KEGG PATHWAY: ccw00260

PATHWAY: ccw00260

Entry

ccw00260                    Pathway

Name

Glycine, serine and threonine metabolism - Corvus cornix (hooded crow)

Description

Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].

Class

Metabolism; Amino acid metabolism

Pathway map

ccw00260

Glycine, serine and threonine metabolism

Module

ccw_M00020

Serine biosynthesis, glycerate-3P => serine [PATH:ccw00260]

ccw_M00047

Creatine pathway [PATH:ccw00260]

ccw_M00338

Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:ccw00260]

ccw_M00555

Betaine biosynthesis, choline => betaine [PATH:ccw00260]

ccw_M00621

Glycine cleavage system [PATH:ccw00260]

ccw_M00974

Betaine metabolism, animals, betaine => glycine [PATH:ccw00260]

Other DBs

GO:	0006544 0006563 0070178 0006566

Organism

Corvus cornix (hooded crow) [GN:ccw]

Gene

104698202

LOW QUALITY PROTEIN: probable low-specificity L-threonine aldolase 2 [KO:K01620] [EC:4.1.2.48]

104684770

SHMT1; serine hydroxymethyltransferase, cytosolic [KO:K00600] [EC:2.1.2.1]

104695842

GRHPR; glyoxylate reductase/hydroxypyruvate reductase isoform X1 [KO:K00049] [EC:1.1.1.79 1.1.1.81]

104683243

GLYCTK; glycerate kinase [KO:K11529] [EC:2.7.1.165]

104697898

PGAM1; phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]

104692259

BPGM; bisphosphoglycerate mutase [KO:K01837] [EC:5.4.2.4 5.4.2.11]

104695603

PHGDH; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]

104691991

PSAT1; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]

104691088

PSPH; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]

104696518

GCAT; 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial [KO:K00639] [EC:2.3.1.29]

104683241

ALAS1; 5-aminolevulinate synthase, nonspecific, mitochondrial [KO:K00643] [EC:2.3.1.37]

120412225

LOW QUALITY PROTEIN: 5-aminolevulinate synthase, erythroid-specific, mitochondrial-like [KO:K00643] [EC:2.3.1.37]

104686235

amine oxidase [flavin-containing] B-like [KO:K00274] [EC:1.4.3.4]

104686357

amine oxidase [flavin-containing] A-like [KO:K00274] [EC:1.4.3.4]

104697770

LOW QUALITY PROTEIN: membrane primary amine oxidase [KO:K00276] [EC:1.4.3.21]

120409621

membrane primary amine oxidase-like [KO:K00276] [EC:1.4.3.21]

120411302

membrane primary amine oxidase-like [KO:K00276] [EC:1.4.3.21]

104685184

GLDC; glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]

104683422

AMT; aminomethyltransferase, mitochondrial [KO:K00605] [EC:2.1.2.10]

104686918

DLD; dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]

104691897

GCSH; glycine cleavage system H protein, mitochondrial [KO:K02437]

104688662

DAO; D-amino-acid oxidase [KO:K00273] [EC:1.4.3.3]

104686756

AGXT2; alanine--glyoxylate aminotransferase 2, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]

104684102

GATM; glycine amidinotransferase, mitochondrial [KO:K00613] [EC:2.1.4.1]

104697066

GAMT; guanidinoacetate N-methyltransferase isoform X1 [KO:K00542] [EC:2.1.1.2]

104683259

CHDH; choline dehydrogenase, mitochondrial [KO:K00108] [EC:1.1.99.1]

104690506

ALDH7A1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]

104695711

betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]

104695710

DMGDH; dimethylglycine dehydrogenase, mitochondrial [KO:K00315] [EC:1.5.8.4]

104691052

PIPOX; peroxisomal sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]

104688488

SARDH; sarcosine dehydrogenase, mitochondrial [KO:K00314] [EC:1.5.8.3]

120411694

GNMT; glycine N-methyltransferase [KO:K00552] [EC:2.1.1.20]

104686257

cystathionine beta-synthase-like protein isoform X1 [KO:K01697] [EC:4.2.1.22]

104686258

cystathionine beta-synthase-like [KO:K01697] [EC:4.2.1.22]

104695486

CTH; cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]

104690224

putative threonine dehydratase isoform X1 [KO:K01754] [EC:4.3.1.19]

104695004

SDSL; serine dehydratase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]

120409651

D-threo-3-hydroxyaspartate dehydratase-like [KO:K20498] [EC:4.3.1.18]

104691063

SRR; serine racemase [KO:K12235] [EC:5.1.1.18]

Compound

C00011

CO2

C00014

Ammonia

C00022

Pyruvate

C00037

Glycine

C00048

Glyoxylate

C00049

L-Aspartate

C00065

L-Serine

C00078

L-Tryptophan

C00097

L-Cysteine

C00101

Tetrahydrofolate

C00109

2-Oxobutanoate

C00114

Choline

C00143

5,10-Methylenetetrahydrofolate

C00168

Hydroxypyruvate

C00188

L-Threonine

C00197

3-Phospho-D-glycerate

C00213

Sarcosine

C00258

D-Glycerate

C00263

L-Homoserine

C00300

Creatine

C00430

5-Aminolevulinate

C00441

L-Aspartate 4-semialdehyde

C00546

Methylglyoxal

C00576

Betaine aldehyde

C00581

Guanidinoacetate

C00631

2-Phospho-D-glycerate

C00719

Betaine

C00740

D-Serine

C00986

1,3-Diaminopropane

C01005

O-Phospho-L-serine

C01026

N,N-Dimethylglycine

C01102

O-Phospho-L-homoserine

C01242

[Protein]-S8-aminomethyldihydrolipoyllysine

C01888

Aminoacetone

C02051

Lipoylprotein

C02291

L-Cystathionine

C02737

Phosphatidylserine

C02972

Dihydrolipoylprotein

C03082

4-Phospho-L-aspartate

C03194

(R)-1-Aminopropan-2-ol

C03232

3-Phosphonooxypyruvate

C03283

L-2,4-Diaminobutanoate

C03508

L-2-Amino-3-oxobutanoic acid

C05519

L-Allothreonine

C06231

Ectoine

C06442

N(gamma)-Acetyldiaminobutyrate

C16432

5-Hydroxyectoine

C19929

N(alpha)-Acetyl-L-2,4-diaminobutyrate

Reference

Authors

Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).

Title

[Cellular Functions and Metabolic Maps] (In Japanese)

Journal

Tokyo Kagaku Dojin (1997)

Reference

PMID:11823218

Authors

Kuhlmann AU, Bremer E.

Title

Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.

Journal

Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002

Reference

PMID:10473374

Authors

Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.

Title

Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.

Journal

Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999

Reference

PMID:17636255

Authors

Bursy J, Pierik AJ, Pica N, Bremer E.

Title

Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.

Journal

J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200

Reference

PMID:16707670

Authors

Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.

Title

The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.

Journal

J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06

Reference

PMID:15470257

Authors

Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J

Title

FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.

Journal

Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004

Reference

PMID:7639721