KEGG   PATHWAY: dnx04144
Entry
dnx04144                    Pathway                                
Name
Endocytosis - Diuraphis noxia (Russian wheat aphid)
Description
Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
Class
Cellular Processes; Transport and catabolism
Pathway map
dnx04144  Endocytosis
dnx04144

Other DBs
GO: 0006897
Organism
Diuraphis noxia (Russian wheat aphid) [GN:dnx]
Gene
107165488  ADP-ribosylation factor 6 [KO:K07941]
107164944  phosphatidylinositol 4-phosphate 5-kinase type-1 gamma-like [KO:K00889] [EC:2.7.1.68]
107162596  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha-like isoform X1 [KO:K00889] [EC:2.7.1.68]
107166728  dynamin isoform X1 [KO:K01528] [EC:3.6.5.5]
107166852  clathrin heavy chain [KO:K04646]
107163847  AP-2 complex subunit alpha [KO:K11824]
107163190  AP-2 complex subunit mu [KO:K11826]
107170752  AP-2 complex subunit sigma [KO:K11827]
107173148  TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
107173963  zinc finger FYVE domain-containing protein 9 [KO:K04679]
107162454  epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
107164289  E3 ubiquitin-protein ligase CBL-B [KO:K04707] [EC:2.3.2.27]
107169790  endophilin-A isoform X1 [KO:K11247]
107169748  endophilin-B1 isoform X1 [KO:K11248]
107167429  myc box-dependent-interacting protein 1 isoform X1 [KO:K12562]
107163425  epsin-2 isoform X1 [KO:K12471]
107171674  epidermal growth factor receptor substrate 15-like 1 [KO:K12472]
107168244  protein spartin [KO:K19366]
107167213  E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
107161622  E3 ubiquitin-protein ligase Mdm2-like isoform X1 [KO:K06643] [EC:2.3.2.27]
107165263  TNF receptor-associated factor 6-like [KO:K03175] [EC:2.3.2.27]
107165425  E3 ubiquitin-protein ligase NRDP1-like [KO:K11981] [EC:2.3.2.27]
107166677  E3 ubiquitin-protein ligase SMURF2 [KO:K04678] [EC:2.3.2.26]
107169827  E3 ubiquitin-protein ligase Su(dx) [KO:K05633] [EC:2.3.2.26]
107169110  low density lipoprotein receptor adapter protein 1-like [KO:K12474]
107167834  uncharacterized protein LOC107167834 isoform X1 [KO:K12475]
107162156  G protein-coupled receptor kinase 1 [KO:K00910] [EC:2.7.11.15]
107168275  G protein-coupled receptor kinase 2 [KO:K08291] [EC:2.7.11.16]
107165262  arrestin red cell isoform 2 [KO:K04439]
107173579  arrestin homolog [KO:K04439]
107167720  neural Wiskott-Aldrich syndrome protein-like [KO:K23612]
107161347  formin-like protein 14 [KO:K23612]
107172073  wiskott-Aldrich syndrome protein-like [KO:K23612]
107165153  actin-related protein 2 [KO:K17260]
107166804  actin-related protein 3 [KO:K18584]
107166276  actin-related protein 2/3 complex subunit 1A [KO:K05757]
107173385  probable actin-related protein 2/3 complex subunit 2 [KO:K05758]
107173983  actin-related protein 2/3 complex subunit 3-like [KO:K05756]
107169295  actin-related protein 2/3 complex subunit 4 [KO:K05755]
107167084  actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
107168869  heat shock protein 68-like [KO:K03283]
107167443  heat shock protein 70 B2-like [KO:K03283]
107163650  heat shock protein 70 A1-like [KO:K03283]
107167510  heat shock protein 70 A1-like [KO:K03283]
107169808  heat shock protein 68-like [KO:K03283]
107163583  heat shock 70 kDa protein cognate 4-like [KO:K03283]
107172656  heat shock protein 70 B2-like [KO:K03283]
