KEGG   PATHWAY: ebg03070
Entry
ebg03070                    Pathway                                
Name
Bacterial secretion system - Enterobacter bugandensis
Description
Gram-negative bacteria secrete a wide range of proteins whose functions include biogenesis of organelles, such as pilli and flagella, nutrient acquisition, virulence, and efflux of drugs and other toxins. Six distinct secretion systems have been shown to mediate protein export through the inner and outer membranes of Gram-negative bacteria. These pathways are highly conserved throughout the Gram-negative bacterial species. In Gram-positive bacteria, secreted proteins are commonly translocated across the single membrane by the Sec pathway or the two-arginine (Tat) pathway.
Class
Environmental Information Processing; Membrane transport
Pathway map
ebg03070  Bacterial secretion system
ebg03070

Other DBs
GO: 0030253 0015628 0030254 0030255 0046819 0033103 0044098 0043952 0043953
Organism
Enterobacter bugandensis [GN:ebg]
Gene
FAI37_10135  tolC; outer membrane channel protein TolC [KO:K12340]
FAI37_22235  gspD; type II secretion system protein GspD [KO:K02453]
FAI37_02185  bacterial type II and III secretion system family protein [KO:K02453]
FAI37_22240  gspC; type II secretion system protein GspC [KO:K02452]
FAI37_22225  gspF; type II secretion system protein GspF [KO:K02455]
FAI37_02155  type II secretion system F family protein [KO:K02455]
FAI37_22220  gspG; type II secretion system protein GspG [KO:K02456]
FAI37_02145  gspG; type II secretion system protein GspG [KO:K02456]
FAI37_02190  type II secretion system protein [KO:K02456]
FAI37_02195  prepilin-type N-terminal cleavage/methylation domain-containing protein [KO:K02456]
FAI37_22215  gspH; type II secretion system protein GspH [KO:K02457]
FAI37_22210  gspI; type II secretion system protein GspI [KO:K02458]
FAI37_22205  gspJ; type II secretion system protein GspJ [KO:K02459]
FAI37_22200  general secretion pathway protein GspK [KO:K02460]
FAI37_22195  type II secretion system protein GspL [KO:K02461]
FAI37_22230  gspE; type II secretion system protein GspE [KO:K02454] [EC:7.4.2.8]
FAI37_02160  type II/IV secretion system protein [KO:K02454] [EC:7.4.2.8]
FAI37_22185  prepilin peptidase [KO:K02464] [EC:3.4.23.43 2.1.1.-]
FAI37_01705  secD; protein translocase subunit SecD [KO:K03072]
FAI37_01700  secF; protein translocase subunit SecF [KO:K03074]
FAI37_05565  secE; preprotein translocase subunit SecE [KO:K03073]
FAI37_09425  secG; preprotein translocase subunit SecG [KO:K03075]
FAI37_08775  secY; preprotein translocase subunit SecY [KO:K03076]
FAI37_01710  yajC; preprotein translocase subunit YajC [KO:K03210]
FAI37_06675  yidC; membrane protein insertase YidC [KO:K03217]
FAI37_02935  secA; preprotein translocase subunit SecA [KO:K03070] [EC:7.4.2.8]
FAI37_02940  secM; secA regulator SecM [KO:K13301]
FAI37_05235  ftsY; signal recognition particle-docking protein FtsY [KO:K03110]
FAI37_05975  secB; protein-export chaperone SecB [KO:K03071]
FAI37_12145  signal recognition particle protein [KO:K03106] [EC:3.6.5.4]
FAI37_07800  tatA; Sec-independent protein translocase subunit TatA [KO:K03116]
FAI37_07805  tatB; Sec-independent protein translocase subunit TatB [KO:K03117]
FAI37_07810  tatC; Sec-independent protein translocase subunit TatC [KO:K03118]
FAI37_00515  tatE; twin-arginine translocase subunit TatE [KO:K03425]
FAI37_13210  vgrG; type VI secretion system tip protein VgrG [KO:K11904]
FAI37_13225  vgrG; type VI secretion system tip protein VgrG [KO:K11904]
FAI37_13245  vgrG; type VI secretion system tip protein VgrG [KO:K11904]
FAI37_16180  tssI; type VI secretion system tip protein VgrG [KO:K11904]
FAI37_16220  type VI secretion system tip protein VgrG [KO:K11904]
FAI37_17780  Hcp family type VI secretion system effector [KO:K11903]
FAI37_00945  Hcp family type VI secretion system effector [KO:K11903]
FAI37_13200  Hcp family type VI secretion system effector [KO:K11903]
FAI37_16115  type VI secretion system tube protein Hcp [KO:K11903]
FAI37_13320  tssJ; type VI secretion system lipoprotein TssJ [KO:K11906]
FAI37_16075  tssJ; type VI secretion system lipoprotein TssJ [KO:K11906]
FAI37_13290  type VI secretion protein VasK [KO:K11891]
FAI37_16090  tssM; type VI secretion system membrane subunit TssM [KO:K11891]
FAI37_13190  DotU family type IV/VI secretion system protein [KO:K11892]
FAI37_16085  DotU family type VI secretion system protein [KO:K11892]
FAI37_13205  tssH; type VI secretion system ATPase TssH [KO:K11907]
FAI37_16165  tssH; type VI secretion system ATPase TssH [KO:K11907]
Compound
C00002  ATP
Reference
PMID:11173102
  Authors
Kim JF.
