KEGG   PATHWAY: chrb02020
Entry
chrb02020                   Pathway                                
Name
Two-component system - Chromobacterium phragmitis IIBBL 274-1
Description
Two-component signal transduction systems enable bacteria to sense, respond, and adapt to changes in their environment or in their intracellular state. Each two-component system consists of a sensor protein-histidine kinase (HK) and a response regulator (RR). In the prototypical two-component pathway, the sensor HK phosphorylates its own conserved His residue in response to a signal(s) in the environment. Subsequently, the phosphoryl group of HK is transferred onto a specific Asp residue on the RR. The activated RR can then effect changes in cellular physiology, often by regulating gene expression. Two-component pathways thus often enable cells to sense and respond to stimuli by inducing changes in transcription.
Class
Environmental Information Processing; Signal transduction
Pathway map
chrb02020  Two-component system
chrb02020

Other DBs
GO: 0000160
Organism
Chromobacterium phragmitis IIBBL 274-1 [GN:chrb]
Gene
DK843_11970  phoR; phosphate regulon sensor histidine kinase PhoR [KO:K07636] [EC:2.7.13.3]
DK843_11975  phoB; phosphate regulon transcriptional regulatory protein PhoB [KO:K07657]
DK843_20630  alkaline phosphatase [KO:K01077] [EC:3.1.3.1]
DK843_20635  alkaline phosphatase [KO:K01077] [EC:3.1.3.1]
DK843_01085  alkaline phosphatase [KO:K01113] [EC:3.1.3.1]
DK843_15485  metallophosphatase [KO:K01113] [EC:3.1.3.1]
DK843_08115  phosphodiesterase [KO:K01113] [EC:3.1.3.1]
DK843_07415  hypothetical protein [KO:K02040]
DK843_07420  hypothetical protein [KO:K02040]
DK843_17645  phosphate ABC transporter substrate-binding protein PstS [KO:K02040]
DK843_13825  two-component sensor histidine kinase [KO:K07638] [EC:2.7.13.3]
DK843_13830  two-component system response regulator OmpR [KO:K07659]
DK843_11060  two-component sensor histidine kinase [KO:K07639] [EC:2.7.13.3]
DK843_09810  two-component system sensor histidine kinase RstB [KO:K07639] [EC:2.7.13.3]
DK843_09805  two-component system response regulator RstA [KO:K07661]
DK843_06870  protease Do [KO:K04771] [EC:3.4.21.107]
DK843_00560  protease Do [KO:K04771] [EC:3.4.21.107]
DK843_03555  multidrug transporter subunit MdtA [KO:K07799]
DK843_03560  multidrug transporter subunit MdtB [KO:K07788]
DK843_03565  multidrug transporter subunit MdtC [KO:K07789]
DK843_05175  two-component sensor histidine kinase [KO:K07645] [EC:2.7.13.3]
DK843_10435  hypothetical protein [KO:K07645] [EC:2.7.13.3]
DK843_05180  DNA-binding response regulator [KO:K07666]
DK843_10440  two-component system response regulator QseB [KO:K07666]
DK843_09900  flagellin FliC [KO:K02406]
DK843_09905  flagellin [KO:K02406]
DK843_02655  flagellin FliC [KO:K02406]
DK843_04835  flagellin [KO:K02406]
DK843_04720  RNA polymerase sigma factor FliA [KO:K02405]
DK843_18110  fliA; RNA polymerase sigma factor FliA [KO:K02405]
DK843_00355  motA; flagellar motor stator protein MotA [KO:K02556]
DK843_04715  flagellar motor stator protein MotA [KO:K02556]
DK843_18105  flagellar motor protein [KO:K02556]
DK843_05315  two-component system sensor histidine kinase KdbD [KO:K07646] [EC:2.7.13.3]
DK843_05320  two-component system response regulator KdpE [KO:K07667]
DK843_05300  potassium-transporting ATPase subunit KdpA [KO:K01546]
DK843_05305  kdpB; K(+)-transporting ATPase subunit B [KO:K01547] [EC:7.2.2.6]
DK843_05310  potassium-transporting ATPase subunit KdpC [KO:K01548]
DK843_08070  sensor histidine kinase [KO:K07649] [EC:2.7.13.3]
DK843_08075  DNA-binding response regulator [KO:K07774]
DK843_11765  heme A synthase [KO:K02259] [EC:1.17.99.9]
DK843_14880  chromosomal replication initiator protein DnaA [KO:K02313]
DK843_22240  hypothetical protein [KO:K14983]
DK843_10385  dipeptidase [KO:K08641] [EC:3.4.13.22]
DK843_17535  D-alanyl-D-alanine dipeptidase [KO:K08641] [EC:3.4.13.22]
DK843_07255  anaerobic C4-dicarboxylate transporter [KO:K07792]
DK843_00815  malate permease [KO:K11616]
DK843_14015  sensor histidine kinase [KO:K08082] [EC:2.7.13.3]
DK843_13875  DNA-binding response regulator [KO:K08083]
DK843_02805  NarX [KO:K07673] [EC:2.7.13.3]
DK843_02810  DNA-binding response regulator [KO:K07684]
DK843_02835  nitrate reductase subunit alpha [KO:K00370] [EC:1.7.5.1 1.7.99.-]
DK843_02830  narH; nitrate reductase subunit beta [KO:K00371] [EC:1.7.5.1 1.7.99.-]
DK843_02820  narI; respiratory nitrate reductase subunit gamma [KO:K00374] [EC:1.7.5.1 1.7.99.-]
DK843_02825  narJ; nitrate reductase molybdenum cofactor assembly chaperone [KO:K00373]
DK843_07250  fumarate reductase (quinol) flavoprotein subunit [KO:K00244] [EC:1.3.5.1]
