KEGG   PATHWAY: csem04622
Entry
csem04622                   Pathway                                
Name
RIG-I-like receptor signaling pathway - Cynoglossus semilaevis (tongue sole)
Description
Specific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular viral replication is recognized by a family of cytosolic RNA helicases termed RIG-I-like receptors (RLRs). The RLR proteins include RIG-I, MDA5, and LGP2 and are expressed in both immune and nonimmune cells. Upon recognition of viral nucleic acids, RLRs recruit specific intracellular adaptor proteins to initiate signaling pathways that lead to the synthesis of type I interferon and other inflammatory cytokines, which are important for eliminating viruses.
Class
Organismal Systems; Immune system
Pathway map
csem04622  RIG-I-like receptor signaling pathway
csem04622

Organism
Cynoglossus semilaevis (tongue sole) [GN:csem]
Gene
103392158  ifih1; LOW QUALITY PROTEIN: interferon-induced helicase C domain-containing protein 1 [KO:K12647] [EC:5.6.2.6]
103386734  NFX1-type zinc finger-containing protein 1 [KO:K27391]
103392605  dhx58; probable ATP-dependent RNA helicase DHX58 [KO:K12649] [EC:5.6.2.6]
103382287  traf3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
103392152  tank; TRAF family member-associated NF-kappa-B activator [KO:K12650]
103388620  azi2; 5-azacytidine-induced protein 2 [KO:K12651]
103381869  tbkbp1; TANK-binding kinase 1-binding protein 1 [KO:K12652]
103393547  TANK-binding kinase 1-binding protein 1-like [KO:K12652]
107989881  TANK-binding kinase 1-binding protein 1-like [KO:K12652]
103384713  ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
103382474  tbk1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
103386082  ikbke; inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
103382011  interferon regulatory factor 3-like [KO:K05411]
103380393  irf7; interferon regulatory factor 7 [KO:K09447]
103378721  tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
103378588  fadd; FAS-associated death domain protein [KO:K02373]
103396277  ripk1; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
103396237  caspase-8-like [KO:K04398] [EC:3.4.22.61]
103396239  caspase-8-like [KO:K04398] [EC:3.4.22.61]
103398848  inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K04467] [EC:2.7.11.10]
103387400  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
103397763  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
103380734  NF-kappa-B inhibitor alpha-like [KO:K04734]
103377625  nfkbia; NF-kappa-B inhibitor alpha [KO:K04734]
103391096  nfkb1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
103385629  putative transcription factor p65 homolog [KO:K04735]
103390066  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
103397592  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
103390226  TNF receptor-associated factor 2-like isoform X1 [KO:K03173] [EC:2.3.2.27]
103380691  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
103378810  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
103382123  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
103391026  mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
103390257  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
103387363  mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:2.7.11.24]
103380409  mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
103382962  mitogen-activated protein kinase 11-like [KO:K04441] [EC:2.7.11.24]
103382963  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
103384903  mitogen-activated protein kinase 13-like [KO:K04441] [EC:2.7.11.24]
103384606  mitogen-activated protein kinase 14A-like isoform X1 [KO:K04441] [EC:2.7.11.24]
103386138  mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
103383721  permeability factor 2-like precursor [KO:K10030]
103388563  interleukin-8-like [KO:K10030]
103391029  C-X-C motif chemokine 10-like [KO:K10030]
103394480  tumor necrosis factor-like [KO:K03156]
103378499  interleukin-12 subunit alpha-like [KO:K05406]
103391417  il12b; interleukin-12 subunit beta [KO:K05425]
103395539  interleukin-12 subunit beta-like [KO:K05425]
103397823  interleukin-12 subunit beta-like [KO:K05425]
103397355  C-X-C motif chemokine 10-like [KO:K12671]
103388211  adar; double-stranded RNA-specific adenosine deaminase [KO:K12968] [EC:3.5.4.37]
103383434  E3 ubiquitin/ISG15 ligase TRIM25-like isoform X2 [KO:K10652] [EC:2.3.2.27]
103384232  trim25; E3 ubiquitin/ISG15 ligase TRIM25 [KO:K10652] [EC:2.3.2.27]
103378277  tripartite motif-containing protein 65-like isoform X1 [KO:K10652] [EC:2.3.2.27]
103384748  E3 ubiquitin/ISG15 ligase TRIM25-like [KO:K10652] [EC:2.3.2.27]
103384956  E3 ubiquitin/ISG15 ligase TRIM25-like [KO:K10652] [EC:2.3.2.27]
103384550  ubiquitin carboxyl-terminal hydrolase CYLD-like isoform X1 [KO:K08601] [EC:3.4.19.12]
103399892  ubiquitin carboxyl-terminal hydrolase CYLD-like isoform X1 [KO:K08601] [EC:3.4.19.12]
103386321  ubiquitin carboxyl-terminal hydrolase CYLD-like [KO:K08601] [EC:3.4.19.12]
103398556  cyld; ubiquitin carboxyl-terminal hydrolase CYLD isoform X1 [KO:K08601] [EC:3.4.19.12]
103388689  atg5; autophagy protein 5 [KO:K08339]
103387824  atg12; ubiquitin-like protein ATG12 [KO:K08336]
103377705  nlrx1; NLR family member X1 isoform X1 [KO:K12653]
103384662  sike1; suppressor of IKBKE 1 [KO:K12656]
103391525  ddx3x; ATP-dependent RNA helicase DDX3X isoform X1 [KO:K11594] [EC:5.6.2.7]
103389314  ATP-dependent RNA helicase DDX3X-like isoform X1 [KO:K11594] [EC:5.6.2.7]
103383495  pin1; peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 [KO:K09578] [EC:5.2.1.8]
103386061  tkfc; triokinase/FMN cyclase [KO:K00863] [EC:2.7.1.28 2.7.1.29 4.6.1.15]
Compound
C00046  RNA
Reference
PMID:15208624
  Authors
Yoneyama M, Kikuchi M, Natsukawa T, Shinobu N, Imaizumi T, Miyagishi M, Taira K, Akira S, Fujita T
  Title
The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses.