  Title
Revisiting the chlamydial type III protein secretion system: clues to the origin of type III protein secretion.
  Journal
Trends Genet 17:65-9 (2001)
DOI:10.1016/S0168-9525(00)02175-2
Reference
PMID:11309112
  Authors
Plano GV, Day JB, Ferracci F.
  Title
Type III export: new uses for an old pathway.
  Journal
Mol Microbiol 40:284-93 (2001)
DOI:10.1046/j.1365-2958.2001.02354.x
Reference
PMID:11413015
  Authors
Gauthier A, Finlay BB.
  Title
Bacterial pathogenesis: the answer to virulence is in the pore.
  Journal
Curr Biol 11:R264-7 (2001)
DOI:10.1016/S0960-9822(01)00134-8
Reference
PMID:10047550
  Authors
Burns DL.
  Title
Biochemistry of type IV secretion.
  Journal
Curr Opin Microbiol 2:25-9 (1999)
DOI:10.1016/S1369-5274(99)80004-6
Reference
PMID:10920394
  Authors
Christie PJ, Vogel JP.
  Title
Bacterial type IV secretion: conjugation systems adapted to deliver effector molecules to host cells.
  Journal
Trends Microbiol 8:354-60 (2000)
DOI:10.1016/S0966-842X(00)01792-3
Reference
PMID:11309113
  Authors
Christie PJ.
  Title
Type IV secretion: intercellular transfer of macromolecules by systems ancestrally related to conjugation machines.
  Journal
Mol Microbiol 40:294-305 (2001)
DOI:10.1046/j.1365-2958.2001.02302.x
Reference
PMID:10481178
  Authors
Nunn D.
  Title
Bacterial type II protein export and pilus biogenesis: more than just homologies?
  Journal
Trends Cell Biol 9:402-8 (1999)
DOI:10.1016/S0962-8924(99)01634-7
Reference
PMID:11309111
  Authors
Sandkvist M.
  Title
Biology of type II secretion.
  Journal
Mol Microbiol 40:271-83 (2001)
DOI:10.1046/j.1365-2958.2001.02403.x
Reference
PMID:11349009
  Authors
Sandkvist M.
  Title
Type II secretion and pathogenesis.
  Journal
Infect Immun 69:3523-35 (2001)
DOI:10.1128/IAI.69.6.3523-3535.2001
Reference
PMID:15546664
  Authors
Delepelaire P
  Title
Type I secretion in gram-negative bacteria.
  Journal
Biochim Biophys Acta 1694:149-61 (2004)
DOI:10.1016/j.bbamcr.2004.05.001
Reference
PMID:18406342
  Authors
Hazes B, Frost L
  Title
Towards a systems biology approach to study type II/IV secretion systems.
  Journal
Biochim Biophys Acta 1778:1839-50 (2008)
DOI:10.1016/j.bbamem.2008.03.011
Reference
PMID:16448494
  Authors
Johnson TL, Abendroth J, Hol WG, Sandkvist M
  Title
Type II secretion: from structure to function.
  Journal
FEMS Microbiol Lett 255:175-86 (2006)
DOI:10.1111/j.1574-6968.2006.00102.x
Reference
PMID:15546665
  Authors
Filloux A
  Title
The underlying mechanisms of type II protein secretion.
  Journal
Biochim Biophys Acta 1694:163-79 (2004)
DOI:10.1016/j.bbamcr.2004.05.003
Reference
PMID:19396170
  Authors
Spreter T, Yip CK, Sanowar S, Andre I, Kimbrough TG, Vuckovic M, Pfuetzner RA, Deng W, Yu AC, Finlay BB, Baker D, Miller SI, Strynadka NC
  Title
A conserved structural motif mediates formation of the periplasmic rings in the type III secretion system.
