Entry
Name
ABC transporters - Cronobacter sakazakii ES15
Description
The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
Class
Environmental Information Processing; Membrane transport
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Cronobacter sakazakii ES15 [GN:
csk ]
Gene
ES15_2676 modF; putative molybdenum transport ATP-binding protein ModF [KO:K05776 ]
ES15_2366 potD; spermidine/putrescine ABC transporter periplasmic substrate-binding protein PotD [KO:K11069 ]
ES15_2365 potC; spermidine/putrescine ABC transporter membrane protein PotC [KO:K11070 ]
ES15_2364 potB; spermidine/putrescine ABC transporter membrane protein PotB [KO:K11071 ]
ES15_2578 potI; putrescine transport system permease protein PotI [KO:K11074 ]
ES15_2579 potH; putrescine transport system permease protein PotH [KO:K11075 ]
ES15_0839 proX; glycine betaine transporter periplasmic subunit [KO:K02002 ]
ES15_1922 putative osmoprotectant transport system substrate-binding protein [KO:K05845 ]
ES15_1351 putative ABC transporter, periplasmic substrate-binding protein [KO:K05845 ]
ES15_1921 opuCB; glycine betaine/carnitine/choline transport system permease OpuCB [KO:K05846 ]
ES15_1923 binding-protein-dependent transport systems inner membrane component [KO:K05846 ]
ES15_1920 opuCA; glycine betaine/carnitine/choline transport ATP-binding protein OpuCA [KO:K05847 ] [EC:7.6.2.9 ]
ES15_0400 malE; ABC-type maltose ABC transporter periplasmic protein [KO:K10108 ]
ES15_0401 malK1; ABC-type maltose/maltodextrin transporter ATP-binding protein [KO:K10111 ] [EC:7.5.2.-]
ES15_3393 lacK; lactose transport ATP-binding protein LacK [KO:K10111 ] [EC:7.5.2.-]
ES15_3537 putative ABC transport system substrate-binding protein [KO:K02067 ]
ES15_3539 yrbF; putative ABC transporter ATP-binding protein YrbF [KO:K02065 ]
ES15_1547 araF; L-arabinose ABC transporter, periplasmic L-arabinose-binding protein [KO:K10537 ]
ES15_1549 araH; L-arabinose ABC transporter, permease protein AraH [KO:K10538 ]
ES15_0532 ytfQ; ABC transporter periplasmic-binding protein YtfQ [KO:K23508 ]
ES15_1330 mglB; galactose ABC transporter, periplasmic galactose-binding protein [KO:K10540 ]
ES15_1332 mglC; beta-methylgalactoside transporter inner membrane component [KO:K10541 ]
ES15_0223 ugpB; ABC-type glycerol-3-phosphate transporter periplasmic binding protein [KO:K05813 ]
ES15_0224 ugpA; ABC-type glycerol-3-phosphate transporter permease [KO:K05814 ]
ES15_0225 ugpE; ABC-type glycerol-3-phosphate transporter membrane protein [KO:K05815 ]
ES15_3900 pstS; phosphate ABC transporter periplasmic substrate-binding protein PstS [KO:K02040 ]
ES15_1162 argT; lysine/arginine/ornithine transport system substrate-binding protein [KO:K10013 ]
ES15_1165 hisM; histidine/lysine/arginine/ornithine ABC transporter permease HisM [KO:K10015 ]
ES15_1164 hisQ; histidine/lysine/arginine/ornithine ABC transporter permease HisQ [KO:K10016 ]
ES15_1163 hisJ; histidine ABC transporter substrate-binding protein HisJ [KO:K10014 ]
ES15_2623 glnH; glutamine ABC transporter periplasmic protein GlnH [KO:K10036 ]
ES15_2624 glnP; glutamine transport system permease protein GlnP [KO:K10037 ]
ES15_2571 artJ; arginine ABC transporter periplasmic arginine-binding protein ArtJ [KO:K09996 ]
ES15_2568 artI; arginine ABC transporter, periplasmic arginine-binding protein ArtI [KO:K09997 ]
ES15_2755 gltK; glutamate/aspartate transport system permease GltK [KO:K10002 ]
ES15_3606 aapJ; putative amino-acid ABC transporter-binding protein AapJ [KO:K09969 ]
ES15_3607 aapQ; putative amino-acid ABC transporter permease AapQ [KO:K09970 ]
ES15_3608 aapM; inner membrane amino-acid ABC transporter permease AapM [KO:K09971 ]
ES15_0216 livK1; leucine ABC transporter subunit substrate-binding protein LivK [KO:K01999 ]
ES15_0219 livH; ABC-type branched-chain amino acid transporter permease subunit LivH [KO:K01997 ]
ES15_0220 livM; ABC-type putative leucine/isoleucine/valine transporter permease subunit [KO:K01998 ]
ES15_0221 livG; ABC-type leucine/isoleucine/valine transporter ATP-binding subunit LivG [KO:K01995 ]
ES15_0222 livF; lABC-type eucine/isoleucine/valine transporter ATP-binding subunit LivF [KO:K01996 ]
ES15_3048 metQ2; D-methionine transport system substrate-binding protein [KO:K02073 ]
ES15_2907 metQ1; putative D-methionine-binding lipoprotein MetQ [KO:K02073 ]
ES15_3132 metQ3; DL-methionine transporter substrate-binding subunit [KO:K02073 ]
ES15_3049 metI2; D-methionine transport system permease protein [KO:K02072 ]
ES15_2909 metI1; putative D-methionine transport system permease metI [KO:K02072 ]
ES15_3050 metN2; D-methionine transport system ATP-binding protein [KO:K02071 ]
ES15_1952 livK2; putative urea ABC transporter urea-binding protein [KO:K11959 ]
ES15_1955 urtC; putative urea ABC transporter, permease protein UrtC [KO:K11961 ]
ES15_1956 urtD; putative urea ABC transporter, ATP-binding protein UrtD [KO:K11962 ]
