KEGG   PATHWAY: gas04371
Entry
gas04371                    Pathway                                
Name
Apelin signaling pathway - Gracilinanus agilis (agile gracile opossum)
Description
Apelin is an endogenous peptide capable of binding the apelin receptor (APJ), which was originally described as an orphan G-protein-coupled receptor. Apelin and APJ are widely expressed in various tissues and organ systems. They are implicated in different key physiological processes such as angiogenesis, cardiovascular functions, cell proliferation and energy metabolism regulation. On the other hand, this ligand receptor couple is also involved in several pathologies including diabetes, obesity, cardiovascular disease and cancer.
Class
Environmental Information Processing; Signal transduction
Pathway map
gas04371  Apelin signaling pathway
gas04371

Other DBs
GO: 0060183
Organism
Gracilinanus agilis (agile gracile opossum) [GN:gas]
Gene
123247570  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
123252650  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
123235004  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
123237960  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
123242354  ADCY5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
123250524  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
123233664  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
123241596  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
123231736  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
123245882  ADCY10; adenylate cyclase type 10 [KO:K11265] [EC:4.6.1.1]
123247653  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
123254019  cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
123232104  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
123251626  APELA; apelin receptor early endogenous ligand [KO:K25355]
123251361  APLNR; apelin receptor [KO:K04174]
123248059  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
123244023  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
123250482  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
123240150  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
123244840  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
123254622  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
123242834  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
123237937  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
123251886  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
123245546  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
123244419  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
123243826  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
123242968  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
123231222  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
123230621  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
123254868  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
123232075  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
123230928  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
123230622  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 isoform X1 [KO:K04548]
123245703  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
123236899  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
123233371  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
123234085  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
123252777  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
123247136  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
123250011  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
123246373  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
123240034  RYR1; ryanodine receptor 1 isoform X1 [KO:K04961]
123246026  RYR2; ryanodine receptor 2 [KO:K04962]
123234093  RYR3; ryanodine receptor 3 [KO:K04963]
123236129  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
123242560  calmodulin-alpha-like [KO:K02183]
123236850  CALM2; calmodulin-2 [KO:K02183]
123256534  calmodulin-1-like [KO:K02183]
123256535  calmodulin-1-like [KO:K02183]
123243054  CALML6; calmodulin-like protein 6 [KO:K02183]
123237842  CALM1; calmodulin-1 isoform X1 [KO:K02183]
123250523  calmodulin-alpha-like [KO:K02183]
123256892  NOS1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
123247380  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
123250621  NOS3; nitric oxide synthase, endothelial isoform X1 [KO:K13242] [EC:1.14.13.39]
123236843  PRKCE; protein kinase C epsilon type [KO:K18050] [EC:2.7.11.13]
123240388  SLC9A1; sodium/hydrogen exchanger 1 isoform X1 [KO:K05742]
123236831  SLC8A1; sodium/calcium exchanger 1 isoform X1 [KO:K05849]
123242977  SLC8A2; sodium/calcium exchanger 2 isoform X1 [KO:K05849]
123237782  SLC8A3; sodium/calcium exchanger 3 [KO:K05849]
123235311  MYLK3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
123235420  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
123242352  MYLK; myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
123240591  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
123232356  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform isoform X1 [KO:K10351]
123230815  MYL3; myosin light chain 3 [KO:K12749]
123246192  MYL4; myosin light chain 4 [KO:K12750]
123248684  KRAS; GTPase KRas isoform X1 [KO:K07827]
123251828  LOW QUALITY PROTEIN: GTPase NRas-like [KO:K07827]
123247194  NRAS; GTPase NRas [KO:K07828]
123232515  GTPase NRas-like [KO:K07828]
123254538  RRAS; ras-related protein R-Ras isoform X1 [KO:K07829]
123252907  RRAS2; ras-related protein R-Ras2 [KO:K07830]
123241522  MRAS; ras-related protein M-Ras [KO:K07831]
123239466  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
123238040  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