  Journal
Nat Immunol 5:730-7 (2004)
DOI:10.1038/ni1087
Reference
PMID:18272355
  Authors
Takeuchi O, Akira S
  Title
MDA5/RIG-I and virus recognition.
  Journal
Curr Opin Immunol 20:17-22 (2008)
DOI:10.1016/j.coi.2008.01.002
Reference
PMID:19120475
  Authors
Yoneyama M, Fujita T
  Title
RNA recognition and signal transduction by RIG-I-like receptors.
  Journal
Immunol Rev 227:54-65 (2009)
DOI:10.1111/j.1600-065X.2008.00727.x
Reference
PMID:19539500
  Authors
Nakhaei P, Genin P, Civas A, Hiscott J
  Title
RIG-I-like receptors: sensing and responding to RNA virus infection.
  Journal
Semin Immunol 21:215-22 (2009)
DOI:10.1016/j.smim.2009.05.001
Reference
PMID:18549796
  Authors
Moore CB, Ting JP
  Title
Regulation of mitochondrial antiviral signaling pathways.
  Journal
Immunity 28:735-9 (2008)
DOI:10.1016/j.immuni.2008.05.005
Reference
PMID:19615405
  Authors
Barral PM, Sarkar D, Su ZZ, Barber GN, DeSalle R, Racaniello VR, Fisher PB
  Title
Functions of the cytoplasmic RNA sensors RIG-I and MDA-5: key regulators of innate immunity.
  Journal
Pharmacol Ther 124:219-34 (2009)
DOI:10.1016/j.pharmthera.2009.06.012
Reference
PMID:19120476
  Authors
Schlee M, Hartmann E, Coch C, Wimmenauer V, Janke M, Barchet W, Hartmann G
  Title
Approaching the RNA ligand for RIG-I?
  Journal
Immunol Rev 227:66-74 (2009)
DOI:10.1111/j.1600-065X.2008.00724.x
Reference
PMID:18591413
  Authors
Saito T, Gale M Jr
  Title
Differential recognition of double-stranded RNA by RIG-I-like receptors in antiviral immunity.
  Journal
J Exp Med 205:1523-7 (2008)
DOI:10.1084/jem.20081210
Reference
PMID:19076341
  Authors
Kawai T, Akira S
  Title
Toll-like receptor and RIG-I-like receptor signaling.
  Journal
Ann N Y Acad Sci 1143:1-20 (2008)
DOI:10.1196/annals.1443.020
Reference
PMID:18439848
  Authors
Michallet MC, Meylan E, Ermolaeva MA, Vazquez J, Rebsamen M, Curran J, Poeck H, Bscheider M, Hartmann G, Konig M, Kalinke U, Pasparakis M, Tschopp J
  Title
TRADD protein is an essential component of the RIG-like helicase antiviral pathway.
  Journal
Immunity 28:651-61 (2008)
DOI:10.1016/j.immuni.2008.03.013
Reference
PMID:18984593
  Authors
Yoshida R, Takaesu G, Yoshida H, Okamoto F, Yoshioka T, Choi Y, Akira S, Kawai T, Yoshimura A, Kobayashi T
  Title
TRAF6 and MEKK1 play a pivotal role in the RIG-I-like helicase antiviral pathway.
  Journal
J Biol Chem 283:36211-20 (2008)
DOI:10.1074/jbc.M806576200
Reference
PMID:19224920
  Authors
Mikkelsen SS, Jensen SB, Chiliveru S, Melchjorsen J, Julkunen I, Gaestel M, Arthur JS, Flavell RA, Ghosh S, Paludan SR
  Title
RIG-I-mediated activation of p38 MAPK is essential for viral induction of interferon and activation of dendritic cells: dependence on TRAF2 and TAK1.
  Journal
J Biol Chem 284:10774-82 (2009)
DOI:10.1074/jbc.M807272200
Reference
PMID:32668226
  Authors
Liu G, Gack MU
  Title
Distinct and Orchestrated Functions of RNA Sensors in Innate Immunity.
  Journal
Immunity 53:26-42 (2020)
DOI:10.1016/j.immuni.2020.03.017
Related
pathway
csem04010  MAPK signaling pathway
csem04120  Ubiquitin mediated proteolysis
csem04210  Apoptosis
KO pathway
ko04622   
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