DK843_07245  succinate dehydrogenase/fumarate reductase iron-sulfur subunit [KO:K00245] [EC:1.3.5.1]
DK843_07240  fumarate reductase subunit C [KO:K00246]
DK843_07235  fumarate reductase subunit FrdD [KO:K00247]
DK843_02255  DNA-binding response regulator [KO:K07687]
DK843_21975  hypothetical protein [KO:K07679] [EC:2.7.13.3]
DK843_22405  hypothetical protein [KO:K07679] [EC:2.7.13.3]
DK843_02250  sensor protein evgS [KO:K07679] [EC:2.7.13.3]
DK843_19680  class C beta-lactamase [KO:K01467] [EC:3.5.2.6]
DK843_19585  molecular chaperone [KO:K07346]
DK843_04350  [protein-PII] uridylyltransferase [KO:K00990] [EC:2.7.7.59]
DK843_00475  P-II family nitrogen regulator [KO:K04751]
DK843_08535  PAS domain-containing sensor histidine kinase [KO:K07708] [EC:2.7.13.3]
DK843_08540  ntrC; nitrogen regulation protein NR(I) [KO:K07712]
DK843_15420  glutamine synthetase [KO:K01915] [EC:6.3.1.2]
DK843_20400  glutamine synthetase [KO:K01915] [EC:6.3.1.2]
DK843_00345  glutamine synthetase [KO:K01915] [EC:6.3.1.2]
DK843_08510  glnA; type I glutamate--ammonia ligase [KO:K01915] [EC:6.3.1.2]
DK843_15580  two-component sensor histidine kinase [KO:K13598] [EC:2.7.13.3]
DK843_15585  sigma-54-dependent Fis family transcriptional regulator [KO:K13599]
DK843_00695  acetyl-CoA C-acetyltransferase [KO:K00626] [EC:2.3.1.9]
DK843_03835  acetyl-CoA C-acetyltransferase [KO:K00626] [EC:2.3.1.9]
DK843_09090  C4-dicarboxylate transporter DctA [KO:K11103]
DK843_14515  histidine kinase [KO:K02668] [EC:2.7.13.3]
DK843_14520  sigma-54-dependent Fis family transcriptional regulator [KO:K02667]
DK843_07070  RNA polymerase factor sigma-54 [KO:K03092]
DK843_18800  prepilin-type cleavage/methylation domain-containing protein [KO:K02650]
DK843_15885  prepilin-type cleavage/methylation domain-containing protein [KO:K02650]
DK843_15835  hypothetical protein [KO:K07711] [EC:2.7.13.3]
DK843_15825  two-component system response regulator GlrR [KO:K07715]
DK843_03990  hypothetical protein [KO:K00575] [EC:2.1.1.80]
DK843_07620  chemotaxis protein CheR [KO:K00575] [EC:2.1.1.80]
DK843_09020  chemotaxis protein CheR [KO:K00575] [EC:2.1.1.80]
DK843_10520  methyl-accepting chemotaxis protein [KO:K03406]
DK843_06570  methyl-accepting chemotaxis protein [KO:K03406]
DK843_19770  methyl-accepting chemotaxis protein [KO:K03406]
DK843_02410  chemotaxis protein [KO:K03406]
DK843_11290  hypothetical protein [KO:K03406]
DK843_19905  methyl-accepting chemotaxis protein [KO:K03406]
DK843_07010  hypothetical protein [KO:K03406]
DK843_15715  hypothetical protein [KO:K03406]
DK843_20220  chemotaxis protein [KO:K03406]
DK843_11670  hypothetical protein [KO:K03406]
DK843_16175  methyl-accepting chemotaxis protein [KO:K03406]
DK843_16180  chemotaxis protein [KO:K03406]
DK843_03170  hypothetical protein [KO:K03406]
DK843_07625  diguanylate cyclase [KO:K03406]
DK843_03640  chemotaxis protein [KO:K03406]
DK843_21055  chemotaxis protein [KO:K03406]
DK843_21175  hypothetical protein [KO:K03406]
DK843_21275  chemotaxis protein [KO:K03406]
DK843_21360  methyl-accepting chemotaxis protein [KO:K03406]
DK843_04040  methyl-accepting chemotaxis protein [KO:K03406]
DK843_04075  methyl-accepting chemotaxis protein [KO:K03406]
DK843_04485  hypothetical protein [KO:K03406]
DK843_08805  hypothetical protein [KO:K03406]
DK843_21955  hypothetical protein [KO:K03406]
DK843_13485  hypothetical protein [KO:K03406]
DK843_22205  chemotaxis protein [KO:K03406]
DK843_00445  hypothetical protein [KO:K03406]
DK843_13575  methyl-accepting chemotaxis protein [KO:K03406]
DK843_18020  methyl-accepting chemotaxis protein [KO:K03406]
DK843_18030  methyl-accepting chemotaxis protein [KO:K03406]
DK843_18405  methyl-accepting chemotaxis protein [KO:K03406]
DK843_10220  methyl-accepting chemotaxis protein [KO:K03406]
DK843_10225  hypothetical protein [KO:K03406]
DK843_10400  methyl-accepting chemotaxis protein [KO:K03406]
DK843_14750  hypothetical protein [KO:K03406]
DK843_15425  methyl-accepting chemotaxis protein [KO:K03406]
DK843_13615  hypothetical protein [KO:K05874]
DK843_03995  chemotaxis protein CheW [KO:K03408]
DK843_07630  chemotaxis protein CheW [KO:K03408]
DK843_18025  chemotaxis protein CheW [KO:K03408]
DK843_07635  chemotaxis protein CheA [KO:K03407] [EC:2.7.13.3]
DK843_18035  chemotaxis protein CheA [KO:K03407] [EC:2.7.13.3]
DK843_04190  two-component system response regulator [KO:K03413]
DK843_07640  response regulator [KO:K03413]
DK843_07665  chemotaxis protein CheY [KO:K03413]
DK843_18045  two-component system response regulator [KO:K03413]
DK843_05895  chemotaxis protein CheB [KO:K03412] [EC:3.1.1.61 3.5.1.44]
DK843_07615  chemotaxis response regulator protein-glutamate methylesterase [KO:K03412] [EC:3.1.1.61 3.5.1.44]
