  Bis(glutathionyl)spermine
C16564  Bis(glutathionyl)spermine disulfide
C16565  Aminopropylcadaverine
C16566  Glutathionylaminopropylcadaverine
C16567  Homotrypanothione
C16568  Homotrypanothione disulfide
C16663  Tryparedoxin
C16664  Tryparedoxin disulfide
Reference
  Authors
Josch C, Klotz LO, Sies H.
  Title
Identification of cytosolic leucyl aminopeptidase (EC 3.4.11.1) as the major cysteinylglycine-hydrolysing activity in rat liver.
  Journal
Biol Chem 384:213-8 (2003)
DOI:10.1515/BC.2003.023
Reference
  Authors
Chu L, Lai Y, Xu X, Eddy S, Yang S, Song L, Kolodrubetz D.
  Title
A 52-kDa leucyl aminopeptidase from treponema denticola is a cysteinylglycinase that mediates the second step of glutathione metabolism.
  Journal
J Biol Chem 283:19351-8 (2008)
DOI:10.1074/jbc.M801034200
Reference
  Authors
Cappiello M, Lazzarotti A, Buono F, Scaloni A, D'Ambrosio C, Amodeo P, Mendez BL, Pelosi P, Del Corso A, Mura U.
  Title
New role for leucyl aminopeptidase in glutathione turnover.
  Journal
Biochem J 378:35-44 (2004)
DOI:10.1042/BJ20031336
Reference
  Authors
Suzuki H, Kamatani S, Kim ES, Kumagai H.
  Title
Aminopeptidases A, B, and N and dipeptidase D are the four cysteinylglycinases of Escherichia coli K-12.
  Journal
J Bacteriol 183:1489-90 (2001)
DOI:10.1128/JB.183.4.1489-1490.2001
Reference
  Authors
Oza SL, Shaw MP, Wyllie S, Fairlamb AH.
  Title
Trypanothione biosynthesis in Leishmania major.
  Journal
Mol Biochem Parasitol 139:107-16 (2005)
DOI:10.1016/j.molbiopara.2004.10.004
Reference
  Authors
Oza SL, Ariyanayagam MR, Fairlamb AH.
  Title
Characterization of recombinant glutathionylspermidine synthetase/amidase from Crithidia fasciculata.
  Journal
Biochem J 364:679-86 (2002)
DOI:10.1042/BJ20011370
Reference
PMID:9677355
  Authors
Tetaud E, Manai F, Barrett MP, Nadeau K, Walsh CT, Fairlamb AH.
  Title
Cloning and characterization of the two enzymes responsible for trypanothione biosynthesis in Crithidia fasciculata.
  Journal
J Biol Chem 273:19383-90 (1998)
DOI:10.1074/jbc.273.31.19383
Reference
  Authors
Ariyanayagam MR, Oza SL, Mehlert A, Fairlamb AH.
  Title
Bis(glutathionyl)spermine and other novel trypanothione analogues in Trypanosoma cruzi.
  Journal
J Biol Chem 278:27612-9 (2003)
DOI:10.1074/jbc.M302750200
Reference
  Authors
Oza SL, Ariyanayagam MR, Aitcheson N, Fairlamb AH.
  Title
Properties of trypanothione synthetase from Trypanosoma brucei.
  Journal
Mol Biochem Parasitol 131:25-33 (2003)
DOI:10.1016/S0166-6851(03)00176-2
Reference
  Authors
Oza SL, Tetaud E, Ariyanayagam MR, Warnon SS, Fairlamb AH.
  Title
A single enzyme catalyses formation of Trypanothione from glutathione and spermidine in Trypanosoma cruzi.
  Journal
J Biol Chem 277:35853-61 (2002)
DOI:10.1074/jbc.M204403200
Reference
  Authors
Comini M, Menge U, Wissing J, Flohe L.
  Title
Trypanothione synthesis in crithidia revisited.
  Journal
J Biol Chem 280:6850-60 (2005)
DOI:10.1074/jbc.M404486200
Reference
PMID:7813456
  Authors
Hunter KJ, Le Quesne SA, Fairlamb AH.
  Title
Identification and biosynthesis of N1,N9-bis(glutathionyl)aminopropylcadaverine (homotrypanothione) in Trypanosoma cruzi.
