KEGG   PATHWAY: csol04150
Entry
csol04150                   Pathway                                
Name
mTOR signaling pathway - Ceratosolen solmsi marchali (fig wasp)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
csol04150  mTOR signaling pathway
csol04150

Organism
Ceratosolen solmsi marchali (fig wasp) [GN:csol]
Gene
105359928  Y+L amino acid transporter 2 [KO:K13780]
105361240  Y+L amino acid transporter 2 [KO:K13780]
105361078  neutral and basic amino acid transport protein rBAT [KO:K06519]
105362017  putative sodium-coupled neutral amino acid transporter 9 [KO:K14995]
105364414  LOW QUALITY PROTEIN: V-type proton ATPase catalytic subunit A isoform 2-like [KO:K02145] [EC:7.1.2.2]
105368156  V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
105367994  V-type proton ATPase subunit B [KO:K02147]
105367322  V-type proton ATPase subunit C isoform X1 [KO:K02148]
105367775  V-type proton ATPase subunit D [KO:K02149]
105362132  LOW QUALITY PROTEIN: V-type proton ATPase subunit E [KO:K02150]
105365544  V-type proton ATPase subunit F [KO:K02151]
105366121  V-type proton ATPase subunit G [KO:K02152]
105363903  V-type proton ATPase subunit H [KO:K02144]
105359152  ragulator complex protein LAMTOR1 [KO:K20397]
105359405  ragulator complex protein LAMTOR2 isoform X1 [KO:K20398]
105368564  ragulator complex protein LAMTOR3-A [KO:K04370]
105363339  ragulator complex protein LAMTOR4 homolog [KO:K20399]
105359841  uncharacterized protein LOC105359841 [KO:K16344]
105359290  folliculin [KO:K09594]
105364094  folliculin-interacting protein 2 [KO:K20401]
105367676  ras-related GTP-binding protein A [KO:K16185]
105368397  ras-related GTP-binding protein C [KO:K16186]
105364570  WD repeat-containing protein mio-B [KO:K20407]
105366036  nucleoporin seh1-A [KO:K14299]
105364543  WD repeat-containing protein 24 isoform X1 [KO:K20408]
105363180  WD repeat-containing protein 59 [KO:K20409]
105364657  protein SEC13 homolog [KO:K14004]
105361937  DEP domain-containing protein 5 [KO:K20404]
105366597  nitrogen permease regulator 2-like protein [KO:K20405]
105367228  LOW QUALITY PROTEIN: nitrogen permease regulator 3-like protein [KO:K20406]
105360476  S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
105362360  regulatory-associated protein of mTOR isoform X1 [KO:K07204]
105365101  uncharacterized protein LOC105365101 [KO:K16184]
105365573  serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
105366923  target of rapamycin complex subunit lst8 [KO:K08266]
105367705  TELO2-interacting protein 1 homolog [KO:K20403]
105363511  CAP-Gly domain-containing linker protein 2 [KO:K10421]
105363134  phosphatidate phosphatase LPIN1 isoform X1 [KO:K15728] [EC:3.1.3.4]
105368928  serine/threonine-protein kinase unc-51 isoform X1 [KO:K08269] [EC:2.7.11.1]
105363949  eukaryotic translation initiation factor 4E type 2 [KO:K03259]
105367572  eukaryotic translation initiation factor 4E-like isoform X1 [KO:K03259]
105359108  ribosomal protein S6 kinase beta-1-like [KO:K04688] [EC:2.7.11.1]
105369023  ribosomal protein S6 kinase beta-1-like [KO:K04688] [EC:2.7.11.1]
105362670  eukaryotic translation initiation factor 4B-like [KO:K03258]
105365799  40S ribosomal protein S6 [KO:K02991]
105361262  STE20-related kinase adapter protein alpha [KO:K08271]
105365004  LOW QUALITY PROTEIN: serine/threonine-protein kinase STK11-like [KO:K07298] [EC:2.7.11.1]
105368736  protein Mo25 isoform X1 [KO:K08272]
105361328  5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
105360272  hamartin [KO:K07206]
105362269  tuberin [KO:K07207]
105363391  TBC1 domain family member 7 [KO:K20396]
105360665  GTP-binding protein Rheb homolog [KO:K07208]
105367696  protein Wnt-1 [KO:K03209]
105362518  protein Wnt-1-like [KO:K00408]
105368807  protein Wnt-5b-like [KO:K00444]
105367707  LOW QUALITY PROTEIN: protein Wnt-6 [KO:K00445]
105362923  protein Wnt-7b isoform X1 [KO:K00572]
105367718  protein Wnt-10a [KO:K01357]
105366203  protein Wnt-11b-2-like [KO:K01384]
105367495  LOW QUALITY PROTEIN: frizzled-2 [KO:K02432]
105368145  frizzled-2-like [KO:K02375]
105367291  frizzled-9-like [KO:K02842]
105364466  low-density lipoprotein receptor-related protein 6 isoform X1 [KO:K03068]
105361264  segment polarity protein dishevelled homolog DVL-3 [KO:K02353]
105361003  glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
105364979  LIRP-like [KO:K04526]
105365464  insulin-like [KO:K05459]
105362095  protein enhancer of sevenless 2B [KO:K04364]
105360242  protein son of sevenless isoform X1 [KO:K03099]
105367931  ras-like protein 1 [KO:K07827]
105368960  raf homolog serine/threonine-protein kinase phl [KO:K04365] [EC:2.7.11.1]
105367539  dual specificity mitogen-activated protein kinase kinase dSOR1 [KO:K04368] [EC:2.7.12.2]
105364278  mitogen-activated protein kinase 1-like isoform X1 [KO:K04371] [EC:2.7.11.24]
105364284  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
105360921  ribosomal protein S6 kinase 2 beta [KO:K04373] [EC:2.7.11.1]
105368177  insulin receptor substrate 1 isoform X2 [KO:K16172]
105361583  uncharacterized protein LOC105361583 [KO:K02649]
105365929  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
105368591  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
105360683  3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
105363260  RAC serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
105359082  inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K04467] [EC:2.7.11.10]
105368790  target of rapamycin complex 2 subunit MAPKAP1 [KO:K20410]
105360813  rapamycin-insensitive companion of mTOR [KO:K08267]
105361334  ras-like GTP-binding protein Rho1 isoform X1 [KO:K04513]
105364907  protein kinase C, brain isozyme isoform X1 [KO:K02677] [EC:2.7.11.13]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
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KO pathway
ko04150   
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