123243007  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
123230857  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
123245714  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
123245982  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
123252917  RPS6KB2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
123231307  RPS6; 40S ribosomal protein S6 [KO:K02991]
123251511  40S ribosomal protein S6-like [KO:K02991]
123248941  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
123244349  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
123247425  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
123242998  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
123237620  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
123240305  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
123237574  EGR1; early growth response protein 1 [KO:K09203]
123251614  SPP1; osteopontin [KO:K06250]
123233373  JAG1; protein jagged-1 [KO:K06052]
123252145  PDE3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase B [KO:K13296] [EC:3.1.4.17]
123252319  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
123250684  PIK3R4; phosphoinositide 3-kinase regulatory subunit 4 [KO:K08333] [EC:2.7.11.1]
123247908  BECN1; beclin-1 [KO:K08334]
123235462  MAP1LC3A; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
123248025  MAP1LC3C; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
123236776  MAP1LC3B; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
123247110  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
123237312  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
123247235  PRKAB2; 5'-AMP-activated protein kinase subunit beta-2 isoform X1 [KO:K07199]
123232400  PRKAB1; 5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
123248612  PRKAG2; 5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200]
123248894  PRKAG1; 5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
123240152  PRKAG3; 5'-AMP-activated protein kinase subunit gamma-3 [KO:K07200]
123236198  PLIN1; perilipin-1 [KO:K08768]
123251628  PPARGC1A; peroxisome proliferator-activated receptor gamma coactivator 1-alpha [KO:K07202]
123248566  NRF1; nuclear respiratory factor 1 [KO:K11831]
123236536  TFAM; transcription factor A, mitochondrial [KO:K11830]
123239315  transcription factor A, mitochondrial-like [KO:K11830]
123232197  KLF2; Krueppel-like factor 2 [KO:K17845]
123245073  SPHK1; sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
123239810  SPHK2; sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
123247196  GNA13; guanine nucleotide-binding protein subunit alpha-13 isoform X1 [KO:K04639]
123231353  CAMK4; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
123247168  HDAC5; histone deacetylase 5 [KO:K11406] [EC:3.5.1.98]
123246923  HDAC4; histone deacetylase 4 [KO:K11406] [EC:3.5.1.98]
123238080  MEF2A; myocyte-specific enhancer factor 2A isoform X1 [KO:K09260]
123232240  MEF2B; myocyte-specific enhancer factor 2B [KO:K09261]
123236477  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
123244149  MEF2D; myocyte-specific enhancer factor 2D isoform X1 [KO:K09262]
123231024  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
123237729  SMAD2; mothers against decapentaplegic homolog 2 [KO:K04500]
123238038  SMAD3; mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
123253784  LOW QUALITY PROTEIN: mothers against decapentaplegic homolog 4-like [KO:K04501]
123254358  mothers against decapentaplegic homolog 4-like [KO:K04501]
123237642  SMAD4; mothers against decapentaplegic homolog 4 [KO:K04501]
123236751  CDH1; cadherin-1 isoform X1 [KO:K05689]
123245578  CCN2; CCN family member 2 [KO:K06827]
123254602  type-1 angiotensin II receptor [KO:K04166]
123240202  AGTR1; type-1 angiotensin II receptor [KO:K04166]
123245045  SERPINE1; plasminogen activator inhibitor 1 isoform X1 [KO:K03982]
123236981  PLAT; tissue-type plasminogen activator [KO:K01343] [EC:3.4.21.68]
Compound
C00076  Calcium cation
C00080  H+
C00165  Diacylglycerol
C00290  Fibrin
C00533  Nitric oxide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
Reference
PMID:26143239
  Authors
Yang P, Maguire JJ, Davenport AP
  Title
Apelin, Elabela/Toddler, and biased agonists as novel therapeutic agents in the cardiovascular system.
  Journal
Trends Pharmacol Sci 36:560-7 (2015)
DOI:10.1016/j.tips.2015.06.002
Reference
PMID:22140623
  Authors
Andersen CU, Hilberg O, Mellemkjaer S, Nielsen-Kudsk JE, Simonsen U
  Title
Apelin and pulmonary hypertension.
  Journal
Pulm Circ 1:334-46 (2011)
DOI:10.4103/2045-8932.87299
Reference
PMID:25275559
  Authors
Chapman NA, Dupre DJ, Rainey JK
  Title
The apelin receptor: physiology, pathology, cell signalling, and ligand modulation of a peptide-activated class A GPCR.
  Journal
Biochem Cell Biol 92:431-40 (2014)
DOI:10.1139/bcb-2014-0072
Reference
PMID:18272138
  Authors
Japp AG, Newby DE
  Title
The apelin-APJ system in heart failure: pathophysiologic relevance and therapeutic potential.
  Journal
Biochem Pharmacol 75:1882-92 (2008)
DOI:10.1016/j.bcp.2007.12.015
Reference
PMID:25652330
  Authors
Folino A, Montarolo PG, Samaja M, Rastaldo R
  Title
Effects of apelin on the cardiovascular system.
  Journal
Heart Fail Rev 20:505-18 (2015)
DOI:10.1007/s10741-015-9475-x
Reference
PMID:23943882
  Authors
O'Carroll AM, Lolait SJ, Harris LE, Pope GR
  Title
The apelin receptor APJ: journey from an orphan to a multifaceted regulator of homeostasis.
  Journal
J Endocrinol 219:R13-35 (2013)
DOI:10.1530/JOE-13-0227
Reference
PMID:23973488
  Authors
Liu QF, Yu HW, You L, Liu MX, Li KY, Tao GZ
  Title
Apelin-13-induced proliferation and migration induced of rat vascular smooth muscle cells is mediated by the upregulation of Egr-1.
