KEGG   PATHWAY: ecos01230
Entry
ecos01230                   Pathway                                
Name
Biosynthesis of amino acids - Escherichia coli O25b:K100:H4-ST131 EC958 (UPEC)
Description
This map presents a modular architecture of the biosynthesis pathways of twenty amino acids, which may be viewed as consisting of the core part and its extensions. The core part is the KEGG module for conversion of three-carbon compounds from glyceraldehyde-3P to pyruvate [MD:M00002], together with the pathways around serine and glycine. This KEGG module is the most conserved one in the KEGG MODULE database and is found in almost all the completely sequenced genomes. The extensions are the pathways containing the reaction modules RM001, RM033, RM032, and RM002 for biosynthesis of branched-chain amino acids (left) and basic amino acids (bottom), and the pathways for biosynthesis of histidine and aromatic amino acids (top right). It is interesting to note that the so-called essential amino acids that cannot be synthesized in human and other organisms generally appear in these extensions. Furthermore, the bottom extension of basic amino acids appears to be most divergent containing multiple pathways for lysine biosynthesis and multiple gene sets for arginine biosynthesis.
Class
Pathway map
ecos01230  Biosynthesis of amino acids
ecos01230

Module
ecos_M00002  Glycolysis, core module involving three-carbon compounds [PATH:ecos01230]
ecos_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:ecos01230]
ecos_M00007  Pentose phosphate pathway, non-oxidative phase, fructose 6P => ribose 5P [PATH:ecos01230]
ecos_M00010  Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate [PATH:ecos01230]
ecos_M00015  Proline biosynthesis, glutamate => proline [PATH:ecos01230]
ecos_M00016  Lysine biosynthesis, succinyl-DAP pathway, aspartate => lysine [PATH:ecos01230]
ecos_M00017  Methionine biosynthesis, aspartate => homoserine => methionine [PATH:ecos01230]
ecos_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:ecos01230]
ecos_M00019  Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine [PATH:ecos01230]
ecos_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:ecos01230]
ecos_M00021  Cysteine biosynthesis, serine => cysteine [PATH:ecos01230]
ecos_M00022  Shikimate pathway, phosphoenolpyruvate + erythrose-4P => chorismate [PATH:ecos01230]
ecos_M00023  Tryptophan biosynthesis, chorismate => tryptophan [PATH:ecos01230]
ecos_M00024  Phenylalanine biosynthesis, chorismate => phenylpyruvate => phenylalanine [PATH:ecos01230]
ecos_M00025  Tyrosine biosynthesis, chorismate => HPP => tyrosine [PATH:ecos01230]
ecos_M00026  Histidine biosynthesis, PRPP => histidine [PATH:ecos01230]
ecos_M00028  Ornithine biosynthesis, glutamate => ornithine [PATH:ecos01230]
ecos_M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate [PATH:ecos01230]
ecos_M00570  Isoleucine biosynthesis, threonine => 2-oxobutanoate => isoleucine [PATH:ecos01230]
ecos_M00844  Arginine biosynthesis, ornithine => arginine [PATH:ecos01230]
Organism
Escherichia coli O25b:K100:H4-ST131 EC958 (UPEC) [GN:ecos]
KO pathway
ko01230   
LinkDB

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