KEGG   PATHWAY: fca05207
Entry
fca05207                    Pathway                                
Name
Chemical carcinogenesis - receptor activation - Felis catus (domestic cat)
Description
Carcinogenesis is a multistage process that consists of initiation, promotion, and progression stages. Chemicals or environmental factors may act at any of these stages to induce and/or enhance the carcinogenic process. Based on their mode-of-action, carcinogens can be classified as genotoxic or non-genotoxic. Genotoxic agent begins their action at the deoxyribonucleic acid (DNA) level, causing DNA damage through several mechanisms. Non-genotoxic carcinogens are chemicals that cause the development of tumors through multiple non-genotoxic events and epigenetic alterations without direct interaction with DNA. One non-genotoxic mechanism involves receptor activation. Biological mechanisms involving receptor activation fall into two broad categories: (i) those that involve cell surface receptors and some intracellular receptors that activate signal transduction pathways, resulting in biological responses, including gene transcription, and (ii) those that involve intracellular receptors that translocate into the nucleus and act as transcription factors regulating gene expression. Both classes of receptors can be involved in mechanisms of carcinogenesis.
Class
Human Diseases; Cancer: overview
Pathway map
fca05207  Chemical carcinogenesis - receptor activation
fca05207

Organism
Felis catus (domestic cat) [GN:fca]
Gene
751113  CHRNA7; neuronal acetylcholine receptor subunit alpha-7 isoform X1 [KO:K04809]
101093558  ARRB2; beta-arrestin-2 isoform X1 [KO:K04439]
101101078  ARRB1; beta-arrestin-1 isoform X4 [KO:K04439]
101100378  SRC; proto-oncogene tyrosine-protein kinase Src isoform X3 [KO:K05704] [EC:2.7.10.2]
101096047  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X2 [KO:K04366] [EC:2.7.11.1]
101101356  RB1; retinoblastoma-associated protein isoform X1 [KO:K06618]
101098454  E2F1; transcription factor E2F1 isoform X3 [KO:K17454]
493835  BIRC5; baculoviral IAP repeat-containing protein 5 [KO:K08731]
101090594  E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
101082791  CDC6; cell division control protein 6 homolog isoform X1 [KO:K02213]
101098445  CDC25A; M-phase inducer phosphatase 1 isoform X1 [KO:K06645] [EC:3.1.3.48]
101088959  JAK2; tyrosine-protein kinase JAK2 isoform X3 [KO:K04447] [EC:2.7.10.2]
101095698  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
101086282  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
100037407  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
101101300  CHRNA4; neuronal acetylcholine receptor subunit alpha-4 isoform X2 [KO:K04806]
101084932  CHRNB2; neuronal acetylcholine receptor subunit beta-2 [KO:K04813]
100037403  CHRNA3; neuronal acetylcholine receptor subunit alpha-3 isoform X1 [KO:K04805]
101089940  CHRNB4; neuronal acetylcholine receptor subunit beta-4 isoform X1 [KO:K04815]
101082923  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
101088394  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X8 [KO:K04851]
101080870  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
654399  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
101087362  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
101094827  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X7 [KO:K04344]
101094274  PIK3CD; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
101091892  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
101097413  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
100271864  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3 [KO:K02649]
101093286  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2 [KO:K02649]
101093586  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101087931  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101092818  AKT3; RAC-gamma serine/threonine-protein kinase isoform X4 [KO:K04456] [EC:2.7.11.1]
100499544  AKT2; RAC-beta serine/threonine-protein kinase isoform X4 [KO:K04456] [EC:2.7.11.1]
101098152  MTOR; serine/threonine-protein kinase mTOR isoform X3 [KO:K07203] [EC:2.7.11.1]
100142683  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
101096604  RELA; transcription factor p65 [KO:K04735]
751103  HRAS; GTPase HRas isoform X1 [KO:K02833]
751104  KRAS; GTPase KRas isoform X2 [KO:K07827]
751105  NRAS; GTPase NRas [KO:K07828]
101081387  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X3 [KO:K04368] [EC:2.7.12.2]
101100281  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
101087614  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101087958  MAPK3; mitogen-activated protein kinase 3 isoform X2 [KO:K04371] [EC:2.7.11.24]
493935  FOS; proto-oncogene c-Fos [KO:K04379]
101097261  JUN; transcription factor AP-1 [KO:K04448]
100379628  MYC; myc proto-oncogene protein [KO:K04377]
493934  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
101086433  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
101088970  PRKCB; protein kinase C beta type isoform X3 [KO:K19662] [EC:2.7.11.13]