DK843_18010  chemotaxis response regulator protein-glutamate methylesterase [KO:K03412] [EC:3.1.1.61 3.5.1.44]
DK843_07655  fused signal transduction protein/response regulator [KO:K03415]
DK843_07660  fused signal transduction protein/response regulator [KO:K03415]
DK843_04965  fused signal transduction protein/response regulator [KO:K03415]
DK843_03980  response regulator [KO:K11443]
DK843_01855  hypothetical protein [KO:K11711] [EC:2.7.13.3]
DK843_04550  DNA-binding response regulator [KO:K11712]
DK843_10310  C4-dicarboxylate ABC transporter [KO:K11688]
DK843_10315  C4-dicarboxylate ABC transporter permease [KO:K11689]
DK843_10320  C4-dicarboxylate ABC transporter permease [KO:K11690]
DK843_17445  two component system sensor kinase [KO:K14978]
DK843_17450  DNA-binding response regulator [KO:K14979]
DK843_07650  histidine kinase [KO:K10942] [EC:2.7.13.3]
DK843_05890  sigma-54-dependent Fis family transcriptional regulator [KO:K10943]
DK843_14100  amino acid ABC transporter ATP-binding protein [KO:K10004] [EC:7.4.2.1]
DK843_14105  amino acid ABC transporter permease [KO:K10002]
DK843_14110  amino acid ABC transporter permease [KO:K10003]
DK843_14115  amino acid ABC transporter substrate-binding protein [KO:K10001]
DK843_11195  cyclic nucleotide-binding protein [KO:K10914]
DK843_04705  Crp/Fnr family transcriptional regulator [KO:K10914]
DK843_16165  glutaminase [KO:K01425] [EC:3.5.1.2]
DK843_10415  sensor histidine kinase [KO:K15011] [EC:2.7.13.3]
DK843_10410  two-component system response regulator [KO:K15012]
DK843_17010  petA; ubiquinol-cytochrome c reductase iron-sulfur subunit [KO:K00411] [EC:7.1.1.8]
DK843_17015  cytochrome b [KO:K00412]
DK843_17020  cytochrome c1 [KO:K00413]
DK843_14370  cytochrome C biogenesis protein CcsA [KO:K08738]
DK843_18895  ccoN; cytochrome-c oxidase, cbb3-type subunit I [KO:K00404] [EC:7.1.1.9]
DK843_18890  ccoO; cytochrome-c oxidase, cbb3-type subunit II [KO:K00405]
DK843_18885  CcoQ/FixQ family Cbb3-type cytochrome c oxidase assembly chaperone [KO:K00407]
DK843_18880  ccoP; cytochrome-c oxidase, cbb3-type subunit III [KO:K00406]
DK843_08850  cytochrome ubiquinol oxidase subunit I [KO:K00425] [EC:7.1.1.7]
DK843_08845  cytochrome BD ubiquinol oxidase subunit II [KO:K00426] [EC:7.1.1.7]
DK843_10145  type I secretion system [KO:K12340]
DK843_10975  sugar ABC transporter substrate-binding protein [KO:K01991]
DK843_05900  protein tyrosine phosphatase [KO:K25307] [EC:3.1.3.48]
DK843_15665  hypothetical protein [KO:K07165]
DK843_01055  hybrid sensor histidine kinase/response regulator [KO:K20974] [EC:2.7.13.3]
DK843_21375  hypothetical protein [KO:K20974] [EC:2.7.13.3]
DK843_03160  hypothetical protein [KO:K20977]
DK843_07935  hypothetical protein [KO:K20977]
DK843_03165  anti-anti-sigma factor [KO:K20978]
DK843_07645  anti-anti-sigma factor [KO:K20978]
DK843_04700  flgM; flagellar biosynthesis anti-sigma factor FlgM [KO:K02398]
DK843_17965  flgM; flagellar biosynthesis anti-sigma factor FlgM [KO:K02398]
Compound
C00007  Oxygen
C00009  Orthophosphate
C00025  L-Glutamate
C00031  D-Glucose
C00034  Manganese
C00036  Oxaloacetate
C00038  Zinc cation
C00042  Succinate
C00049  L-Aspartate
C00064  L-Glutamine
C00070  Copper
C00088  Nitrite
C00092  D-Glucose 6-phosphate
C00122  Fumarate
C00149  (S)-Malate
C00158  Citrate
C00164  Acetoacetate
C00237  CO
C00238  Potassium cation
C00244  Nitrate
C00282  Hydrogen
C00291  Nickel
C00305  Magnesium cation
C00399  Ubiquinone
C00533  Nitric oxide
C00547  L-Noradrenaline
C00697  Nitrogen
C00788  L-Adrenaline
C00828  Menaquinone
C01019  L-Fucose
C01104  Trimethylamine N-oxide
C01667  Bacitracin
C02084  Tetrathionate
C05757  (3R)-3-Hydroxydodecanoyl-[acyl-carrier protein]
C05818  2-Demethylmenaquinone
C06230  Fe-enterobactin
C06689  Vancomycin
C06696  Lead
C11612  Polymyxin B
C11842  N-(3-(S)-Hydroxybutyryl)homoserine lactone
C11849  3-Hydroxy-palmitic acid methyl ester
C12008  Ramoplanin A2
C13768  Colistin sulfate
C14819  Fe3+
C16421  AI-2
C16463  3',5'-Cyclic diGMP
C16640  CAI-1
C16665  12-Methyltetradecanoic acid
C18206  cis-11-Methyl-2-dodecenoic acid
C21220  AIP-1
C21221  CSP
C21241  AIP-2
C21242  AIP-3
C21243  AIP-4
C21245  AgrD1 peptide
D07746  Colistin (INN)
D08401  Polymyxin B (INN)
Reference
PMID:15522865
  Authors
Yamamoto K, Hirao K, Oshima T, Aiba H, Utsumi R, Ishihama A.
  Title
Functional characterization in vitro of all two-component signal transduction systems from Escherichia coli.
  Journal
J Biol Chem 280:1448-56 (2005)
DOI:10.1074/jbc.M410104200
Reference
PMID:16030210
  Authors
Abdel-Fattah WR, Chen Y, Eldakak A, Hulett FM.
  Title
Bacillus subtilis phosphorylated PhoP: direct activation of the E(sigma)A- and repression of the E(sigma)E-responsive phoB-PS+V promoters during pho response.
