KEGG   PATHWAY: cscu04150
Entry
cscu04150                   Pathway                                
Name
mTOR signaling pathway - Centruroides sculpturatus (bark scorpion)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
cscu04150  mTOR signaling pathway
cscu04150

Organism
Centruroides sculpturatus (bark scorpion) [GN:cscu]
Gene
111638538  Y+L amino acid transporter 2-like isoform X1 [KO:K13780]
111640985  large neutral amino acids transporter small subunit 1-like [KO:K13780]
111626191  sodium-coupled neutral amino acid transporter 9-like [KO:K14995]
111642525  V-type proton ATPase catalytic subunit A-like [KO:K02145] [EC:7.1.2.2]
111627015  V-type proton ATPase subunit B [KO:K02147]
111618475  V-type proton ATPase subunit B-like [KO:K02147]
111627433  V-type proton ATPase subunit C-like [KO:K02148]
111619159  V-type proton ATPase subunit D-like [KO:K02149]
111633568  V-type proton ATPase subunit E-like [KO:K02150]
111620185  V-type proton ATPase subunit F-like isoform X1 [KO:K02151]
111632509  V-type proton ATPase subunit G-like [KO:K02152]
111639183  V-type proton ATPase subunit H-like [KO:K02144]
111639184  V-type proton ATPase subunit H-like [KO:K02144]
111639173  V-type proton ATPase subunit H-like [KO:K02144]
111639174  V-type proton ATPase subunit H-like [KO:K02144]
111621734  ragulator complex protein LAMTOR1-like [KO:K20397]
111612583  ragulator complex protein LAMTOR1-like isoform X1 [KO:K20397]
111637427  ragulator complex protein LAMTOR2-like [KO:K20398]
111626697  ragulator complex protein LAMTOR3-like [KO:K04370]
111628554  ragulator complex protein LAMTOR4-like [KO:K20399]
111640518  ragulator complex protein LAMTOR5 homolog [KO:K16344]
111613358  folliculin-like [KO:K09594]
111620610  folliculin-interacting protein 2-like [KO:K20401]
111642347  ras-related GTP-binding protein A [KO:K16185]
111639702  ras-related GTP-binding protein C-like [KO:K16186]
111624668  GATOR complex protein MIOS-B-like [KO:K20407]
111620662  nucleoporin SEH1-like [KO:K14299]
111642662  GATOR complex protein WDR24-like [KO:K20408]
111633333  GATOR complex protein WDR59-like isoform X1 [KO:K20409]
111639340  protein SEC13 homolog [KO:K14004]
111632018  GATOR complex protein DEPDC5-like isoform X1 [KO:K20404]
111627728  GATOR complex protein NPRL2-like isoform X1 [KO:K20405]
111624098  GATOR complex protein NPRL3-like [KO:K20406]
111626608  S-phase kinase-associated protein 2-like [KO:K03875]
111634668  regulatory-associated protein of mTOR-like [KO:K07204]
111637672  uncharacterized protein LOC111637672 [KO:K16184]
111634091  uncharacterized protein LOC111634091 isoform X1 [KO:K16184]
111620923  serine/threonine-protein kinase mTOR-like [KO:K07203] [EC:2.7.11.1]
111628040  target of rapamycin complex subunit lst8-like [KO:K08266]
111626995  telomere length regulation protein TEL2 homolog [KO:K11137]
111638757  TELO2-interacting protein 1 homolog [KO:K20403]
111638571  CAP-Gly domain-containing linker protein 2-like [KO:K10421]
111618348  phosphatidate phosphatase LPIN1-like [KO:K15728] [EC:3.1.3.4]
111618352  phosphatidate phosphatase LPIN1-like [KO:K15728] [EC:3.1.3.4]
111622333  serine/threonine-protein kinase ULK2-like [KO:K08269] [EC:2.7.11.1]
111630776  serine/threonine-protein kinase unc-51-like [KO:K08269] [EC:2.7.11.1]
111633095  eukaryotic translation initiation factor 4E-binding protein 1-like [KO:K07205]
111618862  eukaryotic translation initiation factor 4E-like [KO:K03259]
111626994  eukaryotic translation initiation factor 4E-like [KO:K03259]
111631869  eukaryotic translation initiation factor 4E-1A-like [KO:K03259]
111631876  eukaryotic translation initiation factor 4E-1A-like [KO:K03259]
111640833  eukaryotic translation initiation factor 4E type 2-like [KO:K03259]
111640927  ribosomal protein S6 kinase beta-1-like [KO:K04688] [EC:2.7.11.1]
111613817  eukaryotic translation initiation factor 4B-like [KO:K03258]
111616949  40S ribosomal protein S6-like [KO:K02991]
111615497  40S ribosomal protein S6-like [KO:K02991]
111618298  40S ribosomal protein S6-like [KO:K02991]
111631064  STE20-related kinase adapter protein alpha-like [KO:K08271]
