KEGG   PATHWAY: gfr04514
Entry
gfr04514                    Pathway                                
Name
Cell adhesion molecules - Geospiza fortis (medium ground-finch)
Description
Cell adhesion molecules (CAMs) are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, embryogenesis, and development of neuronal tissue. There are four main groups: the integrin family, the immunoglobulin superfamily, selectins, and cadherins. Membrane proteins that mediate immune cell–cell interactions fall into different categories, namely those involved in antigen recognition, costimulation and cellular adhesion. Furthermore cell-cell adhesions are important for brain morphology and highly coordinated brain functions such as memory and learning. During early development of the nervous system, neurons elongate their axons towards their targets and establish and maintain synapses through formation of cell-cell adhesions. Cell-cell adhesions also underpin axon-axon contacts and link neurons with supporting schwann cells and oligodendrocytes.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
gfr04514  Cell adhesion molecules
gfr04514

Other DBs
GO: 0050839
Organism
Geospiza fortis (medium ground-finch) [GN:gfr]
Gene
102034620  CD58; T-cell surface antigen CD2 [KO:K06492]
102040268  CD2; T-cell surface antigen CD2 [KO:K06449]
102034448  IGSF11; immunoglobulin superfamily member 11 [KO:K06791]
102041110  CD80; CD80 molecule [KO:K05412]
102040903  CD274; CD274 molecule [KO:K06745]
102040186  CD28; CD28 molecule [KO:K06470]
102039756  CD86; CD86 molecule [KO:K05413]
102040356  CTLA4; cytotoxic T-lymphocyte associated protein 4 [KO:K06538]
102035985  ICOSLG; inducible T-cell costimulator ligand [KO:K06710]
102040645  ICOS; inducible T-cell costimulator [KO:K06713]
102043437  class II histocompatibility antigen, B-L beta chain-like [KO:K06752]
106632136  HLA class II histocompatibility antigen, DM beta chain-like [KO:K06752]
102032919  HLA class II histocompatibility antigen, DRB1-14 beta chain-like [KO:K06752]
106632040  PRSS1; protease, serine 1 [KO:K10785]
102039868  CD4; T-cell surface glycoprotein CD4 [KO:K06454]
102039800  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
102034923  FCGRT; Fc fragment of IgG receptor and transporter [KO:K06751]
102039671  CD8A; CD8a molecule [KO:K06458]
106632204  T-cell surface glycoprotein CD8 alpha chain-like [KO:K06458]
102037506  CD8B; CD8b molecule [KO:K06459]
102037953  PDCD1LG2; programmed cell death 1 ligand 2 [KO:K06708]
102044995  CD276; CD276 molecule [KO:K06746]
102036468  VTCN1; V-set domain containing T cell activation inhibitor 1 [KO:K06747]
102042563  CD40; CD40 molecule [KO:K03160]
102031951  CD40LG; CD40 ligand [KO:K03161]
102043420  ALCAM; activated leukocyte cell adhesion molecule [KO:K06547]
102032554  CD226; CD226 molecule [KO:K06567]
102035991  ITGB2; integrin subunit beta 2 [KO:K06464]
102035230  PTPRC; protein tyrosine phosphatase, receptor type C [KO:K06478] [EC:3.1.3.48]
102039109  SIGLEC1; sialic acid binding Ig like lectin 1 [KO:K06548]
102043784  NECTIN3; nectin cell adhesion molecule 3 [KO:K06592]
102040961  CLDN34; claudin 34 [KO:K06087]
102036343  CLDN22; claudin-22 [KO:K06087]
102040195  CLDN16; claudin 16 [KO:K06087]
102036295  CLDN2; claudin 2 [KO:K06087]
102031661  CLDN20; claudin 20 [KO:K06087]
102040485  CLDN1; claudin 1 [KO:K06087]
102043287  CLDN11; claudin 11 [KO:K06087]
102043703  CLDN25; claudin 25 [KO:K06087]
102033285  CLDN18; claudin 18 [KO:K06087]
102036998  CLDN4; claudin-4 [KO:K06087]
102033620  claudin-4-like [KO:K06087]
102040401  CLDN19; claudin 19 [KO:K06087]
102040574  claudin-16-like [KO:K06087]
102032339  CLDN10; claudin 10 [KO:K06087]