107163219  heat shock 70 kDa protein cognate 4 [KO:K03283]
107167485  LOW QUALITY PROTEIN: WASH complex subunit 7 [KO:K18465]
107165829  WASH complex subunit strumpellin [KO:K18464]
107170252  WAS protein family homolog 1 [KO:K18461]
107173143  WASH complex subunit CCDC53 [KO:K18463]
107168936  F-actin-capping protein subunit alpha-like [KO:K10364]
107168394  F-actin-capping protein subunit alpha-like [KO:K10364]
107166467  F-actin-capping protein subunit beta [KO:K10365]
107162083  vacuolar protein sorting-associated protein 29 [KO:K18467]
107170702  vacuolar protein sorting-associated protein 26B-like [KO:K18466]
107171655  vacuolar protein sorting-associated protein 35 [KO:K18468]
107166628  sorting nexin-12 [KO:K17918]
107166881  LOW QUALITY PROTEIN: ras-related protein Rab-7a [KO:K07897]
107170148  hepatocyte growth factor-regulated tyrosine kinase substrate [KO:K12182]
107162323  signal transducing adapter molecule 1-like [KO:K04705]
107162324  signal transducing adapter molecule 1-like [KO:K04705]
107161884  tumor susceptibility gene 101 protein [KO:K12183]
107168029  multivesicular body subunit 12B [KO:K12186]
107161286  vacuolar protein sorting-associated protein 28 homolog [KO:K12184]
107165595  vacuolar protein sorting-associated protein 37A isoform X1 [KO:K12185]
107166024  vacuolar protein sorting-associated protein 37B [KO:K12185]
107163046  vacuolar-sorting protein SNF8 [KO:K12188]
107167868  vacuolar protein-sorting-associated protein 36 [KO:K12190]
107164334  vacuolar protein-sorting-associated protein 25 [KO:K12189]
107162035  charged multivesicular body protein 6 [KO:K12195]
107165148  charged multivesicular body protein 4c-like [KO:K12194]
107165159  charged multivesicular body protein 4b-like [KO:K12194]
107164397  charged multivesicular body protein 4b [KO:K12194]
107167463  charged multivesicular body protein 3-like [KO:K12193]
107166215  charged multivesicular body protein 3-like [KO:K12193]
107173745  charged multivesicular body protein 2a [KO:K12191]
107163569  charged multivesicular body protein 7 [KO:K15053]
107165365  vacuolar protein sorting-associated protein 4B [KO:K12196]
107173878  vacuolar protein sorting-associated protein VTA1 homolog [KO:K12199]
107173077  charged multivesicular body protein 1b [KO:K12197]
107163213  charged multivesicular body protein 5 [KO:K12198]
107161551  IST1 homolog [KO:K19476]
107163352  programmed cell death 6-interacting protein [KO:K12200]
107169982  maspardin-like [KO:K19367]
107166968  sorting nexin-2-like [KO:K17917]
107168371  sorting nexin-32 [KO:K17920]
107167712  tyrosine-protein kinase Src64B [KO:K05704] [EC:2.7.10.2]
107164866  ras-like GTP-binding protein Rho1 [KO:K04513]
107164867  ras-like GTP-binding protein Rho1 [KO:K04513]
107165831  ras-like GTP-binding protein Rho1 [KO:K04513]
107164901  ras-related protein Rab-5C [KO:K07889]
107162945  RUN and FYVE domain-containing protein 2 [KO:K12480]
107161775  rabenosyn-5 [KO:K12481]
107163160  EH domain-containing protein 4-like [KO:K12483]
107161351  EH domain-containing protein 1 [KO:K12483]
107162922  vacuolar protein sorting-associated protein 45 [KO:K12479]
107162764  sorting nexin-4-like [KO:K17919]
107161667  ras-related protein Rab-10 [KO:K07903]
107161372  ras-related protein Rab-8B isoform X1 [KO:K07901]
107169482  ras-related protein Rab-35 [KO:K07876]