  Journal
J Bacteriol 187:5166-78 (2005)
DOI:10.1128/JB.187.15.5166-5178.2005
Reference
PMID:15813739
  Authors
Navarre WW, Halsey TA, Walthers D, Frye J, McClelland M, Potter JL, Kenney LJ, Gunn JS, Fang FC, Libby SJ.
  Title
Co-regulation of Salmonella enterica genes required for virulence and resistance to antimicrobial peptides by SlyA and PhoP/PhoQ.
  Journal
Mol Microbiol 56:492-508 (2005)
DOI:10.1111/j.1365-2958.2005.04553.x
Reference
PMID:11973328
  Authors
Cai SJ, Inouye M.
  Title
EnvZ-OmpR interaction and osmoregulation in Escherichia coli.
  Journal
J Biol Chem 277:24155-61 (2002)
DOI:10.1074/jbc.M110715200
Reference
PMID:16077119
  Authors
Batchelor E, Walthers D, Kenney LJ, Goulian M.
  Title
The Escherichia coli CpxA-CpxR envelope stress response system regulates expression of the porins ompF and ompC.
  Journal
J Bacteriol 187:5723-31 (2005)
DOI:10.1128/JB.187.16.5723-5731.2005
Reference
PMID:12107133
  Authors
Nagakubo S, Nishino K, Hirata T, Yamaguchi A.
  Title
The putative response regulator BaeR stimulates multidrug resistance of Escherichia coli via a novel multidrug exporter system, MdtABC.
  Journal
J Bacteriol 184:4161-7 (2002)
DOI:10.1128/JB.184.15.4161-4167.2002
Reference
PMID:15322361
  Authors
Hagiwara D, Yamashino T, Mizuno T.
  Title
A Genome-wide view of the Escherichia coli BasS-BasR two-component system implicated in iron-responses.
  Journal
Biosci Biotechnol Biochem 68:1758-67 (2004)
DOI:10.1271/bbb.68.1758
Reference
PMID:11004187
  Authors
Munson GP, Lam DL, Outten FW, O'Halloran TV.
  Title
Identification of a copper-responsive two-component system on the chromosome of Escherichia coli K-12.
  Journal
J Bacteriol 182:5864-71 (2000)
DOI:10.1128/JB.182.20.5864-5871.2000
Reference
PMID:11929534
  Authors
Sperandio V, Torres AG, Kaper JB.
  Title
Quorum sensing Escherichia coli regulators B and C (QseBC): a novel two-component regulatory system involved in the regulation of flagella and motility by quorum sensing in E. coli.
  Journal
Mol Microbiol 43:809-21 (2002)
DOI:10.1046/j.1365-2958.2002.02803.x
Reference
PMID:14604015
  Authors
Epstein W.
  Title
The roles and regulation of potassium in bacteria.
  Journal
Prog Nucleic Acid Res Mol Biol 75:293-320 (2003)
DOI:10.1016/S0079-6603(03)75008-9
Reference
PMID:10648521
  Authors
Ansaldi M, Simon G, Lepelletier M, Mejean V.
  Title
The TorR high-affinity binding site plays a key role in both torR autoregulation and torCAD operon expression in Escherichia coli.
  Journal
J Bacteriol 182:961-6 (2000)
DOI:10.1128/JB.182.4.961-966.2000
Reference
PMID:15326287
  Authors
Malpica R, Franco B, Rodriguez C, Kwon O, Georgellis D.
  Title
Identification of a quinone-sensitive redox switch in the ArcB sensor kinase.
  Journal
Proc Natl Acad Sci U S A 101:13318-23 (2004)
DOI:10.1073/pnas.0403064101
Reference
PMID:2666399
  Authors
Widenhorn KA, Somers JM, Kay WW.
  Title
Genetic regulation of the tricarboxylate transport operon (tctI) of Salmonella typhimurium.
  Journal
J Bacteriol 171:4436-41 (1989)
DOI:10.1128/JB.171.8.4436-4441.1989
Reference
PMID:11555295
  Authors
Hyyrylainen HL, Bolhuis A, Darmon E, Muukkonen L, Koski P, Vitikainen M, Sarvas M, Pragai Z, Bron S, van Dijl JM, Kontinen VP.
  Title
A novel two-component regulatory system in Bacillus subtilis for the survival of severe secretion stress.
  Journal
Mol Microbiol 41:1159-72 (2001)
DOI:10.1046/j.1365-2958.2001.02576.x
Reference
PMID:10972837
  Authors
Zhang X, Hulett FM.
  Title
ResD signal transduction regulator of aerobic respiration in Bacillus subtilis: ctaA promoter regulation.
  Journal
Mol Microbiol 37:1208-19 (2000)
DOI:10.1046/j.1365-2958.2000.02076.x
Reference
PMID:15937169
  Authors
Senadheera MD, Guggenheim B, Spatafora GA, Huang YC, Choi J, Hung DC, Treglown JS, Goodman SD, Ellen RP, Cvitkovitch DG.
  Title
A VicRK signal transduction system in Streptococcus mutans affects gtfBCD, gbpB, and ftf expression, biofilm formation, and genetic competence development.
  Journal
J Bacteriol 187:4064-76 (2005)
DOI:10.1128/JB.187.12.4064-4076.2005
Reference
PMID:15601704
  Authors
He H, Zahrt TC.
  Title
Identification and characterization of a regulatory sequence recognized by Mycobacterium tuberculosis persistence regulator MprA.
  Journal
J Bacteriol 187:202-12 (2005)
DOI:10.1128/JB.187.1.202-212.2005
Reference
PMID:17448786
  Authors
Hutchings MI
  Title
Unusual two-component signal transduction pathways in the actinobacteria.
  Journal
Adv Appl Microbiol 61:1-26 (2007)
DOI:10.1016/S0065-2164(06)61001-0
Reference
PMID:19308662
  Authors
Kramer R
  Title
Osmosensing and osmosignaling in Corynebacterium glutamicum.
  Journal
Amino Acids 37:487-97 (2009)
DOI:10.1007/s00726-009-0271-6
Reference
PMID:7751278
  Authors
Eraso JM, Kaplan S.
