KEGG   PATHWAY: cmax04144
Entry
cmax04144                   Pathway                                
Name
Endocytosis - Cucurbita maxima (winter squash)
Description
Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
Class
Cellular Processes; Transport and catabolism
Pathway map
cmax04144  Endocytosis
cmax04144

Other DBs
GO: 0006897
Organism
Cucurbita maxima (winter squash) [GN:cmax]
Gene
111487370  phosphatidylinositol 4-phosphate 5-kinase 1 [KO:K00889] [EC:2.7.1.68]
111467034  phosphatidylinositol 4-phosphate 5-kinase 8-like [KO:K00889] [EC:2.7.1.68]
111498268  phosphatidylinositol 4-phosphate 5-kinase 9-like [KO:K00889] [EC:2.7.1.68]
111473312  putative phosphatidylinositol 4-phosphate 5-kinase 11 [KO:K00889] [EC:2.7.1.68]
111489272  phosphatidylinositol 4-phosphate 5-kinase 1-like [KO:K00889] [EC:2.7.1.68]
111476839  phosphatidylinositol 4-phosphate 5-kinase 1-like [KO:K00889] [EC:2.7.1.68]
111480122  phosphatidylinositol 4-phosphate 5-kinase 10 [KO:K00889] [EC:2.7.1.68]
111480242  phosphatidylinositol 4-phosphate 5-kinase 1-like [KO:K00889] [EC:2.7.1.68]
111486632  phosphatidylinositol 4-phosphate 5-kinase 8-like isoform X1 [KO:K00889] [EC:2.7.1.68]
111481577  phosphatidylinositol 4-phosphate 5-kinase 9 [KO:K00889] [EC:2.7.1.68]
111486113  phosphatidylinositol 4-phosphate 5-kinase 6-like isoform X1 [KO:K00889] [EC:2.7.1.68]
111467162  phosphatidylinositol 4-phosphate 5-kinase 4-like isoform X1 [KO:K00889] [EC:2.7.1.68]
111466264  phosphatidylinositol 4-phosphate 5-kinase 5-like [KO:K00889] [EC:2.7.1.68]
111466538  phosphatidylinositol 4-phosphate 5-kinase 6-like [KO:K00889] [EC:2.7.1.68]
111489692  phosphatidylinositol 4-phosphate 5-kinase 6-like isoform X1 [KO:K00889] [EC:2.7.1.68]
111477987  phospholipase D delta [KO:K01115] [EC:3.1.4.4]
111494587  phospholipase D alpha 1 [KO:K01115] [EC:3.1.4.4]
111494428  phospholipase D zeta 1 isoform X1 [KO:K01115] [EC:3.1.4.4]
111498336  phospholipase D beta 1-like [KO:K01115] [EC:3.1.4.4]
111499024  phospholipase D beta 1-like [KO:K01115] [EC:3.1.4.4]
111499069  phospholipase D zeta 1-like [KO:K01115] [EC:3.1.4.4]
111491747  phospholipase D alpha 1-like [KO:K01115] [EC:3.1.4.4]
111492040  phospholipase D delta-like [KO:K01115] [EC:3.1.4.4]
111494170  phospholipase D gamma 1-like isoform X1 [KO:K01115] [EC:3.1.4.4]
111497320  phospholipase D delta-like isoform X1 [KO:K01115] [EC:3.1.4.4]
111492613  phospholipase D alpha 4 [KO:K01115] [EC:3.1.4.4]
111493365  phospholipase D alpha 1-like [KO:K01115] [EC:3.1.4.4]
111493911  phospholipase D zeta 2 [KO:K01115] [EC:3.1.4.4]
111487449  dynamin-2A-like [KO:K01528] [EC:3.6.5.5]
111489807  dynamin-2A-like [KO:K01528] [EC:3.6.5.5]
111471934  dynamin-2A-like isoform X1 [KO:K01528] [EC:3.6.5.5]
111472029  dynamin-2A-like isoform X1 [KO:K01528] [EC:3.6.5.5]
111487380  clathrin heavy chain 1 isoform X1 [KO:K04646]
111489252  clathrin heavy chain 1-like isoform X1 [KO:K04646]
111491565  AP-2 complex subunit alpha-1-like [KO:K11824]
111484056  AP-2 complex subunit alpha-1-like [KO:K11824]
111470635  AP-2 complex subunit mu [KO:K11826]
111491241  AP-2 complex subunit mu-like [KO:K11826]
111475477  AP-2 complex subunit sigma [KO:K11827]
111475461  uncharacterized protein LOC111475461 [KO:K11827]
111479101  ENTH domain-containing protein C794.11c-like isoform X1 [KO:K12471]
111488524  clathrin interactor EPSIN 3-like [KO:K12471]
111492730  clathrin interactor EPSIN 1 [KO:K12471]
111479344  clathrin interactor EPSIN 2-like isoform X1 [KO:K12471]
111498084  clathrin interactor EPSIN 3-like isoform X1 [KO:K12471]
111470693  clathrin interactor EPSIN 2-like [KO:K12471]
111495979  clathrin interactor EPSIN 1-like isoform X1 [KO:K12471]