107165030  rab11 family-interacting protein 5 [KO:K12484]
107162189  kinesin heavy chain [KO:K10396]
107167937  rab11 family-interacting protein 4 isoform X1 [KO:K12485]
107168593  partitioning defective 3 homolog isoform X1 [KO:K04237]
107168695  partitioning defective protein 6 [KO:K06093]
107165574  atypical protein kinase C [KO:K06069] [EC:2.7.11.13]
107168783  atypical protein kinase C-like [KO:K06069] [EC:2.7.11.13]
107164525  cdc42 homolog [KO:K04393]
107169870  stromal membrane-associated protein 1 [KO:K12486]
107168269  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2-like [KO:K12489]
107162508  centaurin-gamma-1A isoform X1 [KO:K12491]
107173076  ADP-ribosylation factor GTPase-activating protein 1 isoform X1 [KO:K12492]
107163245  ADP-ribosylation factor GTPase-activating protein 2 [KO:K12493]
107163474  PH and SEC7 domain-containing protein 2 [KO:K12494]
107165206  IQ motif and SEC7 domain-containing protein 1 isoform X1 [KO:K12495]
107170082  cytohesin-1 [KO:K18441]
107167396  brefeldin A-inhibited guanine nucleotide-exchange protein 1 [KO:K18442]
107170823  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 [KO:K18443]
107166368  ADP-ribosylation factor 1 [KO:K07937]
107167784  ADP-ribosylation factor 2 [KO:K07939]
Compound
C00035  GDP
C00044  GTP
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
Reference
  Authors
Acconcia F, Sigismund S, Polo S
  Title
Ubiquitin in trafficking: the network at work.
  Journal
Exp Cell Res 315:1610-8 (2009)
DOI:10.1016/j.yexcr.2008.10.014
Reference
  Authors
Donaldson JG, Porat-Shliom N, Cohen LA
  Title
Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling.
  Journal
Cell Signal 21:1-6 (2009)
DOI:10.1016/j.cellsig.2008.06.020
Reference
  Authors
Sorkin A
  Title
Cargo recognition during clathrin-mediated endocytosis: a team effort.
  Journal
Curr Opin Cell Biol 16:392-9 (2004)
DOI:10.1016/j.ceb.2004.06.001
Reference
  Authors
Raiborg C, Stenmark H
  Title
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins.
  Journal
Nature 458:445-52 (2009)
DOI:10.1038/nature07961
Reference
  Authors
Scita G, Di Fiore PP
  Title
The endocytic matrix.
  Journal
Nature 463:464-73 (2010)
DOI:10.1038/nature08910
Reference
  Authors
Le Roy C, Wrana JL
  Title
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling.
  Journal
Nat Rev Mol Cell Biol 6:112-26 (2005)
DOI:10.1038/nrm1571
Reference
  Authors
Jovic M, Sharma M, Rahajeng J, Caplan S
  Title
The early endosome: a busy sorting station for proteins at the crossroads.
  Journal
Histol Histopathol 25:99-112 (2010)
DOI:10.14670/HH-25.99
Reference
  Authors
Pietiainen VM, Marjomaki V, Heino J, Hyypia T
  Title
Viral entry, lipid rafts and caveosomes.
  Journal
Ann Med 37:394-403 (2005)
DOI:10.1080/07853890510011976
Reference
  Authors
Grant BD, Donaldson JG
  Title
Pathways and mechanisms of endocytic recycling.
  Journal
Nat Rev Mol Cell Biol 10:597-608 (2009)
DOI:10.1038/nrm2755
Reference
  Authors
Cullen PJ, Korswagen HC
  Title
Sorting nexins provide diversity for retromer-dependent trafficking events.
  Journal
Nat Cell Biol 14:29-37 (2012)
DOI:10.1038/ncb2374
Related
pathway
dnx04070  Phosphatidylinositol signaling system
dnx04130  SNARE interactions in vesicular transport
dnx04142  Lysosome
dnx04350  TGF-beta signaling pathway
KO pathway
ko04144   
LinkDB

DBGET integrated database retrieval system