KEGG   PATHWAY: hqd02010
Entry
hqd02010                    Pathway                                
Name
ABC transporters - Halomonas qaidamensis
Description
The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
Class
Environmental Information Processing; Membrane transport
Pathway map
hqd02010  ABC transporters
hqd02010

Other DBs
GO: 0043190 0043191 0043192
TC: 3.A.1
Organism
Halomonas qaidamensis [GN:hqd]
Gene
K1Y77_05655  cysP; thiosulfate ABC transporter substrate-binding protein CysP [KO:K02048]
K1Y77_05650  cysT; sulfate ABC transporter permease subunit CysT [KO:K02046]
K1Y77_05645  cysW; sulfate ABC transporter permease subunit CysW [KO:K02047]
K1Y77_05640  TOBE-like domain-containing protein [KO:K02045] [EC:7.3.2.3]
K1Y77_10630  substrate-binding domain-containing protein [KO:K05772]
K1Y77_10620  ABC transporter permease [KO:K05773]
K1Y77_10625  ATP-binding cassette domain-containing protein [KO:K06857] [EC:7.3.2.6]
K1Y77_08020  ABC transporter substrate-binding protein [KO:K15598]
K1Y77_13355  modA; molybdate ABC transporter substrate-binding protein [KO:K02020]
K1Y77_13350  modB; molybdate ABC transporter permease subunit [KO:K02018]
K1Y77_13345  ABC transporter ATP-binding protein [KO:K02017] [EC:7.3.2.5]
K1Y77_14240  putative 2-aminoethylphosphonate ABC transporter substrate-binding protein [KO:K02012]
K1Y77_15820  ABC transporter substrate-binding protein [KO:K02012]
K1Y77_02575  Fe(3+) ABC transporter substrate-binding protein [KO:K02012]
K1Y77_14230  putative 2-aminoethylphosphonate ABC transporter permease subunit [KO:K02011]
K1Y77_15825  iron ABC transporter permease [KO:K02011]
K1Y77_02585  iron ABC transporter permease [KO:K02011]
K1Y77_14235  putative 2-aminoethylphosphonate ABC transporter ATP-binding protein [KO:K02010] [EC:7.2.2.7]
K1Y77_15830  ABC transporter ATP-binding protein [KO:K02010] [EC:7.2.2.7]
K1Y77_02580  ABC transporter ATP-binding protein [KO:K02010] [EC:7.2.2.7]
K1Y77_05535  polyamine ABC transporter substrate-binding protein [KO:K11073]
K1Y77_05550  ABC transporter permease subunit [KO:K11074]
K1Y77_05545  ABC transporter permease subunit [KO:K11075]
K1Y77_05540  potA; polyamine ABC transporter ATP-binding protein [KO:K11076] [EC:7.6.2.16]
K1Y77_12785  glycine betaine ABC transporter substrate-binding protein [KO:K02002]
K1Y77_09300  choline ABC transporter substrate-binding protein [KO:K02002]
K1Y77_10720  ABC transporter substrate-binding protein [KO:K02002]
K1Y77_12780  proline/glycine betaine ABC transporter permease [KO:K02001]
K1Y77_12775  glycine betaine/L-proline ABC transporter ATP-binding protein [KO:K02000] [EC:7.6.2.9]
K1Y77_07850  ABC transporter substrate-binding protein [KO:K05845]
K1Y77_07865  ABC transporter permease [KO:K05846]
K1Y77_07855  ABC transporter permease [KO:K05846]
K1Y77_07860  ABC transporter ATP-binding protein [KO:K05847] [EC:7.6.2.9]
K1Y77_06615  malE; maltose/maltodextrin ABC transporter substrate-binding protein MalE [KO:K10108]
K1Y77_06610  malF; maltose ABC transporter permease MalF [KO:K10109]
K1Y77_06605  malG; maltose ABC transporter permease MalG [KO:K10110]
K1Y77_06545  ugpC; sn-glycerol-3-phosphate ABC transporter ATP-binding protein UgpC [KO:K10111] [EC:7.5.2.-]
K1Y77_06505  ugpC; sn-glycerol-3-phosphate ABC transporter ATP-binding protein UgpC [KO:K10111] [EC:7.5.2.-]
K1Y77_04895  ABC transporter ATP-binding protein [KO:K10112] [EC:7.5.2.-]