  Journal
Eur J Biochem 226:1019-27 (1994)
DOI:10.1111/j.1432-1033.1994.t01-1-01019.x
Reference
  Authors
Krauth-Siegel RL, Meiering SK, Schmidt H.
  Title
The parasite-specific trypanothione metabolism of trypanosoma and leishmania.
  Journal
Biol Chem 384:539-49 (2003)
DOI:10.1515/BC.2003.062
Reference
  Authors
Krauth-Siegel RL, Comini MA.
  Title
Redox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolism.
  Journal
Biochim Biophys Acta 1780:1236-48 (2008)
DOI:10.1016/j.bbagen.2008.03.006
Reference
PMID:8892297
  Authors
Krauth-Siegel RL, Ludemann H.
  Title
Reduction of dehydroascorbate by trypanothione.
  Journal
Mol Biochem Parasitol 80:203-8 (1996)
DOI:10.1016/0166-6851(96)02689-8
Reference
  Authors
Dormeyer M, Reckenfelderbaumer N, Ludemann H, Krauth-Siegel RL.
  Title
Trypanothione-dependent synthesis of deoxyribonucleotides by Trypanosoma brucei ribonucleotide reductase.
  Journal
J Biol Chem 276:10602-6 (2001)
DOI:10.1074/jbc.M010352200
Reference
  Authors
Schmidt H, Krauth-Siegel RL.
  Title
Functional and physicochemical characterization of the thioredoxin system in Trypanosoma brucei.
  Journal
J Biol Chem 278:46329-36 (2003)
DOI:10.1074/jbc.M305338200
Reference
PMID:9851611
  Authors
Tetaud E, Fairlamb AH.
  Title
Cloning, expression and reconstitution of the trypanothione-dependent peroxidase system of Crithidia fasciculata.
  Journal
Mol Biochem Parasitol 96:111-23 (1998)
DOI:10.1016/S0166-6851(98)00120-0
Reference
  Authors
Castro H, Sousa C, Santos M, Cordeiro-da-Silva A, Flohe L, Tomas AM.
  Title
Complementary antioxidant defense by cytoplasmic and mitochondrial peroxiredoxins in Leishmania infantum.
  Journal
Free Radic Biol Med 33:1552-62 (2002)
DOI:10.1016/S0891-5849(02)01089-4
Reference
  Authors
Wilkinson SR, Temperton NJ, Mondragon A, Kelly JM.
  Title
Distinct mitochondrial and cytosolic enzymes mediate trypanothione-dependent peroxide metabolism in Trypanosoma cruzi.
  Journal
J Biol Chem 275:8220-5 (2000)
DOI:10.1074/jbc.275.11.8220
Reference
  Authors
Konig J, Fairlamb AH.
  Title
A comparative study of type I and type II tryparedoxin peroxidases in Leishmania major.
  Journal
FEBS J 274:5643-58 (2007)
DOI:10.1111/j.1742-4658.2007.06087.x
Reference
  Authors
Hillebrand H, Schmidt A, Krauth-Siegel RL.
  Title
A second class of peroxidases linked to the trypanothione metabolism.
  Journal
J Biol Chem 278:6809-15 (2003)
DOI:10.1074/jbc.M210392200
Reference
  Authors
Soksawatmaekhin W, Kuraishi A, Sakata K, Kashiwagi K, Igarashi K.
  Title
Excretion and uptake of cadaverine by CadB and its physiological functions in Escherichia coli.
  Journal
Mol Microbiol 51:1401-12 (2004)
DOI:10.1046/j.1365-2958.2003.03913.x
Reference
PMID:6798961
  Authors
Pegg AE, Shuttleworth K, Hibasami H.
  Title
Specificity of mammalian spermidine synthase and spermine synthase.
  Journal
Biochem J 197:315-20 (1981)
DOI:10.1042/bj1970315
Related
pathway
bur00220  Arginine biosynthesis
bur00250  Alanine, aspartate and glutamate metabolism
bur00270  Cysteine and methionine metabolism
bur00430  Taurine and hypotaurine metabolism
bur00460  Cyanoamino acid metabolism
KO pathway
ko00480   
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