KEGG PATHWAY: cne03420

KEGG

PATHWAY: cne03420

Entry

cne03420                    Pathway

Name

Nucleotide excision repair - Cryptococcus neoformans var. neoformans JEC21

Description

Nucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the NER pathway are linked to at least three diseases: xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD). The repair of damaged DNA involves at least 30 polypeptides within two different sub-pathways of NER known as transcription-coupled repair (TCR-NER) and global genome repair (GGR-NER). TCR refers to the expedited repair of lesions located in the actively transcribed strand of genes by RNA polymerase II (RNAP II). In GGR-NER the first step of damage recognition involves XPC-hHR23B complex together with XPE complex (in prokaryotes, uvrAB complex). The following steps of GGR-NER and TCR-NER are similar.

Class

Genetic Information Processing; Replication and repair

Pathway map

Nucleotide excision repair

Other DBs

GO:

Organism

Cryptococcus neoformans var. neoformans JEC21 [GN:cne]

Gene

ATP-dependent DNA helicase pcra, putative [KO:K03657] [EC:5.6.2.4]

ubiquitin-protein ligase, putative [KO:K03868] [EC:2.3.2.32]

ubiquitin-protein ligase, putative [KO:K10609]

conserved hypothetical protein [KO:K10610]

hypothetical protein [KO:K10838]

uv excision repair protein rhp23, putative [KO:K10839]

DNA-directed RNA polymerase II largest subunit, putative [KO:K03006] [EC:2.7.7.6]

DNA-dependent RNA polymerase II RPB140, putative [KO:K03010] [EC:2.7.7.6]

RNA polymerase II subunit 3, putative [KO:K03011]

hypothetical protein [KO:K03012]

DNA-directed RNA polymerases II 24 kda polypeptide, putative [KO:K03013]

DNA-directed RNA polymerases I, II, and III polypeptide, putative [KO:K03014]

conserved hypothetical protein [KO:K03015]

DNA-directed RNA polymerases I, II, and III 17.1 kda polypeptide, putative [KO:K03016]

hypothetical protein [KO:K03017]

DNA-directed RNA polymerases I, II, and III 8.3 kda polypeptide, putative [KO:K03007]

DNA-directed RNA polymerase II 13.3 kda polypeptide, putative [KO:K03008]

cyclin-dependent protein kinase, putative [KO:K02202] [EC:2.7.11.22 2.7.11.23]

transcription/repair factor TFIIH subunit Tfb3, putative [KO:K10842]

cyclin-dependent protein kinase regulator, putative [KO:K06634]

general RNA polymerase II transcription factor, putative [KO:K10843] [EC:5.6.2.4]

general RNA polymerase II transcription factor, putative [KO:K10844] [EC:5.6.2.3]

hypothetical protein [KO:K10845]

expressed protein [KO:K03141]

RNA polymerase II transcription factor, putative [KO:K03142]

hypothetical protein [KO:K03143]

hypothetical protein [KO:K03144]

single-stranded DNA specific endodeoxyribonuclease, putative [KO:K10846]

hydrophilic protein, putative [KO:K10847]

damaged DNA binding protein, putative [KO:K07466]

conserved hypothetical protein [KO:K10739]

single-stranded DNA binding protein 12k chain, putative [KO:K10740]

conserved hypothetical protein [KO:K10848] [EC:3.1.-.-]

mating-type switching protein swi10, putative [KO:K10849]

delta DNA polymerase, putative [KO:K02327] [EC:2.7.7.7]

DNA polymerase Delta, small subunit, putative [KO:K02328]

expressed protein [KO:K03504]

hypothetical protein [KO:K03505]

DNA polymerase epsilon, catalytic subunit a, putative [KO:K02324] [EC:2.7.7.7]

epsilon DNA polymerase, putative [KO:K02325] [EC:2.7.7.7]

expressed protein [KO:K02326] [EC:2.7.7.7]

DNA polymerase epsilon p12 subunit (dna polymerase epsilon subunit 4), putative [KO:K03506] [EC:2.7.7.7]

DNA polymerase processivity factor, putative [KO:K04802]

purine nucleotide binding protein, putative [KO:K10754]

activator 1 41 kda subunit, putative [KO:K10755]

Activator 1 40 kDa subunit, putative [KO:K10755]

DNA replication factor, putative [KO:K10756]

DNA clamp loader, putative [KO:K10756]

DNA ligase, putative [KO:K10747] [EC:6.5.1.1 6.5.1.6 6.5.1.7]

Reference

Authors

Sugasawa K.

Title

[Molecular mechanism of mammalian nucleotide excision repair]

Journal

Tanpakushitsu Kakusan Koso 46:893-901 (2001)

Reference

Authors

Nakatsu Y.

Title

[Transcription-coupled repair and Cockayne syndrome]

Journal

Tanpakushitsu Kakusan Koso 46:908-15 (2001)

Reference

Authors

Nakagawa N, Masui R, Kuramitsu S.

Title

[Structure and function of DNA repair enzyme UvrB from Thermus thermophilus HB8]

Journal

Tanpakushitsu Kakusan Koso 46:968-75 (2001)

Reference

Authors

Kraemer KH, Patronas NJ, Schiffmann R, Brooks BP, Tamura D, DiGiovanna JJ.

Title

Xeroderma pigmentosum, trichothiodystrophy and Cockayne syndrome: a complex genotype-phenotype relationship.

Journal

Neuroscience 145:1388-96 (2007)
DOI:10.1016/j.neuroscience.2006.12.020

Reference

Authors

Saldivar JS, Wu X, Follen M, Gershenson D.

Title

Nucleotide excision repair pathway review I: implications in ovarian cancer and platinum sensitivity.

Journal

Gynecol Oncol 107:S56-71 (2007)
DOI:10.1016/j.ygyno.2007.07.043

Reference

Authors

Sugasawa K.

Title

[DNA repair pathways involving Cul4A ubiquitin ligases]

Journal

Tanpakushitsu Kakusan Koso 51:1339-44 (2006)

Reference

Authors

Ito S, Ando D, Tanaka K.

Title

[Cross-talk between DNA repair and transcription: molecular mechanism and disorders]

Journal

Tanpakushitsu Kakusan Koso 52:1823-31 (2007)

Related
pathway

RNA polymerase

Ubiquitin mediated proteolysis

KO pathway

LinkDB

DBGET integrated database retrieval system