KEGG   PATHWAY: ges02020
Entry
ges02020                    Pathway                                
Name
Two-component system - Gemmata sp. SH-PL17
Description
Two-component signal transduction systems enable bacteria to sense, respond, and adapt to changes in their environment or in their intracellular state. Each two-component system consists of a sensor protein-histidine kinase (HK) and a response regulator (RR). In the prototypical two-component pathway, the sensor HK phosphorylates its own conserved His residue in response to a signal(s) in the environment. Subsequently, the phosphoryl group of HK is transferred onto a specific Asp residue on the RR. The activated RR can then effect changes in cellular physiology, often by regulating gene expression. Two-component pathways thus often enable cells to sense and respond to stimuli by inducing changes in transcription.
Class
Environmental Information Processing; Signal transduction
Pathway map
ges02020  Two-component system
ges02020

Other DBs
GO: 0000160
Organism
Gemmata sp. SH-PL17 [GN:ges]
Gene
VT84_26560  baeR; Transcriptional regulatory protein BaeR [KO:K07657]
VT84_22230  phoD; Alkaline phosphatase D precursor [KO:K01113] [EC:3.1.3.1]
VT84_20900  pstS; Phosphate-binding protein PstS precursor [KO:K02040]
VT84_02295  mucD_1; putative periplasmic serine endoprotease DegP-like precursor [KO:K04771] [EC:3.4.21.107]
VT84_16105  mucD_3; putative periplasmic serine endoprotease DegP-like precursor [KO:K04771] [EC:3.4.21.107]
VT84_17815  degP1; putative periplasmic serine endoprotease DegP-like precursor [KO:K04771] [EC:3.4.21.107]
VT84_09860  degQ_1; Periplasmic pH-dependent serine endoprotease DegQ precursor [KO:K04771] [EC:3.4.21.107]
VT84_18915  htrA_2; Putative serine protease HtrA [KO:K04771] [EC:3.4.21.107]
VT84_18920  mucD_5; putative periplasmic serine endoprotease DegP-like precursor [KO:K04771] [EC:3.4.21.107]
VT84_34065  mucD_9; putative periplasmic serine endoprotease DegP-like precursor [KO:K04771] [EC:3.4.21.107]
VT84_25765  mucD_6; putative periplasmic serine endoprotease DegP-like precursor [KO:K04771] [EC:3.4.21.107]
VT84_25770  mucD_7; putative periplasmic serine endoprotease DegP-like precursor [KO:K04771] [EC:3.4.21.107]
VT84_27520  htrA_4; Putative serine protease HtrA [KO:K04771] [EC:3.4.21.107]
VT84_11800  mucD_2; putative periplasmic serine endoprotease DegP-like precursor [KO:K04771] [EC:3.4.21.107]
VT84_15755  hhoA_1; Putative serine protease HhoA precursor [KO:K04771] [EC:3.4.21.107]
VT84_18910  mucD_4; putative periplasmic serine endoprotease DegP-like precursor [KO:K04771] [EC:3.4.21.107]
VT84_37740  hypothetical protein [KO:K04771] [EC:3.4.21.107]
VT84_24645  mdtA_2; Multidrug resistance protein MdtA precursor [KO:K07799]
VT84_12790  cusS_2; Sensor kinase CusS [KO:K07644] [EC:2.7.13.3]
VT84_08060  cusR; Transcriptional regulatory protein CusR [KO:K07665]
VT84_12805  czcR_2; Transcriptional activator protein CzcR [KO:K07665]
VT84_11490  fliC; A-type flagellin [KO:K02406]
VT84_14610  sigD_1; RNA polymerase sigma-D factor [KO:K02405]
VT84_35965  fliA; RNA polymerase sigma factor FliA [KO:K02405]
VT84_11615  motA; Motility protein A [KO:K02556]
