KEGG   PATHWAY: fya00260
Entry
fya00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Flammeovirga yaeyamensis
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
fya00260  Glycine, serine and threonine metabolism
fya00260

Module
fya_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:fya00260]
fya_M00621  Glycine cleavage system [PATH:fya00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Flammeovirga yaeyamensis [GN:fya]
Gene
KMW28_09710  aspartate kinase [KO:K00928] [EC:2.7.2.4]
KMW28_09810  aspartate kinase [KO:K00928] [EC:2.7.2.4]
KMW28_20175  thrA; bifunctional aspartate kinase/homoserine dehydrogenase I [KO:K12524] [EC:2.7.2.4 1.1.1.3]
KMW28_03090  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
KMW28_20170  homoserine kinase [KO:K00872] [EC:2.7.1.39]
KMW28_18770  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
KMW28_02205  aminotransferase class V-fold PLP-dependent enzyme [KO:K01620] [EC:4.1.2.48]
KMW28_20280  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
KMW28_11110  glycerate kinase [KO:K00865] [EC:2.7.1.165]
KMW28_18505  gpmI; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
KMW28_02900  phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
KMW28_07830  serA; phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
KMW28_08770  aminotransferase class V-fold PLP-dependent enzyme [KO:K00831] [EC:2.6.1.52]
KMW28_16060  SDR family NAD(P)-dependent oxidoreductase [KO:K16066] [EC:1.1.1.381 1.1.1.-]
KMW28_10580  aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme [KO:K00639] [EC:2.3.1.29]
KMW28_22290  kbl; glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]
KMW28_22285  tdh; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
KMW28_10265  FAD-dependent oxidoreductase [KO:K00274] [EC:1.4.3.4]
KMW28_15855  gcvP; aminomethyl-transferring glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
KMW28_09560  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
KMW28_08995  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
KMW28_19370  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
KMW28_19745  gcvH; glycine cleavage system protein GcvH [KO:K02437]
KMW28_10855  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
KMW28_00265  pyridoxal-phosphate dependent enzyme [KO:K01697] [EC:4.2.1.22]
KMW28_10740  sdaAB; L-serine ammonia-lyase, iron-sulfur-dependent subunit beta [KO:K01752] [EC:4.3.1.17]
KMW28_18395  sdaAA; L-serine ammonia-lyase, iron-sulfur-dependent, subunit alpha [KO:K01752] [EC:4.3.1.17]
KMW28_15770  ilvA; threonine ammonia-lyase [KO:K01754] [EC:4.3.1.19]
KMW28_03165  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
KMW28_18830  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
KMW28_17315  aspartate aminotransferase family protein [KO:K13745] [EC:4.1.1.86]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
fya00010  Glycolysis / Gluconeogenesis
fya00020  Citrate cycle (TCA cycle)
fya00230  Purine metabolism
fya00250  Alanine, aspartate and glutamate metabolism
fya00270  Cysteine and methionine metabolism
fya00290  Valine, leucine and isoleucine biosynthesis
fya00300  Lysine biosynthesis
fya00330  Arginine and proline metabolism
fya00460  Cyanoamino acid metabolism
fya00470  D-Amino acid metabolism
fya00564  Glycerophospholipid metabolism
fya00600  Sphingolipid metabolism
fya00620  Pyruvate metabolism
fya00630  Glyoxylate and dicarboxylate metabolism
fya00640  Propanoate metabolism
fya00680  Methane metabolism
fya00860  Porphyrin metabolism
fya00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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