KEGG   PATHWAY: dct00480
Entry
dct00480                    Pathway                                
Name
Glutathione metabolism - Dendrobium catenatum
Class
Metabolism; Metabolism of other amino acids
Pathway map
dct00480  Glutathione metabolism
dct00480

Module
dct_M00118  Glutathione biosynthesis, glutamate => glutathione [PATH:dct00480]
Other DBs
GO: 0006749
Organism
Dendrobium catenatum [GN:dct]
Gene
110099957  glutathione hydrolase 3 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
110108755  glutathione hydrolase 1-like [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
110103744  gamma-glutamylcyclotransferase 2-2 [KO:K22596] [EC:4.3.2.9]
110100720  gamma-glutamylcyclotransferase 2-3 isoform X1 [KO:K22596] [EC:4.3.2.9]
110104628  gamma-glutamylcyclotransferase 2-2 isoform X1 [KO:K22596] [EC:4.3.2.9]
110106274  gamma-glutamylcyclotransferase 2-1 [KO:K22596] [EC:4.3.2.9]
110101391  5-oxoprolinase [KO:K01469] [EC:3.5.2.9]
110092179  glutamate--cysteine ligase, chloroplastic [KO:K01919] [EC:6.3.2.2]
110097765  glutathione synthetase, chloroplastic [KO:K21456] [EC:6.3.2.3]
110114669  leucine aminopeptidase 2, chloroplastic [KO:K01255] [EC:3.4.11.1]
110102475  leucine aminopeptidase 2, chloroplastic [KO:K01255] [EC:3.4.11.1]
110094437  leucine aminopeptidase 2, chloroplastic [KO:K01255] [EC:3.4.11.1]
110097659  puromycin-sensitive aminopeptidase isoform X1 [KO:K01256] [EC:3.4.11.2]
110111551  microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
110101897  glutathione S-transferase U17-like [KO:K00799] [EC:2.5.1.18]
110116428  probable glutathione S-transferase GSTF1 isoform X1 [KO:K00799] [EC:2.5.1.18]
110108305  glutathione S-transferase U17-like [KO:K00799] [EC:2.5.1.18]
110092849  glutathione S-transferase U17 [KO:K00799] [EC:2.5.1.18]
110113091  glutathione S-transferase U25-like isoform X1 [KO:K00799] [EC:2.5.1.18]
110105972  protein IN2-1 homolog B [KO:K00799] [EC:2.5.1.18]
110115470  glutathione S-transferase U18 [KO:K00799] [EC:2.5.1.18]
110115479  glutathione S-transferase U17 [KO:K00799] [EC:2.5.1.18]
110115489  glutathione S-transferase U18-like [KO:K00799] [EC:2.5.1.18]
110115508  glutathione S-transferase U18-like [KO:K00799] [EC:2.5.1.18]
110097588  glutathione S-transferase F11 [KO:K00799] [EC:2.5.1.18]
110106018  protein IN2-1 homolog B-like isoform X1 [KO:K00799] [EC:2.5.1.18]
110106023  protein IN2-1 homolog B [KO:K00799] [EC:2.5.1.18]
110095248  glutathione S-transferase T1 [KO:K00799] [EC:2.5.1.18]
110097304  probable glutathione S-transferase parA [KO:K00799] [EC:2.5.1.18]
110103374  glutathione S-transferase U24-like [KO:K00799] [EC:2.5.1.18]
110100070  glutathione S-transferase F8, chloroplastic [KO:K00799] [EC:2.5.1.18]
110100107  probable glutathione S-transferase GSTF1 [KO:K00799] [EC:2.5.1.18]
110106085  glutathione S-transferase F12-like [KO:K00799] [EC:2.5.1.18]
110113600  glutathione S-transferase T1-like [KO:K00799] [EC:2.5.1.18]
110103395  glutathione S-transferase U24-like [KO:K00799] [EC:2.5.1.18]
110103396  glutathione S-transferase U24-like [KO:K00799] [EC:2.5.1.18]
110103397  probable glutathione S-transferase parC [KO:K00799] [EC:2.5.1.18]
110111445  glutathione S-transferase U8-like [KO:K00799] [EC:2.5.1.18]
110099092  probable glutathione S-transferase GSTU6 [KO:K00799] [EC:2.5.1.18]
110100121  probable glutathione S-transferase GSTF1 [KO:K00799] [EC:2.5.1.18]
110100122  probable glutathione S-transferase GSTF1 [KO:K00799] [EC:2.5.1.18]
110112172  glutathione S-transferase F10 [KO:K00799] [EC:2.5.1.18]
110112177  glutathione S-transferase F12-like [KO:K00799] [EC:2.5.1.18]
110105492  glutathione transferase GST 23 [KO:K00799] [EC:2.5.1.18]
110106491  glutathione S-transferase U17 [KO:K00799] [EC:2.5.1.18]
110101865  glutathione S-transferase U18-like [KO:K00799] [EC:2.5.1.18]
110109485  glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