K1Y77_06525  ABC transporter substrate-binding protein [KO:K10236]
K1Y77_06520  sugar ABC transporter permease [KO:K10237]
K1Y77_06515  carbohydrate ABC transporter permease [KO:K10238]
K1Y77_10190  ABC transporter substrate-binding protein [KO:K07323]
K1Y77_10195  mlaD; outer membrane lipid asymmetry maintenance protein MlaD [KO:K02067]
K1Y77_07895  MlaD family protein [KO:K02067]
K1Y77_10200  mlaE; lipid asymmetry maintenance ABC transporter permease subunit MlaE [KO:K02066]
K1Y77_07905  ABC transporter permease [KO:K02066]
K1Y77_10185  STAS domain-containing protein [KO:K07122]
K1Y77_10205  ATP-binding cassette domain-containing protein [KO:K02065]
K1Y77_07900  ATP-binding cassette domain-containing protein [KO:K02065]
K1Y77_04880  ABC transporter substrate-binding protein [KO:K17315]
K1Y77_04885  sugar ABC transporter permease [KO:K17316]
K1Y77_04890  carbohydrate ABC transporter permease [KO:K17317]
K1Y77_14625  sugar ABC transporter substrate-binding protein [KO:K10439]
K1Y77_14615  ABC transporter permease [KO:K10440]
K1Y77_14620  ABC transporter permease [KO:K10440]
K1Y77_14610  sugar ABC transporter ATP-binding protein [KO:K10441] [EC:7.5.2.7]
K1Y77_09350  ABC transporter substrate-binding protein [KO:K17321]
K1Y77_09335  sugar ABC transporter permease [KO:K17322]
K1Y77_09340  carbohydrate ABC transporter permease [KO:K17323]
K1Y77_09325  ABC transporter ATP-binding protein [KO:K17324]
K1Y77_09330  ABC transporter ATP-binding protein [KO:K17325]
K1Y77_15760  ABC transporter substrate-binding protein [KO:K05813]
K1Y77_01245  ugpB; sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB [KO:K05813]
K1Y77_15765  sugar ABC transporter permease [KO:K05814]
K1Y77_01240  ugpA; sn-glycerol-3-phosphate ABC transporter permease UgpA [KO:K05814]
K1Y77_15770  carbohydrate ABC transporter permease [KO:K05815]
K1Y77_01235  ugpE; sn-glycerol-3-phosphate ABC transporter permease UgpE [KO:K05815]
K1Y77_15755  ABC transporter ATP-binding protein [KO:K05816] [EC:7.6.2.10]
K1Y77_01230  sn-glycerol-3-phosphate import ATP-binding protein UgpC [KO:K05816] [EC:7.6.2.10]
K1Y77_16590  phosphate ABC transporter substrate-binding protein [KO:K02040]
K1Y77_05965  substrate-binding domain-containing protein [KO:K02040]
K1Y77_16595  ABC transporter permease subunit [KO:K02037]
K1Y77_05970  pstC; phosphate ABC transporter permease subunit PstC [KO:K02037]
K1Y77_16600  pstA; phosphate ABC transporter permease PstA [KO:K02038]
K1Y77_05975  pstA; phosphate ABC transporter permease PstA [KO:K02038]
K1Y77_16605  pstB; phosphate ABC transporter ATP-binding protein PstB [KO:K02036] [EC:7.3.2.1]
K1Y77_05980  pstB; phosphate ABC transporter ATP-binding protein PstB [KO:K02036] [EC:7.3.2.1]
K1Y77_16060  phnD; phosphate/phosphite/phosphonate ABC transporter substrate-binding protein [KO:K02044]
K1Y77_16045  phnE; phosphonate ABC transporter, permease protein PhnE [KO:K02042]
K1Y77_16050  phnE; phosphonate ABC transporter, permease protein PhnE [KO:K02042]
K1Y77_16055  phnC; phosphonate ABC transporter ATP-binding protein [KO:K02041] [EC:7.3.2.2]
K1Y77_16910  transporter substrate-binding domain-containing protein [KO:K10036]
K1Y77_16905  amino acid ABC transporter permease [KO:K10037]
K1Y77_16900  amino acid ABC transporter ATP-binding protein [KO:K10038] [EC:7.4.2.1]
K1Y77_15395  amino acid ABC transporter substrate-binding protein [KO:K09969]
K1Y77_15400  amino acid ABC transporter substrate-binding protein [KO:K09969]