101082196  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
493845  VEGFA; vascular endothelial growth factor A precursor [KO:K05448]
100135772  FGF2; fibroblast growth factor 2 isoform X1 [KO:K18497]
493971  ADRB1; beta-1 adrenergic receptor [KO:K04141]
493767  ADRB2; beta-2 adrenergic receptor [KO:K04142]
493930  ADRB3; beta-3 adrenergic receptor [KO:K04143]
101098453  guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X2 [KO:K04632]
102900772  neuroendocrine secretory protein 55 [KO:K04632]
101101375  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
101094327  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
101088157  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
101097735  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
101100749  ADCY5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
101091211  ADCY6; adenylate cyclase type 6 isoform X2 [KO:K08046] [EC:4.6.1.1]
101094148  ADCY7; adenylate cyclase type 7 isoform X2 [KO:K08047] [EC:4.6.1.1]
101087555  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
101095942  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
101090494  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X3 [KO:K04345] [EC:2.7.11.11]
101095353  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
101090884  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
101084297  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
101089838  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
101100293  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
101100442  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X4 [KO:K09048]
101093555  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
101087097  CREB3L1; LOW QUALITY PROTEIN: cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
101084784  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X7 [KO:K09047]
101094849  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X4 [KO:K09049]
101092837  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
101100320  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
101089679  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
768269  BAD; bcl2-associated agonist of cell death [KO:K02158]
101081220  CHRNA9; neuronal acetylcholine receptor subunit alpha-9 [KO:K04810]
101082546  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
101086492  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X2 [KO:K04373] [EC:2.7.11.1]
101099466  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
101094163  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
552888  ESR1; estrogen receptor [KO:K08550]
101086317  ESR2; estrogen receptor beta [KO:K08551]
100316614  VDR; vitamin D3 receptor isoform X2 [KO:K08539]
101101311  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
100510799  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
101099916  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
101098862  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
101088847  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
101088571  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
101091812  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X3 [KO:K04688] [EC:2.7.11.1]
101092561  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X2 [KO:K04688] [EC:2.7.11.1]
101082327  PAQR7; membrane progestin receptor alpha [KO:K25039]
109499700  PAQR8; membrane progestin receptor beta [KO:K25040]
101098465  PAQR5; membrane progestin receptor gamma isoform X4 [KO:K25041]
101098742  PGR; progesterone receptor isoform X1 [KO:K08556]
724036  TNFSF11; tumor necrosis factor ligand superfamily member 11 [KO:K05473]
101090913  STAT5A; signal transducer and activator of transcription 5A isoform X1 [KO:K11223]
101090663  STAT5B; signal transducer and activator of transcription 5B isoform X1 [KO:K11224]
101096665  BCL6; B-cell lymphoma 6 protein [KO:K15618]
101082619  KLF5; Krueppel-like factor 5 isoform X2 [KO:K09206]
100379626  KLF4; Krueppel-like factor 4 [KO:K17846]
101094190  WNT1; proto-oncogene Wnt-1 [KO:K03209]
101091800  NOTCH2; neurogenic locus notch homolog protein 2 isoform X1 [KO:K20994]
101093427  JAG1; protein jagged-1 isoform X1 [KO:K06052]
101081787  AR; androgen receptor isoform X1 [KO:K08557]
493978  EGF; pro-epidermal growth factor precursor [KO:K04357]
100136904  FGF5; fibroblast growth factor 5 precursor [KO:K04358]
101084335  FGF9; fibroblast growth factor 9 [KO:K04358]
101090606  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
101091459  FGF6; fibroblast growth factor 6 [KO:K04358]
101084778  FGF16; fibroblast growth factor 16 [KO:K04358]
101097982  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
101098518  FGF18; fibroblast growth factor 18 [KO:K04358]
111556546  FGF4; fibroblast growth factor 4 [KO:K04358]
111556666  FGF3; fibroblast growth factor 3 [KO:K04358]
101084652  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
101083745  FGF22; fibroblast growth factor 22 [KO:K04358]
101090489  FGF10; fibroblast growth factor 10 [KO:K04358]
101083766  FGF20; fibroblast growth factor 20 [KO:K04358]
