KEGG   PATHWAY: ecoc03060
Entry
ecoc03060                   Pathway                                
Name
Protein export - Escherichia coli K-12 C3026
Description
The protein export is the active transport of proteins from the cytoplasm to the exterior of the cell, or to the periplasmic compartment in Gram-negative bacteria. The sec dependent pathway is the general protein export system that transports newly synthesized proteins into or across the cell membrane. The translocation channel is formed from a conserved trimeric membrane protein complex, called the Sec61/SecY complex. The twin-arginine translocation (Tat) pathway is another protein transport system that transports folded proteins in bacteria, archaea, and chloroplasts. Many Tat systems comprise three functionally different membrane proteins, TatA, TatB, and TatC, but TatA and TatE seem to have overlapping functions, with TatA having by far the more important role.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
ecoc03060  Protein export
ecoc03060

Other DBs
GO: 0043952 0043953
Organism
Escherichia coli K-12 C3026 [GN:ecoc]
Gene
C3026_17940  secY; preprotein translocase subunit SecY [KO:K03076]
C3026_21505  secE; preprotein translocase subunit SecE [KO:K03073]
C3026_17290  secG; preprotein translocase subunit SecG [KO:K03075]
C3026_01985  secD; preprotein translocase subunit SecD [KO:K03072]
C3026_01990  preprotein translocase subunit SecF [KO:K03074]
C3026_01980  yajC; preprotein translocase subunit YajC [KO:K03210]
C3026_20090  membrane protein insertase YidC [KO:K03217]
C3026_00395  secA; preprotein translocase subunit SecA [KO:K03070] [EC:7.4.2.8]
C3026_19570  preprotein translocase subunit SecB [KO:K03071]
C3026_00390  SecA regulator SecM [KO:K13301]
C3026_14450  signal recognition particle [KO:K03106] [EC:3.6.5.4]
C3026_18765  signal recognition particle-docking protein FtsY [KO:K03110]
C3026_20755  tatA; preprotein translocase subunit SecA [KO:K03116]
C3026_20760  preprotein translocase [KO:K03117]
C3026_20765  twin-arginine protein translocation system subunit TatC [KO:K03118]
C3026_03130  tatE; preprotein translocase subunit SecE [KO:K03425]
C3026_14225  S26 family signal peptidase [KO:K03100] [EC:3.4.21.89]
C3026_00130  lspA; signal peptidase II [KO:K03101] [EC:3.4.23.36]
Reference
  Authors
Dalbey RE, Robinson C.
  Title
Protein translocation into and across the bacterial plasma membrane and the plant thylakoid membrane.
  Journal
Trends Biochem Sci 24:17-22 (1999)
DOI:10.1016/S0968-0004(98)01333-4
Reference
  Authors
Berks BC, Sargent F, Palmer T.
  Title
The Tat protein export pathway.
  Journal
Mol Microbiol 35:260-74 (2000)
DOI:10.1046/j.1365-2958.2000.01719.x
Reference
  Authors
Wexler M, Sargent F, Jack RL, Stanley NR, Bogsch EG, Robinson C, Berks BC, Palmer T.
  Title
TatD is a cytoplasmic protein with DNase activity. No requirement for TatD family proteins in sec-independent protein export.
  Journal
J Biol Chem 275:16717-22 (2000)
DOI:10.1074/jbc.M000800200
Reference
  Authors
Jongbloed JD, Martin U, Antelmann H, Hecker M, Tjalsma H, Venema G, Bron S, van Dijl JM, Muller J.
  Title
TatC is a specificity determinant for protein secretion via the twin-arginine translocation pathway.
  Journal
J Biol Chem 275:41350-7 (2000)
DOI:10.1074/jbc.M004887200
Reference
  Authors
Rapoport TA
  Title
Protein translocation across the eukaryotic endoplasmic reticulum and bacterial plasma membranes.
  Journal
Nature 450:663-9 (2007)
DOI:10.1038/nature06384
Reference
  Authors
Flower AM
  Title
The SecY translocation complex: convergence of genetics and structure.
  Journal
Trends Microbiol 15:203-10 (2007)
DOI:10.1016/j.tim.2007.03.001
Reference
  Authors
Osborne AR, Rapoport TA, van den Berg B
  Title
Protein translocation by the Sec61/SecY channel.
  Journal
Annu Rev Cell Dev Biol 21:529-50 (2005)
DOI:10.1146/annurev.cellbio.21.012704.133214
Reference
  Authors
Paetzel M, Karla A, Strynadka NC, Dalbey RE
  Title
Signal peptidases.
  Journal
Chem Rev 102:4549-80 (2002)
DOI:10.1021/cr010166y
Reference
  Authors
Paetzel M, Dalbey RE, Strynadka NC
  Title
The structure and mechanism of bacterial type I signal peptidases. A novel antibiotic target.
  Journal
Pharmacol Ther 87:27-49 (2000)
DOI:10.1016/S0163-7258(00)00064-4
Reference
  Authors
Ng SY, Chaban B, VanDyke DJ, Jarrell KF
  Title
Archaeal signal peptidases.
  Journal
Microbiology 153:305-14 (2007)
DOI:10.1099/mic.0.2006/003087-0
Reference
  Authors
Desvaux M, Hebraud M, Talon R, Henderson IR
  Title
Secretion and subcellular localizations of bacterial proteins: a semantic awareness issue.
  Journal
Trends Microbiol 17:139-45 (2009)
DOI:10.1016/j.tim.2009.01.004
Reference
  Authors
Nakatogawa H, Murakami A, Ito K
  Title
Control of SecA and SecM translation by protein secretion.
  Journal
Curr Opin Microbiol 7:145-50 (2004)
DOI:10.1016/j.mib.2004.01.001
KO pathway
ko03060   
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