KEGG   PATHWAY: cmac04150
Entry
cmac04150                   Pathway                                
Name
mTOR signaling pathway - Chlamydotis macqueenii (Macqueen's bustard)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
cmac04150  mTOR signaling pathway
cmac04150

Organism
Chlamydotis macqueenii (Macqueen's bustard) [GN:cmac]
Gene
104486903  SLC7A5; large neutral amino acids transporter small subunit 1 [KO:K13780]
104486558  SLC38A9; putative sodium-coupled neutral amino acid transporter 9 [KO:K14995]
104476045  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
104473866  ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
104476587  ATP6V1C2; V-type proton ATPase subunit C 2 [KO:K02148]
104474065  ATP6V1C1; V-type proton ATPase subunit C 1 [KO:K02148]
104482114  ATP6V1D; V-type proton ATPase subunit D [KO:K02149]
104485702  ATP6V1E1; V-type proton ATPase subunit E 1 isoform X1 [KO:K02150]
104479574  ATP6V1G3; V-type proton ATPase subunit G 3 [KO:K02152]
104481689  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
104484969  ATP6V1H; V-type proton ATPase subunit H [KO:K02144]
104474865  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
104474008  FLCN; folliculin [KO:K09594]
104473148  FNIP1; folliculin-interacting protein 1 [KO:K20400]
104484086  FNIP2; LOW QUALITY PROTEIN: folliculin-interacting protein 2 [KO:K20401]
104474044  ras-related GTP-binding protein A [KO:K16185]
104484754  RRAGC; ras-related GTP-binding protein C [KO:K16186]
104474595  RRAGD; ras-related GTP-binding protein D [KO:K16186]
104482847  GATSL2; GATS-like protein 2 [KO:K23081]
104473884  MIOS; WD repeat-containing protein mio [KO:K20407]
104474043  SEH1L; nucleoporin SEH1 [KO:K14299]
104485650  WDR59; WD repeat-containing protein 59 [KO:K20409]
104483400  SEC13; protein SEC13 homolog [KO:K14004]
104480719  DEPDC5; DEP domain-containing protein 5 isoform X1 [KO:K20404]
104474282  NPRL2; nitrogen permease regulator 2-like protein [KO:K20405]
104483026  NPRL3; nitrogen permease regulator 3-like protein isoform X1 [KO:K20406]
104486391  SKP2; S-phase kinase-associated protein 2 [KO:K03875]
104486446  RNF152; E3 ubiquitin-protein ligase RNF152 isoform X1 [KO:K15705] [EC:2.3.2.27]
104484098  DEPTOR; DEP domain-containing mTOR-interacting protein [KO:K20402]
104487014  DEP domain-containing mTOR-interacting protein-like [KO:K20402]
104477563  MLST8; target of rapamycin complex subunit LST8 [KO:K08266]
104482177  telomere length regulation protein TEL2 homolog [KO:K11137]
104486629  TTI1; TELO2-interacting protein 1 homolog [KO:K20403]
104474160  CLIP1; CAP-Gly domain-containing linker protein 1 [KO:K10421]
104484358  GRB10; growth factor receptor-bound protein 10 [KO:K20064]
104474122  phosphatidate phosphatase LPIN3-like [KO:K15728] [EC:3.1.3.4]
104483229  LPIN2; phosphatidate phosphatase LPIN2 [KO:K15728] [EC:3.1.3.4]
104486691  LPIN1; phosphatidate phosphatase LPIN1 [KO:K15728] [EC:3.1.3.4]
104477342  ULK1; LOW QUALITY PROTEIN: serine/threonine-protein kinase ULK1 [KO:K21357] [EC:2.7.11.1]
104473493  ULK2; serine/threonine-protein kinase ULK2 [KO:K08269] [EC:2.7.11.1]
104486009  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
104481268  EIF4E2; eukaryotic translation initiation factor 4E type 2 [KO:K03259]
104474658  EIF4E; eukaryotic translation initiation factor 4E [KO:K03259]
104487008  eukaryotic translation initiation factor 4E-like [KO:K03259]
104484380  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
104486668  EIF4B; eukaryotic translation initiation factor 4B [KO:K03258]
104480552  RPS6; LOW QUALITY PROTEIN: 40S ribosomal protein S6 [KO:K02991]
104485644  STRADA; LOW QUALITY PROTEIN: STE20-related kinase adapter protein alpha [KO:K08271]
104486207  STRADB; STE20-related kinase adapter protein beta [KO:K17532]
104475745  STK11; serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
104475714  CAB39; calcium-binding protein 39 [KO:K08272]
104474274  CAB39L; calcium-binding protein 39-like [KO:K08272]
104484403  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
104475863  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