110114969  glutathione transferase GST 23 [KO:K00799] [EC:2.5.1.18]
110105673  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
110115496  glutathione S-transferase U18-like [KO:K00799] [EC:2.5.1.18]
110113601  glutathione S-transferase T1-like [KO:K00799] [EC:2.5.1.18]
110106556  probable glutathione S-transferase GSTU6 [KO:K00799] [EC:2.5.1.18]
110105563  probable glutathione S-transferase DHAR1, cytosolic [KO:K21888] [EC:1.8.5.1 2.5.1.18]
110094742  glutathione S-transferase DHAR3, chloroplastic [KO:K21888] [EC:1.8.5.1 2.5.1.18]
110100677  glutathione reductase, chloroplastic [KO:K00383] [EC:1.8.1.7]
110101467  glutathione reductase, cytosolic [KO:K00383] [EC:1.8.1.7]
110092234  cytosolic isocitrate dehydrogenase [NADP] [KO:K00031] [EC:1.1.1.42]
110100741  cytosolic isocitrate dehydrogenase [NADP] [KO:K00031] [EC:1.1.1.42]
110108482  cytosolic isocitrate dehydrogenase [NADP]-like [KO:K00031] [EC:1.1.1.42]
110115152  6-phosphogluconate dehydrogenase, decarboxylating 1 [KO:K00033] [EC:1.1.1.44 1.1.1.343]
110115606  6-phosphogluconate dehydrogenase, decarboxylating 1, chloroplastic isoform X3 [KO:K00033] [EC:1.1.1.44 1.1.1.343]
110094568  glucose-6-phosphate 1-dehydrogenase 2, chloroplastic [KO:K00036] [EC:1.1.1.49 1.1.1.363]
110104442  glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform isoform X1 [KO:K00036] [EC:1.1.1.49 1.1.1.363]
110114956  glucose-6-phosphate 1-dehydrogenase, chloroplastic isoform X1 [KO:K00036] [EC:1.1.1.49 1.1.1.363]
110113114  putative glutathione peroxidase 7, chloroplastic [KO:K00432] [EC:1.11.1.9]
110094260  probable phospholipid hydroperoxide glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
110094262  probable phospholipid hydroperoxide glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
110101854  probable glutathione peroxidase 5 [KO:K00432] [EC:1.11.1.9]
110094429  probable phospholipid hydroperoxide glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
110101652  spermine synthase [KO:K00797] [EC:2.5.1.16]
110096815  spermidine synthase 2 isoform X1 [KO:K00797] [EC:2.5.1.16]
110094846  probable L-ascorbate peroxidase 4, peroxisomal [KO:K00434] [EC:1.11.1.11]
110097560  probable L-ascorbate peroxidase 6, chloroplastic/mitochondrial isoform X1 [KO:K00434] [EC:1.11.1.11]
110107707  L-ascorbate peroxidase, cytosolic [KO:K00434] [EC:1.11.1.11]
110101121  L-ascorbate peroxidase, cytosolic isoform X1 [KO:K00434] [EC:1.11.1.11]
110102819  putative L-ascorbate peroxidase 6 [KO:K00434] [EC:1.11.1.11]
110107491  ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
110104785  ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
110101316  ribonucleoside-diphosphate reductase small chain [KO:K10808] [EC:1.17.4.1]
110113673  ribonucleoside-diphosphate reductase small chain [KO:K10808] [EC:1.17.4.1]
Compound
C00005  NADPH
C00006  NADP+
C00024  Acetyl-CoA
C00025  L-Glutamate
C00037  Glycine
C00051  Glutathione
C00072  Ascorbate
C00077  L-Ornithine
C00097  L-Cysteine
C00127  Glutathione disulfide
C00134  Putrescine
C00151  L-Amino acid
C00315  Spermidine
C00669  gamma-L-Glutamyl-L-cysteine
C00750  Spermine
C01322  RX
C01419  Cys-Gly
C01672  Cadaverine
C01879  5-Oxoproline
C02090  Trypanothione
C02320  R-S-Glutathione
C03170  Trypanothione disulfide
C03646  Bis-gamma-glutamylcystine
C03740  (5-L-Glutamyl)-L-amino acid
C05422  Dehydroascorbate
C05726  S-Substituted L-cysteine
C05727  S-Substituted N-acetyl-L-cysteine
C05729  R-S-Cysteinylglycine
C05730  Glutathionylspermidine
C16562  Glutathionylspermine
C16563  Bis(glutathionyl)spermine
C16564  Bis(glutathionyl)spermine disulfide
C16565  Aminopropylcadaverine
C16566  Glutathionylaminopropylcadaverine
C16567  Homotrypanothione
C16568  Homotrypanothione disulfide
C16663  Tryparedoxin
C16664  Tryparedoxin disulfide
Reference
  Authors
Josch C, Klotz LO, Sies H.