VT84_27225  kdpD; Sensor protein KdpD [KO:K07646] [EC:2.7.13.3]
VT84_27205  kdpA; Potassium-transporting ATPase A chain [KO:K01546]
VT84_27200  kdpB; Potassium-transporting ATPase B chain [KO:K01547] [EC:7.2.2.6]
VT84_27195  kdpC; Potassium-transporting ATPase C chain [KO:K01548]
VT84_09015  ctaA; Heme A synthase [KO:K02259] [EC:1.17.99.9]
VT84_00005  dnaA_1; Chromosomal replication initiator protein DnaA [KO:K02313]
VT84_37970  dnaA_2; Chromosomal replication initiator protein DnaA [KO:K02313]
VT84_07635  hypothetical protein [KO:K18353]
VT84_09770  triphosphoribosyl-dephospho-CoA synthase [KO:K05966] [EC:2.4.2.52]
VT84_38590  drrA_7; Daunorubicin/doxorubicin resistance ATP-binding protein DrrA [KO:K09697] [EC:7.2.2.4]
VT84_36510  ABC-2 family transporter protein [KO:K09696]
VT84_00575  barA_1; Signal transduction histidine-protein kinase BarA [KO:K07678] [EC:2.7.13.3]
VT84_01610  hypothetical protein [KO:K03563]
VT84_34280  hypothetical protein [KO:K03563]
VT84_29940  csrA; Carbon storage regulator [KO:K03563]
VT84_17350  Flp/Fap pilin component [KO:K02651]
VT84_17355  Flp/Fap pilin component [KO:K02651]
VT84_32480  Flp/Fap pilin component [KO:K02651]
VT84_32485  Flp/Fap pilin component [KO:K02651]
VT84_32495  SAF domain protein [KO:K02279]
VT84_32500  pulD_2; Type II secretion system protein D precursor [KO:K02280]
VT84_34360  hypothetical protein [KO:K02282]
VT84_32505  minD_1; Septum site-determining protein MinD [KO:K02282]
VT84_03995  hypothetical protein [KO:K02283] [EC:7.4.2.8]
VT84_34365  Putative conjugal transfer protein [KO:K02283] [EC:7.4.2.8]
VT84_32510  Putative conjugal transfer protein [KO:K02283] [EC:7.4.2.8]
VT84_32515  Bacterial type II secretion system protein F domain protein [KO:K12510]
VT84_32520  Bacterial type II secretion system protein F domain protein [KO:K12511]
VT84_18390  glnG_2; Nitrogen regulation protein NR(I) [KO:K07712]
VT84_01335  glnA_1; Glutamine synthetase [KO:K01915] [EC:6.3.1.2]
VT84_34185  glnA_2; Glutamine synthetase [KO:K01915] [EC:6.3.1.2]
VT84_23550  zraS_8; Sensor protein ZraS [KO:K07709] [EC:2.7.13.3]
VT84_10015  zraS_3; Sensor protein ZraS [KO:K07709] [EC:2.7.13.3]
VT84_07755  zraS_2; Sensor protein ZraS [KO:K07709] [EC:2.7.13.3]
VT84_05515  zraR_4; Transcriptional regulatory protein ZraR [KO:K07713]
VT84_34710  zraR_12; Transcriptional regulatory protein ZraR [KO:K07713]
VT84_38735  zraR_13; Transcriptional regulatory protein ZraR [KO:K07713]
VT84_03140  zraR_1; Transcriptional regulatory protein ZraR [KO:K07713]
VT84_11380  glnG_1; Nitrogen regulation protein NR(I) [KO:K07714]
VT84_10020  ntrC_2; Nitrogen assimilation regulatory protein [KO:K07714]
VT84_38840  glnG_5; Nitrogen regulation protein NR(I) [KO:K07714]
VT84_23555  zraR_10; Transcriptional regulatory protein ZraR [KO:K07714]
VT84_29765  thlA; Acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
VT84_18770  rpoN; RNA polymerase sigma-54 factor [KO:K03092]
VT84_27220  kinB; Alginate biosynthesis sensor protein KinB [KO:K11383] [EC:2.7.13.3]
VT84_27215  algB; Alginate biosynthesis transcriptional regulatory protein AlgB [KO:K11384]
VT84_22475  cheR2_4; Chemotaxis protein methyltransferase Cher2 [KO:K00575] [EC:2.1.1.80]
