KEGG PATHWAY: cvf00260

PATHWAY: cvf00260

Entry

cvf00260                    Pathway

Name

Glycine, serine and threonine metabolism - Charadrius vociferus (killdeer)

Description

Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].

Class

Metabolism; Amino acid metabolism

Pathway map

cvf00260

Glycine, serine and threonine metabolism

Module

cvf_M00020

Serine biosynthesis, glycerate-3P => serine [PATH:cvf00260]

cvf_M00047

Creatine pathway [PATH:cvf00260]

cvf_M00338

Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:cvf00260]

cvf_M00555

Betaine biosynthesis, choline => betaine [PATH:cvf00260]

cvf_M00621

Glycine cleavage system [PATH:cvf00260]

cvf_M00974

Betaine metabolism, animals, betaine => glycine [PATH:cvf00260]

Other DBs

GO:	0006544 0006563 0070178 0006566

Organism

Charadrius vociferus (killdeer) [GN:cvf]

Gene

104283143

probable low-specificity L-threonine aldolase 2 [KO:K01620] [EC:4.1.2.48]

104289573

SHMT1; serine hydroxymethyltransferase, cytosolic [KO:K00600] [EC:2.1.2.1]

104282067

SHMT2; LOW QUALITY PROTEIN: serine hydroxymethyltransferase, mitochondrial [KO:K00600] [EC:2.1.2.1]

104293556

AGXT; serine--pyruvate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]

104282457

GRHPR; LOW QUALITY PROTEIN: glyoxylate reductase/hydroxypyruvate reductase [KO:K00049] [EC:1.1.1.79 1.1.1.81]

104291932

GLYCTK; glycerate kinase [KO:K11529] [EC:2.7.1.165]

104288831

PGAM1; phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]

104281617

BPGM; bisphosphoglycerate mutase [KO:K01837] [EC:5.4.2.4 5.4.2.11]

104293389

PHGDH; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]

104284399

PSAT1; LOW QUALITY PROTEIN: phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]

104286540

PSPH; phosphoserine phosphatase isoform X1 [KO:K01079] [EC:3.1.3.3]

104283685

GCAT; 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial [KO:K00639] [EC:2.3.1.29]

104289051

L-threonine 3-dehydrogenase, mitochondrial [KO:K15789] [EC:1.1.1.103]

104291968

ALAS1; 5-aminolevulinate synthase, nonspecific, mitochondrial [KO:K00643] [EC:2.3.1.37]

104293757

amine oxidase [flavin-containing] A-like isoform X1 [KO:K00274] [EC:1.4.3.4]

104293764

amine oxidase [flavin-containing] B-like [KO:K00274] [EC:1.4.3.4]

104295748

membrane primary amine oxidase-like [KO:K00276] [EC:1.4.3.21]

104295846

membrane primary amine oxidase-like [KO:K00276] [EC:1.4.3.21]

104295942

membrane primary amine oxidase-like [KO:K00276] [EC:1.4.3.21]

104291430

GLDC; glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]

104294722

uncharacterized protein LOC104294722 [KO:K00605] [EC:2.1.2.10]

104291611

DLD; dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]

104291195

GCSH; glycine cleavage system H protein, mitochondrial [KO:K02437]

104282291

DAO; D-amino-acid oxidase [KO:K00273] [EC:1.4.3.3]

104295014

AGXT2; LOW QUALITY PROTEIN: alanine--glyoxylate aminotransferase 2, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]

104287456

GATM; glycine amidinotransferase, mitochondrial [KO:K00613] [EC:2.1.4.1]

104286016

GAMT; guanidinoacetate N-methyltransferase [KO:K00542] [EC:2.1.1.2]

104282801

CHDH; choline dehydrogenase, mitochondrial [KO:K00108] [EC:1.1.99.1]

104294242

ALDH7A1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]

104285791

betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]

104285792

DMGDH; dimethylglycine dehydrogenase, mitochondrial [KO:K00315] [EC:1.5.8.4]

104292890

SARDH; sarcosine dehydrogenase, mitochondrial [KO:K00314] [EC:1.5.8.3]

104295130

GNMT; glycine N-methyltransferase isoform X1 [KO:K00552] [EC:2.1.1.20]

104292031

cystathionine beta-synthase-like [KO:K01697] [EC:4.2.1.22]

104292032

cystathionine beta-synthase-like [KO:K01697] [EC:4.2.1.22]

104285526

CTH; cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]

104286035

serine racemase-like [KO:K01754] [EC:4.3.1.19]

104286615

SRR; serine racemase [KO:K12235] [EC:5.1.1.18]

Compound

C00011

CO2

C00014

Ammonia

C00022

Pyruvate

C00037

Glycine

C00048

Glyoxylate

C00049

L-Aspartate

C00065

L-Serine

C00078

L-Tryptophan

C00097

L-Cysteine

C00101

Tetrahydrofolate

C00109

2-Oxobutanoate

C00114

Choline

C00143

5,10-Methylenetetrahydrofolate

C00168

Hydroxypyruvate

C00188

L-Threonine

C00197

3-Phospho-D-glycerate

C00213

Sarcosine

C00258

D-Glycerate

C00263

L-Homoserine

C00300

Creatine

C00430

5-Aminolevulinate

C00441

L-Aspartate 4-semialdehyde

C00546

Methylglyoxal

C00576

Betaine aldehyde

C00581

Guanidinoacetate

C00631

2-Phospho-D-glycerate

C00719

Betaine

C00740

D-Serine

C00986

1,3-Diaminopropane

C01005

O-Phospho-L-serine

C01026

N,N-Dimethylglycine

C01102

O-Phospho-L-homoserine

C01242

[Protein]-S8-aminomethyldihydrolipoyllysine

C01888

Aminoacetone

C02051

Lipoylprotein

C02291

L-Cystathionine

C02737

Phosphatidylserine

C02972

Dihydrolipoylprotein

C03082

4-Phospho-L-aspartate

C03194

(R)-1-Aminopropan-2-ol

C03232

3-Phosphonooxypyruvate

C03283

L-2,4-Diaminobutanoate

C03508

L-2-Amino-3-oxobutanoic acid

C05519

L-Allothreonine

C06231

Ectoine

C06442

N(gamma)-Acetyldiaminobutyrate

C16432

5-Hydroxyectoine

C19929

N(alpha)-Acetyl-L-2,4-diaminobutyrate

Reference

Authors

Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).

Title

[Cellular Functions and Metabolic Maps] (In Japanese)

Journal

Tokyo Kagaku Dojin (1997)

Reference

PMID:11823218

Authors

Kuhlmann AU, Bremer E.

Title

Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.

Journal

Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002

Reference

PMID:10473374

Authors

Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.

Title

Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.

Journal

Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999

Reference

PMID:17636255

Authors

Bursy J, Pierik AJ, Pica N, Bremer E.

Title

Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.

Journal

J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200

Reference

PMID:16707670

Authors

Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.

Title

The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.

Journal

J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06

Reference

PMID:15470257

Authors

Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J

Title

FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.

Journal

Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004

Reference

PMID:7639721