111492065  clathrin interactor EPSIN 1-like isoform X1 [KO:K12471]
111476375  epidermal growth factor receptor substrate 15-like 1 [KO:K12472]
111468099  epidermal growth factor receptor substrate 15-like 1 [KO:K12472]
111486407  actin cytoskeleton-regulatory complex protein PAN1-like [KO:K12472]
111481180  epidermal growth factor receptor substrate 15-like 1 isoform X1 [KO:K12472]
111470033  protein EARLY-RESPONSIVE TO DEHYDRATION 7, chloroplastic-like [KO:K19366]
111469818  protein EARLY-RESPONSIVE TO DEHYDRATION 7, chloroplastic-like [KO:K19366]
111465176  senescence/dehydration-associated protein At3g51250-like [KO:K19366]
111476580  extensin-3-like [KO:K23612]
111487379  actin-related protein 2 [KO:K17260]
111489043  actin-related protein 2-like isoform X1 [KO:K17260]
111492757  actin-related protein 3 [KO:K18584]
111466308  actin-related protein 3-like isoform X1 [KO:K18584]
111468429  actin-related protein 2/3 complex subunit 1B isoform X1 [KO:K05757]
111486386  actin-related protein 2/3 complex subunit 1A-like [KO:K05757]
111479113  actin-related protein 2/3 complex subunit 2B [KO:K05758]
111487620  actin-related protein 2/3 complex subunit 2A [KO:K05758]
111493556  actin-related protein 2/3 complex subunit 3-like [KO:K05756]
111465702  actin-related protein 2/3 complex subunit 3 [KO:K05756]
111499158  actin-related protein 2/3 complex subunit 4 [KO:K05755]
111486990  actin-related protein 2/3 complex subunit 5A isoform X1 [KO:K05754]
111471170  heat shock cognate 70 kDa protein 2-like [KO:K03283]
111472615  stromal 70 kDa heat shock-related protein, chloroplastic-like [KO:K03283]
111486983  probable mediator of RNA polymerase II transcription subunit 37c [KO:K03283]
111489179  probable mediator of RNA polymerase II transcription subunit 37c [KO:K03283]
111489317  heat shock cognate 70 kDa protein 2-like [KO:K03283]
111474026  stromal 70 kDa heat shock-related protein, chloroplastic-like [KO:K03283]
111487808  heat shock cognate 70 kDa protein 2-like [KO:K03283]
111478145  heat shock cognate 70 kDa protein 2 [KO:K03283]
111468887  stromal 70 kDa heat shock-related protein, chloroplastic [KO:K03283]
111485762  heat shock 70 kDa protein [KO:K03283]
111465611  F-actin-capping protein subunit alpha-like [KO:K10364]
111493782  F-actin-capping protein subunit alpha-like [KO:K10364]
111488953  probable F-actin-capping protein subunit beta [KO:K10365]
111471518  vacuolar protein sorting-associated protein 29-like [KO:K18467]
111484824  vacuolar protein sorting-associated protein 29 [KO:K18467]
111496278  vacuolar protein sorting-associated protein 26A-like isoform X1 [KO:K18466]
111467243  vacuolar protein sorting-associated protein 26A [KO:K18466]
111470176  vacuolar protein sorting-associated protein 35A-like [KO:K18468]
111500194  vacuolar protein sorting-associated protein 35A-like [KO:K18468]
111481301  vacuolar protein sorting-associated protein 35B-like [KO:K18468]
111476410  vacuolar protein sorting-associated protein 35B-like isoform X1 [KO:K18468]
111489995  AMSH-like ubiquitin thioesterase 1 isoform X1 [KO:K11866] [EC:3.4.19.12]
111494356  AMSH-like ubiquitin thioesterase 3 [KO:K11866] [EC:3.4.19.12]
111491760  AMSH-like ubiquitin thioesterase 2 isoform X1 [KO:K11866] [EC:3.4.19.12]
111499142  AMSH-like ubiquitin thioesterase 3 isoform X1 [KO:K11866] [EC:3.4.19.12]
111495308  AMSH-like ubiquitin thioesterase 1 [KO:K11866] [EC:3.4.19.12]
111471043  ras-related protein Rab7 [KO:K07897]
111470179  ras-related protein Rab7-like [KO:K07897]
111471402  ras-related protein Rab7 isoform X1 [KO:K07897]
111494651  ras-related protein Rab7 [KO:K07897]