  Title
Identification of cytosolic leucyl aminopeptidase (EC 3.4.11.1) as the major cysteinylglycine-hydrolysing activity in rat liver.
  Journal
Biol Chem 384:213-8 (2003)
DOI:10.1515/BC.2003.023
Reference
  Authors
Chu L, Lai Y, Xu X, Eddy S, Yang S, Song L, Kolodrubetz D.
  Title
A 52-kDa leucyl aminopeptidase from treponema denticola is a cysteinylglycinase that mediates the second step of glutathione metabolism.
  Journal
J Biol Chem 283:19351-8 (2008)
DOI:10.1074/jbc.M801034200
Reference
  Authors
Cappiello M, Lazzarotti A, Buono F, Scaloni A, D'Ambrosio C, Amodeo P, Mendez BL, Pelosi P, Del Corso A, Mura U.
  Title
New role for leucyl aminopeptidase in glutathione turnover.
  Journal
Biochem J 378:35-44 (2004)
DOI:10.1042/BJ20031336
Reference
  Authors
Suzuki H, Kamatani S, Kim ES, Kumagai H.
  Title
Aminopeptidases A, B, and N and dipeptidase D are the four cysteinylglycinases of Escherichia coli K-12.
  Journal
J Bacteriol 183:1489-90 (2001)
DOI:10.1128/JB.183.4.1489-1490.2001
Reference
  Authors
Oza SL, Shaw MP, Wyllie S, Fairlamb AH.
  Title
Trypanothione biosynthesis in Leishmania major.
  Journal
Mol Biochem Parasitol 139:107-16 (2005)
DOI:10.1016/j.molbiopara.2004.10.004
Reference
  Authors
Oza SL, Ariyanayagam MR, Fairlamb AH.
  Title
Characterization of recombinant glutathionylspermidine synthetase/amidase from Crithidia fasciculata.
  Journal
Biochem J 364:679-86 (2002)
DOI:10.1042/BJ20011370
Reference
PMID:9677355
  Authors
Tetaud E, Manai F, Barrett MP, Nadeau K, Walsh CT, Fairlamb AH.
  Title
Cloning and characterization of the two enzymes responsible for trypanothione biosynthesis in Crithidia fasciculata.
  Journal
J Biol Chem 273:19383-90 (1998)
DOI:10.1074/jbc.273.31.19383
Reference
  Authors
Ariyanayagam MR, Oza SL, Mehlert A, Fairlamb AH.
  Title
Bis(glutathionyl)spermine and other novel trypanothione analogues in Trypanosoma cruzi.
  Journal
J Biol Chem 278:27612-9 (2003)
DOI:10.1074/jbc.M302750200
Reference
  Authors
Oza SL, Ariyanayagam MR, Aitcheson N, Fairlamb AH.
  Title
Properties of trypanothione synthetase from Trypanosoma brucei.
  Journal
Mol Biochem Parasitol 131:25-33 (2003)
DOI:10.1016/S0166-6851(03)00176-2
Reference
  Authors
Oza SL, Tetaud E, Ariyanayagam MR, Warnon SS, Fairlamb AH.
  Title
A single enzyme catalyses formation of Trypanothione from glutathione and spermidine in Trypanosoma cruzi.
  Journal
J Biol Chem 277:35853-61 (2002)
DOI:10.1074/jbc.M204403200
Reference
  Authors
Comini M, Menge U, Wissing J, Flohe L.
  Title
Trypanothione synthesis in crithidia revisited.