101086978  DLL4; delta-like protein 4 [KO:K06051]
101095456  DLL3; delta-like protein 3 isoform X1 [KO:K06051]
101083683  DLL1; delta-like protein 1 [KO:K06051]
101087496  PTGES3; prostaglandin E synthase 3 isoform X1 [KO:K15730] [EC:5.3.99.3]
101089053  AIPL1; aryl-hydrocarbon-interacting protein-like 1 isoform X3 [KO:K17767]
101092293  AIP; AH receptor-interacting protein isoform X1 [KO:K17767]
101084947  AHR; aryl hydrocarbon receptor isoform X1 [KO:K09093]
101101073  aryl hydrocarbon receptor-like isoform X1 [KO:K09093]
101095825  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
101094857  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
101082249  HSP90B1; endoplasmin [KO:K09487]
101086837  KPNA1; importin subunit alpha-5 isoform X2 [KO:K23940]
101085417  KPNA2; importin subunit alpha-1 [KO:K15043]
101095459  KPNA7; importin subunit alpha-8 isoform X1 [KO:K15043]
101082935  KPNA4; importin subunit alpha-3 isoform X2 [KO:K23583]
101099351  KPNA3; importin subunit alpha-4 [KO:K23583]
101092365  KPNA5; importin subunit alpha-6 isoform X1 [KO:K15042]
101097823  KPNA6; importin subunit alpha-7 isoform X1 [KO:K15042]
101086517  KPNB1; importin subunit beta-1 [KO:K14293]
101093627  ARNT; aryl hydrocarbon receptor nuclear translocator isoform X2 [KO:K09097]
554347  CYP1A1; cytochrome P450 1A1 [KO:K07408] [EC:1.14.14.1]
101099873  CYP1B1; cytochrome P450 1B1 [KO:K07410] [EC:1.14.14.1]
101085519  EPHX1; epoxide hydrolase 1 [KO:K01253] [EC:3.3.2.9]
101092355  EPHX2; bifunctional epoxide hydrolase 2 isoform X2 [KO:K08726] [EC:3.3.2.10 3.1.3.76]
101099782  EPHX3; epoxide hydrolase 3 [KO:K22368] [EC:3.3.2.10]
101096907  EPHX4; epoxide hydrolase 4 [KO:K22369] [EC:3.3.-.-]
101090936  MGST2; microsomal glutathione S-transferase 2 isoform X1 [KO:K00799] [EC:2.5.1.18]
101096317  glutathione S-transferase A2 [KO:K00799] [EC:2.5.1.18]
101097351  GSTO1; glutathione S-transferase omega-1 isoform X2 [KO:K00799] [EC:2.5.1.18]
101099565  MGST1; microsomal glutathione S-transferase 1 isoform X2 [KO:K00799] [EC:2.5.1.18]
101090141  GSTO2; glutathione S-transferase omega-2 isoform X1 [KO:K00799] [EC:2.5.1.18]
101080760  MGST3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
100169963  GSTM3; glutathione S-transferase Mu 3 [KO:K00799] [EC:2.5.1.18]
101083114  glutathione S-transferase theta-3-like isoform X1 [KO:K00799] [EC:2.5.1.18]
101083370  glutathione S-transferase theta-1 isoform X1 [KO:K00799] [EC:2.5.1.18]
101092550  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
101085041  GSTA4; glutathione S-transferase A4 [KO:K00799] [EC:2.5.1.18]
101092798  LOW QUALITY PROTEIN: glutathione S-transferase theta-2B-like [KO:K00799] [EC:2.5.1.18]
101100824  glutathione S-transferase Mu 4 [KO:K00799] [EC:2.5.1.18]
101084793  glutathione S-transferase A4-like isoform X1 [KO:K00799] [EC:2.5.1.18]
101083623  glutathione S-transferase theta-4-like [KO:K00799] [EC:2.5.1.18]
493955  UGT1A1; UDP-glucuronosyltransferase 1-1 precursor [KO:K00699] [EC:2.4.1.17]
101087059  UDP-glucuronosyltransferase 2A1 isoform X4 [KO:K00699] [EC:2.4.1.17]
101087662  UDP-glucuronosyltransferase 2C1-like isoform X1 [KO:K00699] [EC:2.4.1.17]
105259649  CYP2B6; cytochrome P450 2B11 [KO:K07412] [EC:1.14.14.1]
105260134  cytochrome P450 2B11-like [KO:K07412] [EC:1.14.14.1]
101088457  NR1I3; nuclear receptor subfamily 1 group I member 3 isoform X1 [KO:K08541]
101085757  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
101085801  RXRB; retinoic acid receptor RXR-beta isoform X1 [KO:K08525]
101081273  RXRG; retinoic acid receptor RXR-gamma isoform X2 [KO:K08526]
100652377  CYP3A131; cytochrome P450 family 3 subfamily A member 131 [KO:K07424] [EC:1.14.14.1]
100642187  CYP3A132; cytochrome P450 family 3 subfamily A member 132 [KO:K07424] [EC:1.14.14.1]
554345  CYP1A2; cytochrome P450 1A2 precursor [KO:K07409] [EC:1.14.14.1]
101095837  PPARA; peroxisome proliferator-activated receptor alpha isoform X2 [KO:K07294]
Compound
C00076  Calcium cation
C00410  Progesterone
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00745  Nicotine
C00780  Serotonin
C00788  L-Adrenaline
C00951  Estradiol-17beta
C03690  Bis(2-ethylhexyl)phthalate
C04623  DDT
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06697  Arsenite
C06790  Trichloroethene
C06916  Clofibrate
C07020  Gemfibrozil
C07434  Phenobarbital
C07535  Benzo[a]pyrene
C07557  2,3,7,8-Tetrachlorodibenzodioxin
C08150  Medroxyprogesterone acetate
C11042  Hexachlorobenzene
C11150  Trichloroacetate
C11371  Nafenopin
C11906  Sodium arsenite
C13624  Bisphenol A
C14240  Di(2-ethylhexyl) adipate
C14573  3,3',4,4',5-Pentachlorobiphenyl
C15995  Bombesin
C16452  N'-Nitrosonornicotine
C16453  4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone
Reference
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PMID:19631282
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Mutat Res 682:94-109 (2009)
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PMID:21444681
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Nicotinic acetylcholine receptor-based blockade: applications of molecular targets for cancer therapy.