K1Y77_15405  amino acid ABC transporter permease [KO:K09970]
K1Y77_15410  amino acid ABC transporter permease [KO:K09971]
K1Y77_15415  amino acid ABC transporter ATP-binding protein [KO:K09972] [EC:7.4.2.1]
K1Y77_11975  transporter substrate-binding domain-containing protein [KO:K10022]
K1Y77_11980  transporter substrate-binding domain-containing protein [KO:K10022]
K1Y77_11970  ABC transporter permease [KO:K10023]
K1Y77_11965  ABC transporter permease [KO:K10024]
K1Y77_11960  ATP-binding cassette domain-containing protein [KO:K10025] [EC:7.4.2.1]
K1Y77_00780  ABC transporter substrate-binding protein [KO:K01999]
K1Y77_06125  ABC transporter substrate-binding protein [KO:K01999]
K1Y77_09550  ABC transporter substrate-binding protein [KO:K01999]
K1Y77_00790  branched-chain amino acid ABC transporter permease [KO:K01997]
K1Y77_09545  branched-chain amino acid ABC transporter permease [KO:K01997]
K1Y77_09540  branched-chain amino acid ABC transporter permease [KO:K01998]
K1Y77_00785  branched-chain amino acid ABC transporter permease [KO:K01998]
K1Y77_00800  ABC transporter ATP-binding protein [KO:K01995]
K1Y77_09560  ABC transporter ATP-binding protein [KO:K01995]
K1Y77_00795  ABC transporter ATP-binding protein [KO:K01996]
K1Y77_09555  ABC transporter ATP-binding protein [KO:K01996]
K1Y77_07375  MetQ/NlpA family ABC transporter substrate-binding protein [KO:K02073]
K1Y77_07380  ABC transporter permease [KO:K02072]
K1Y77_07385  methionine ABC transporter ATP-binding protein [KO:K02071]
K1Y77_15260  urtA; urea ABC transporter substrate-binding protein [KO:K11959]
K1Y77_15255  urtB; urea ABC transporter permease subunit UrtB [KO:K11960]
K1Y77_15250  urtC; urea ABC transporter permease subunit UrtC [KO:K11961]
K1Y77_15245  urtD; urea ABC transporter ATP-binding protein UrtD [KO:K11962]
K1Y77_15240  urtE; urea ABC transporter ATP-binding subunit UrtE [KO:K11963]
K1Y77_07950  extracellular solute-binding protein [KO:K13893]
K1Y77_07945  microcin C ABC transporter permease YejB [KO:K13894]
K1Y77_07940  ABC transporter permease [KO:K13895]
K1Y77_07935  dipeptide ABC transporter ATP-binding protein [KO:K13896]
K1Y77_15200  iron-siderophore ABC transporter substrate-binding protein [KO:K25286]
K1Y77_12715  ABC transporter substrate-binding protein [KO:K25286]
K1Y77_12710  iron ABC transporter permease [KO:K23186]
K1Y77_15205  iron ABC transporter permease [KO:K23186]
K1Y77_12705  iron ABC transporter permease [KO:K23187]
K1Y77_15210  iron chelate uptake ABC transporter family permease subunit [KO:K23187]
K1Y77_12695  ABC transporter ATP-binding protein [KO:K23188] [EC:7.2.2.17 7.2.2.-]
K1Y77_16130  ABC transporter substrate-binding protein [KO:K23227]
K1Y77_03980  fhuB; Fe(3+)-hydroxamate ABC transporter permease FhuB [KO:K23228]
K1Y77_03975  ATP-binding cassette domain-containing protein [KO:K10829] [EC:7.2.2.16]
K1Y77_09255  metal ABC transporter permease [KO:K19976]
K1Y77_09505  zinc ABC transporter substrate-binding protein [KO:K09815]
K1Y77_09515  metal ABC transporter permease [KO:K09816]
K1Y77_09510  ATP-binding cassette domain-containing protein [KO:K09817] [EC:7.2.2.20]
K1Y77_11250  chain-length determining protein [KO:K10107]
K1Y77_11255  ABC transporter permease [KO:K09688]
K1Y77_11230  ATP-binding cassette domain-containing protein [KO:K09689] [EC:7.6.2.12]
K1Y77_09970  lipoprotein-releasing ABC transporter permease subunit [KO:K09808]