  Journal
Biochem Biophys Res Commun 439:235-40 (2013)
DOI:10.1016/j.bbrc.2013.08.051
Reference
PMID:26254105
  Authors
Novakova V, Sandhu GS, Dragomir-Daescu D, Klabusay M
  Title
Apelinergic system in endothelial cells and its role in angiogenesis in myocardial ischemia.
  Journal
Vascul Pharmacol 76:1-10 (2016)
DOI:10.1016/j.vph.2015.08.005
Reference
PMID:21725702
  Authors
Castan-Laurell I, Dray C, Attane C, Duparc T, Knauf C, Valet P
  Title
Apelin, diabetes, and obesity.
  Journal
Endocrine 40:1-9 (2011)
DOI:10.1007/s12020-011-9507-9
Reference
PMID:23924696
  Authors
Li L, Li L, Xie F, Zhang Z, Guo Y, Tang G, Lv D, Lu Q, Chen L, Li J
  Title
Jagged-1/Notch3 signaling transduction pathway is involved in apelin-13-induced vascular smooth muscle cells proliferation.
  Journal
Acta Biochim Biophys Sin (Shanghai) 45:875-81 (2013)
DOI:10.1093/abbs/gmt085
Reference
PMID:24990699
  Authors
Wu D, He L, Chen L
  Title
Apelin/APJ system: a promising therapy target for hypertension.
  Journal
Mol Biol Rep 41:6691-703 (2014)
DOI:10.1007/s11033-014-3552-4
Reference
PMID:20539939
  Authors
Liu C, Su T, Li F, Li L, Qin X, Pan W, Feng F, Chen F, Liao D, Chen L
  Title
PI3K/Akt signaling transduction pathway is involved in rat vascular smooth muscle cell proliferation induced by apelin-13.
  Journal
Acta Biochim Biophys Sin (Shanghai) 42:396-402 (2010)
DOI:10.1093/abbs/gmq035
Reference
PMID:26607438
  Authors
Xie F, Liu W, Feng F, Li X, He L, Lv D, Qin X, Li L, Li L, Chen L
  Title
Apelin-13 promotes cardiomyocyte hypertrophy via PI3K-Akt-ERK1/2-p70S6K and PI3K-induced autophagy.
  Journal
Acta Biochim Biophys Sin (Shanghai) 47:969-80 (2015)
DOI:10.1093/abbs/gmv111
Reference
PMID:27979574
  Authors
Lu L, Wu D, Li L, Chen L
  Title
Apelin/APJ system: A bifunctional target for cardiac hypertrophy.
  Journal
Int J Cardiol 230:164-170 (2017)
DOI:10.1016/j.ijcard.2016.11.215
Reference
PMID:16182514
  Authors
Carmen GY, Victor SM
  Title
Signalling mechanisms regulating lipolysis.
  Journal
Cell Signal 18:401-8 (2006)
DOI:10.1016/j.cellsig.2005.08.009
Reference
PMID:27650065
  Authors
Hu H, He L, Li L, Chen L
  Title
Apelin/APJ system as a therapeutic target in diabetes and its complications.
  Journal
Mol Genet Metab 119:20-7 (2016)
DOI:10.1016/j.ymgme.2016.07.012
Reference
PMID:25914650
  Authors
Bertrand C, Valet P, Castan-Laurell I
  Title
Apelin and energy metabolism.
  Journal
Front Physiol 6:115 (2015)
DOI:10.3389/fphys.2015.00115
Reference
PMID:26385179
  Authors
Yao F, Lv YC, Zhang M, Xie W, Tan YL, Gong D, Cheng HP, Liu D, Li L, Liu XY, Zheng XL, Tang CK
  Title
Apelin-13 impedes foam cell formation by activating Class III PI3K/Beclin-1-mediated autophagic pathway.
  Journal
Biochem Biophys Res Commun 466:637-43 (2015)
DOI:10.1016/j.bbrc.2015.09.045
Reference
PMID:22842084
  Authors
Than A, Cheng Y, Foh LC, Leow MK, Lim SC, Chuah YJ, Kang Y, Chen P
  Title
Apelin inhibits adipogenesis and lipolysis through distinct molecular pathways.
  Journal
Mol Cell Endocrinol 362:227-41 (2012)
DOI:10.1016/j.mce.2012.07.002
Reference
PMID:24055369
  Authors
Yu XH, Tang ZB, Liu LJ, Qian H, Tang SL, Zhang DW, Tian GP, Tang CK
  Title
Apelin and its receptor APJ in cardiovascular diseases.
