KEGG   PATHWAY: ddd00260
Entry
ddd00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Dickeya dadantii 3937
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
ddd00260  Glycine, serine and threonine metabolism
ddd00260

Module
ddd_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:ddd00260]
ddd_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:ddd00260]
ddd_M00555  Betaine biosynthesis, choline => betaine [PATH:ddd00260]
ddd_M00621  Glycine cleavage system [PATH:ddd00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Dickeya dadantii 3937 [GN:ddd]
Gene
Dda3937_02135  lysC; aspartokinase III [KO:K00928] [EC:2.7.2.4]
Dda3937_00394  thrA; bifunctional aspartokinase I/homoserine dehydrogenase I [KO:K12524] [EC:2.7.2.4 1.1.1.3]
Dda3937_03889  metL; bifunctional aspartokinase/homoserine dehydrogenase [KO:K12525] [EC:2.7.2.4 1.1.1.3]
Dda3937_00326  asd; aspartate-semialdehyde dehydrogenase, NAD(P)-binding protein [KO:K00133] [EC:1.2.1.11]
Dda3937_00393  thrB; homoserine kinase [KO:K00872] [EC:2.7.1.39]
Dda3937_00392  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
Dda3937_02384  glyA; Serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
Dda3937_03024  ycdW; D-3-phosphoglycerate dehydrogenase [KO:K12972] [EC:1.1.1.79 1.1.1.81]
Dda3937_01015  tkrA; 2-keto-D-gluconate reductase (glyoxalate reductase) (2-ketoaldonate reductase) [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
Dda3937_00192  garK; glycerate kinase I [KO:K00865] [EC:2.7.1.165]
Dda3937_03989  gpmA; phosphoglyceromutase 1 [KO:K01834] [EC:5.4.2.11]
Dda3937_00399  ytjC; phosphoglyceromutase 2, co-factor independent [KO:K15634] [EC:5.4.2.11]
Dda3937_00861  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
Dda3937_00407  serA; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
Dda3937_04327  serC; 3-phosphoserine/phosphohydroxythreonine aminotransferase [KO:K00831] [EC:2.6.1.52]
Dda3937_01041  Phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
Dda3937_02676  serB; Phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
Dda3937_04134  ydfG; NADP-dependent L-serine/L-allo-threonine dehydrogenase ydfG [KO:K16066] [EC:1.1.1.381 1.1.1.-]
Dda3937_02042  kbl; glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]
Dda3937_02043  tdh; threonine 3-dehydrogenase, NAD(P)-binding protein [KO:K00060] [EC:1.1.1.103]
Dda3937_02306  gcvP; glycine decarboxylase, PLP-dependent, subunit (protein P) of glycine cleavage complex [KO:K00281] [EC:1.4.4.2]
Dda3937_02308  gcvT; aminomethyltransferase, tetrahydrofolate-dependent, subunit (T protein) of glycine cleavage complex [KO:K00605] [EC:2.1.2.10]
Dda3937_03096  lpd; lipoamide dehydrogenase, E3 component is part of three enzyme complexes [KO:K00382] [EC:1.8.1.4]
Dda3937_02307  gcvH; glycine cleavage complex lipoylprotein [KO:K02437]
Dda3937_00887  pssA; phosphatidylserine synthase (CDP-diacylglycerol-serine O-phosphatidyltransferase) [KO:K00998] [EC:2.7.8.8]
Dda3937_03411  betA; Choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
Dda3937_03412  betB; Betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
Dda3937_03721  sdaA; L-serine deaminase I [KO:K01752] [EC:4.3.1.17]
Dda3937_01685  sdaB; L-serine deaminase II [KO:K01752] [EC:4.3.1.17]
Dda3937_00252  ilvA; Threonine dehydratase biosynthetic [KO:K01754] [EC:4.3.1.19]
Dda3937_01146  dsdA; D-serine dehydratase [KO:K01753] [EC:4.3.1.18]
Dda3937_00572  trpA; tryptophan synthase, alpha subunit [KO:K01695] [EC:4.2.1.20]
Dda3937_00573  trpB; tryptophan synthase, beta subunit [KO:K01696] [EC:4.2.1.20]
Dda3937_02856  acsF; 4-aminobutyrate aminotransferase [KO:K00836] [EC:2.6.1.76]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
ddd00010  Glycolysis / Gluconeogenesis
ddd00020  Citrate cycle (TCA cycle)
ddd00230  Purine metabolism
ddd00250  Alanine, aspartate and glutamate metabolism
ddd00270  Cysteine and methionine metabolism
ddd00290  Valine, leucine and isoleucine biosynthesis
ddd00300  Lysine biosynthesis
ddd00330  Arginine and proline metabolism
ddd00460  Cyanoamino acid metabolism
ddd00470  D-Amino acid metabolism
ddd00564  Glycerophospholipid metabolism
ddd00600  Sphingolipid metabolism
ddd00620  Pyruvate metabolism
ddd00630  Glyoxylate and dicarboxylate metabolism
ddd00640  Propanoate metabolism
ddd00680  Methane metabolism
ddd00860  Porphyrin metabolism
ddd00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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