ES15_1957 urtE; putative urea ABC transporter ATP-binding protein UrtE [KO:K11963 ]
ES15_1767 oppA1; oligopeptide ABC transporter substrate-binding protein OppA [KO:K15580 ]
ES15_1770 oppD; oligopeptide transporter ATP-binding component OppD [KO:K15583 ]
ES15_1771 oppF; oligopeptide ABC transporter ATP-binding protein OppF [KO:K10823 ]
ES15_0160 dppA; ABC-type periplasmic dipeptide transport protein [KO:K12368 ]
ES15_0163 dppD; ABC-type dipeptide transport ATP-binding protein DppD [KO:K12371 ]
ES15_0164 dppF; ABC-type dipeptide transport ATP-binding protein DppF [KO:K12372 ]
ES15_1823 sapA; antimicrobial peptide ABC transporter periplasmic binding protein SapA [KO:K19226 ]
ES15_1822 sapB; antimicrobial peptide ABC transporter permease SapB [KO:K19227 ]
ES15_1821 sapC; antimicrobial peptide ABC transporter permease SapC [KO:K19228 ]
ES15_1820 sapD; antimicrobial peptide ABC transporter ATP-binding protein SapD [KO:K19229 ]
ES15_1819 sapF; antimicrobial peptide ABC system ATP-binding protein SapF [KO:K19230 ]
ES15_2603 gsiB; glutathione ABC transporter substrate-binding protein GsiB [KO:K13889 ]
ES15_1307 yejA; putative ABC transporter periplasmic substrate-binding protein YejA [KO:K13893 ]
ES15_1305 yejE; inner membrane ABC transporter permease protein YejE [KO:K13895 ]
ES15_1304 yejF; microcin C ABC transporter ATP-binding protein YejF [KO:K13896 ]
ES15_1064 iron-enterobactin transporter periplasmic binding protein [KO:K23185 ]
ES15_1062 fepD; iron-enterobactin transporter membrane protein FepD [KO:K23186 ]
ES15_3176 iron-hydroxamate transporter substrate-binding subunit [KO:K23227 ]
ES15_1597 znuA; high-affinity zinc transporter periplasmic component [KO:K09815 ]
ES15_1595 znuB; high-affinity zinc uptake system membrane protein [KO:K09816 ]
ES15_3327 kpsE; capsule polysaccharide export inner-membrane protein KpsE [KO:K10107 ]
ES15_2369 lolE; outer membrane-specific lipoprotein transporter subunit LolE [KO:K09808 ]
ES15_2371 lolC; outer membrane-specific lipoprotein transporter subunit LolC [KO:K09808 ]
ES15_2370 lolD; lipoprotein-releasing system ATP-binding protein lolD [KO:K09810 ] [EC:7.6.2.-]
ES15_3423 lptF; lipopolysaccharide ABC transporter permease LptF [KO:K07091 ]
ES15_3422 lptG; lipopolysaccharide ABC transporter permease LptG [KO:K11720 ]
ES15_2931 mdlA; multidrug resistance-like ATP-binding protein MdlA [KO:K18889 ]
ES15_2930 putative multidrug transporter membrane/ATP-binding component [KO:K18890 ]
ES15_2554 macB; macrolide transporter ATP-binding/permease protein MacB [KO:K05685 ] [EC:7.6.2.-]
ES15_1229 multidrug transporter membrane component/ATP-binding component [KO:K06159 ]
Compound
C00093 sn-Glycerol 3-phosphate
C01153 Orthophosphoric monoester
C01181 4-Trimethylammoniobutanoate
C01279 4-Amino-5-hydroxymethyl-2-methylpyrimidine
C03557 2-Aminoethylphosphonate
C03611 Galactose oligosaccharide
C03619 Methyl beta-D-galactoside
C04114 (E)-4-(Trimethylammonio)but-2-enoate
C06705 Capsular polysaccharide
C19872 N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20570 alpha-1,5-L-Arabinobiose
C20571 alpha-1,5-L-Arabinotriose
C20572 alpha-1,5-L-Arabinotetraose
Reference
Authors
Tomii K, Kanehisa M.
Title
A comparative analysis of ABC transporters in complete microbial genomes.
Journal
Reference
Authors
Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A
Title
Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.
Journal
Reference
Authors
Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ
Title
Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
Journal
Reference
Authors
Omata T, Price GD, Badger MR, Okamura M, Gohta S, Ogawa T
Title
Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942.
Journal
Reference
Authors
Quintero MJ, Montesinos ML, Herrero A, Flores E
Title
Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence.
Journal
Reference
Authors
Picossi S, Montesinos ML, Pernil R, Lichtle C, Herrero A, Flores E
Title
ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.
Journal
Reference
Authors
Valladares A, Montesinos ML, Herrero A, Flores E.
Title
An ABC-type, high-affinity urea permease identified in cyanobacteria.
Journal
Reference
Authors
Richard-Fogal CL, Frawley ER, Kranz RG
Title
Topology and function of CcmD in cytochrome c maturation.
Journal
Reference
Authors
Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H
Title
The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
Journal
Reference
Authors
Novikova M, Metlitskaya A, Datsenko K, Kazakov T, Kazakov A, Wanner B, Severinov K
Title
The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C.
Journal
Reference
Authors
Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI
Title
Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.
Journal
Reference
Authors
Yamanaka H, Kobayashi H, Takahashi E, Okamoto K
Title
MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II.
Journal
KO pathway
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