111473540  ras-related protein Rab7-like [KO:K07897]
111470406  ras-related protein RABG3a-like [KO:K07897]
111488718  ras-related protein Rab7-like [KO:K07897]
111466449  protein ELC-like [KO:K12183]
111485153  protein ELC-like [KO:K12183]
111478075  vacuolar protein sorting-associated protein 28 homolog 2 [KO:K12184]
111498295  vacuolar protein-sorting-associated protein 37 homolog 1-like [KO:K12185]
111481746  vacuolar protein-sorting-associated protein 37 homolog 1-like [KO:K12185]
111476717  vacuolar protein sorting-associated protein 22 homolog 1 [KO:K12188]
111492139  vacuolar protein sorting-associated protein 36 [KO:K12190]
111498518  vacuolar protein sorting-associated protein 25 [KO:K12189]
111466101  vacuolar protein sorting-associated protein 20 homolog 2-like [KO:K12195]
111467276  vacuolar protein sorting-associated protein 20 homolog 2-like [KO:K12195]
111485275  vacuolar protein sorting-associated protein 32 homolog 2-like [KO:K12194]
111498451  vacuolar protein sorting-associated protein 32 homolog 2-like [KO:K12194]
111465657  vacuolar protein sorting-associated protein 32 homolog 2 [KO:K12194]
111493861  vacuolar protein sorting-associated protein 32 homolog 2-like [KO:K12194]
111493421  vacuolar protein sorting-associated protein 24 homolog 1-like [KO:K12193]
111469281  vacuolar protein sorting-associated protein 24 homolog 1 isoform X1 [KO:K12193]
111467516  vacuolar protein sorting-associated protein 2 homolog 1 [KO:K12191]
111497397  vacuolar protein sorting-associated protein 2 homolog 2-like [KO:K12191]
111494308  vacuolar protein sorting-associated protein 2 homolog 1-like [KO:K12191]
111485577  vacuolar protein sorting-associated protein 2 homolog 1-like [KO:K12191]
111488711  vacuolar protein sorting-associated protein 2 homolog 1-like [KO:K12191]
111497975  vacuolar protein sorting-associated protein 2 homolog 3-like [KO:K12192]
111488210  vacuolar protein sorting-associated protein 2 homolog 3-like [KO:K12192]
111489435  charged multivesicular body protein 7 [KO:K15053]
111490739  protein SUPPRESSOR OF K(+) TRANSPORT GROWTH DEFECT 1-like [KO:K12196]
111483960  protein SUPPRESSOR OF K(+) TRANSPORT GROWTH DEFECT 1 [KO:K12196]
111465034  protein HOMOLOG OF MAMMALIAN LYST-INTERACTING PROTEIN 5-like [KO:K12199]
111498411  protein HOMOLOG OF MAMMALIAN LYST-INTERACTING PROTEIN 5-like [KO:K12199]
111488721  ESCRT-related protein CHMP1B-like [KO:K12197]
111492980  ESCRT-related protein CHMP1B-like [KO:K12197]
111494652  ESCRT-related protein CHMP1B [KO:K12197]
111467579  vacuolar protein sorting-associated protein 60.1-like [KO:K12198]
111483361  vacuolar protein sorting-associated protein 60.2 [KO:K12198]
111489129  vacuolar-sorting protein BRO1 [KO:K12200]
111491662  maspardin-like [KO:K19367]
111469170  maspardin-like isoform X1 [KO:K19367]
111478062  sorting nexin 1-like isoform X1 [KO:K17917]
111471228  sorting nexin 1-like [KO:K17917]
111489127  ras-related protein RABF1-like [KO:K07889]
111489640  ras-related protein RABF1-like [KO:K07889]
111487316  ras-related protein RABF1-like [KO:K07889]
111500283  EH domain-containing protein 1-like isoform X1 [KO:K12483]
111498381  EH domain-containing protein 1-like [KO:K12483]
111490347  EH domain-containing protein 1-like [KO:K12483]
111495658  EH domain-containing protein 1-like [KO:K12483]
111486867  vacuolar protein sorting-associated protein 45 homolog [KO:K12479]
111489742  vacuolar protein sorting-associated protein 45 homolog [KO:K12479]
111484528  ras-related protein RABE1c-like [KO:K07901]
111467302  ras-related protein RABE1c-like [KO:K07901]
111478540  ras-related protein RABE1a [KO:K07901]
111499594  ras-related protein RABE1c-like [KO:K07901]