K1Y77_09965  ATP-binding cassette domain-containing protein [KO:K09810] [EC:7.6.2.-]
K1Y77_03610  heme ABC transporter permease [KO:K02195]
K1Y77_03605  ccmB; heme exporter protein CcmB [KO:K02194]
K1Y77_03600  ccmA; cytochrome c biogenesis heme-transporting ATPase CcmA [KO:K02193] [EC:7.6.2.5]
K1Y77_02910  lptF; LPS export ABC transporter permease LptF [KO:K07091]
K1Y77_02915  lptG; LPS export ABC transporter permease LptG [KO:K11720]
K1Y77_10230  lptB; LPS export ABC transporter ATP-binding protein [KO:K06861] [EC:7.5.2.5]
K1Y77_02260  ftsX; permease-like cell division protein FtsX [KO:K09811]
K1Y77_02255  ftsE; cell division ATP-binding protein FtsE [KO:K09812]
K1Y77_09950  msbA; lipid A export permease/ATP-binding protein MsbA [KO:K11085] [EC:7.5.2.6]
K1Y77_12450  ABC transporter ATP-binding protein/permease [KO:K18893]
K1Y77_11660  type I secretion system permease/ATPase [KO:K12541]
K1Y77_02875  type I secretion system permease/ATPase [KO:K12541]
K1Y77_07605  cydC; thiol reductant ABC exporter subunit CydC [KO:K16012]
K1Y77_07600  cydD; thiol reductant ABC exporter subunit CydD [KO:K16013]
Compound
C00009  Orthophosphate
C00025  L-Glutamate
C00031  D-Glucose
C00032  Heme
C00034  Manganese
C00037  Glycine
C00038  Zinc cation
C00041  L-Alanine
C00047  L-Lysine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00062  L-Arginine
C00064  L-Glutamine
C00065  L-Serine
C00070  Copper
C00077  L-Ornithine
C00079  L-Phenylalanine
C00086  Urea
C00088  Nitrite
C00089  Sucrose
C00093  sn-Glycerol 3-phosphate
C00095  D-Fructose
C00098  Oligopeptide
C00107  Dipeptide
C00114  Choline
C00116  Glycerol
C00120  Biotin
C00121  D-Ribose
C00123  L-Leucine
C00134  Putrescine
C00135  L-Histidine
C00137  myo-Inositol
C00140  N-Acetyl-D-glucosamine
C00148  L-Proline
C00151  L-Amino acid
C00159  D-Mannose
C00175  Cobalt ion
C00181  D-Xylose
C00183  L-Valine
C00185  Cellobiose
C00188  L-Threonine
C00208  Maltose
C00212  Adenosine
C00243  Lactose
C00244  Nitrate
C00245  Taurine
C00255  Riboflavin
C00259  L-Arabinose
C00288  HCO3-
C00291  Nickel
C00294  Inosine
C00299  Uridine
C00315  Spermidine
C00320  Thiosulfate
C00330  Deoxyguanosine
C00333  D-Galacturonate
C00338  Lipopolysaccharide
C00378  Thiamine
C00379  Xylitol
C00387  Guanosine
C00392  Mannitol
C00407  L-Isoleucine
C00430  5-Aminolevulinate
C00470  Pectate
C00475  Cytidine
C00487  Carnitine
C00491  L-Cystine
C00492  Raffinose
C00503  Erythritol
C00526  Deoxyuridine
C00559  Deoxyadenosine
C00719  Betaine
C00794  D-Sorbitol
C00855  D-Methionine
C00865  Phospholipid
C00881  Deoxycytidine
C00919  Choline sulfate
C00973  Cyclomaltodextrin
C01083  alpha,alpha-Trehalose
C01153  Orthophosphoric monoester
C01157  Hydroxyproline
C01177  Inositol 1-phosphate
C01181  4-Trimethylammoniobutanoate
C01279  4-Amino-5-hydroxymethyl-2-methylpyrimidine
C01330  Sodium cation
C01417  Cyanate
C01487  D-Allose
C01606  Phthalate
C01630  Xylobiose
C01667  Bacitracin
C01674  Chitobiose
C01682  Nopaline
C01684  D-Rhamnose
C01762  Xanthosine
C01834  Lipoprotein
C01835  Maltotriose
C01935  Maltodextrin
C01946  Oleandomycin
C02160  Isomaltotriose
C02273  Digalacturonate
C03557  2-Aminoethylphosphonate
C03611  Galactose oligosaccharide
C03619  Methyl beta-D-galactoside
C04114  (E)-4-(Trimethylammonio)but-2-enoate
C04137  Octopine
C05349  Ciprofloxacin
C05402  Melibiose
C05512  Deoxyinosine
C05776  Vitamin B12
C06227  Fe(III)hydroxamate
C06229  Fe(III)dicitrate