  Title
Oxygen-insensitive synthesis of the photosynthetic membranes of Rhodobacter sphaeroides: a mutant histidine kinase.
  Journal
J Bacteriol 177:2695-706 (1995)
DOI:10.1128/JB.177.10.2695-2706.1995
Reference
PMID:10089160
  Authors
Haydel SE, Dunlap NE, Benjamin WH Jr.
  Title
In vitro evidence of two-component system phosphorylation between the Mycobacterium tuberculosis TrcR/TrcS proteins.
  Journal
Microb Pathog 26:195-206 (1999)
DOI:10.1006/mpat.1998.0265
Reference
PMID:11673427
  Authors
Quisel JD, Burkholder WF, Grossman AD.
  Title
In vivo effects of sporulation kinases on mutant Spo0A proteins in Bacillus subtilis.
  Journal
J Bacteriol 183:6573-8 (2001)
DOI:10.1128/JB.183.22.6573-6578.2001
Reference
PMID:11889485
  Authors
Kaspar S, Bott M.
  Title
The sensor kinase CitA (DpiB) of Escherichia coli functions as a high-affinity citrate receptor.
  Journal
Arch Microbiol 177:313-21 (2002)
DOI:10.1007/s00203-001-0393-z
Reference
PMID:12167640
  Authors
Janausch IG, Garcia-Moreno I, Unden G.
  Title
Function of DcuS from Escherichia coli as a fumarate-stimulated histidine protein kinase in vitro.
  Journal
J Biol Chem 277:39809-14 (2002)
DOI:10.1074/jbc.M204482200
Reference
PMID:8550490
  Authors
Brunskill EW, Bayles KW.
  Title
Identification and molecular characterization of a putative regulatory locus that affects autolysis in Staphylococcus aureus.
  Journal
J Bacteriol 178:611-8 (1996)
DOI:10.1128/JB.178.3.611-618.1996
Reference
PMID:10940023
  Authors
Fujimoto DF, Brunskill EW, Bayles KW.
  Title
Analysis of genetic elements controlling Staphylococcus aureus lrgAB expression: potential role of DNA topology in SarA regulation.
  Journal
J Bacteriol 182:4822-8 (2000)
DOI:10.1128/JB.182.17.4822-4828.2000
Reference
PMID:11807079
  Authors
Dufour P, Jarraud S, Vandenesch F, Greenland T, Novick RP, Bes M, Etienne J, Lina G.
  Title
High genetic variability of the agr locus in Staphylococcus species.
  Journal
J Bacteriol 184:1180-6 (2002)
DOI:10.1128/JB.184.4.1180-1186.2002
Reference
PMID:8501030
  Authors
Rabin RS, Stewart V.
  Title
Dual response regulators (NarL and NarP) interact with dual sensors (NarX and NarQ) to control nitrate- and nitrite-regulated gene expression in Escherichia coli K-12.
  Journal
J Bacteriol 175:3259-68 (1993)
DOI:10.1128/JB.175.11.3259-3268.1993
Reference
PMID:9220011
  Authors
Chiang RC, Cavicchioli R, Gunsalus RP.
  Title
'Locked-on' and 'locked-off' signal transduction mutations in the periplasmic domain of the Escherichia coli NarQ and NarX sensors affect nitrate- and nitrite-dependent regulation by NarL and NarP.
  Journal
Mol Microbiol 24:1049-60 (1997)
DOI:10.1046/j.1365-2958.1997.4131779.x
Reference
PMID:12107138
  Authors
Verhamme DT, Postma PW, Crielaard W, Hellingwerf KJ.
  Title
Cooperativity in signal transfer through the Uhp system of Escherichia coli.
  Journal
J Bacteriol 184:4205-10 (2002)
DOI:10.1128/JB.184.15.4205-4210.2002
Reference
PMID:13129944
  Authors
Hagiwara D, Sugiura M, Oshima T, Mori H, Aiba H, Yamashino T, Mizuno T.
  Title
Genome-wide analyses revealing a signaling network of the RcsC-YojN-RcsB phosphorelay system in Escherichia coli.
  Journal
J Bacteriol 185:5735-46 (2003)
DOI:10.1128/JB.185.19.5735-5746.2003
Reference
PMID:12951338
  Authors
Hirakawa H, Nishino K, Yamada J, Hirata T, Yamaguchi A.
  Title
Beta-lactam resistance modulated by the overexpression of response regulators of two-component signal transduction systems in Escherichia coli.
  Journal
J Antimicrob Chemother 52:576-82 (2003)
DOI:10.1093/jac/dkg406
Reference
PMID:12193630
  Authors
Suzuki K, Wang X, Weilbacher T, Pernestig AK, Melefors O, Georgellis D, Babitzke P, Romeo T.
  Title
Regulatory circuitry of the CsrA/CsrB and BarA/UvrY systems of Escherichia coli.
  Journal
J Bacteriol 184:5130-40 (2002)
DOI:10.1128/JB.184.18.5130-5140.2002
Reference
PMID:10923791
  Authors
Kato A, Ohnishi H, Yamamoto K, Furuta E, Tanabe H, Utsumi R.
  Title
Transcription of emrKY is regulated by the EvgA-EvgS two-component system in Escherichia coli K-12.
  Journal
Biosci Biotechnol Biochem 64:1203-9 (2000)
DOI:10.1271/bbb.64.1203
Reference
PMID:14679219
  Authors
Ansaldi M, Dubnau D.
  Title
Diversifying selection at the Bacillus quorum-sensing locus and determinants of modification specificity during synthesis of the ComX pheromone.
  Journal
J Bacteriol 186:15-21 (2004)
DOI:10.1128/JB.186.1.15-21.2004
Reference
PMID:16035234
  Authors
Gabdrakhmanova L, Vishniakov I, Sharipova M, Balaban N, Kostrov S, Leshchinskaya I.
  Title
Salt stress induction of glutamyl endopeptidase biosynthesis in Bacillus intermedius.
  Journal
Microbiol Res 160:233-42 (2005)
DOI:10.1016/j.micres.2004.05.005
Reference
PMID:11285232
  Authors
Aguilar PS, Hernandez-Arriaga AM, Cybulski LE, Erazo AC, de Mendoza D.