111471246  ras-related protein RABE1a-like [KO:K07901]
111498760  ras-related protein RABE1a-like [KO:K07901]
111476448  ras-related protein RABE1c-like [KO:K07901]
111487405  ras-related protein Rab2BV-like [KO:K07904]
111490479  ras-related protein RABA1c [KO:K07904]
111466102  ras-related protein RABA4d [KO:K07904]
111470815  ras-related protein RABA5d-like [KO:K07904]
111495392  ras-related protein RABA1c-like [KO:K07904]
111478500  ras-related protein Rab11A [KO:K07904]
111497198  ras-related protein RABA1c-like [KO:K07904]
111481478  ras-related protein RABA1b-like [KO:K07904]
111486147  ras-related protein Rab11D [KO:K07904]
111468314  ras-related protein Rab11D-like [KO:K07904]
111499821  ras-related protein Rab11C [KO:K07904]
111486978  ras-related protein RABA2a-like [KO:K07904]
111466304  ras-related protein RABA5a-like isoform X1 [KO:K07904]
111482421  ras-related protein RGP1-like [KO:K07904]
111478625  ras-related protein RABA1c-like [KO:K07904]
111484527  ras-related protein Rab11C-like [KO:K07904]
111493112  ras-related protein RABA4c-like [KO:K07904]
111479471  ras-related protein RABA5d-like [KO:K07904]
111482671  ras-related protein RABA1b-like [KO:K07904]
111482705  ras-related protein RABA2a [KO:K07904]
111467275  ras-related protein RABA4d-like [KO:K07904]
111495497  ras-related protein RABA5a-like [KO:K07904]
111496809  ras-related protein Rab11A-like [KO:K07904]
111489726  ras-related protein Rab2BV-like [KO:K07904]
111480945  ras-related protein RABA1f [KO:K07904]
111491175  kinesin-like protein KIN-UA isoform X1 [KO:K10396]
111472735  kinesin-like protein KIN-UB [KO:K10396]
111487176  kinesin-like protein KIN-UC isoform X1 [KO:K10396]
111479661  kinesin-like protein KIN-UB isoform X1 [KO:K10396]
111489329  kinesin-like protein KIN-UC [KO:K10396]
111490533  probable ADP-ribosylation factor GTPase-activating protein AGD15 isoform X1 [KO:K12486]
111488976  probable ADP-ribosylation factor GTPase-activating protein AGD11 [KO:K12486]
111480572  probable ADP-ribosylation factor GTPase-activating protein AGD5 [KO:K12486]
111497129  ADP-ribosylation factor GTPase-activating protein AGD12-like [KO:K12486]
111476504  probable ADP-ribosylation factor GTPase-activating protein AGD11 [KO:K12486]
111495353  ADP-ribosylation factor GTPase-activating protein AGD12-like [KO:K12486]
111466413  probable ADP-ribosylation factor GTPase-activating protein AGD11 isoform X1 [KO:K12486]
111495837  probable ADP-ribosylation factor GTPase-activating protein AGD15 [KO:K12486]
111476869  probable ADP-ribosylation factor GTPase-activating protein AGD5 [KO:K12486]
111487847  probable ADP-ribosylation factor GTPase-activating protein AGD11 isoform X1 [KO:K12486]
111490447  ADP-ribosylation factor GTPase-activating protein AGD12-like isoform X1 [KO:K12486]
111478698  probable ADP-ribosylation factor GTPase-activating protein AGD13 [KO:K12486]
111480072  ADP-ribosylation factor GTPase-activating protein AGD3-like [KO:K12489]
111483326  ADP-ribosylation factor GTPase-activating protein AGD4-like isoform X1 [KO:K12489]
111470702  ADP-ribosylation factor GTPase-activating protein AGD3-like isoform X1 [KO:K12489]
111484517  ADP-ribosylation factor GTPase-activating protein AGD4-like isoform X1 [KO:K12489]
111482439  probable ADP-ribosylation factor GTPase-activating protein AGD6 [KO:K12492]
111470040  ADP-ribosylation factor GTPase-activating protein AGD7-like [KO:K12492]
111500159  probable ADP-ribosylation factor GTPase-activating protein AGD8 [KO:K12493]
111498418  probable ADP-ribosylation factor GTPase-activating protein AGD8 [KO:K12493]
