KEGG   PATHWAY: dya03420
Entry
dya03420                    Pathway                                
Name
Nucleotide excision repair - Drosophila yakuba
Description
Nucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the NER pathway are linked to at least three diseases: xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD). The repair of damaged DNA involves at least 30 polypeptides within two different sub-pathways of NER known as transcription-coupled repair (TCR-NER) and global genome repair (GGR-NER). TCR refers to the expedited repair of lesions located in the actively transcribed strand of genes by RNA polymerase II (RNAP II). In GGR-NER the first step of damage recognition involves XPC-hHR23B complex together with XPE complex (in prokaryotes, uvrAB complex). The following steps of GGR-NER and TCR-NER are similar.
Class
Genetic Information Processing; Replication and repair
Pathway map
dya03420  Nucleotide excision repair
dya03420

Other DBs
GO: 0006289
Organism
Drosophila yakuba [GN:dya]
Gene
Dyak_GE16630  uncharacterized protein [KO:K03868] [EC:2.3.2.32]
Dyak_GE21084  uncharacterized protein [KO:K03868] [EC:2.3.2.32]
Dyak_GE17622  uncharacterized protein [KO:K03868] [EC:2.3.2.32]
Dyak_GE23323  uncharacterized protein [KO:K10609]
Dyak_GE26244  uncharacterized protein [KO:K10610]
Dyak_GE13643  uncharacterized protein, isoform C [KO:K10838]
Dyak_GE14546  uncharacterized protein, isoform A [KO:K10839]
Dyak_GE23445  uncharacterized protein [KO:K10839]
Dyak_GE17292  Dyak_RpII215; RNA polymerase II 215kD subunit [KO:K03006] [EC:2.7.7.6]
Dyak_GE24221  uncharacterized protein [KO:K03010] [EC:2.7.7.6]
Dyak_GE18688  uncharacterized protein [KO:K03011]
Dyak_GE25222  uncharacterized protein, isoform B [KO:K03012]
Dyak_GE13062  uncharacterized protein [KO:K03013]
Dyak_GE25464  uncharacterized protein [KO:K03014]
Dyak_GE28893  uncharacterized protein [KO:K03014]
Dyak_GE26402  uncharacterized protein [KO:K03015]
Dyak_GE23031  uncharacterized protein [KO:K03016]
Dyak_GE19787  uncharacterized protein [KO:K03016]
Dyak_GE24228  uncharacterized protein [KO:K03017]
Dyak_GE23508  uncharacterized protein [KO:K03007]
Dyak_GE12262  uncharacterized protein [KO:K03009]
Dyak_GE13140  uncharacterized protein [KO:K03008]
Dyak_GE11206  uncharacterized protein [KO:K21987]
Dyak_GE25591  uncharacterized protein [KO:K21987]
Dyak_GE28067  uncharacterized protein [KO:K21987]
Dyak_GE16821  uncharacterized protein [KO:K02202] [EC:2.7.11.22 2.7.11.23]
Dyak_GE13079  uncharacterized protein [KO:K10842]
Dyak_GE23026  uncharacterized protein [KO:K06634]
Dyak_GE19794  uncharacterized protein [KO:K06634]
Dyak_GE21750  uncharacterized protein [KO:K10843] [EC:5.6.2.4]
Dyak_GE12176  uncharacterized protein [KO:K10844] [EC:5.6.2.3]
Dyak_GE18705  uncharacterized protein [KO:K10845]
Dyak_GE13578  uncharacterized protein, isoform A [KO:K03141]
Dyak_GE22646  uncharacterized protein [KO:K03142]
Dyak_GE15755  uncharacterized protein [KO:K03143]
Dyak_GE22863  uncharacterized protein [KO:K03144]
Dyak_GE22864  uncharacterized protein [KO:K03144]
Dyak_GE18773  uncharacterized protein [KO:K10846]
Dyak_GE16873  uncharacterized protein [KO:K10847]
Dyak_GE24866  uncharacterized protein [KO:K07466]
Dyak_GE13014  uncharacterized protein [KO:K10739]
Dyak_GE17609  uncharacterized protein [KO:K10740]
Dyak_GE16862  uncharacterized protein, isoform A [KO:K10848] [EC:3.1.-.-]
Dyak_GE13614  uncharacterized protein, isoform A [KO:K10849]
Dyak_GE23127  uncharacterized protein [KO:K02327] [EC:2.7.7.7]
Dyak_GE28381  uncharacterized protein [KO:K02327] [EC:2.7.7.7]
Dyak_GE21185  uncharacterized protein [KO:K02328]
Dyak_GE19412  uncharacterized protein [KO:K03504]
Dyak_GE10366  uncharacterized protein [KO:K02324] [EC:2.7.7.7]
Dyak_GE20528  uncharacterized protein [KO:K02325] [EC:2.7.7.7]
Dyak_GE18772  Dyak_Chrac-14; Chrac-14 [KO:K02326] [EC:2.7.7.7]
Dyak_GE14182  uncharacterized protein [KO:K03506] [EC:2.7.7.7]
Dyak_GE12637  uncharacterized protein [KO:K04802]
Dyak_GE13815  Dyak_mus209; mus209 [KO:K04802]
Dyak_GE25440  uncharacterized protein [KO:K10754]
Dyak_GE20646  uncharacterized protein [KO:K10755]
Dyak_GE15569  uncharacterized protein [KO:K10755]
Dyak_GE12972  uncharacterized protein [KO:K10756]
Dyak_GE18941  uncharacterized protein [KO:K10756]
Reference
PMID:11436314
  Authors
Sugasawa K.
  Title
[Molecular mechanism of mammalian nucleotide excision repair]
  Journal
Tanpakushitsu Kakusan Koso 46:893-901 (2001)
Reference
PMID:11436316
  Authors
Nakatsu Y.
  Title
[Transcription-coupled repair and Cockayne syndrome]
  Journal
Tanpakushitsu Kakusan Koso 46:908-15 (2001)
Reference
PMID:11436323
  Authors
Nakagawa N, Masui R, Kuramitsu S.
  Title
[Structure and function of DNA repair enzyme UvrB from Thermus thermophilus HB8]
  Journal
Tanpakushitsu Kakusan Koso 46:968-75 (2001)
Reference
PMID:17276014
  Authors
Kraemer KH, Patronas NJ, Schiffmann R, Brooks BP, Tamura D, DiGiovanna JJ.
  Title
Xeroderma pigmentosum, trichothiodystrophy and Cockayne syndrome: a complex genotype-phenotype relationship.
  Journal
Neuroscience 145:1388-96 (2007)
DOI:10.1016/j.neuroscience.2006.12.020
Reference
PMID:17884153
  Authors
Saldivar JS, Wu X, Follen M, Gershenson D.
  Title
Nucleotide excision repair pathway review I: implications in ovarian cancer and platinum sensitivity.
  Journal
Gynecol Oncol 107:S56-71 (2007)
DOI:10.1016/j.ygyno.2007.07.043
Reference
PMID:16922398
  Authors
Sugasawa K.
  Title
[DNA repair pathways involving Cul4A ubiquitin ligases]
  Journal
Tanpakushitsu Kakusan Koso 51:1339-44 (2006)
Reference
PMID:18018633
  Authors
Ito S, Ando D, Tanaka K.
  Title
[Cross-talk between DNA repair and transcription: molecular mechanism and disorders]
  Journal
Tanpakushitsu Kakusan Koso 52:1823-31 (2007)
Related
pathway
dya03020  RNA polymerase
dya04120  Ubiquitin mediated proteolysis
KO pathway
ko03420   
LinkDB

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