VT84_09935  cheR2_2; Chemotaxis protein methyltransferase Cher2 [KO:K00575] [EC:2.1.1.80]
VT84_11180  cheR2_3; Chemotaxis protein methyltransferase Cher2 [KO:K00575] [EC:2.1.1.80]
VT84_26760  cheR; Chemotaxis protein methyltransferase [KO:K00575] [EC:2.1.1.80]
VT84_02910  cheR2_1; Chemotaxis protein methyltransferase Cher2 [KO:K13924] [EC:2.1.1.80 3.1.1.61]
VT84_03775  tar_1; Methyl-accepting chemotaxis protein II [KO:K03406]
VT84_04950  tar_2; Methyl-accepting chemotaxis protein II [KO:K03406]
VT84_09950  bdlA; Biofilm dispersion protein BdlA [KO:K03406]
VT84_11190  mcp4_1; Methyl-accepting chemotaxis protein 4 [KO:K03406]
VT84_13455  tar_4; Methyl-accepting chemotaxis protein II [KO:K03406]
VT84_23730  tar_6; Methyl-accepting chemotaxis protein II [KO:K03406]
VT84_26775  tar_9; Methyl-accepting chemotaxis protein II [KO:K03406]
VT84_26780  tar_10; Methyl-accepting chemotaxis protein II [KO:K03406]
VT84_26785  tar_11; Methyl-accepting chemotaxis protein II [KO:K03406]
VT84_26790  tar_12; Methyl-accepting chemotaxis protein II [KO:K03406]
VT84_27625  tar_13; Methyl-accepting chemotaxis protein II [KO:K03406]
VT84_27630  tar_14; Methyl-accepting chemotaxis protein II [KO:K03406]
VT84_28370  tar_15; Methyl-accepting chemotaxis protein II [KO:K03406]
VT84_28365  tsr_2; Methyl-accepting chemotaxis protein I [KO:K03406]
VT84_00975  cheW_1; Chemotaxis protein CheW [KO:K03408]
VT84_04945  cheW_2; Chemotaxis protein CheW [KO:K03408]
VT84_24960  cheW_6; Chemotaxis protein CheW [KO:K03408]
VT84_18400  cheW_5; Chemotaxis protein CheW [KO:K03408]
VT84_09955  cheW_3; Chemotaxis protein CheW [KO:K03408]
VT84_11195  cheW_4; Chemotaxis protein CheW [KO:K03408]
VT84_26795  cheW_8; Chemotaxis protein CheW [KO:K03408]
VT84_27620  cheW_9; Chemotaxis protein CheW [KO:K03408]
VT84_09960  cheA_1; Chemotaxis protein CheA [KO:K03407] [EC:2.7.13.3]
VT84_11200  cheA_2; Chemotaxis protein CheA [KO:K03407] [EC:2.7.13.3]
VT84_26800  cheA_5; Chemotaxis protein CheA [KO:K03407] [EC:2.7.13.3]
VT84_09945  hypothetical protein [KO:K03413]
VT84_26740  hypothetical protein [KO:K03413]
VT84_26815  hypothetical protein [KO:K03413]
VT84_02900  cheB_1; Chemotaxis response regulator protein-glutamate methylesterase [KO:K03412] [EC:3.1.1.61 3.5.1.44]
VT84_22480  cheB_4; Chemotaxis response regulator protein-glutamate methylesterase [KO:K03412] [EC:3.1.1.61 3.5.1.44]
VT84_09940  cheB_2; Chemotaxis response regulator protein-glutamate methylesterase [KO:K03412] [EC:3.1.1.61 3.5.1.44]
VT84_11185  cheB_3; Chemotaxis response regulator protein-glutamate methylesterase [KO:K03412] [EC:3.1.1.61 3.5.1.44]
VT84_26745  cheB_6; Chemotaxis response regulator protein-glutamate methylesterase [KO:K03412] [EC:3.1.1.61 3.5.1.44]
VT84_25975  wspC; putative biofilm formation methyltransferase WspC [KO:K13486]
VT84_25965  mcp4_2; Methyl-accepting chemotaxis protein 4 [KO:K13487]
VT84_25970  cheW_7; Chemotaxis protein CheW [KO:K13488]
VT84_25980  CheW-like domain protein [KO:K13489]
VT84_25985  cheA_4; Chemotaxis protein CheA [KO:K13490]
VT84_25990  cheB_5; Chemotaxis response regulator protein-glutamate methylesterase [KO:K13491] [EC:3.1.1.61]