  Journal
J Biol Chem 280:6850-60 (2005)
DOI:10.1074/jbc.M404486200
Reference
PMID:7813456
  Authors
Hunter KJ, Le Quesne SA, Fairlamb AH.
  Title
Identification and biosynthesis of N1,N9-bis(glutathionyl)aminopropylcadaverine (homotrypanothione) in Trypanosoma cruzi.
  Journal
Eur J Biochem 226:1019-27 (1994)
DOI:10.1111/j.1432-1033.1994.t01-1-01019.x
Reference
  Authors
Krauth-Siegel RL, Meiering SK, Schmidt H.
  Title
The parasite-specific trypanothione metabolism of trypanosoma and leishmania.
  Journal
Biol Chem 384:539-49 (2003)
DOI:10.1515/BC.2003.062
Reference
  Authors
Krauth-Siegel RL, Comini MA.
  Title
Redox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolism.
  Journal
Biochim Biophys Acta 1780:1236-48 (2008)
DOI:10.1016/j.bbagen.2008.03.006
Reference
PMID:8892297
  Authors
Krauth-Siegel RL, Ludemann H.
  Title
Reduction of dehydroascorbate by trypanothione.
  Journal
Mol Biochem Parasitol 80:203-8 (1996)
DOI:10.1016/0166-6851(96)02689-8
Reference
  Authors
Dormeyer M, Reckenfelderbaumer N, Ludemann H, Krauth-Siegel RL.
  Title
Trypanothione-dependent synthesis of deoxyribonucleotides by Trypanosoma brucei ribonucleotide reductase.
  Journal
J Biol Chem 276:10602-6 (2001)
DOI:10.1074/jbc.M010352200
Reference
  Authors
Schmidt H, Krauth-Siegel RL.
  Title
Functional and physicochemical characterization of the thioredoxin system in Trypanosoma brucei.
  Journal
J Biol Chem 278:46329-36 (2003)
DOI:10.1074/jbc.M305338200
Reference
PMID:9851611
  Authors
Tetaud E, Fairlamb AH.
  Title
Cloning, expression and reconstitution of the trypanothione-dependent peroxidase system of Crithidia fasciculata.
  Journal
Mol Biochem Parasitol 96:111-23 (1998)
DOI:10.1016/S0166-6851(98)00120-0
Reference
  Authors
Castro H, Sousa C, Santos M, Cordeiro-da-Silva A, Flohe L, Tomas AM.
  Title
Complementary antioxidant defense by cytoplasmic and mitochondrial peroxiredoxins in Leishmania infantum.
  Journal
Free Radic Biol Med 33:1552-62 (2002)
DOI:10.1016/S0891-5849(02)01089-4
Reference
  Authors
Wilkinson SR, Temperton NJ, Mondragon A, Kelly JM.
  Title
Distinct mitochondrial and cytosolic enzymes mediate trypanothione-dependent peroxide metabolism in Trypanosoma cruzi.
  Journal
J Biol Chem 275:8220-5 (2000)
DOI:10.1074/jbc.275.11.8220
Reference
  Authors
Konig J, Fairlamb AH.
  Title
A comparative study of type I and type II tryparedoxin peroxidases in Leishmania major.
  Journal
FEBS J 274:5643-58 (2007)
DOI:10.1111/j.1742-4658.2007.06087.x
Reference
  Authors
Hillebrand H, Schmidt A, Krauth-Siegel RL.
  Title
A second class of peroxidases linked to the trypanothione metabolism.
  Journal
J Biol Chem 278:6809-15 (2003)
DOI:10.1074/jbc.M210392200
Reference
  Authors
Soksawatmaekhin W, Kuraishi A, Sakata K, Kashiwagi K, Igarashi K.
  Title
Excretion and uptake of cadaverine by CadB and its physiological functions in Escherichia coli.
  Journal
Mol Microbiol 51:1401-12 (2004)
DOI:10.1046/j.1365-2958.2003.03913.x
Reference
PMID:6798961
  Authors
Pegg AE, Shuttleworth K, Hibasami H.
  Title
Specificity of mammalian spermidine synthase and spermine synthase.
  Journal
Biochem J 197:315-20 (1981)
DOI:10.1042/bj1970315
Related
pathway
dct00220  Arginine biosynthesis
dct00250  Alanine, aspartate and glutamate metabolism
dct00270  Cysteine and methionine metabolism
dct00430  Taurine and hypotaurine metabolism
dct00460  Cyanoamino acid metabolism
KO pathway
ko00480   
LinkDB

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