111466994  probable ADP-ribosylation factor GTPase-activating protein AGD9 [KO:K12493]
111486404  brefeldin A-inhibited guanine nucleotide-exchange protein 1-like [KO:K18442]
111472704  brefeldin A-inhibited guanine nucleotide-exchange protein 2-like [KO:K18442]
111479644  brefeldin A-inhibited guanine nucleotide-exchange protein 2-like [KO:K18442]
111468096  brefeldin A-inhibited guanine nucleotide-exchange protein 1 [KO:K18442]
111465412  ARF guanine-nucleotide exchange factor GNL2 [KO:K18443]
111490452  ARF guanine-nucleotide exchange factor GNOM-like [KO:K18443]
111476959  ARF guanine-nucleotide exchange factor GNOM-like [KO:K18443]
111487366  ADP-ribosylation factor 1-like [KO:K07937]
111497095  ADP-ribosylation factor 1-like [KO:K07937]
111486323  ADP-ribosylation factor-like isoform X1 [KO:K07937]
111486324  ADP-ribosylation factor 1-like [KO:K07937]
111491996  ADP-ribosylation factor 1 [KO:K07937]
111466470  ADP-ribosylation factor 2 [KO:K07937]
111481854  ADP-ribosylation factor 1-like [KO:K07937]
111481855  ADP-ribosylation factor 1-like [KO:K07937]
111497893  ADP-ribosylation factor-like isoform X1 [KO:K07937]
111489103  ADP-ribosylation factor 1 isoform X1 [KO:K07937]
111470705  ADP-ribosylation factor-like [KO:K07937]
111470966  ADP-ribosylation factor 1-like isoform X1 [KO:K07937]
111488101  ADP-ribosylation factor-like isoform X1 [KO:K07937]
111469127  ADP-ribosylation factor-like [KO:K07937]
111490937  ADP-ribosylation factor-like [KO:K07937]
Compound
C00035  GDP
C00044  GTP
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
Reference
PMID:19007773
  Authors
Acconcia F, Sigismund S, Polo S
  Title
Ubiquitin in trafficking: the network at work.
  Journal
Exp Cell Res 315:1610-8 (2009)
DOI:10.1016/j.yexcr.2008.10.014
Reference
PMID:18647649
  Authors
Donaldson JG, Porat-Shliom N, Cohen LA
  Title
Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling.
  Journal
Cell Signal 21:1-6 (2009)
DOI:10.1016/j.cellsig.2008.06.020
Reference
PMID:15261671
  Authors
Sorkin A
  Title
Cargo recognition during clathrin-mediated endocytosis: a team effort.
  Journal
Curr Opin Cell Biol 16:392-9 (2004)
DOI:10.1016/j.ceb.2004.06.001
Reference
PMID:19325624
  Authors
Raiborg C, Stenmark H
  Title
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins.
  Journal
Nature 458:445-52 (2009)
DOI:10.1038/nature07961
Reference
PMID:20110990
  Authors
Scita G, Di Fiore PP
  Title
The endocytic matrix.
  Journal
Nature 463:464-73 (2010)
DOI:10.1038/nature08910
Reference
PMID:15687999
  Authors
Le Roy C, Wrana JL
  Title
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling.
  Journal
Nat Rev Mol Cell Biol 6:112-26 (2005)
DOI:10.1038/nrm1571
Reference
PMID:19924646
  Authors
Jovic M, Sharma M, Rahajeng J, Caplan S
  Title
The early endosome: a busy sorting station for proteins at the crossroads.
  Journal
Histol Histopathol 25:99-112 (2010)
DOI:10.14670/HH-25.99
Reference
PMID:16203612
  Authors
Pietiainen VM, Marjomaki V, Heino J, Hyypia T
  Title
Viral entry, lipid rafts and caveosomes.
  Journal
Ann Med 37:394-403 (2005)
DOI:10.1080/07853890510011976
Reference
PMID:19696797
  Authors
Grant BD, Donaldson JG
  Title
Pathways and mechanisms of endocytic recycling.
  Journal
Nat Rev Mol Cell Biol 10:597-608 (2009)
DOI:10.1038/nrm2755
Reference
PMID:22193161
  Authors
Cullen PJ, Korswagen HC
  Title
Sorting nexins provide diversity for retromer-dependent trafficking events.
  Journal
Nat Cell Biol 14:29-37 (2012)
DOI:10.1038/ncb2374
Related
pathway
cmax04070  Phosphatidylinositol signaling system
cmax04130  SNARE interactions in vesicular transport
KO pathway
ko04144   
LinkDB

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