104479773  TSC1; hamartin isoform X1 [KO:K07206]
104478259  TSC2; LOW QUALITY PROTEIN: tuberin [KO:K07207]
104483076  TBC1D7; TBC1 domain family member 7 isoform X1 [KO:K20396]
104481929  RHEB; GTP-binding protein Rheb [KO:K07208]
104486825  WNT1; LOW QUALITY PROTEIN: proto-oncogene Wnt-1 [KO:K03209]
104485974  WNT2; protein Wnt-2 [KO:K00182]
104483796  protein Wnt-3a [KO:K00312]
104484692  protein Wnt-3b [KO:K00312]
104476900  WNT4; protein Wnt-4 [KO:K00408]
104483792  protein Wnt-5b [KO:K00444]
104481427  protein Wnt-5a [KO:K00444]
104485222  WNT6; protein Wnt-6 [KO:K00445]
104478426  WNT7A; protein Wnt-7a [KO:K00572]
104474808  WNT7B; protein Wnt-7b [KO:K00572]
104478782  WNT8B; protein Wnt-8b [KO:K00714]
104482435  protein Wnt-8c [KO:K00714]
104483421  WNT9A; protein Wnt-9a [KO:K01064]
104480199  LOW QUALITY PROTEIN: protein Wnt-9b-like [KO:K01064]
104485310  LOW QUALITY PROTEIN: protein Wnt-10a-like [KO:K01357]
104485151  WNT11; protein Wnt-11 [KO:K01384]
104487031  LOW QUALITY PROTEIN: protein Wnt-11b-like [KO:K01384]
104486891  WNT16; protein Wnt-16 [KO:K01558]
104477357  frizzled-7 [KO:K02432]
104483884  frizzled-2 [KO:K02235]
104479633  FZD3; frizzled-3 [KO:K02329]
104486463  FZD4; frizzled-4 [KO:K02354]
104475907  FZD6; frizzled-6 [KO:K02376]
104480580  FZD10; frizzled-10 [KO:K02842]
104484674  low-density lipoprotein receptor-related protein 6 [KO:K03068]
104483154  DVL3; segment polarity protein dishevelled homolog DVL-3 [KO:K02353]
104475911  DVL1; segment polarity protein dishevelled homolog DVL-1 [KO:K02353]
104479955  tumor necrosis factor receptor superfamily member 1A-like [KO:K03158]
104484702  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
104484558  INS; insulin [KO:K04526]
104477534  IGF1; insulin-like growth factor I [KO:K05459]
104478591  LOW QUALITY PROTEIN: insulin receptor-like [KO:K04527] [EC:2.7.10.1]
104485700  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
104478493  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
104481790  SOS2; son of sevenless homolog 2 [KO:K03099]
104487373  HRAS; GTPase HRas [KO:K02833]
104475393  KRAS; GTPase KRas isoform X1 [KO:K07827]
104480086  GTPase NRas [KO:K07828]
104479333  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
104477214  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
104484433  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
104480033  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
104486553  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
104483249  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
104484420  ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
104475913  ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
104481692  RPS6KA1; LOW QUALITY PROTEIN: ribosomal protein S6 kinase alpha-1 [KO:K04373] [EC:2.7.11.1]
104478394  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
104478819  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
104478657  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
104487224  PIK3CD; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
104482796  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
104477938  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
104480561  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
104485389  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
104481650  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
104482587  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
104480685  RICTOR; rapamycin-insensitive companion of mTOR [KO:K08267]
104477044  PRR5; proline-rich protein 5 [KO:K20411]
104473516  PRR5L; proline-rich protein 5-like [KO:K20411]
104478567  transforming protein RhoA [KO:K04513]
104477497  protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
104477406  SGK1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
cmac00561  Glycerolipid metabolism
cmac04010  MAPK signaling pathway
cmac04140  Autophagy - animal
cmac04810  Regulation of actin cytoskeleton
cmac04910  Insulin signaling pathway
KO pathway
ko04150   
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