  Title
Molecular basis of thermosensing: a two-component signal transduction thermometer in Bacillus subtilis.
  Journal
EMBO J 20:1681-91 (2001)
DOI:10.1093/emboj/20.7.1681
Reference
PMID:12864861
  Authors
Kuroda M, Kuroda H, Oshima T, Takeuchi F, Mori H, Hiramatsu K.
  Title
Two-component system VraSR positively modulates the regulation of cell-wall biosynthesis pathway in Staphylococcus aureus.
  Journal
Mol Microbiol 49:807-21 (2003)
DOI:10.1046/j.1365-2958.2003.03599.x
Reference
PMID:15073296
  Authors
Saini DK, Malhotra V, Dey D, Pant N, Das TK, Tyagi JS.
  Title
DevR-DevS is a bona fide two-component system of Mycobacterium tuberculosis that is hypoxia-responsive in the absence of the DNA-binding domain of DevR.
  Journal
Microbiology 150:865-75 (2004)
DOI:10.1099/mic.0.26218-0
Reference
PMID:12426351
  Authors
Fedtke I, Kamps A, Krismer B, Gotz F.
  Title
The nitrate reductase and nitrite reductase operons and the narT gene of Staphylococcus carnosus are positively controlled by the novel two-component system NreBC.
  Journal
J Bacteriol 184:6624-34 (2002)
DOI:10.1128/JB.184.23.6624-6634.2002
Reference
PMID:8416895
  Authors
Shiau SP, Chen P, Reitzer LJ.
  Title
Effects of insertions and deletions in glnG (ntrC) of Escherichia coli on nitrogen regulator I-dependent DNA binding and transcriptional activation.
  Journal
J Bacteriol 175:190-9 (1993)
DOI:10.1128/JB.175.1.190-199.1993
Reference
PMID:11243806
  Authors
Leonhartsberger S, Huber A, Lottspeich F, Bock A.
  Title
The hydH/G Genes from Escherichia coli code for a zinc and lead responsive two-component regulatory system.
  Journal
J Mol Biol 307:93-105 (2001)
DOI:10.1006/jmbi.2000.4451
Reference
PMID:15200682
  Authors
Lioliou EE, Kyriakidis DA.
  Title
The role of bacterial antizyme: From an inhibitory protein to AtoC transcriptional regulator.
  Journal
Microb Cell Fact 3:8 (2004)
DOI:10.1186/1475-2859-3-8
Reference
PMID:15773991
  Authors
Yamamoto K, Ishihama A
  Title
Transcriptional response of Escherichia coli to external copper.
  Journal
Mol Microbiol 56:215-27 (2005)
DOI:10.1111/j.1365-2958.2005.04532.x
Reference
PMID:10585546
  Authors
Ashby MK, Mullineaux CW
  Title
Cyanobacterial ycf27 gene products regulate energy transfer from phycobilisomes to photosystems I and II.
  Journal
FEMS Microbiol Lett 181:253-60 (1999)
DOI:10.1111/j.1574-6968.1999.tb08852.x
Reference
PMID:11849552
  Authors
Lopez-Maury L, Garcia-Dominguez M, Florencio FJ, Reyes JC
  Title
A two-component signal transduction system involved in nickel sensing in the cyanobacterium Synechocystis sp. PCC 6803.
  Journal
Mol Microbiol 43:247-56 (2002)
DOI:10.1046/j.1365-2958.2002.02741.x
Reference
PMID:17526710
  Authors
Glover RT, Kriakov J, Garforth SJ, Baughn AD, Jacobs WR Jr
  Title
The two-component regulatory system senX3-regX3 regulates phosphate-dependent gene expression in Mycobacterium smegmatis.
  Journal
J Bacteriol 189:5495-503 (2007)
DOI:10.1128/JB.00190-07
Reference
PMID:15175302
  Authors
Hsiao HY, He Q, Van Waasbergen LG, Grossman AR
  Title
Control of photosynthetic and high-light-responsive genes by the histidine kinase DspA: negative and positive regulation and interactions between signal transduction pathways.
  Journal
J Bacteriol 186:3882-8 (2004)
DOI:10.1128/JB.186.12.3882-3888.2004
Reference
PMID:12626498
  Authors
Mutsuda M, Michel KP, Zhang X, Montgomery BL, Golden SS
  Title
Biochemical properties of CikA, an unusual phytochrome-like histidine protein kinase that resets the circadian clock in Synechococcus elongatus PCC 7942.
  Journal
J Biol Chem 278:19102-10 (2003)
DOI:10.1074/jbc.M213255200
Reference
PMID:9278513
  Authors
Yeh KC, Wu SH, Murphy JT, Lagarias JC
  Title
A cyanobacterial phytochrome two-component light sensory system.
  Journal
Science 277:1505-8 (1997)
DOI:10.1126/science.277.5331.1505
Reference
PMID:7635815
  Authors
Niu S, Jiang SQ, Hong J
  Title
Salmonella typhimurium pgtB mutants conferring constitutive expression of phosphoglycerate transporter pgtP independent of pgtC.
  Journal
J Bacteriol 177:4297-302 (1995)
DOI:10.1128/JB.177.15.4297-4302.1995
Reference
PMID:16882723
  Authors
Takai N, Nakajima M, Oyama T, Kito R, Sugita C, Sugita M, Kondo T, Iwasaki H
  Title
A KaiC-associating SasA-RpaA two-component regulatory system as a major circadian timing mediator in cyanobacteria.
  Journal
Proc Natl Acad Sci U S A 103:12109-14 (2006)
DOI:10.1073/pnas.0602955103
Reference
PMID:11803016
  Authors
Janausch IG, Zientz E, Tran QH, Kroger A, Unden G
  Title
C4-dicarboxylate carriers and sensors in bacteria.
  Journal
Biochim Biophys Acta 1553:39-56 (2002)
DOI:10.1016/S0005-2728(01)00233-X
Reference
PMID:18725229
  Authors
Zhou YF, Nan B, Nan J, Ma Q, Panjikar S, Liang YH, Wang Y, Su XD
  Title
C4-dicarboxylates sensing mechanism revealed by the crystal structures of DctB sensor domain.