  Journal
Nat Struct Mol Biol 16:468-76 (2009)
DOI:10.1038/nsmb.1603
Reference
PMID:15590783
  Authors
Ghosh P
  Title
Process of protein transport by the type III secretion system.
  Journal
Microbiol Mol Biol Rev 68:771-95 (2004)
DOI:10.1128/MMBR.68.4.771-795.2004
Reference
PMID:12360191
  Authors
Cornelis GR
  Title
The Yersinia Ysc-Yop 'type III' weaponry.
  Journal
Nat Rev Mol Cell Biol 3:742-52 (2002)
DOI:10.1038/nrm932
Reference
PMID:17215876
  Authors
Baron C
  Title
VirB8: a conserved type IV secretion system assembly factor and drug target.
  Journal
Biochem Cell Biol 84:890-9 (2006)
DOI:10.1139/o06-148
Reference
PMID:17943123
  Authors
Kwok T, Zabler D, Urman S, Rohde M, Hartig R, Wessler S, Misselwitz R, Berger J, Sewald N, Konig W, Backert S
  Title
Helicobacter exploits integrin for type IV secretion and kinase activation.
  Journal
Nature 449:862-6 (2007)
DOI:10.1038/nature06187
Reference
PMID:16092524
  Authors
Christie PJ, Cascales E
  Title
Structural and dynamic properties of bacterial type IV secretion systems (review).
  Journal
Mol Membr Biol 22:51-61 (2005)
DOI:10.1080/09687860500063316
Reference
PMID:15546668
  Authors
Christie PJ
  Title
Type IV secretion: the Agrobacterium VirB/D4 and related conjugation systems.
  Journal
Biochim Biophys Acta 1694:219-34 (2004)
DOI:10.1016/j.bbamcr.2004.02.013
Reference
PMID:15590781
  Authors
Henderson IR, Navarro-Garcia F, Desvaux M, Fernandez RC, Ala'Aldeen D
  Title
Type V protein secretion pathway: the autotransporter story.
  Journal
Microbiol Mol Biol Rev 68:692-744 (2004)
DOI:10.1128/MMBR.68.4.692-744.2004
Reference
PMID:9778731
  Authors
Henderson IR, Navarro-Garcia F, Nataro JP
  Title
The great escape: structure and function of the autotransporter proteins.
  Journal
Trends Microbiol 6:370-8 (1998)
DOI:10.1016/S0966-842X(98)01318-3
Reference
PMID:18524912
  Authors
Filloux A, Hachani A, Bleves S
  Title
The bacterial type VI secretion machine: yet another player for protein transport across membranes.
  Journal
Microbiology 154:1570-83 (2008)
DOI:10.1099/mic.0.2008/016840-0
Reference
PMID:19251641
  Authors
Leiman PG, Basler M, Ramagopal UA, Bonanno JB, Sauder JM, Pukatzki S, Burley SK, Almo SC, Mekalanos JJ
  Title
Type VI secretion apparatus and phage tail-associated protein complexes share a common evolutionary origin.
  Journal
Proc Natl Acad Sci U S A 106:4154-9 (2009)
DOI:10.1073/pnas.0813360106
Reference
PMID:17603507
  Authors
Kulasekara HD, Miller SI
  Title
Threonine phosphorylation times bacterial secretion.
  Journal
Nat Cell Biol 9:734-6 (2007)
DOI:10.1038/ncb0707-734
Reference
PMID:18078384
  Authors
Driessen AJ, Nouwen N
  Title
Protein translocation across the bacterial cytoplasmic membrane.
  Journal
Annu Rev Biochem 77:643-67 (2008)
DOI:10.1146/annurev.biochem.77.061606.160747
Reference
PMID:14641032
  Authors
Pool MR
  Title
Getting to the membrane: how is co-translational protein targeting to the endoplasmic reticulum regulated?
  Journal
Biochem Soc Trans 31:1232-7 (2003)
DOI:10.1042/bst0311232
Reference
PMID:19299134
  Authors
Desvaux M, Hebraud M, Talon R, Henderson IR
  Title
Secretion and subcellular localizations of bacterial proteins: a semantic awareness issue.
  Journal
Trends Microbiol 17:139-45 (2009)
DOI:10.1016/j.tim.2009.01.004
Reference
PMID:15063851
  Authors
Nakatogawa H, Murakami A, Ito K
  Title
Control of SecA and SecM translation by protein secretion.
  Journal
Curr Opin Microbiol 7:145-50 (2004)
DOI:10.1016/j.mib.2004.01.001
KO pathway
ko03070   
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