KEGG   PATHWAY: dwi04150
Entry
dwi04150                    Pathway                                
Name
mTOR signaling pathway - Drosophila willistoni
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
dwi04150  mTOR signaling pathway
dwi04150

Organism
Drosophila willistoni [GN:dwi]
Gene
6651935  Y+L amino acid transporter 2 [KO:K13780]
6648019  Y+L amino acid transporter 2 [KO:K13780]
6646589  large neutral amino acids transporter small subunit 1 [KO:K13780]
6651393  4F2 cell-surface antigen heavy chain [KO:K06519]
6642550  V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
6642547  V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
6642548  V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
6651503  V-type proton ATPase subunit B [KO:K02147]
6640212  V-type proton ATPase subunit C isoform X1 [KO:K02148]
6643441  V-type proton ATPase subunit D [KO:K02149]
6652337  V-type proton ATPase subunit D 1 [KO:K02149]
6649354  probable V-type proton ATPase subunit D 2 [KO:K02149]
6649405  V-type proton ATPase subunit E [KO:K02150]
6647141  V-type proton ATPase subunit F 1 [KO:K02151]
6648570  V-type proton ATPase subunit F [KO:K02151]
6650299  V-type proton ATPase subunit F [KO:K02151]
111519755  V-type proton ATPase subunit F-like [KO:K02151]
111519696  V-type proton ATPase subunit F-like [KO:K02151]
6649611  V-type proton ATPase subunit G [KO:K02152]
6641905  V-type proton ATPase subunit H isoform X1 [KO:K02144]
6642986  uncharacterized protein LOC6642986 [KO:K20397]
6652445  ragulator complex protein LAMTOR2 homolog [KO:K20398]
6643755  ragulator complex protein LAMTOR3 homolog [KO:K04370]
6643047  LOW QUALITY PROTEIN: ragulator complex protein LAMTOR4 homolog [KO:K20399]
6641460  uncharacterized protein LOC6641460 [KO:K16344]
6645194  folliculin isoform X1 [KO:K09594]
6645821  uncharacterized protein LOC6645821 isoform X1 [KO:K20401]
6649243  ras-related GTP-binding protein A [KO:K16185]
6652163  ras-related GTP-binding protein C [KO:K16186]
6642007  GATOR complex protein MIOS-like [KO:K20407]
6640011  nucleoporin seh1 [KO:K14299]
6647952  GATOR complex protein WDR24 [KO:K20408]
6651782  GATOR complex protein Wdr59 [KO:K20409]
6649648  protein SEC13 homolog [KO:K14004]
6638904  GATOR complex protein Iml1 isoform X7 [KO:K20404]
6648264  GATOR complex protein NPRL2 [KO:K20405]
6643044  GATOR complex protein NPRL3 [KO:K20406]
6647714  S-phase kinase-associated protein 2 [KO:K03875]
26529589  regulatory-associated protein of mTOR [KO:K07204]
124460213  serine/threonine-protein kinase Tor-like [KO:K07203] [EC:2.7.11.1]
6642343  serine/threonine-protein kinase Tor [KO:K07203] [EC:2.7.11.1]
6648475  protein LST8 homolog [KO:K08266]
6646957  uncharacterized protein LOC6646957 [KO:K20403]
6652096  phosphatidate phosphatase LPIN3 isoform X1 [KO:K15728] [EC:3.1.3.4]
6638962  serine/threonine-protein kinase unc-51 [KO:K08269] [EC:2.7.11.1]
6648736  eukaryotic translation initiation factor 4E1 [KO:K03259]
6647288  eukaryotic translation initiation factor 4E1 [KO:K03259]
6639115  eukaryotic translation initiation factor 4E1 [KO:K03259]
6644714  eukaryotic translation initiation factor 4E1 [KO:K03259]
6645007  eukaryotic translation initiation factor 4E1 [KO:K03259]
6643007  eukaryotic translation initiation factor 4E1 isoform X2 [KO:K03259]
6651220  eukaryotic translation initiation factor 4E1 isoform X2 [KO:K03259]
6646043  eukaryotic translation initiation factor 4E1 [KO:K03259]
6647466  eukaryotic translation initiation factor 4E type 2 [KO:K03259]
6638935  ribosomal protein S6 kinase beta-1 isoform X2 [KO:K04688] [EC:2.7.11.1]
26529267  eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
6649307  40S ribosomal protein S6 [KO:K02991]
6651086  serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
6646040  protein Mo25 [KO:K08272]
6653054  5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
6647663  hamartin [KO:K07206]
6639548  tuberin [KO:K07207]
6650801  TBC1 domain family member 7 [KO:K20396]
6649681  GTP-binding protein Rheb homolog [KO:K07208]
6644100  protein wingless [KO:K03209]
6640063  protein Wnt-5 [KO:K00444]
6644099  protein Wnt-6 [KO:K00445]
6640767  protein Wnt-2 isoform X1 [KO:K00572]
6650873  wnt inhibitor of Dorsal protein [KO:K00714]
6644101  protein Wnt-4 isoform X2 [KO:K01064]
6644098  protein Wnt-10b [KO:K01357]
6645254  frizzled [KO:K02432]
6648692  frizzled-4 [KO:K02354]
6645567  frizzled-2 [KO:K02375]
6641124  frizzled-3 [KO:K04690]
6640991  low-density lipoprotein receptor-related protein 6 [KO:K03068]
6648635  segment polarity protein dishevelled [KO:K02353]
6649874  putative glycogen synthase kinase-3 homolog [KO:K03083] [EC:2.7.11.26]
6648991  uncharacterized protein LOC6648991 isoform X1 [KO:K03083] [EC:2.7.11.26]
26529178  inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
26529296  probable insulin-like peptide 5 [KO:K04526]
124460625  probable insulin-like peptide 3 [KO:K04526]
6645318  probable insulin-like peptide 2 [KO:K04526]
6645319  probable insulin-like peptide 1 [KO:K04526]
6638043  uncharacterized protein LOC6638043 [KO:K05459]
6647111  insulin-like receptor [KO:K05087] [EC:2.7.10.1]
6647336  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
6637889  growth factor receptor-bound protein 2 [KO:K04364]
6644072  protein son of sevenless isoform X2 [KO:K03099]
6650000  ras-like protein 1 [KO:K07827]
6648391  raf homolog serine/threonine-protein kinase Raf isoform X1 [KO:K04365] [EC:2.7.11.1]
6648268  dual specificity mitogen-activated protein kinase kinase dSOR1 isoform X1 [KO:K04368] [EC:2.7.12.2]
6652698  mitogen-activated protein kinase ERK-A [KO:K04371] [EC:2.7.11.24]
6649272  ribosomal protein S6 kinase 2 beta [KO:K04373] [EC:2.7.11.1]
6652608  insulin receptor substrate 1 isoform X1 [KO:K16172]
6651829  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
6649394  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
6642648  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
6643143  3-phosphoinositide-dependent protein kinase 1 isoform X2 [KO:K06276] [EC:2.7.11.1]
6651427  RAC serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
6651428  RAC serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
6639914  stress-activated map kinase-interacting protein 1 [KO:K20410]
6644474  rapamycin-insensitive companion of mTOR [KO:K08267]
6652390  ras-like GTP-binding protein Rho1 [KO:K04513]
6640138  protein kinase C, brain isozyme isoform X1 [KO:K02677] [EC:2.7.11.13]
6640135  protein kinase C, eye isozyme [KO:K19662] [EC:2.7.11.13]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
dwi00561  Glycerolipid metabolism
dwi04140  Autophagy - animal
KO pathway
ko04150   
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