KEGG PATHWAY: dpo03460

KEGG

PATHWAY: dpo03460

Entry

dpo03460                    Pathway

Name

Fanconi anemia pathway - Drosophila pseudoobscura

Description

The Fanconi anemia pathway is required for the efficient repair of damaged DNA, especially interstrand cross-links (ICLs). DNA ICL is directly recognized by FANCM and associated proteins, that recruit the FA core complex. The FA core complex monoubiquitinates FANCD2 and FANCI. The monoubiquitinated FANCD2/FANCI becomes an active form and interacts with a series of DNA repair proteins and facilitates downstream repair pathways. Fanconi anemia is caused by mutations in one of at least 13 FA genes and is characterized by congenital growth abnormalities, bone marrow failure and cancer predisposition.

Class

Genetic Information Processing; Replication and repair

Pathway map

Fanconi anemia pathway

Other DBs

GO:

Organism

Drosophila pseudoobscura [GN:dpo]

Gene

serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]

uncharacterized protein LOC6897155 isoform X2 [KO:K10896]

uncharacterized protein LOC4800774 [KO:K10606] [EC:2.3.2.27]

WD repeat-containing protein 48 homolog [KO:K15361]

uncharacterized protein LOC4800465 isoform X1 [KO:K11832] [EC:3.4.19.12]

Fanconi anemia group I protein homolog [KO:K10895]

Fanconi anemia group D2 protein homolog [KO:K10891]

DNA repair protein RAD51 homolog 3 [KO:K10870]

DNA repair protein Rad51 homolog [KO:K04482]

DNA mismatch repair protein Mlh1 [KO:K08734]

mismatch repair endonuclease PMS2 isoform X2 [KO:K10858]

DNA repair protein REV1 isoform X1 [KO:K03515] [EC:2.7.7.-]

DNA polymerase zeta catalytic subunit isoform X1 [KO:K02350] [EC:2.7.7.7]

DNA polymerase eta [KO:K03509] [EC:2.7.7.7]

DNA polymerase iota [KO:K03510] [EC:2.7.7.7]

DNA topoisomerase 3-beta [KO:K03165] [EC:5.6.2.1]

DNA topoisomerase 3-alpha [KO:K03165] [EC:5.6.2.1]

Bloom syndrome protein homolog [KO:K10901] [EC:5.6.2.4]

replication protein A 70 kDa DNA-binding subunit [KO:K07466]

replication protein A 32 kDa subunit [KO:K10739]

replication protein A 14 kDa subunit A [KO:K10740]

crossover junction endonuclease MUS81 [KO:K08991] [EC:3.1.22.-]

crossover junction endonuclease EME1 [KO:K10882] [EC:3.1.22.-]

DNA repair endonuclease XPF [KO:K10848] [EC:3.1.-.-]

DNA excision repair protein ERCC-1 [KO:K10849]

structure-specific endonuclease subunit SLX1 homolog [KO:K15078] [EC:3.6.1.-]

Reference

Authors

Jacquemont C, Taniguchi T

Title

The Fanconi anemia pathway and ubiquitin.

Journal

BMC Biochem 8 Suppl 1:S10 (2007)
DOI:10.1186/1471-2091-8-S1-S10

Reference

Authors

Bhagwat N, Olsen AL, Wang AT, Hanada K, Stuckert P, Kanaar R, D'Andrea A, Niedernhofer LJ, McHugh PJ

Title

XPF-ERCC1 participates in the Fanconi anemia pathway of cross-link repair.

Journal

Mol Cell Biol 29:6427-37 (2009)
DOI:10.1128/MCB.00086-09

Reference

Authors

Deans AJ, West SC

Title

DNA interstrand crosslink repair and cancer.

Journal

Nat Rev Cancer 11:467-80 (2011)
DOI:10.1038/nrc3088

Reference

Authors

Deans AJ, West SC

Title

FANCM connects the genome instability disorders Bloom's Syndrome and Fanconi Anemia.

Journal

Mol Cell 36:943-53 (2009)
DOI:10.1016/j.molcel.2009.12.006

Reference

Authors

Muniandy PA, Liu J, Majumdar A, Liu ST, Seidman MM

Title

DNA interstrand crosslink repair in mammalian cells: step by step.

Journal

Crit Rev Biochem Mol Biol 45:23-49 (2010)
DOI:10.3109/10409230903501819

Reference

Authors

Ciccia A, McDonald N, West SC

Title

Structural and functional relationships of the XPF/MUS81 family of proteins.

Journal

Annu Rev Biochem 77:259-87 (2008)
DOI:10.1146/annurev.biochem.77.070306.102408

Related
pathway

Mismatch repair

Homologous recombination

KO pathway

LinkDB

DBGET integrated database retrieval system