  Journal
J Mol Biol 383:49-61 (2008)
DOI:10.1016/j.jmb.2008.08.010
Reference
PMID:14523104
  Authors
Novick RP, Jiang D
  Title
The staphylococcal saeRS system coordinates environmental signals with agr quorum sensing.
  Journal
Microbiology 149:2709-17 (2003)
DOI:10.1099/mic.0.26575-0
Reference
PMID:17981963
  Authors
Leech AJ, Sprinkle A, Wood L, Wozniak DJ, Ohman DE
  Title
The NtrC family regulator AlgB, which controls alginate biosynthesis in mucoid Pseudomonas aeruginosa, binds directly to the algD promoter.
  Journal
J Bacteriol 190:581-9 (2008)
DOI:10.1128/JB.01307-07
Reference
PMID:18455986
  Authors
Paul R, Jaeger T, Abel S, Wiederkehr I, Folcher M, Biondi EG, Laub MT, Jenal U
  Title
Allosteric regulation of histidine kinases by their cognate response regulator determines cell fate.
  Journal
Cell 133:452-61 (2008)
DOI:10.1016/j.cell.2008.02.045
Reference
PMID:15101991
  Authors
Whitchurch CB, Leech AJ, Young MD, Kennedy D, Sargent JL, Bertrand JJ, Semmler AB, Mellick AS, Martin PR, Alm RA, Hobbs M, Beatson SA, Huang B, Nguyen L, Commolli JC, Engel JN, Darzins A, Mattick JS.
  Title
Characterization of a complex chemosensory signal transduction system which controls twitching motility in Pseudomonas aeruginosa.
  Journal
Mol Microbiol 52:873-93 (2004)
DOI:10.1111/j.1365-2958.2004.04026.x
Reference
PMID:15170479
  Authors
Yoshihara S, Ikeuchi M.
  Title
Phototactic motility in the unicellular cyanobacterium Synechocystis sp. PCC 6803.
  Journal
Photochem Photobiol Sci 3:512-8 (2004)
DOI:10.1039/b402320j
Reference
PMID:12039966
  Authors
Ogawa T, Bao DH, Katoh H, Shibata M, Pakrasi HB, Bhattacharyya-Pakrasi M
  Title
A two-component signal transduction pathway regulates manganese homeostasis in Synechocystis 6803, a photosynthetic organism.
  Journal
J Biol Chem 277:28981-6 (2002)
DOI:10.1074/jbc.M204175200
Reference
PMID:12417709
  Authors
Yamaguchi K, Suzuki I, Yamamoto H, Lyukevich A, Bodrova I, Los DA, Piven I, Zinchenko V, Kanehisa M, Murata N
  Title
A two-component Mn2+-sensing system negatively regulates expression of the mntCAB operon in Synechocystis.
  Journal
Plant Cell 14:2901-13 (2002)
DOI:10.1105/tpc.006262
Reference
PMID:15273097
  Authors
Mascher T, Zimmer SL, Smith TA, Helmann JD
  Title
Antibiotic-inducible promoter regulated by the cell envelope stress-sensing two-component system LiaRS of Bacillus subtilis.
  Journal
Antimicrob Agents Chemother 48:2888-96 (2004)
DOI:10.1128/AAC.48.8.2888-2896.2004
Reference
PMID:15856219
  Authors
Hyyrylainen HL, Sarvas M, Kontinen VP
  Title
Transcriptome analysis of the secretion stress response of Bacillus subtilis.
  Journal
Appl Microbiol Biotechnol 67:389-96 (2005)
DOI:10.1007/s00253-005-1898-1
Reference
PMID:15941986
  Authors
Serizawa M, Sekiguchi J
  Title
The Bacillus subtilis YdfHI two-component system regulates the transcription of ydfJ, a member of the RND superfamily.
  Journal
Microbiology 151:1769-78 (2005)
DOI:10.1099/mic.0.27619-0
Reference
PMID:12890034
  Authors
Ohki R, Giyanto, Tateno K, Masuyama W, Moriya S, Kobayashi K, Ogasawara N
  Title
The BceRS two-component regulatory system induces expression of the bacitracin transporter, BceAB, in Bacillus subtilis.
  Journal
Mol Microbiol 49:1135-44 (2003)
DOI:10.1046/j.1365-2958.2003.03653.x
Reference
PMID:17322186
  Authors
Ogura M, Tsukahara K, Hayashi K, Tanaka T
  Title
The Bacillus subtilis NatK-NatR two-component system regulates expression of the natAB operon encoding an ABC transporter for sodium ion extrusion.
  Journal
Microbiology 153:667-75 (2007)
DOI:10.1099/mic.0.2006/003673-0
Reference
PMID:10972810
  Authors
Yamamoto H, Murata M, Sekiguchi J
  Title
The CitST two-component system regulates the expression of the Mg-citrate transporter in Bacillus subtilis.
  Journal
Mol Microbiol 37:898-912 (2000)
DOI:10.1046/j.1365-2958.2000.02055.x
Reference
PMID:15995196
  Authors
Satomura T, Shimura D, Asai K, Sadaie Y, Hirooka K, Fujita Y
  Title
Enhancement of glutamine utilization in Bacillus subtilis through the GlnK-GlnL two-component regulatory system.
  Journal
J Bacteriol 187:4813-21 (2005)
DOI:10.1128/JB.187.14.4813-4821.2005
Reference
PMID:12949160
  Authors
Doan T, Servant P, Tojo S, Yamaguchi H, Lerondel G, Yoshida K, Fujita Y, Aymerich S
  Title
The Bacillus subtilis ywkA gene encodes a malic enzyme and its transcription is activated by the YufL/YufM two-component system in response to malate.
  Journal
Microbiology 149:2331-43 (2003)
DOI:10.1099/mic.0.26256-0
Reference
PMID:12949159
  Authors
Tanaka K, Kobayashi K, Ogasawara N
  Title
The Bacillus subtilis YufLM two-component system regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium.