102042359  CLDN15; claudin 15 [KO:K06087]
102043436  CLDN14; claudin 14 [KO:K06087]
102035780  CLDN12; claudin 12 [KO:K06087]
102033814  OCLN; occludin [KO:K06088]
102031755  F11R; junctional adhesion molecule A [KO:K06089]
102038919  JAM2; junctional adhesion molecule 2 [KO:K06735]
102040403  JAM3; junctional adhesion molecule 3 [KO:K06785]
102038022  ESAM; endothelial cell-selective adhesion molecule [KO:K06787]
102041869  CDH5; cadherin 5 [KO:K06533]
102037837  PECAM1; platelet and endothelial cell adhesion molecule 1 [KO:K06471]
102037994  XG; Xg blood group [KO:K06520]
102038163  CD99; CD99 molecule [KO:K06520]
102042229  CD99L2; CD99 molecule like 2 [KO:K06520]
102044403  TMEM119; transmembrane protein 119 [KO:K06544]
102042252  SELP; P-selectin [KO:K06496]
102045380  ITGA4; integrin subunit alpha 4 [KO:K06483]
102039987  ITGB1; integrin subunit beta 1 [KO:K05719]
102032026  ITGA9; integrin subunit alpha 9 [KO:K06585]
102035627  VCAM1; vascular cell adhesion molecule 1 [KO:K06527]
102034808  TPGS1; tubulin polyglutamylase complex subunit 1 [KO:K06779]
102042074  GLG1; golgi glycoprotein 1 [KO:K06816]
102033226  SELE; selectin E [KO:K06494]
102037014  NECTIN1; nectin cell adhesion molecule 1 [KO:K06081]
102040596  CDH2; cadherin 2 [KO:K06736]
102032403  NCAM1; neural cell adhesion molecule 1 [KO:K06491]
102040342  NCAM2; neural cell adhesion molecule 2 [KO:K06491]
102035412  CADM1; cell adhesion molecule 1 [KO:K06781]
102036836  NEGR1; neuronal growth regulator 1 [KO:K06775]
102041572  NTNG1; netrin G1 [KO:K07522]
102040998  LRRC4C; leucine rich repeat containing 4C [KO:K07523]
102041102  NTNG2; netrin G2 [KO:K16359]
102035485  LRRC4; leucine rich repeat containing 4 [KO:K16351]
102034572  PTPRF; protein tyrosine phosphatase, receptor type F [KO:K05695] [EC:3.1.3.48]
102036081  SDC1; syndecan 1 [KO:K06257]
102033212  SDC2; syndecan 2 [KO:K16336]
102038465  SDC3; syndecan 3 [KO:K16337]
102043527  SDC4; syndecan 4 [KO:K16338]
102036333  ITGAV; integrin subunit alpha V [KO:K06487]
102035625  ITGB8; integrin subunit beta 8 [KO:K06591]
102032097  ITGA8; integrin subunit alpha 8 [KO:K06584]
102042939  NRXN3; neurexin 3 [KO:K07377]
102045085  NRXN1; neurexin 1 [KO:K07377]
102044224  NLGN3; neuroligin 3 [KO:K07378]
102037362  NLGN1; neuroligin 1 [KO:K07378]
102041751  NLGN4X; neuroligin 4, X-linked [KO:K07378]
102032245  PTPRS; protein tyrosine phosphatase, receptor type S [KO:K06778] [EC:3.1.3.48]
102042790  SLITRK1; SLIT and NTRK like family member 1 [KO:K25832]
102045455  SLITRK2; SLIT and NTRK like family member 2 [KO:K25833]
102045624  SLITRK4; SLIT and NTRK like family member 4 [KO:K25835]
102036264  SLITRK5; SLIT and NTRK like family member 5 [KO:K25836]
102036099  SLITRK6; SLIT and NTRK like family member 6 [KO:K25837]
102039192  PTPRD; protein tyrosine phosphatase, receptor type D [KO:K06777] [EC:3.1.3.48]
102044784  SLITRK3; SLIT and NTRK like family member 3 [KO:K25834]
102042833  CADM3; cell adhesion molecule 3 [KO:K06780]
102037064  NRCAM; neuronal cell adhesion molecule [KO:K06756]
102039887  CNTN1; contactin 1 [KO:K06759]
102032628  PTPRM; protein tyrosine phosphatase, receptor type M [KO:K05693] [EC:3.1.3.48]
102041771  CNTN2; contactin 2 [KO:K06760]
102040749  NFASC; neurofascin [KO:K06757]
102042162  CNTNAP1; contactin associated protein 1 [KO:K07379]
102038335  CNTNAP2; contactin associated protein-like 2 [KO:K07380]
102038538  MPZ; myelin protein zero [KO:K06770]
102040110  CDH1; cadherin-1 [KO:K05689]
102042715  ITGA6; integrin subunit alpha 6 [KO:K06485]
102040724  CDH4; cadherin 4 [KO:K06797]
102040282  NEO1; neogenin 1 [KO:K06766]
Reference
PMID:14690046
  Authors
Barclay AN.
