KEGG   PATHWAY: dvi04150
Entry
dvi04150                    Pathway                                
Name
mTOR signaling pathway - Drosophila virilis
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
dvi04150  mTOR signaling pathway
dvi04150

Organism
Drosophila virilis [GN:dvi]
Gene
6622649  Y+L amino acid transporter 2 [KO:K13780]
6629757  large neutral amino acids transporter small subunit 1 [KO:K13780]
6627882  large neutral amino acids transporter small subunit 1 [KO:K13780]
6633146  uncharacterized protein LOC6633146 [KO:K06519]
6627360  V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
6627364  V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
116649743  V-type proton ATPase catalytic subunit A-like [KO:K02145] [EC:7.1.2.2]
6635081  V-type proton ATPase subunit B [KO:K02147]
6636319  V-type proton ATPase subunit C isoform X2 [KO:K02148]
6633407  probable V-type proton ATPase subunit D 2 [KO:K02149]
6625342  V-type proton ATPase subunit D 1 [KO:K02149]
6629563  V-type proton ATPase subunit E [KO:K02150]
6632328  V-type proton ATPase subunit F 1 [KO:K02151]
6635116  V-type proton ATPase subunit F isoform X4 [KO:K02151]
6636756  V-type proton ATPase subunit F 1 isoform X1 [KO:K02151]
6630237  V-type proton ATPase subunit G [KO:K02152]
6628447  V-type proton ATPase subunit H isoform X1 [KO:K02144]
6622819  uncharacterized protein LOC6622819 [KO:K20397]
6625074  ragulator complex protein LAMTOR2 homolog [KO:K20398]
6627985  ragulator complex protein LAMTOR3 homolog [KO:K04370]
6636825  ragulator complex protein LAMTOR4 homolog [KO:K20399]
6631757  uncharacterized protein LOC6631757 [KO:K16344]
6623385  folliculin [KO:K09594]
6622528  uncharacterized protein LOC6622528 [KO:K20401]
6631234  ras-related GTP-binding protein A [KO:K16185]
6626435  ras-related GTP-binding protein C [KO:K16186]
6628750  GATOR complex protein MIOS [KO:K20407]
116651675  GATOR complex protein MIOS [KO:K20407]
6626548  nucleoporin seh1 [KO:K14299]
6632259  GATOR complex protein WDR24 isoform X2 [KO:K20408]
6627916  GATOR complex protein Wdr59 [KO:K20409]
6629310  protein SEC13 homolog [KO:K14004]
6622911  GATOR complex protein Iml1 isoform X2 [KO:K20404]
6631983  GATOR complex protein NPRL2 [KO:K20405]
6624321  GATOR complex protein NPRL3 [KO:K20406]
6634913  S-phase kinase-associated protein 2 [KO:K03875]
6627365  serine/threonine-protein kinase Tor [KO:K07203] [EC:2.7.11.1]
6632088  protein LST8 homolog [KO:K08266]
6629889  uncharacterized protein LOC6629889 [KO:K20403]
6626433  phosphatidate phosphatase LPIN3 isoform X1 [KO:K15728] [EC:3.1.3.4]
116649865  serine/threonine-protein kinase unc-51-like [KO:K08269] [EC:2.7.11.1]
6622677  serine/threonine-protein kinase unc-51 [KO:K08269] [EC:2.7.11.1]
6636939  eukaryotic translation initiation factor 4E1 [KO:K03259]
6622052  eukaryotic translation initiation factor 4E1 [KO:K03259]
6623437  eukaryotic translation initiation factor 4E1 isoform X2 [KO:K03259]
6623452  eukaryotic translation initiation factor 4E1 isoform X1 [KO:K03259]
6622444  ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
26530460  eukaryotic translation initiation factor 4B isoform X2 [KO:K03258]
6622185  putative serine/threonine-protein kinase STE20-like [KO:K08271]
6630974  serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
6622978  protein Mo25 [KO:K08272]
6634781  5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
6624080  tuberin [KO:K07207]
6635148  TBC1 domain family member 7 [KO:K20396]
6630766  GTP-binding protein Rheb homolog [KO:K07208]
6628632  protein wingless [KO:K03209]
6625997  protein Wnt-5 [KO:K00444]
6628631  protein Wnt-6 [KO:K00445]
6636452  protein Wnt-2 isoform X1 [KO:K00572]
6632420  wnt inhibitor of Dorsal protein [KO:K00714]
6628630  LOW QUALITY PROTEIN: protein Wnt-10b [KO:K01357]
6624400  frizzled [KO:K02432]
6633528  frizzled-4 [KO:K02354]
6623963  frizzled-2 [KO:K02375]
6631448  frizzled-3 [KO:K04690]
6635341  low-density lipoprotein receptor-related protein 6 [KO:K03068]
6635449  segment polarity protein dishevelled [KO:K02353]
6631043  glycogen synthase kinase-3 [KO:K03083] [EC:2.7.11.26]
6632206  protein kinase shaggy isoform X5 [KO:K03083] [EC:2.7.11.26]
6631291  inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
6634337  protein son of sevenless [KO:K03099]
6633354  raf homolog serine/threonine-protein kinase Raf [KO:K04365] [EC:2.7.11.1]
6631656  dual specificity mitogen-activated protein kinase kinase dSOR1 isoform X1 [KO:K04368] [EC:2.7.12.2]
6629054  mitogen-activated protein kinase ERK-A [KO:K04371] [EC:2.7.11.24]
6631945  ribosomal protein S6 kinase 2 beta [KO:K04373] [EC:2.7.11.1]
6628686  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
6629966  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
6629131  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X2 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
6622672  3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
6630333  RAC serine/threonine-protein kinase isoform X3 [KO:K04456] [EC:2.7.11.1]
6624802  stress-activated map kinase-interacting protein 1 [KO:K20410]
6631431  rapamycin-insensitive companion of mTOR [KO:K08267]
6626322  ras-like GTP-binding protein Rho1 [KO:K04513]
6626720  ras-like GTP-binding protein Rho1 [KO:K04513]
6625036  protein kinase C, brain isozyme isoform X1 [KO:K02677] [EC:2.7.11.13]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
dvi00561  Glycerolipid metabolism
dvi04140  Autophagy - animal
KO pathway
ko04150   
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