  Journal
Microbiology 149:2317-29 (2003)
DOI:10.1099/mic.0.26257-0
Reference
PMID:10708364
  Authors
Asai K, Baik SH, Kasahara Y, Moriya S, Ogasawara N
  Title
Regulation of the transport system for C4-dicarboxylic acids in Bacillus subtilis.
  Journal
Microbiology 146 ( Pt 2):263-71 (2000)
DOI:10.1099/00221287-146-2-263
Reference
PMID:8455557
  Authors
Hamblin MJ, Shaw JG, Kelly DJ
  Title
Sequence analysis and interposon mutagenesis of a sensor-kinase (DctS) and response-regulator (DctR) controlling synthesis of the high-affinity C4-dicarboxylate transport system in Rhodobacter capsulatus.
  Journal
Mol Gen Genet 237:215-24 (1993)
DOI:10.1007/BF00282803
Reference
PMID:9287004
  Authors
Forward JA, Behrendt MC, Wyborn NR, Cross R, Kelly DJ
  Title
TRAP transporters: a new family of periplasmic solute transport systems encoded by the dctPQM genes of Rhodobacter capsulatus and by homologs in diverse gram-negative bacteria.
  Journal
J Bacteriol 179:5482-93 (1997)
DOI:10.1128/JB.179.17.5482-5493.1997
Reference
PMID:16820295
  Authors
Martin B, Quentin Y, Fichant G, Claverys JP
  Title
Independent evolution of competence regulatory cascades in streptococci?
  Journal
Trends Microbiol 14:339-45 (2006)
DOI:10.1016/j.tim.2006.06.007
Reference
PMID:10231485
  Authors
Hensel M, Hinsley AP, Nikolaus T, Sawers G, Berks BC
  Title
The genetic basis of tetrathionate respiration in Salmonella typhimurium.
  Journal
Mol Microbiol 32:275-87 (1999)
DOI:10.1046/j.1365-2958.1999.01345.x
Reference
PMID:18028314
  Authors
Guvener ZT, Harwood CS
  Title
Subcellular location characteristics of the Pseudomonas aeruginosa GGDEF protein, WspR, indicate that it produces cyclic-di-GMP in response to growth on surfaces.
  Journal
Mol Microbiol 66:1459-73 (2007)
DOI:10.1111/j.1365-2958.2007.06008.x
Reference
PMID:17339222
  Authors
Bantinaki E, Kassen R, Knight CG, Robinson Z, Spiers AJ, Rainey PB
  Title
Adaptive divergence in experimental populations of Pseudomonas fluorescens. III. Mutational origins of wrinkly spreader diversity.
  Journal
Genetics 176:441-53 (2007)
DOI:10.1534/genetics.106.069906
Reference
PMID:11069677
  Authors
Jiang M, Shao W, Perego M, Hoch JA
  Title
Multiple histidine kinases regulate entry into stationary phase and sporulation in Bacillus subtilis.
  Journal
Mol Microbiol 38:535-42 (2000)
DOI:10.1046/j.1365-2958.2000.02148.x
Reference
PMID:19781638
  Authors
Jenal U
  Title
The role of proteolysis in the Caulobacter crescentus cell cycle and development.
  Journal
Res Microbiol 160:687-95 (2009)
DOI:10.1016/j.resmic.2009.09.006
Reference
PMID:19246239
  Authors
Jenal U, Galperin MY
  Title
Single domain response regulators: molecular switches with emerging roles in cell organization and dynamics.
  Journal
Curr Opin Microbiol 12:152-60 (2009)
DOI:10.1016/j.mib.2009.01.010
Reference
PMID:16640581
  Authors
Drepper T, Wiethaus J, Giaourakis D, Gross S, Schubert B, Vogt M, Wiencek Y, McEwan AG, Masepohl B
  Title
Cross-talk towards the response regulator NtrC controlling nitrogen metabolism in Rhodobacter capsulatus.
  Journal
FEMS Microbiol Lett 258:250-6 (2006)
DOI:10.1111/j.1574-6968.2006.00228.x
Reference
PMID:1661370
  Authors
Pawlowski K, Klosse U, de Bruijn FJ
  Title
Characterization of a novel Azorhizobium caulinodans ORS571 two-component regulatory system, NtrY/NtrX, involved in nitrogen fixation and metabolism.
  Journal
Mol Gen Genet 231:124-38 (1991)
DOI:10.1007/BF00293830
Reference
PMID:18422428
  Authors
Chatterjee S, Almeida RP, Lindow S
  Title
Living in two worlds: the plant and insect lifestyles of Xylella fastidiosa.
  Journal
Annu Rev Phytopathol 46:243-71 (2008)
DOI:10.1146/annurev.phyto.45.062806.094342
Reference
PMID:18506032
  Authors
Dow M
  Title
Diversification of the function of cell-to-cell signaling in regulation of virulence within plant pathogenic xanthomonads.
  Journal
Sci Signal 1:pe23 (2008)
DOI:10.1126/stke.121pe23
Reference
PMID:17902112
  Authors
Colnaghi Simionato AV, da Silva DS, Lambais MR, Carrilho E
  Title
Characterization of a putative Xylella fastidiosa diffusible signal factor by HRGC-EI-MS.
  Journal
J Mass Spectrom 42:1375-81 (2007)
DOI:10.1002/jms.1325
Reference
PMID:19203648
  Authors
Miller LD, Russell MH, Alexandre G
  Title
Diversity in bacterial chemotactic responses and niche adaptation.
  Journal
Adv Appl Microbiol 66:53-75 (2009)
DOI:10.1016/S0065-2164(08)00803-4
Reference
PMID:8760916
  Authors
Eder S, Shi L, Jensen K, Yamane K, Hulett FM
  Title
A Bacillus subtilis secreted phosphodiesterase/alkaline phosphatase is the product of a Pho regulon gene, phoD.
  Journal
Microbiology 142 ( Pt 8):2041-7 (1996)
DOI:10.1099/13500872-142-8-2041
Related
pathway
chrb00190  Oxidative phosphorylation
chrb00550  Peptidoglycan biosynthesis
chrb00910  Nitrogen metabolism
chrb02030  Bacterial chemotaxis
chrb02040  Flagellar assembly
chrb03070  Bacterial secretion system
KO pathway
ko02020   
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