  Title
Membrane proteins with immunoglobulin-like domains--a master superfamily of interaction molecules.
  Journal
Semin Immunol 15:215-23 (2003)
DOI:10.1016/S1044-5323(03)00047-2
Reference
PMID:11910893
  Authors
Sharpe AH, Freeman GJ.
  Title
The B7-CD28 superfamily.
  Journal
Nat Rev Immunol 2:116-26 (2002)
DOI:10.1038/nri727
Reference
PMID:9597126
  Authors
Grewal IS, Flavell RA.
  Title
CD40 and CD154 in cell-mediated immunity.
  Journal
Annu Rev Immunol 16:111-35 (1998)
DOI:10.1146/annurev.immunol.16.1.111
Reference
PMID:16034094
  Authors
Dardalhon V, Schubart AS, Reddy J, Meyers JH, Monney L, Sabatos CA, Ahuja R, Nguyen K, Freeman GJ, Greenfield EA, Sobel RA, Kuchroo VK.
  Title
CD226 is specifically expressed on the surface of Th1 cells and regulates their expansion and effector functions.
  Journal
J Immunol 175:1558-65 (2005)
DOI:10.4049/jimmunol.175.3.1558
Reference
PMID:12234363
  Authors
Montoya MC, Sancho D, Vicente-Manzanares M, Sanchez-Madrid F.
  Title
Cell adhesion and polarity during immune interactions.
  Journal
Immunol Rev 186:68-82 (2002)
DOI:10.1034/j.1600-065X.2002.18607.x
Reference
PMID:15071551
  Authors
Dejana E.
  Title
Endothelial cell-cell junctions: happy together.
  Journal
Nat Rev Mol Cell Biol 5:261-70 (2004)
DOI:10.1038/nrm1357
Reference
PMID:14519386
  Authors
Bazzoni G.
  Title
The JAM family of junctional adhesion molecules.
  Journal
Curr Opin Cell Biol 15:525-30 (2003)
DOI:10.1016/S0955-0674(03)00104-2
Reference
PMID:10798271
  Authors
Becker BF, Heindl B, Kupatt C, Zahler S.
  Title
Endothelial function and hemostasis.
  Journal
Z Kardiol 89:160-7 (2000)
DOI:10.1007/PL00007320
Reference
PMID:9150551
  Authors
Elangbam CS, Qualls CW Jr, Dahlgren RR.
  Title
Cell adhesion molecules--update.
  Journal
Vet Pathol 34:61-73 (1997)
DOI:10.1177/030098589703400113
Reference
PMID:12810109
  Authors
Muller WA.
  Title
Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response.
  Journal
Trends Immunol 24:327-34 (2003)
DOI:10.1016/S1471-4906(03)00117-0
Reference
PMID:14519398
  Authors
Yamagata M, Sanes JR, Weiner JA.
  Title
Synaptic adhesion molecules.
  Journal
Curr Opin Cell Biol 15:621-32 (2003)
DOI:10.1016/S0955-0674(03)00107-8
Reference
PMID:15882774
  Authors
Ethell IM, Pasquale EB.
  Title
Molecular mechanisms of dendritic spine development and remodeling.