VT84_10305  cph1_1; Phytochrome-like protein cph1 [KO:K11354] [EC:2.7.13.3]
VT84_10340  Blue-light-activated protein [KO:K13587] [EC:2.7.13.3]
VT84_11355  Blue-light-activated protein [KO:K13587] [EC:2.7.13.3]
VT84_13065  Blue-light-activated protein [KO:K13587] [EC:2.7.13.3]
VT84_13225  Blue-light-activated protein [KO:K13587] [EC:2.7.13.3]
VT84_15355  Blue-light-activated protein [KO:K13587] [EC:2.7.13.3]
VT84_14250  Blue-light-activated protein [KO:K13587] [EC:2.7.13.3]
VT84_14715  Blue-light-activated protein [KO:K13587] [EC:2.7.13.3]
VT84_15120  Blue-light-activated protein [KO:K13587] [EC:2.7.13.3]
VT84_22830  Blue-light-activated protein [KO:K13587] [EC:2.7.13.3]
VT84_34425  Blue-light-activated protein [KO:K13587] [EC:2.7.13.3]
VT84_32715  zraS_9; Sensor protein ZraS [KO:K13587] [EC:2.7.13.3]
VT84_33745  Blue-light-activated protein [KO:K13587] [EC:2.7.13.3]
VT84_03045  Blue-light-activated protein [KO:K13587] [EC:2.7.13.3]
VT84_07715  Blue-light-activated protein [KO:K13587] [EC:2.7.13.3]
VT84_18725  fixL_2; Sensor protein FixL [KO:K14986] [EC:2.7.13.3]
VT84_13445  tdiR; Transcriptional regulatory protein TdiR [KO:K14987]
VT84_34455  hypothetical protein [KO:K10914]
VT84_36170  hypothetical protein [KO:K00404] [EC:7.1.1.9]
VT84_36165  Cytochrome C oxidase, mono-heme subunit/FixO [KO:K00405]
VT84_02800  Polysaccharide biosynthesis/export protein [KO:K01991]
VT84_03705  Polysaccharide biosynthesis/export protein [KO:K01991]
VT84_24565  Polysaccharide biosynthesis/export protein [KO:K01991]
VT84_13315  SLBB domain protein [KO:K01991]
VT84_25300  Polysaccharide biosynthesis/export protein [KO:K01991]
VT84_35075  Polysaccharide biosynthesis/export protein [KO:K01991]
VT84_25265  wbpI; UDP-2,3-diacetamido-2,3-dideoxy-D-glucuronate 2-epimerase [KO:K01791] [EC:5.1.3.14]
Compound
C00007  Oxygen
C00009  Orthophosphate
C00025  L-Glutamate
C00031  D-Glucose
C00034  Manganese
C00036  Oxaloacetate
C00038  Zinc cation
C00042  Succinate
C00049  L-Aspartate
C00064  L-Glutamine
C00070  Copper
C00088  Nitrite
C00092  D-Glucose 6-phosphate
C00122  Fumarate
C00149  (S)-Malate
C00158  Citrate
C00164  Acetoacetate
C00237  CO
C00238  Potassium cation
C00244  Nitrate
C00282  Hydrogen
C00291  Nickel
C00305  Magnesium cation
C00399  Ubiquinone
C00533  Nitric oxide
C00547  L-Noradrenaline
C00697  Nitrogen
C00788  L-Adrenaline
C00828  Menaquinone
C01019  L-Fucose
C01104  Trimethylamine N-oxide
C01667  Bacitracin
C02084  Tetrathionate
C05757  (3R)-3-Hydroxydodecanoyl-[acyl-carrier protein]
C05818  2-Demethylmenaquinone
C06230  Fe-enterobactin
C06689  Vancomycin
C06696  Lead
C11612  Polymyxin B
C11842  N-(3-(S)-Hydroxybutyryl)homoserine lactone
C11849  3-Hydroxy-palmitic acid methyl ester
C12008  Ramoplanin A2
C13768  Colistin sulfate
C14819  Fe3+
C16421  AI-2
C16463  3',5'-Cyclic diGMP
C16640  CAI-1
C16665  12-Methyltetradecanoic acid
C18206  cis-11-Methyl-2-dodecenoic acid
C21220  AIP-1
C21221  CSP
C21241  AIP-2
C21242  AIP-3
C21243  AIP-4
C21245  AgrD1 peptide
D07746  Colistin (INN)
D08401  Polymyxin B (INN)
Reference
PMID:15522865
  Authors
Yamamoto K, Hirao K, Oshima T, Aiba H, Utsumi R, Ishihama A.