C06230  Fe-enterobactin
C06232  Molybdate
C06687  Norfloxacin
C06705  Capsular polysaccharide
C06706  Lipo-oligosaccharide
C06707  Teichoic acid
C06767  Hemine
C07662  Sparfloxacin
C07663  Moxifloxacin
C11612  Polymyxin B
C13768  Colistin sulfate
C14818  Fe2+
C14819  Fe3+
C15521  Alkanesulfonate
C15719  Coelichelin
C16421  AI-2
C16692  Mannopine
C19609  Nickel(2+)
C19872  N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20570  alpha-1,5-L-Arabinobiose
C20571  alpha-1,5-L-Arabinotriose
C20572  alpha-1,5-L-Arabinotetraose
C20573  Aldotetraouronic acid
C20679  Tungstate
C21066  D-Galactofuranose
C22040  S-Methyl-L-cysteine
G00457  Maltotetraose
Reference
PMID:9799792
  Authors
Tomii K, Kanehisa M.
  Title
A comparative analysis of ABC transporters in complete microbial genomes.
  Journal
Genome Res 8:1048-59 (1998)
DOI:10.1101/gr.8.10.1048
Reference
PMID:18424520
  Authors
Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A
  Title
Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
J Bacteriol 190:4460-9 (2008)
DOI:10.1128/JB.00270-08
Reference
PMID:18375759
  Authors
Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ
  Title
Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
Proc Natl Acad Sci U S A 105:5537-42 (2008)
DOI:10.1073/pnas.0801196105
Reference
PMID:10557362
  Authors
Omata T, Price GD, Badger MR, Okamura M, Gohta S, Ogawa T
  Title
Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942.
  Journal
Proc Natl Acad Sci U S A 96:13571-6 (1999)
DOI:10.1073/pnas.96.23.13571
Reference
PMID:11731493
  Authors
Quintero MJ, Montesinos ML, Herrero A, Flores E
  Title
Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence.
  Journal
Genome Res 11:2034-40 (2001)
DOI:10.1101/gr.196301
Reference
PMID:16135226
  Authors
Picossi S, Montesinos ML, Pernil R, Lichtle C, Herrero A, Flores E
  Title
ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.
  Journal
Mol Microbiol 57:1582-92 (2005)
DOI:10.1111/j.1365-2958.2005.04791.x
Reference
PMID:11929526
  Authors
Valladares A, Montesinos ML, Herrero A, Flores E.
  Title
An ABC-type, high-affinity urea permease identified in cyanobacteria.
  Journal
Mol Microbiol 43:703-15 (2002)
DOI:10.1046/j.1365-2958.2002.02778.x
Reference
PMID:18326572
  Authors
Richard-Fogal CL, Frawley ER, Kranz RG
  Title
Topology and function of CcmD in cytochrome c maturation.
  Journal
J Bacteriol 190:3489-93 (2008)
DOI:10.1128/JB.00146-08
Reference
PMID:16109926
  Authors
Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H
  Title
The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
  Journal
J Bacteriol 187:5861-7 (2005)
DOI:10.1128/JB.187.17.5861-5867.2005
Reference
PMID:17873039
  Authors
Novikova M, Metlitskaya A, Datsenko K, Kazakov T, Kazakov A, Wanner B, Severinov K
  Title
The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C.
  Journal
J Bacteriol 189:8361-5 (2007)
DOI:10.1128/JB.01028-07
Reference
PMID:17214741
  Authors
Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI
  Title
Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.
  Journal
Mol Microbiol 63:895-910 (2007)
DOI:10.1111/j.1365-2958.2006.05549.x
Reference
PMID:18805970
  Authors
Yamanaka H, Kobayashi H, Takahashi E, Okamoto K
  Title
MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II.
  Journal
J Bacteriol 190:7693-8 (2008)
DOI:10.1128/JB.00853-08
KO pathway
ko02010   
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