  Journal
Prog Neurobiol 75:161-205 (2005)
DOI:10.1016/j.pneurobio.2005.02.003
Reference
PMID:11050419
  Authors
Benson DL, Schnapp LM, Shapiro L, Huntley GW.
  Title
Making memories stick: cell-adhesion molecules in synaptic plasticity.
  Journal
Trends Cell Biol 10:473-82 (2000)
DOI:10.1016/S0962-8924(00)01838-9
Reference
PMID:11860281
  Authors
Rosdahl JA, Mourton TL, Brady-Kalnay SM.
  Title
Protein kinase C delta (PKCdelta) is required for protein tyrosine phosphatase mu (PTPmu)-dependent neurite outgrowth.
  Journal
Mol Cell Neurosci 19:292-306 (2002)
DOI:10.1006/mcne.2001.1071
Reference
PMID:10964748
  Authors
Dunican DJ, Doherty P.
  Title
The generation of localized calcium rises mediated by cell adhesion molecules and their role in neuronal growth cone motility.
  Journal
Mol Cell Biol Res Commun 3:255-63 (2000)
DOI:10.1006/mcbr.2000.0225
Reference
PMID:12367625
  Authors
Girault JA, Peles E.
  Title
Development of nodes of Ranvier.
  Journal
Curr Opin Neurobiol 12:476-85 (2002)
DOI:10.1016/S0959-4388(02)00370-7
Reference
PMID:10664064
  Authors
Arroyo EJ, Scherer SS.
  Title
On the molecular architecture of myelinated fibers.
  Journal
Histochem Cell Biol 113:1-18 (2000)
DOI:10.1007/s004180050001
Reference
PMID:14556710
  Authors
Salzer JL.
  Title
Polarized domains of myelinated axons.
  Journal
Neuron 40:297-318 (2003)
DOI:10.1016/S0896-6273(03)00628-7
Reference
PMID:15561584
  Authors
Irie K, Shimizu K, Sakisaka T, Ikeda W, Takai Y.
  Title
Roles and modes of action of nectins in cell-cell adhesion.
  Journal
Semin Cell Dev Biol 15:643-56 (2004)
DOI:10.1016/j.semcdb.2004.09.002
Reference
PMID:15551862
  Authors
Nakanishi H, Takai Y.
  Title
Roles of nectins in cell adhesion, migration and polarization.
  Journal
Biol Chem 385:885-92 (2004)
DOI:10.1515/BC.2004.116
Reference
PMID:15115723
  Authors
Siu MK, Cheng CY.
  Title
Extracellular matrix: recent advances on its role in junction dynamics in the seminiferous epithelium during spermatogenesis.
  Journal
Biol Reprod 71:375-91 (2004)
DOI:10.1095/biolreprod.104.028225
Reference
PMID:15056568
  Authors
Lee NP, Cheng CY.
  Title
Adaptors, junction dynamics, and spermatogenesis.
  Journal
Biol Reprod 71:392-404 (2004)
DOI:10.1095/biolreprod.104.027268
Reference
PMID:15728677
  Authors
Inagaki M, Irie K, Ishizaki H, Tanaka-Okamoto M, Morimoto K, Inoue E, Ohtsuka T, Miyoshi J, Takai Y.
  Title
Roles of cell-adhesion molecules nectin 1 and nectin 3 in ciliary body development.
  Journal
Development 132:1525-37 (2005)
DOI:10.1242/dev.01697
Reference
PMID:12500939
  Authors
Marthiens V, Gavard J, Lambert M, Mege RM.
  Title
Cadherin-based cell adhesion in neuromuscular development.
  Journal
Biol Cell 94:315-26 (2002)
DOI:10.1016/S0248-4900(02)00005-9
Reference
PMID:15923648
  Authors
Krauss RS, Cole F, Gaio U, Takaesu G, Zhang W, Kang JS.
  Title
Close encounters: regulation of vertebrate skeletal myogenesis by cell-cell contact.
  Journal
J Cell Sci 118:2355-62 (2005)
DOI:10.1242/jcs.02397
Related
pathway
gfr04520  Adherens junction
gfr04530  Tight junction
KO pathway
ko04514   
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