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Clin Cancer Res 17:3533-41 (2011)
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PMID:19194381
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Is cancer triggered by altered signalling of nicotinic acetylcholine receptors?
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Nat Rev Cancer 9:195-205 (2009)
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Reference
PMID:21541211
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Singh S, Pillai S, Chellappan S
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Nicotinic acetylcholine receptor signaling in tumor growth and metastasis.
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J Oncol 2011:456743 (2011)
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PMID:31956359
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Cheng WL, Chen KY, Lee KY, Feng PH, Wu SM
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Nicotinic-nAChR signaling mediates drug resistance in lung cancer.
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J Cancer 11:1125-1140 (2020)
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Reference
PMID:24827506
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Grando SA
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Connections of nicotine to cancer.
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Nat Rev Cancer 14:419-29 (2014)
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PMID:24398389
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PMID:21640716
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Nicotinic acetylcholine receptor-mediated mechanisms in lung cancer.
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Biochem Pharmacol 82:1015-21 (2011)
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PMID:18262664
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Trends Pharmacol Sci 29:151-8 (2008)
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PMID:24830349
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Cancers (Basel) 6:1138-56 (2014)
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Reference
PMID:21801603
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Lung carcinoma signaling pathways activated by smoking.
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Chin J Cancer 30:551-8 (2011)
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PMID:28664511
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The Role of Nitrosamine (NNK) in Breast Cancer Carcinogenesis.
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J Mammary Gland Biol Neoplasia 22:159-170 (2017)
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IKBKE is induced by STAT3 and tobacco carcinogen and determines chemosensitivity in non-small cell lung cancer.
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Oncogene 32:151-9 (2013)
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PMID:20106947
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Chen RJ, Ho YS, Guo HR, Wang YJ
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Long-term nicotine exposure-induced chemoresistance is mediated by activation of Stat3 and downregulation of ERK1/2 via nAChR and beta-adrenoceptors in human bladder cancer cells.
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Toxicol Sci 115:118-30 (2010)
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PMID:20953833
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Lee CH, Chang YC, Chen CS, Tu SH, Wang YJ, Chen LC, Chang YJ, Wei PL, Chang HW, Chang CH, Huang CS, Wu CH, Ho YS
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Crosstalk between nicotine and estrogen-induced estrogen receptor activation induces alpha9-nicotinic acetylcholine receptor expression in human breast cancer cells.
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Breast Cancer Res Treat 129:331-45 (2011)
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PMID:16421368
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Estrogen carcinogenesis in breast cancer.
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N Engl J Med 354:270-82 (2006)
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Reference
PMID:29229539
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Murata M, Kang JH
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Bisphenol A (BPA) and cell signaling pathways.
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Biotechnol Adv 36:311-327 (2018)
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Reference
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Related
pathway
fca00980  Metabolism of xenobiotics by cytochrome P450
fca03320  PPAR signaling pathway
fca04010  MAPK signaling pathway
fca04024  cAMP signaling pathway
fca04150  mTOR signaling pathway
fca04151  PI3K-Akt signaling pathway
fca04370  VEGF signaling pathway
fca04915  Estrogen signaling pathway
fca05204  Chemical carcinogenesis - DNA adducts
fca05206  MicroRNAs in cancer
fca05208  Chemical carcinogenesis - reactive oxygen species
KO pathway
ko05207   
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