  Title
Functional characterization in vitro of all two-component signal transduction systems from Escherichia coli.
  Journal
J Biol Chem 280:1448-56 (2005)
DOI:10.1074/jbc.M410104200
Reference
PMID:16030210
  Authors
Abdel-Fattah WR, Chen Y, Eldakak A, Hulett FM.
  Title
Bacillus subtilis phosphorylated PhoP: direct activation of the E(sigma)A- and repression of the E(sigma)E-responsive phoB-PS+V promoters during pho response.
  Journal
J Bacteriol 187:5166-78 (2005)
DOI:10.1128/JB.187.15.5166-5178.2005
Reference
PMID:15813739
  Authors
Navarre WW, Halsey TA, Walthers D, Frye J, McClelland M, Potter JL, Kenney LJ, Gunn JS, Fang FC, Libby SJ.
  Title
Co-regulation of Salmonella enterica genes required for virulence and resistance to antimicrobial peptides by SlyA and PhoP/PhoQ.
  Journal
Mol Microbiol 56:492-508 (2005)
DOI:10.1111/j.1365-2958.2005.04553.x
Reference
PMID:11973328
  Authors
Cai SJ, Inouye M.
  Title
EnvZ-OmpR interaction and osmoregulation in Escherichia coli.
  Journal
J Biol Chem 277:24155-61 (2002)
DOI:10.1074/jbc.M110715200
Reference
PMID:16077119
  Authors
Batchelor E, Walthers D, Kenney LJ, Goulian M.
  Title
The Escherichia coli CpxA-CpxR envelope stress response system regulates expression of the porins ompF and ompC.
  Journal
J Bacteriol 187:5723-31 (2005)
DOI:10.1128/JB.187.16.5723-5731.2005
Reference
PMID:12107133
  Authors
Nagakubo S, Nishino K, Hirata T, Yamaguchi A.
  Title
The putative response regulator BaeR stimulates multidrug resistance of Escherichia coli via a novel multidrug exporter system, MdtABC.
  Journal
J Bacteriol 184:4161-7 (2002)
DOI:10.1128/JB.184.15.4161-4167.2002
Reference
PMID:15322361
  Authors
Hagiwara D, Yamashino T, Mizuno T.
  Title
A Genome-wide view of the Escherichia coli BasS-BasR two-component system implicated in iron-responses.
  Journal
Biosci Biotechnol Biochem 68:1758-67 (2004)
DOI:10.1271/bbb.68.1758
Reference
PMID:11004187
  Authors
Munson GP, Lam DL, Outten FW, O'Halloran TV.
  Title
Identification of a copper-responsive two-component system on the chromosome of Escherichia coli K-12.
  Journal
J Bacteriol 182:5864-71 (2000)
DOI:10.1128/JB.182.20.5864-5871.2000
Reference
PMID:11929534
  Authors
Sperandio V, Torres AG, Kaper JB.
  Title
Quorum sensing Escherichia coli regulators B and C (QseBC): a novel two-component regulatory system involved in the regulation of flagella and motility by quorum sensing in E. coli.
  Journal
Mol Microbiol 43:809-21 (2002)
DOI:10.1046/j.1365-2958.2002.02803.x
Reference
PMID:14604015
  Authors
Epstein W.
  Title
The roles and regulation of potassium in bacteria.
  Journal
Prog Nucleic Acid Res Mol Biol 75:293-320 (2003)
DOI:10.1016/S0079-6603(03)75008-9
Reference
PMID:10648521
  Authors
Ansaldi M, Simon G, Lepelletier M, Mejean V.
  Title
The TorR high-affinity binding site plays a key role in both torR autoregulation and torCAD operon expression in Escherichia coli.
  Journal
J Bacteriol 182:961-6 (2000)
DOI:10.1128/JB.182.4.961-966.2000
Reference
PMID:15326287
  Authors
Malpica R, Franco B, Rodriguez C, Kwon O, Georgellis D.
  Title
Identification of a quinone-sensitive redox switch in the ArcB sensor kinase.
  Journal
Proc Natl Acad Sci U S A 101:13318-23 (2004)
DOI:10.1073/pnas.0403064101
Reference
PMID:2666399
  Authors
Widenhorn KA, Somers JM, Kay WW.