  Journal
Clin Chim Acta 428:1-8 (2014)
DOI:10.1016/j.cca.2013.09.001
Reference
PMID:25931124
  Authors
Than A, He HL, Chua SH, Xu D, Sun L, Leow MK, Chen P
  Title
Apelin Enhances Brown Adipogenesis and Browning of White Adipocytes.
  Journal
J Biol Chem 290:14679-91 (2015)
DOI:10.1074/jbc.M115.643817
Reference
PMID:25139773
  Authors
Fu J, Li Z, Zhang H, Mao Y, Wang A, Wang X, Zou Z, Zhang X
  Title
Molecular pathways regulating the formation of brown-like adipocytes in white adipose tissue.
  Journal
Diabetes Metab Res Rev 31:433-52 (2015)
DOI:10.1002/dmrr.2600
Reference
PMID:21464822
  Authors
Aharoni-Simon M, Hann-Obercyger M, Pen S, Madar Z, Tirosh O
  Title
Fatty liver is associated with impaired activity of PPARgamma-coactivator 1alpha (PGC1alpha) and mitochondrial biogenesis in mice.
  Journal
Lab Invest 91:1018-28 (2011)
DOI:10.1038/labinvest.2011.55
Reference
PMID:22995518
  Authors
McLean DL, Kim J, Kang Y, Shi H, Atkins GB, Jain MK, Chun HJ
  Title
Apelin/APJ signaling is a critical regulator of statin effects in vascular endothelial cells--brief report.
  Journal
Arterioscler Thromb Vasc Biol 32:2640-3 (2012)
DOI:10.1161/ATVBAHA.112.300317
Reference
PMID:22028387
  Authors
Pchejetski D, Foussal C, Alfarano C, Lairez O, Calise D, Guilbeau-Frugier C, Schaak S, Seguelas MH, Wanecq E, Valet P, Parini A, Kunduzova O
  Title
Apelin prevents cardiac fibroblast activation and collagen production through inhibition of sphingosine kinase 1.
  Journal
Eur Heart J 33:2360-9 (2012)
DOI:10.1093/eurheartj/ehr389
Reference
PMID:26944568
  Authors
Huang S, Chen L, Lu L, Li L
  Title
The apelin-APJ axis: A novel potential therapeutic target for organ fibrosis.
  Journal
Clin Chim Acta 456:81-8 (2016)
DOI:10.1016/j.cca.2016.02.025
Reference
PMID:19093215
  Authors
Liu G, Han J, Profirovic J, Strekalova E, Voyno-Yasenetskaya TA
  Title
Galpha13 regulates MEF2-dependent gene transcription in endothelial cells: role in angiogenesis.
  Journal
Angiogenesis 12:1-15 (2009)
DOI:10.1007/s10456-008-9123-3
Reference
PMID:23603510
  Authors
Kang Y, Kim J, Anderson JP, Wu J, Gleim SR, Kundu RK, McLean DL, Kim JD, Park H, Jin SW, Hwa J, Quertermous T, Chun HJ
  Title
Apelin-APJ signaling is a critical regulator of endothelial MEF2 activation in cardiovascular development.
  Journal
Circ Res 113:22-31 (2013)
DOI:10.1161/CIRCRESAHA.113.301324
Reference
PMID:25164121
  Authors
Wang LY, Diao ZL, Zhang DL, Zheng JF, Zhang QD, Ding JX, Liu WH
  Title
The regulatory peptide apelin: a novel inhibitor of renal interstitial fibrosis.
  Journal
Amino Acids 46:2693-704 (2014)
DOI:10.1007/s00726-014-1826-8
Reference
PMID:26756969
  Authors
Zhou Y, Deng L, Zhao D, Chen L, Yao Z, Guo X, Liu X, Lv L, Leng B, Xu W, Qiao G, Shan H
  Title
MicroRNA-503 promotes angiotensin II-induced cardiac fibrosis by targeting Apelin-13.
  Journal
J Cell Mol Med 20:495-505 (2016)
DOI:10.1111/jcmm.12754
Reference
PMID:27825851
  Authors
Zhong JC, Zhang ZZ, Wang W, McKinnie SM, Vederas JC, Oudit GY
  Title
Targeting the apelin pathway as a novel therapeutic approach for cardiovascular diseases.
  Journal
Biochim Biophys Acta 1863:1942-1950 (2017)
DOI:10.1016/j.bbadis.2016.11.007
Related
pathway
gas04010  MAPK signaling pathway
gas04020  Calcium signaling pathway
gas04140  Autophagy - animal
gas04150  mTOR signaling pathway
gas04151  PI3K-Akt signaling pathway
gas04152  AMPK signaling pathway
gas04270  Vascular smooth muscle contraction
gas04530  Tight junction
gas04923  Regulation of lipolysis in adipocytes
KO pathway
ko04371   
LinkDB

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