KEGG PATHWAY: cfo04145

KEGG

PATHWAY: cfo04145

Entry

cfo04145                    Pathway

Name

Phagosome - Camponotus floridanus (Florida carpenter ant)

Description

Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.

Class

Cellular Processes; Transport and catabolism

Pathway map

Phagosome

Other DBs

GO:

Organism

Camponotus floridanus (Florida carpenter ant) [GN:cfo]

Gene

syntaxin-12 [KO:K08488]

actin-5C [KO:K05692]

syntaxin-18 [KO:K08492]

vesicle-trafficking protein SEC22b-B [KO:K08517]

ras-related protein Rab-5C [KO:K07889]

phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]

hepatocyte growth factor-regulated tyrosine kinase substrate [KO:K12182]

V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]

V-type proton ATPase subunit B [KO:K02147]

V-type proton ATPase subunit C [KO:K02148]

V-type proton ATPase subunit D [KO:K02149]

V-type proton ATPase subunit D [KO:K02149]

V-type proton ATPase subunit E [KO:K02150]

V-type proton ATPase subunit F [KO:K02151]

V-type proton ATPase subunit G [KO:K02152]

V-type proton ATPase subunit e 2-like [KO:K02153]

V-type proton ATPase 116 kDa subunit a isoform X2 [KO:K02154]

V-type proton ATPase 116 kDa subunit a [KO:K02154]

V-type proton ATPase subunit d [KO:K02146]

V-type proton ATPase subunit H isoform X1 [KO:K02144]

V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]

V-type proton ATPase 21 kDa proteolipid subunit [KO:K03661]

uncharacterized protein LOC105248469 [KO:K03662]

ras-related protein rab7 [KO:K07897]

dynein heavy chain, cytoplasmic isoform X1 [KO:K10413]

cytoplasmic dynein 1 intermediate chain isoform X1 [KO:K10415]

cytoplasmic dynein 1 light intermediate chain 2 isoform X1 [KO:K10416]

tubulin alpha-1 chain [KO:K07374]

tubulin alpha chain [KO:K07374]

tubulin alpha-1 chain isoform X2 [KO:K07374]

tubulin alpha chain [KO:K07374]

tubulin alpha-1 chain [KO:K07374]

tubulin alpha-2 chain [KO:K07374]

tubulin beta chain [KO:K07375]

tubulin beta chain [KO:K07375]

tubulin beta chain-like [KO:K07375]

tubulin beta-1 chain [KO:K07375]

tubulin beta chain [KO:K07375]

lysosome-associated membrane glycoprotein 1 [KO:K06528]

1-phosphatidylinositol 3-phosphate 5-kinase isoform X1 [KO:K00921] [EC:2.7.1.150]

uncharacterized protein LOC105252892 isoform X1 [KO:K10089]

nitric oxide synthase, salivary gland [KO:K13240] [EC:1.14.13.39]

cathepsin L1 [KO:K01365] [EC:3.4.22.15]

cathepsin L1 [KO:K01365] [EC:3.4.22.15]

protein transport protein Sec61 subunit alpha [KO:K10956]

protein transport protein Sec61 subunit beta [KO:K09481]

protein transport protein Sec61 subunit gamma [KO:K07342]

calreticulin [KO:K08057]

calnexin-like [KO:K08054]

integrin beta-PS isoform X2 [KO:K05719]

integrin beta-PS [KO:K05719]

cartilage oligomeric matrix protein [KO:K04659]

scavenger receptor class B member 1 [KO:K13885]

scavenger receptor class B member 1 [KO:K13885]

scavenger receptor class B member 1 [KO:K13885]

sensory neuron membrane protein 1 [KO:K13885]

scavenger receptor class B member 1 [KO:K13885]

protein croquemort [KO:K13885]

scavenger receptor class B member 1 isoform X1 [KO:K13885]

protein croquemort isoform X1 [KO:K13885]

ras-like GTP-binding protein RhoL [KO:K04392]

ras-related protein Rac1 [KO:K04392]

ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]

Compound

1-Phosphatidyl-1D-myo-inositol 3-phosphate

Reference

Authors

Stuart LM, Ezekowitz RA

Title

Phagocytosis: elegant complexity.

Journal

Immunity 22:539-50 (2005)
DOI:10.1016/j.immuni.2005.05.002

Reference

Authors

Tjelle TE, Lovdal T, Berg T

Title

Phagosome dynamics and function.

Journal

Bioessays 22:255-63 (2000)
DOI:10.1002/(SICI)1521-1878(200003)22:3<255::AID-BIES7>3.0.CO;2-R

Reference

Authors

Dupuy AG, Caron E

Title

Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.

Journal

J Cell Sci 121:1773-83 (2008)
DOI:10.1242/jcs.018036

Reference

Authors

Brumell JH, Grinstein S

Title

Salmonella redirects phagosomal maturation.

Journal

Curr Opin Microbiol 7:78-84 (2004)
DOI:10.1016/j.mib.2003.12.005

Reference

Authors

Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S

Title

LAMP proteins are required for fusion of lysosomes with phagosomes.

Journal

EMBO J 26:313-24 (2007)
DOI:10.1038/sj.emboj.7601511

Reference

Authors

Luzio JP, Pryor PR, Bright NA

Title

Lysosomes: fusion and function.

Journal

Nat Rev Mol Cell Biol 8:622-32 (2007)
DOI:10.1038/nrm2217

Reference

Authors

Sumimoto H

Title

Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.

Journal

FEBS J 275:3249-77 (2008)
DOI:10.1111/j.1742-4658.2008.06488.x

Related
pathway

Lysosome

Endocytosis

KO pathway

LinkDB

DBGET integrated database retrieval system