  Title
Genetic regulation of the tricarboxylate transport operon (tctI) of Salmonella typhimurium.
  Journal
J Bacteriol 171:4436-41 (1989)
DOI:10.1128/JB.171.8.4436-4441.1989
Reference
PMID:11555295
  Authors
Hyyrylainen HL, Bolhuis A, Darmon E, Muukkonen L, Koski P, Vitikainen M, Sarvas M, Pragai Z, Bron S, van Dijl JM, Kontinen VP.
  Title
A novel two-component regulatory system in Bacillus subtilis for the survival of severe secretion stress.
  Journal
Mol Microbiol 41:1159-72 (2001)
DOI:10.1046/j.1365-2958.2001.02576.x
Reference
PMID:10972837
  Authors
Zhang X, Hulett FM.
  Title
ResD signal transduction regulator of aerobic respiration in Bacillus subtilis: ctaA promoter regulation.
  Journal
Mol Microbiol 37:1208-19 (2000)
DOI:10.1046/j.1365-2958.2000.02076.x
Reference
PMID:15937169
  Authors
Senadheera MD, Guggenheim B, Spatafora GA, Huang YC, Choi J, Hung DC, Treglown JS, Goodman SD, Ellen RP, Cvitkovitch DG.
  Title
A VicRK signal transduction system in Streptococcus mutans affects gtfBCD, gbpB, and ftf expression, biofilm formation, and genetic competence development.
  Journal
J Bacteriol 187:4064-76 (2005)
DOI:10.1128/JB.187.12.4064-4076.2005
Reference
PMID:15601704
  Authors
He H, Zahrt TC.
  Title
Identification and characterization of a regulatory sequence recognized by Mycobacterium tuberculosis persistence regulator MprA.
  Journal
J Bacteriol 187:202-12 (2005)
DOI:10.1128/JB.187.1.202-212.2005
Reference
PMID:17448786
  Authors
Hutchings MI
  Title
Unusual two-component signal transduction pathways in the actinobacteria.
  Journal
Adv Appl Microbiol 61:1-26 (2007)
DOI:10.1016/S0065-2164(06)61001-0
Reference
PMID:19308662
  Authors
Kramer R
  Title
Osmosensing and osmosignaling in Corynebacterium glutamicum.
  Journal
Amino Acids 37:487-97 (2009)
DOI:10.1007/s00726-009-0271-6
Reference
PMID:7751278
  Authors
Eraso JM, Kaplan S.
  Title
Oxygen-insensitive synthesis of the photosynthetic membranes of Rhodobacter sphaeroides: a mutant histidine kinase.
  Journal
J Bacteriol 177:2695-706 (1995)
DOI:10.1128/JB.177.10.2695-2706.1995
Reference
PMID:10089160
  Authors
Haydel SE, Dunlap NE, Benjamin WH Jr.
  Title
In vitro evidence of two-component system phosphorylation between the Mycobacterium tuberculosis TrcR/TrcS proteins.
  Journal
Microb Pathog 26:195-206 (1999)
DOI:10.1006/mpat.1998.0265
Reference
PMID:11673427
  Authors
Quisel JD, Burkholder WF, Grossman AD.
  Title
In vivo effects of sporulation kinases on mutant Spo0A proteins in Bacillus subtilis.
  Journal
J Bacteriol 183:6573-8 (2001)
DOI:10.1128/JB.183.22.6573-6578.2001
Reference
PMID:11889485
  Authors
Kaspar S, Bott M.
  Title
The sensor kinase CitA (DpiB) of Escherichia coli functions as a high-affinity citrate receptor.
  Journal
Arch Microbiol 177:313-21 (2002)
DOI:10.1007/s00203-001-0393-z
Reference
PMID:12167640
  Authors
Janausch IG, Garcia-Moreno I, Unden G.
  Title
Function of DcuS from Escherichia coli as a fumarate-stimulated histidine protein kinase in vitro.
  Journal
J Biol Chem 277:39809-14 (2002)
DOI:10.1074/jbc.M204482200
Reference
PMID:8550490
  Authors
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Related
pathway
ges00190  Oxidative phosphorylation
ges00550  Peptidoglycan biosynthesis
ges00910  Nitrogen metabolism
ges02030  Bacterial chemotaxis
ges02040  Flagellar assembly
ges03070  Bacterial secretion system
KO pathway
ko02020   
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