111633404  serine/threonine-protein kinase STK11-like [KO:K07298] [EC:2.7.11.1]
111633432  protein Mo25-like [KO:K08272]
111636091  protein Mo25-like [KO:K08272]
111634229  5'-AMP-activated protein kinase catalytic subunit alpha-2-like [KO:K07198] [EC:2.7.11.31]
111629794  LOW QUALITY PROTEIN: hamartin-like [KO:K07206]
111629796  uncharacterized protein LOC111629796 [KO:K07206]
111639480  tuberin-like [KO:K07207]
111642195  TBC1 domain family member 7-like [KO:K20396]
111613161  GTP-binding protein Rheb homolog isoform X1 [KO:K07208]
111621430  protein Wnt-1-like [KO:K03209]
111629169  protein Wnt-1-like [KO:K03209]
111625291  protein Wnt-2b-like isoform X1 [KO:K00182]
111623767  protein Wnt-4-like isoform X1 [KO:K00408]
111620760  protein Wnt-4-like [KO:K00408]
111618001  protein Wnt-5b-like [KO:K00444]
111621431  protein Wnt-6-like isoform X1 [KO:K00445]
111629161  protein Wnt-6-like [KO:K00445]
111618003  protein Wnt-7b-like [KO:K00572]
111622537  protein Wnt-7b-like [KO:K00572]
111629170  protein Wnt-9a-like isoform X1 [KO:K01064]
111638841  protein Wnt-11b-like [KO:K01384]
111628547  protein Wnt-11b-1-like isoform X1 [KO:K01384]
111625292  protein Wnt-16-like [KO:K01558]
111629656  frizzled-2-like [KO:K02432]
111632851  frizzled-4-like [KO:K02354]
111621996  frizzled-4-like [KO:K02354]
111629537  frizzled-5-like [KO:K02375]
111617124  frizzled-5-like [KO:K02375]
111623209  frizzled-9-like [KO:K02842]
111637877  low-density lipoprotein receptor-related protein 6-like [KO:K03068]
111612719  segment polarity protein dishevelled homolog DVL-3-like isoform X1 [KO:K02353]
111632902  inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K07209] [EC:2.7.11.10]
111637650  probable insulin-like peptide 5 [KO:K04526]
111637652  probable insulin-like peptide 5 [KO:K04526]
111637654  insulin-like [KO:K04526]
111624064  bombyxin A-2 homolog [KO:K04526]
111634212  insulin-like [KO:K04526]
111627661  protein enhancer of sevenless 2B [KO:K04364]
111623193  protein enhancer of sevenless 2B-like [KO:K04364]
111634592  son of sevenless homolog 1-like [KO:K03099]
111613070  GTPase KRas-like [KO:K07827]
111633508  GTPase HRas isoform X1 [KO:K07827]
111640304  serine/threonine-protein kinase B-raf-like [KO:K04365] [EC:2.7.11.1]
111628403  dual specificity mitogen-activated protein kinase kinase 1-like isoform X1 [KO:K04368] [EC:2.7.12.2]
111630604  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
111632069  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
111617916  ribosomal protein S6 kinase alpha-1-like [KO:K04373] [EC:2.7.11.1]
111631661  ribosomal protein S6 kinase 2 beta-like [KO:K04373] [EC:2.7.11.1]
111622797  insulin receptor substrate 1-like [KO:K16172]
111623544  phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1 [KO:K02649]
111627700  phosphatidylinositol 3-kinase regulatory subunit alpha-like [KO:K02649]
111629891  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform-like isoform X1 [KO:K00922] [EC:2.7.1.153]
111639926  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
111622749  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN-like [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
111640149  3-phosphoinositide-dependent protein kinase 1-like [KO:K06276] [EC:2.7.11.1]
111612887  LOW QUALITY PROTEIN: RAC serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
111628449  serine/threonine-protein kinase Aurora-3-like isoform X1 [KO:K04456] [EC:2.7.11.1]
111633610  target of rapamycin complex 2 subunit MAPKAP1-like [KO:K20410]
111629798  rapamycin-insensitive companion of mTOR-like [KO:K08267]
111615147  proline-rich protein 5-like isoform X1 [KO:K20411]
111623706  ras-like GTP-binding protein Rho1 isoform X1 [KO:K04513]
111622135  ras-like GTP-binding protein Rho1 isoform X1 [KO:K04513]
111613091  protein kinase C, brain isozyme-like isoform X1 [KO:K02677] [EC:2.7.11.13]
111640734  protein kinase C, brain isozyme-like [KO:K02677] [EC:2.7.11.13]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
cscu00561  Glycerolipid metabolism
cscu04140  Autophagy - animal
KO pathway
ko04150   
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